Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
sheep |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cat, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
pig, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller PG |
Year: |
2015 |
Journal: |
J Immunol |
Title: |
Transmembrane TNF-TNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression. |
Volume: |
195 |
Issue: |
6 |
Pages: |
2633-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quintana FJ |
Year: |
2012 |
Journal: |
Nat Immunol |
Title: |
Aiolos promotes TH17 differentiation by directly silencing Il2 expression. |
Volume: |
13 |
Issue: |
8 |
Pages: |
770-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martins GA |
Year: |
2008 |
Journal: |
J Exp Med |
Title: |
Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival. |
Volume: |
205 |
Issue: |
9 |
Pages: |
1959-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cismasiu VB |
Year: |
2006 |
Journal: |
Blood |
Title: |
BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. |
Volume: |
108 |
Issue: |
8 |
Pages: |
2695-702 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baine I |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. |
Volume: |
190 |
Issue: |
3 |
Pages: |
1008-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nair VS |
Year: |
2014 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Down-regulation of Tet2 prevents TSDR demethylation in IL2 deficient regulatory T cells. |
Volume: |
450 |
Issue: |
1 |
Pages: |
918-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
McKarns SC |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure. |
Volume: |
181 |
Issue: |
2 |
Pages: |
1272-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clark DJ |
Year: |
2019 |
Journal: |
Elife |
Title: |
Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion. |
Volume: |
8 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sin JH |
Year: |
2019 |
Journal: |
J Exp Med |
Title: |
The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. |
Volume: |
216 |
Issue: |
9 |
Pages: |
2024-2037 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
63
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
63
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamanouchi J |
Year: |
2007 |
Journal: |
Nat Genet |
Title: |
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. |
Volume: |
39 |
Issue: |
3 |
Pages: |
329-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi Y |
Year: |
2002 |
Journal: |
Eur J Immunol |
Title: |
Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. |
Volume: |
32 |
Issue: |
3 |
Pages: |
677-85 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
150
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
150
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
155
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
149
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
169
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokota T |
Year: |
1985 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. |
Volume: |
82 |
Issue: |
1 |
Pages: |
68-72 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Publication |
First Author: |
Naramura M |
Year: |
1998 |
Journal: |
Immunity |
Title: |
Mice with a fluorescent marker for interleukin 2 gene activation. |
Volume: |
9 |
Issue: |
2 |
Pages: |
209-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Podolin PL |
Year: |
2000 |
Journal: |
Cytokine |
Title: |
Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene? |
Volume: |
12 |
Issue: |
5 |
Pages: |
477-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Webb GC |
Year: |
1990 |
Journal: |
Cytogenet Cell Genet |
Title: |
Mapping the gene for murine T-cell growth factor, Il-2, to bands B-C on chromosome 3 and for the alpha chain of the IL2-receptor, Il-2ra, to bands A2-A3 on chromosome 2. |
Volume: |
54 |
Issue: |
3-4 |
Pages: |
164-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2002 |
Journal: |
J Hematother Stem Cell Res |
Title: |
Hematopoietic stem cell functional failure in interleukin-2-deficient mice. |
Volume: |
11 |
Issue: |
6 |
Pages: |
905-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao W |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. |
Volume: |
9 |
Issue: |
11 |
Pages: |
1288-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Waysbort N |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Coupled IL-2-dependent extracellular feedbacks govern two distinct consecutive phases of CD4 T cell activation. |
Volume: |
191 |
Issue: |
12 |
Pages: |
5822-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto M |
Year: |
2013 |
Journal: |
Cytokine |
Title: |
Ontogeny and localization of the cells produce IL-2 in healthy animals. |
Volume: |
61 |
Issue: |
3 |
Pages: |
831-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krulová M |
Year: |
1997 |
Journal: |
Genomics |
Title: |
IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations. |
Volume: |
42 |
Issue: |
1 |
Pages: |
11-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teuscher C |
Year: |
1996 |
Journal: |
J Exp Med |
Title: |
Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3. |
Volume: |
183 |
Issue: |
2 |
Pages: |
631-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Denny P |
Year: |
1997 |
Journal: |
Diabetes |
Title: |
Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene. |
Volume: |
46 |
Issue: |
4 |
Pages: |
695-700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sgouroudis E |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. |
Volume: |
181 |
Issue: |
9 |
Pages: |
6283-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikegami H |
Year: |
2002 |
Journal: |
Ann N Y Acad Sci |
Title: |
Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping. |
Volume: |
958 |
|
Pages: |
325-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goudy KS |
Year: |
2011 |
Journal: |
Eur J Immunol |
Title: |
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity. |
Volume: |
41 |
Issue: |
5 |
Pages: |
1480-1490 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Key role for IL-21 in experimental autoimmune uveitis. |
Volume: |
108 |
Issue: |
23 |
Pages: |
9542-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Novak TJ |
Year: |
1990 |
Journal: |
Nucleic Acids Res |
Title: |
Regulatory anatomy of the murine interleukin-2 gene. |
Volume: |
18 |
Issue: |
15 |
Pages: |
4523-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koga T |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus. |
Volume: |
189 |
Issue: |
7 |
Pages: |
3490-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khan AA |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice. |
Volume: |
4 |
Issue: |
12 |
Pages: |
e8473 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chawla AS |
Year: |
2020 |
Journal: |
Immunology |
Title: |
A role for cell-autocrine interleukin-2 in regulatory T-cell homeostasis. |
Volume: |
160 |
Issue: |
3 |
Pages: |
295-309 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shameli A |
Year: |
2013 |
Journal: |
Eur J Immunol |
Title: |
IL-2 promotes the function of memory-like autoregulatory CD8+ T cells but suppresses their development via FoxP3+ Treg cells. |
Volume: |
43 |
Issue: |
2 |
Pages: |
394-403 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Brien S |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production. |
Volume: |
192 |
Issue: |
11 |
Pages: |
5118-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peperzak V |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production. |
Volume: |
120 |
Issue: |
1 |
Pages: |
168-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGuire HM |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. |
Volume: |
106 |
Issue: |
46 |
Pages: |
19438-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Popmihajlov Z |
Year: |
2012 |
Journal: |
Front Immunol |
Title: |
Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. |
Volume: |
3 |
|
Pages: |
102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma R |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation. |
Volume: |
186 |
Issue: |
2 |
Pages: |
1268-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Owen DL |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis. |
Volume: |
200 |
Issue: |
12 |
Pages: |
3926-3933 |
|
•
•
•
•
•
|
Publication |
First Author: |
Motegi H |
Year: |
2011 |
Journal: |
Genes Cells |
Title: |
TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling. |
Volume: |
16 |
Issue: |
2 |
Pages: |
179-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lyons PA |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. |
Volume: |
10 |
Issue: |
4 |
Pages: |
446-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pandiyan P |
Year: |
2007 |
Journal: |
Nat Immunol |
Title: |
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. |
Volume: |
8 |
Issue: |
12 |
Pages: |
1353-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikegami H |
Year: |
2003 |
Journal: |
Ann N Y Acad Sci |
Title: |
Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse. |
Volume: |
1005 |
|
Pages: |
196-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keck S |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. |
Volume: |
111 |
Issue: |
41 |
Pages: |
14852-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han D |
Year: |
2013 |
Journal: |
Immunity |
Title: |
Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. |
Volume: |
38 |
Issue: |
6 |
Pages: |
1211-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amado IF |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
IL-2 coordinates IL-2-producing and regulatory T cell interplay. |
Volume: |
210 |
Issue: |
12 |
Pages: |
2707-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hemmers S |
Year: |
2019 |
Journal: |
J Exp Med |
Title: |
IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. |
Volume: |
216 |
Issue: |
11 |
Pages: |
2466-2478 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bourel C |
Year: |
2023 |
Journal: |
Immunol Cell Biol |
Title: |
Uncoupling of Natural Killer cell functional maturation and cytolytic function in NOD mice. |
Volume: |
101 |
Issue: |
9 |
Pages: |
867-874 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitchell JS |
Year: |
2024 |
Journal: |
Immunity |
Title: |
CD4(+) TÂ cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes. |
Volume: |
57 |
Issue: |
10 |
Pages: |
2399-2415.e8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Kashima N |
Year: |
1985 |
Journal: |
Nature |
Title: |
Unique structure of murine interleukin-2 as deduced from cloned cDNAs. |
Volume: |
313 |
Issue: |
6001 |
Pages: |
402-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matesanz F |
Year: |
1993 |
Journal: |
Immunogenetics |
Title: |
Existence of at least five interleukin-2 molecules in different mouse strains. |
Volume: |
38 |
Issue: |
4 |
Pages: |
300-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reya T |
Year: |
1998 |
Journal: |
Dev Immunol |
Title: |
Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. |
Volume: |
5 |
Issue: |
4 |
Pages: |
287-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matesanz F |
Year: |
1996 |
Journal: |
Eur J Immunol |
Title: |
Glutamine and tetrapeptide repeat variations affect the biological activity of different mouse interleukin-2 alleles. |
Volume: |
26 |
Issue: |
8 |
Pages: |
1675-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mathews CE |
Year: |
2003 |
Journal: |
Immunogenetics |
Title: |
Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress. |
Volume: |
55 |
Issue: |
7 |
Pages: |
491-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ashcroft AJ |
Year: |
2003 |
Journal: |
Immunity |
Title: |
Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. |
Volume: |
19 |
Issue: |
6 |
Pages: |
849-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
DiToro D |
Year: |
2018 |
Journal: |
Science |
Title: |
Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. |
Volume: |
361 |
Issue: |
6407 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Seixas E |
Year: |
2002 |
Journal: |
Parasite Immunol |
Title: |
The influence of gammadelta T cells on the CD4+ T cell and antibody response during a primary Plasmodium chabaudi chabaudi infection in mice. |
Volume: |
24 |
Issue: |
3 |
Pages: |
131-40 |
|
•
•
•
•
•
|