Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Indian hedgehog protein (IHH, MEROPS identifier C46.003) is important for the development and growth of bone and cartilage in the embryo []. IHH is synthesized as a precursor and activates itself by cleavage of Gly-Cys bond, in which the thiol group of the cysteine is the nucleophile []. This results in the release of the N-terminal effector domain, and no further proteolytic activity takes place. The differentiation of chondrocytes in embryonic mouse limbs, induction of the expression of nodal in the lateral plate mesoderm of early chick embryos, and affinities for hedgehog-binding proteins have been compared for Sonic, Indian and Desert hedgehog proteins []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Valentini RP |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Post-translational processing and renal expression of mouse Indian hedgehog. |
Volume: |
272 |
Issue: |
13 |
Pages: |
8466-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vortkamp A |
Year: |
1996 |
Journal: |
Science |
Title: |
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. |
Volume: |
273 |
Issue: |
5275 |
Pages: |
613-22 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
411
 |
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447304 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-01-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:5447314 |
Age: |
embryonic day 12.0 |
Image: |
1A ihh |
|
Specimen Label: |
1A ihh |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447304 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-01-02 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3262326 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:5447314 |
Age: |
embryonic day 18.0 |
Image: |
2A ihh |
Note: |
Expression restricted to mature and early hypertrophic chondrocytes. |
Specimen Label: |
2A ihh |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447304 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-01-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3550628 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:5447314 |
Age: |
postnatal week 10 |
Image: |
2D ihh |
Note: |
Expression restricted to mature and early hypertrophic chondrocytes of the growth plate. |
Specimen Label: |
2D ihh |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447304 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-01-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3262622 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5447314 |
Age: |
embryonic day 14.5 |
Image: |
1C ihh |
Note: |
Expression restricted to mature and early hypertrophic chondrocytes. |
Specimen Label: |
1C ihh |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447304 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-01-02 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:5447314 |
Age: |
postnatal week 10 |
Image: |
2D ihh |
Note: |
Very low levels of expression detected in secondary ossification center. |
Specimen Label: |
2D ihh |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3043194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-06-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914326 |
|
Stage: |
TS26 |
Assay Id: |
MGI:3043265 |
Age: |
embryonic day 18.5 |
Image: |
8 -/- femur Ihh |
|
Specimen Label: |
8 -/- femur Ihh |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742821 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:5446498 |
Age: |
embryonic day 13.5 |
Image: |
4 Ihh 13.5 spdh/spdh |
|
Specimen Label: |
4 Ihh 13.5 spdh/spdh |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742822 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:5446498 |
Age: |
embryonic day 14.5 |
Image: |
4 Ihh 14.5 wt |
|
Specimen Label: |
4 Ihh 14.5 wt |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742822 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5446498 |
Age: |
embryonic day 14.5 |
Image: |
4 Ihh 14.5 spdh/spdh |
Note: |
Expression domains partially fused with each other. |
Specimen Label: |
4 Ihh 14.5 spdh/spdh |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742824 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:5446498 |
Age: |
embryonic day 16.5 |
Image: |
4 Ihh 16.5 wt |
|
Specimen Label: |
4 Ihh 16.5 wt |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742824 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:5446498 |
Age: |
embryonic day 16.5 |
Image: |
4 Ihh 16.5 spdh/spdh |
Note: |
Expression was completely absent, except for digit 1 and distal phalanges that were somewhat spared. |
Specimen Label: |
4 Ihh 16.5 spdh/spdh |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3539127 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:5446498 |
Age: |
postnatal newborn |
Image: |
4 Ihh Newborn wt |
|
Specimen Label: |
4 Ihh Newborn wt |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7789030 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-12-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745822 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7790593 |
Age: |
embryonic day 14.5 |
Image: |
S2A Ihh WT |
|
Specimen Label: |
S2A Ihh WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7789030 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-12-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745822 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7790593 |
Age: |
embryonic day 14.5 |
Image: |
S2A Ihh Opt-/- |
Note: |
Chondrocyte organization and maturation appears normal. |
Specimen Label: |
S2A Ihh Opt-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2158649 |
Assay Type: |
RNA in situ |
Annotation Date: |
2002-05-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1815522 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:2178838 |
Age: |
embryonic day 14.5 |
Image: |
5 Ihh E14.5 WT |
Note: |
Expression was present in prehypertrophic chondrocytes. |
Specimen Label: |
5 Ihh E14.5 WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2158649 |
Assay Type: |
RNA in situ |
Annotation Date: |
2002-05-09 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1815522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:2178838 |
Age: |
embryonic day 14.5 |
Image: |
5 Ihh E14.5 Ihh |
|
Specimen Label: |
5 Ihh E14.5 Ihh |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2158649 |
Assay Type: |
RNA in situ |
Annotation Date: |
2002-05-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1815522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:2178838 |
Age: |
embryonic day 14.5 |
Image: |
5 Ihh E14.5 Cre10;Smo |
Note: |
Expression was present in prehypertrophic chondrocytes similar to wild type. |
Specimen Label: |
5 Ihh E14.5 Cre10;Smo |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3263921 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:5446498 |
Age: |
embryonic day 13.5 |
Image: |
4 Ihh 13.5 wt |
Note: |
Expression in pre-hypertrophic chondrocytes and also in digital anlagen. Expression at three sites in each phalangeal anlagen. |
Specimen Label: |
4 Ihh 13.5 wt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3539227 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:5446498 |
Age: |
postnatal newborn |
Image: |
4 Ihh Newborn spdh/spdh |
Note: |
Expression at sides of bones in ectopic areas of ossification. |
Specimen Label: |
4 Ihh Newborn spdh/spdh |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2158649 |
Assay Type: |
RNA in situ |
Annotation Date: |
2002-05-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914226 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:2178838 |
Age: |
embryonic day 18.5 |
Image: |
5 Ihh E18.5 WT |
|
Specimen Label: |
5 Ihh E18.5 WT |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3043194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-06-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914226 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:3043265 |
Age: |
embryonic day 18.5 |
Image: |
8 +/+ tibia Ihh |
Note: |
Expression was detected in prehypertrophic and hypertrophic chondrocytes but was weak in terminal hypertrophic chondrocytes. |
Specimen Label: |
8 +/+ tibia Ihh |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3043194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-06-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914226 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:3043265 |
Age: |
embryonic day 18.5 |
Image: |
8 -/- tibia Ihh |
Note: |
Expression was detected in prehypertrophic and hypertrophic chondrocytes but was weak in terminal hypertrophic chondrocytes. |
Specimen Label: |
8 -/- tibia Ihh |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2158649 |
Assay Type: |
RNA in situ |
Annotation Date: |
2002-05-09 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914226 |
|
Stage: |
TS26 |
Assay Id: |
MGI:2178838 |
Age: |
embryonic day 18.5 |
Image: |
5 Ihh E18.5 Ihh |
|
Specimen Label: |
5 Ihh E18.5 Ihh |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2158649 |
Assay Type: |
RNA in situ |
Annotation Date: |
2002-05-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914226 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:2178838 |
Age: |
embryonic day 18.5 |
Image: |
5 Ihh E18.5 Cre10;Smo |
Note: |
Expression was maintained along the longitudinal axis of the tibia similar to the wild type. |
Specimen Label: |
5 Ihh E18.5 Cre10;Smo |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pathi S |
Year: |
2001 |
Journal: |
Mech Dev |
Title: |
Comparative biological responses to human Sonic, Indian, and Desert hedgehog. |
Volume: |
106 |
Issue: |
1-2 |
Pages: |
107-17 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
449
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Long F |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Independent regulation of skeletal growth by Ihh and IGF signaling. |
Volume: |
298 |
Issue: |
1 |
Pages: |
327-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugito H |
Year: |
2011 |
Journal: |
J Dent Res |
Title: |
Ihh signaling regulates mandibular symphysis development and growth. |
Volume: |
90 |
Issue: |
5 |
Pages: |
625-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koziel L |
Year: |
2005 |
Journal: |
Development |
Title: |
Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. |
Volume: |
132 |
Issue: |
23 |
Pages: |
5249-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li S |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Knockdown Indian Hedgehog (Ihh) does not delay Fibular Fracture Healing in genetic deleted Ihh mice and pharmaceutical inhibited Ihh Mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
10351 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piao J |
Year: |
2013 |
Journal: |
Sci Rep |
Title: |
Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. |
Volume: |
3 |
|
Pages: |
3022 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1910624 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:3687194 |
Age: |
embryonic day 16.5 |
|
Note: |
Expression was in the core of the humerus and lining the bone collar. |
Specimen Label: |
7 Ihh top |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6459909 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1910623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6459913 |
Age: |
embryonic day 15.5 |
|
Note: |
Most expression localized to prehypertrophic zone. |
Specimen Label: |
2C IHH WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7310473 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-07-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3550523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7310480 |
Age: |
embryonic day 15.5 |
|
Note: |
Expression patterns not markedly affected compared with wild type. |
Specimen Label: |
1d -/- Ihh |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1910624 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:3687194 |
Age: |
embryonic day 16.5 |
|
Note: |
Expression was in the core of the humerus and lining the bone collar at close to wild type levels. |
Specimen Label: |
7 Ihh bottom |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6459909 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-06 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1910623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6459913 |
Age: |
embryonic day 15.5 |
|
Note: |
Substantially reduced expression in prehypertrophic zone. |
Specimen Label: |
2C IHH Mutant |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7310473 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-07-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3550523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7310480 |
Age: |
embryonic day 15.5 |
|
Note: |
Expression in prehypertrophic zone |
Specimen Label: |
1d +/+ Ihh |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koziel L |
Year: |
2004 |
Journal: |
Dev Cell |
Title: |
Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. |
Volume: |
6 |
Issue: |
6 |
Pages: |
801-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurio N |
Year: |
2018 |
Journal: |
Matrix Biol |
Title: |
Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage. |
Volume: |
67 |
|
Pages: |
15-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klopocki E |
Year: |
2011 |
Journal: |
Am J Hum Genet |
Title: |
Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis. |
Volume: |
88 |
Issue: |
1 |
Pages: |
70-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2009 |
Journal: |
Development |
Title: |
Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. |
Volume: |
136 |
Issue: |
24 |
Pages: |
4143-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim EJ |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model. |
Volume: |
8 |
Issue: |
2 |
Pages: |
e55296 |
|
•
•
•
•
•
|
Publication |
First Author: |
Long F |
Year: |
2004 |
Journal: |
Development |
Title: |
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. |
Volume: |
131 |
Issue: |
6 |
Pages: |
1309-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murgai A |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Cooperation of BMP and IHH signaling in interdigital cell fate determination. |
Volume: |
13 |
Issue: |
5 |
Pages: |
e0197535 |
|
•
•
•
•
•
|
Publication |
First Author: |
Später D |
Year: |
2006 |
Journal: |
Development |
Title: |
Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. |
Volume: |
133 |
Issue: |
15 |
Pages: |
3039-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang WF |
Year: |
2002 |
Journal: |
Dev Dyn |
Title: |
Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. |
Volume: |
224 |
Issue: |
1 |
Pages: |
79-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bellon E |
Year: |
2009 |
Journal: |
J Cell Biol |
Title: |
delta-EF1 is a negative regulator of Ihh in the developing growth plate. |
Volume: |
187 |
Issue: |
5 |
Pages: |
685-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao B |
Year: |
2009 |
Journal: |
Nature |
Title: |
A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. |
Volume: |
458 |
Issue: |
7242 |
Pages: |
1196-200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Will AJ |
Year: |
2017 |
Journal: |
Nat Genet |
Title: |
Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog). |
Volume: |
49 |
Issue: |
10 |
Pages: |
1539-1545 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang H |
Year: |
2019 |
Journal: |
Int J Mol Sci |
Title: |
Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism. |
Volume: |
20 |
Issue: |
15 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cai H |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. |
Volume: |
113 |
Issue: |
51 |
Pages: |
14751-14756 |
|
•
•
•
•
•
|
Publication |
First Author: |
Veistinen LK |
Year: |
2017 |
Journal: |
Front Physiol |
Title: |
Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets. |
Volume: |
8 |
|
Pages: |
1036 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maeda Y |
Year: |
2010 |
Journal: |
Bone |
Title: |
Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor. |
Volume: |
46 |
Issue: |
2 |
Pages: |
472-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amano K |
Year: |
2016 |
Journal: |
Bone |
Title: |
Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones. |
Volume: |
83 |
|
Pages: |
256-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang XM |
Year: |
2001 |
Journal: |
Cell |
Title: |
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. |
Volume: |
106 |
Issue: |
2 |
Pages: |
781-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kasiri S |
Year: |
2020 |
Journal: |
Oncogene |
Title: |
Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species. |
Volume: |
39 |
Issue: |
16 |
Pages: |
3258-3275 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joeng KS |
Year: |
2009 |
Journal: |
Development |
Title: |
The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. |
Volume: |
136 |
Issue: |
24 |
Pages: |
4177-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pierre M |
Year: |
2009 |
Journal: |
Exp Hematol |
Title: |
VEGF and IHH rescue definitive hematopoiesis in Gata-4 and Gata-6-deficient murine embryoid bodies. |
Volume: |
37 |
Issue: |
9 |
Pages: |
1038-53 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7C |
Note: |
Ihh is expressed in the cartilage. |
Specimen Label: |
7C |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7264388 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-06-17 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1771322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7286336 |
Age: |
embryonic day 14.5 |
Image: |
1D 11Enh-Cre; Sox9 |
Note: |
Ihh expression was almost completely lost. |
Specimen Label: |
1D 11Enh-Cre; Sox9 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603920 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7G |
Note: |
Ihh is ectopically expressed in the branchial arches. |
Specimen Label: |
7G |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 10.5 |
|
Note: |
No ectopic Ihh expression is detected in mutants. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603920 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7H |
Note: |
Ihh is ectopically expressed in the branchial arches. |
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6473146 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-11-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914227 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:6473192 |
Age: |
postnatal day 0 |
Image: |
3A Smad2 |
Note: |
The zone of Ihh expression was increased compared with control. |
Specimen Label: |
3A Smad2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603920 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7D |
Note: |
Ihh is ectopically expressed in the branchial arches. |
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603920 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7E |
Note: |
Ihh is ectopically expressed in the branchial arches. |
Specimen Label: |
7E |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6473146 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-11-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914227 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:6473192 |
Age: |
postnatal day 0 |
Image: |
3A Smad3<-/-> |
Note: |
The zone of Ihh expression was increased compared with control. |
Specimen Label: |
3A Smad3<-/-> |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7264388 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-06-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1771321 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:7286336 |
Age: |
embryonic day 13.5 |
Image: |
3B 11Prom-Cre; Sox9 |
Note: |
The distance between the two Ihh expression domains was increased in the conditional mutant. |
Specimen Label: |
3B 11Prom-Cre; Sox9 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7D |
Note: |
Ihh is also ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7G |
Note: |
Ihh is also ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7G |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7F |
Note: |
Ihh is ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7F |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7I |
Note: |
Ihh is ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7I |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7E |
Note: |
Ihh is also ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7E |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7H |
Note: |
Ihh is also ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1725119 |
|
Stage: |
TS19 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 11.5 |
Image: |
6D/E |
Note: |
Ectopic Ihh expression was not detected in the distal ectoderm and the AER. |
Specimen Label: |
6D/E |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1724719 |
|
Stage: |
TS19 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 11.5 |
Image: |
6D/E |
Note: |
Ectopic Ihh expression was not detected in the distal ectoderm and the AER. |
Specimen Label: |
6D/E |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7D |
Note: |
Ihh is also ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7G |
Note: |
Ihh is also ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7G |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7F |
Note: |
Ihh is ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7F |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7I |
Note: |
Ihh is ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7I |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7E |
Note: |
Ihh is also ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7E |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
7H |
Note: |
Ihh is also ectopically expressed in the dorsal and ventral metacarpal region and future elbow. |
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640619 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 11.5 |
Image: |
6D/E |
Note: |
Ectopic Ihh expression in the distal limb bud was quite superficial and was absent in the 'core' mesenchyme. |
Specimen Label: |
6D/E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
6C |
Note: |
Ihh expression is down-regulated in the apical region whereas its expression in the anterior limb bud remained strong. |
Specimen Label: |
6C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1677919 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 11.5 |
Image: |
6D/E |
Note: |
Ectopic Ihh expression in the distal limb bud was quite superficial and was absent in the 'core' mesenchyme. |
Specimen Label: |
6D/E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:19209 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-03-04 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741220 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1331157 |
Age: |
embryonic day 12.5 |
Image: |
6C |
Note: |
Ihh expression is down-regulated in the apical region whereas its expression in the anterior limb bud remained strong. |
Specimen Label: |
6C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6473146 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-11-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914227 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:6473192 |
Age: |
postnatal day 0 |
Image: |
3A Smad2;Smad3<-/-> |
Note: |
The zone of Ihh expression was increased compared with control. The double mutant had elevated levels of Ihh compared to both single mutants. |
Specimen Label: |
3A Smad2;Smad3<-/-> |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|