Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
IL-15 receptor (IL-15R) composed of IL-15Ralpha, IL-2/15Rbeta (CD122), and gamma(c) (CD132) subunits []. IL-15 is a cytokine that plays an important role in innate and adaptive immunity []. Syk kinase interacts with IL-15Ralpha and may play a key role in mediating IL-15-induced signal transduction []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson DM |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. |
Volume: |
270 |
Issue: |
50 |
Pages: |
29862-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loro E |
Year: |
2017 |
Journal: |
Bone |
Title: |
IL15RA is required for osteoblast function and bone mineralization. |
Volume: |
103 |
|
Pages: |
20-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Connell G |
Year: |
2015 |
Journal: |
J Appl Physiol (1985) |
Title: |
Muscle-specific deletion of exons 2 and 3 of the IL15RA gene in mice: effects on contractile properties of fast and slow muscles. |
Volume: |
118 |
Issue: |
4 |
Pages: |
437-48 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
263
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
123
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
155
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ratthé C |
Year: |
2004 |
Journal: |
J Leukoc Biol |
Title: |
Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. |
Volume: |
76 |
Issue: |
1 |
Pages: |
162-8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336711 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760622 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7336721 |
Age: |
embryonic day 14.5 |
|
Note: |
At E14.5, Il15ra staining was detected in the axons of olfactory neurons, and was co-localized with Gap43, a marker of immature neurons. |
Specimen Label: |
1f |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336711 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760626 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7336721 |
Age: |
embryonic day 18.5 |
|
Note: |
At E18.5, Il15ra staining was detected in the axons of olfactory neurons, where it overlapped with OMP, a marker of olfactory receptor neurons. |
Specimen Label: |
1h |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato N |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells. |
Volume: |
104 |
Issue: |
2 |
Pages: |
588-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Z |
Year: |
2008 |
Journal: |
Blood |
Title: |
The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation. |
Volume: |
112 |
Issue: |
12 |
Pages: |
4411-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loro E |
Year: |
2019 |
Journal: |
Front Physiol |
Title: |
Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions. |
Volume: |
10 |
|
Pages: |
1439 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loro E |
Year: |
2018 |
Journal: |
J Cell Sci |
Title: |
Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA. |
Volume: |
131 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pistilli EE |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
Loss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles. |
Volume: |
121 |
Issue: |
8 |
Pages: |
3120-32 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulanova E |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
Mast cells express novel functional IL-15 receptor alpha isoforms. |
Volume: |
170 |
Issue: |
10 |
Pages: |
5045-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lodolce JP |
Year: |
1998 |
Journal: |
Immunity |
Title: |
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. |
Volume: |
9 |
Issue: |
5 |
Pages: |
669-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ochoa MC |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy. |
Volume: |
7 |
Issue: |
12 |
Pages: |
e52370 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pistilli EE |
Year: |
2013 |
Journal: |
Cytokine |
Title: |
IL-15Rα deficiency leads to mitochondrial and myofiber differences in fast mouse muscles. |
Volume: |
61 |
Issue: |
1 |
Pages: |
41-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emoto M |
Year: |
2010 |
Journal: |
Infect Immun |
Title: |
Alpha-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation. |
Volume: |
78 |
Issue: |
6 |
Pages: |
2667-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ota N |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
No requirement of trans presentations of IL-15 for human CD8 T cell proliferation. |
Volume: |
185 |
Issue: |
10 |
Pages: |
6041-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lodolce JP |
Year: |
2001 |
Journal: |
J Exp Med |
Title: |
T cell-independent interleukin 15Ralpha signals are required for bystander proliferation. |
Volume: |
194 |
Issue: |
8 |
Pages: |
1187-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su YC |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Effector function-deficient memory CD8+ T cells clonally expand in the liver and give rise to peripheral memory CD8+ T cells. |
Volume: |
185 |
Issue: |
12 |
Pages: |
7498-506 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koka R |
Year: |
2003 |
Journal: |
J Exp Med |
Title: |
Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice. |
Volume: |
197 |
Issue: |
8 |
Pages: |
977-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
He Y |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory. |
Volume: |
30 |
Issue: |
13 |
Pages: |
4725-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee JM |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
IL-15Ralpha is a negative regulator of TCR-activated proliferation in CD4+ T cells. |
Volume: |
173 |
Issue: |
5 |
Pages: |
3155-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chow KP |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Selective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice. |
Volume: |
7 |
Issue: |
3 |
Pages: |
e33152 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang CL |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
IL-15Rα of radiation-resistant cells is necessary and sufficient for thymic invariant NKT cell survival and functional maturation. |
Volume: |
187 |
Issue: |
3 |
Pages: |
1235-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen JP |
Year: |
2005 |
Journal: |
Eur J Immunol |
Title: |
Reduced 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity response in IL-15 receptor alpha-deficient mice correlates with diminished CCL5/RANTES and CXCL10/IP-10 expression. |
Volume: |
35 |
Issue: |
3 |
Pages: |
690-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu X |
Year: |
2010 |
Journal: |
J Neurochem |
Title: |
Expression and signaling of novel IL15Ralpha splicing variants in cerebral endothelial cells of the blood-brain barrier. |
Volume: |
114 |
Issue: |
1 |
Pages: |
122-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burkett PR |
Year: |
2004 |
Journal: |
J Exp Med |
Title: |
Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. |
Volume: |
200 |
Issue: |
7 |
Pages: |
825-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulanova E |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15. |
Volume: |
282 |
Issue: |
18 |
Pages: |
13167-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burkett PR |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory. |
Volume: |
100 |
Issue: |
8 |
Pages: |
4724-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Connell GC |
Year: |
2015 |
Journal: |
Mitochondrion |
Title: |
IL-15Rα deficiency in skeletal muscle alters respiratory function and the proteome of mitochondrial subpopulations independent of changes to the mitochondrial genome. |
Volume: |
25 |
|
Pages: |
87-97 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336716 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760620 |
|
Stage: |
TS20 |
Assay Id: |
MGI:7336718 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
E12.5 OE |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336716 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760622 |
|
Stage: |
TS22 |
Assay Id: |
MGI:7336718 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
E14.5 OE |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336716 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7336718 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
E18.5 OE |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336716 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7336718 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Adult OE |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336716 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7336718 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Adult OB |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal day 2-3 |
Image: |
P2/3 |
Note: |
Expression was detected in the outer neuroblastic layer. |
Specimen Label: |
P2/3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915527 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal day 2-3 |
Image: |
P2/3 |
Note: |
Expression was detected in the inner neuroblastic layer. |
Specimen Label: |
P2/3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716828 |
Pattern: |
Uniform |
Stage: |
TS28 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal day 4-5 |
Image: |
P4/5 |
Note: |
Expression was panretinal. |
Specimen Label: |
P4/5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal day 6-7 |
Image: |
P6/7 |
|
Specimen Label: |
P6/7 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal day 6-7 |
Image: |
P6/7 |
Note: |
Expression was detected in the inner nuclear layer and tentatively in amacrine cells. |
Specimen Label: |
P6/7 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal day 8-10 |
Image: |
P8/10 |
|
Specimen Label: |
P8/10 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal day 8-10 |
Image: |
P8/10 |
|
Specimen Label: |
P8/10 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Adult |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1915528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Adult |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1085419 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1647028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585519 |
Age: |
postnatal day 6 |
|
Note: |
Expression was widespread. |
Specimen Label: |
CNS |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336711 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760620 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:7336721 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336711 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760622 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7336721 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
1f |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336711 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7336721 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
1h |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giri JG |
Year: |
1995 |
Journal: |
EMBO J |
Title: |
Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. |
Volume: |
14 |
Issue: |
15 |
Pages: |
3654-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Budagian V |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17). |
Volume: |
279 |
Issue: |
39 |
Pages: |
40368-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baumann NS |
Year: |
2018 |
Journal: |
PLoS Pathog |
Title: |
Tissue maintenance of CMV-specific inflationary memory T cells by IL-15. |
Volume: |
14 |
Issue: |
4 |
Pages: |
e1006993 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castillo EF |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation. |
Volume: |
183 |
Issue: |
8 |
Pages: |
4948-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stonier SW |
Year: |
2008 |
Journal: |
Blood |
Title: |
Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation. |
Volume: |
112 |
Issue: |
12 |
Pages: |
4546-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mortier E |
Year: |
2008 |
Journal: |
J Exp Med |
Title: |
IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. |
Volume: |
205 |
Issue: |
5 |
Pages: |
1213-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patel S |
Year: |
2016 |
Journal: |
Immunology |
Title: |
Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1β responses. |
Volume: |
148 |
Issue: |
4 |
Pages: |
352-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kohlhapp FJ |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
CD8(+) T cells sabotage their own memory potential through IFN-γ-dependent modification of the IL-12/IL-15 receptor α axis on dendritic cells. |
Volume: |
188 |
Issue: |
8 |
Pages: |
3639-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koka R |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells. |
Volume: |
173 |
Issue: |
6 |
Pages: |
3594-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bergamaschi C |
Year: |
2012 |
Journal: |
Blood |
Title: |
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum. |
Volume: |
120 |
Issue: |
1 |
Pages: |
e1-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loro E |
Year: |
2015 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
IL-15Rα is a determinant of muscle fuel utilization, and its loss protects against obesity. |
Volume: |
309 |
Issue: |
8 |
Pages: |
R835-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yajima T |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
IL-15 regulates CD8+ T cell contraction during primary infection. |
Volume: |
176 |
Issue: |
1 |
Pages: |
507-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sandau MM |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells. |
Volume: |
173 |
Issue: |
11 |
Pages: |
6537-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castillo EF |
Year: |
2010 |
Journal: |
Blood |
Title: |
Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation. |
Volume: |
116 |
Issue: |
14 |
Pages: |
2494-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato N |
Year: |
2011 |
Journal: |
Blood |
Title: |
Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα. |
Volume: |
117 |
Issue: |
15 |
Pages: |
4032-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rückert R |
Year: |
2003 |
Journal: |
Eur J Immunol |
Title: |
Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses. |
Volume: |
33 |
Issue: |
12 |
Pages: |
3493-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou X |
Year: |
2019 |
Journal: |
Nat Immunol |
Title: |
The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming. |
Volume: |
20 |
Issue: |
7 |
Pages: |
879-889 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Connell GC |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Interleukin-15 directly stimulates pro-oxidative gene expression in skeletal muscle in-vitro via a mechanism that requires interleukin-15 receptor alpha. |
Volume: |
458 |
Issue: |
3 |
Pages: |
614-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma LJ |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. |
Volume: |
183 |
Issue: |
2 |
Pages: |
1044-54 |
|
•
•
•
•
•
|