Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Tongmuang N |
Year: |
2024 |
Journal: |
Cells |
Title: |
Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues. |
Volume: |
13 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ngo VL |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria. |
Volume: |
117 |
Issue: |
44 |
Pages: |
27540-27548 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Medina-Contreras O |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage. |
Volume: |
196 |
Issue: |
1 |
Pages: |
34-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi Y |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
IL36G-producing neutrophil-like monocytes promote cachexia in cancer. |
Volume: |
15 |
Issue: |
1 |
Pages: |
7662 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goldstein JD |
Year: |
2020 |
Journal: |
Life Sci Alliance |
Title: |
IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis. |
Volume: |
3 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Born TL |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. |
Volume: |
275 |
Issue: |
39 |
Pages: |
29946-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tongmuang N |
Year: |
2024 |
Journal: |
Vaccines (Basel) |
Title: |
UL56 Is Essential for Herpes Simplex Virus-1 Virulence In Vivo but Is Dispensable for Induction of Host-Protective Immunity. |
Volume: |
12 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bozoyan L |
Year: |
2015 |
Journal: |
J Neuroinflammation |
Title: |
Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis. |
Volume: |
12 |
|
Pages: |
173 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giannoudaki E |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. |
Volume: |
10 |
Issue: |
1 |
Pages: |
4003 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou H |
Year: |
2022 |
Journal: |
EMBO Rep |
Title: |
Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner. |
Volume: |
23 |
Issue: |
6 |
Pages: |
e53791 |
|
•
•
•
•
•
|
Publication |
First Author: |
Russell SE |
Year: |
2016 |
Journal: |
Mucosal Immunol |
Title: |
IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation. |
Volume: |
9 |
Issue: |
5 |
Pages: |
1193-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kovach MA |
Year: |
2017 |
Journal: |
Mucosal Immunol |
Title: |
IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia. |
Volume: |
10 |
Issue: |
5 |
Pages: |
1320-1334 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vigne S |
Year: |
2011 |
Journal: |
Blood |
Title: |
IL-36R ligands are potent regulators of dendritic and T cells. |
Volume: |
118 |
Issue: |
22 |
Pages: |
5813-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blumberg H |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. |
Volume: |
185 |
Issue: |
7 |
Pages: |
4354-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Z |
Year: |
2017 |
Journal: |
J Invest Dermatol |
Title: |
IL-36γ Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A. |
Volume: |
137 |
Issue: |
12 |
Pages: |
2620-2629 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blumberg H |
Year: |
2007 |
Journal: |
J Exp Med |
Title: |
Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. |
Volume: |
204 |
Issue: |
11 |
Pages: |
2603-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patrick GJ |
Year: |
2021 |
Journal: |
J Clin Invest |
Title: |
Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease. |
Volume: |
131 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Vigne S |
Year: |
2012 |
Journal: |
Blood |
Title: |
IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. |
Volume: |
120 |
Issue: |
17 |
Pages: |
3478-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tortola L |
Year: |
2012 |
Journal: |
J Clin Invest |
Title: |
Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. |
Volume: |
122 |
Issue: |
11 |
Pages: |
3965-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harusato A |
Year: |
2017 |
Journal: |
Mucosal Immunol |
Title: |
IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors. |
Volume: |
10 |
Issue: |
6 |
Pages: |
1455-1467 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ngo VL |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage. |
Volume: |
115 |
Issue: |
22 |
Pages: |
E5076-E5085 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2015 |
Journal: |
Cancer Cell |
Title: |
IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses. |
Volume: |
28 |
Issue: |
3 |
Pages: |
296-306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agoro R |
Year: |
2016 |
Journal: |
Eur J Immunol |
Title: |
IL-1R1-MyD88 axis elicits papain-induced lung inflammation. |
Volume: |
46 |
Issue: |
11 |
Pages: |
2531-2541 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li T |
Year: |
2019 |
Journal: |
Sci Transl Med |
Title: |
TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. |
Volume: |
11 |
Issue: |
491 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wang G |
Year: |
2021 |
Journal: |
Cell Host Microbe |
Title: |
Bacteria induce skin regeneration via IL-1β signaling. |
Volume: |
29 |
Issue: |
5 |
Pages: |
777-791.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2017 |
Journal: |
Cell Host Microbe |
Title: |
Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses. |
Volume: |
22 |
Issue: |
5 |
Pages: |
653-666.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schwartz C |
Year: |
2019 |
Journal: |
Allergy |
Title: |
Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. |
Volume: |
74 |
Issue: |
10 |
Pages: |
1920-1933 |
|
•
•
•
•
•
|
Publication |
First Author: |
Egawa G |
Year: |
2009 |
Journal: |
J Invest Dermatol |
Title: |
Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis. |
Volume: |
129 |
Issue: |
10 |
Pages: |
2386-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Copeland NG |
Year: |
1999 |
Journal: |
Database Release |
Title: |
Copeland-Jenkins (Frederick) Interspecific Backcross Mapping Data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
178
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
interleukin 1 receptor-like 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
interleukin 2; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
interleukin 1 receptor-like 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
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Publication |
First Author: |
Mahil SK |
Year: |
2017 |
Journal: |
Sci Transl Med |
Title: |
An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target. |
Volume: |
9 |
Issue: |
411 |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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