Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
23
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiroiwa W |
Year: |
2007 |
Journal: |
Int Immunol |
Title: |
IL-4Ralpha polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus. |
Volume: |
19 |
Issue: |
2 |
Pages: |
175-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Groot AE |
Year: |
2022 |
Journal: |
Neoplasia |
Title: |
Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype. |
Volume: |
32 |
|
Pages: |
100830 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Noah TK |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice. |
Volume: |
12 |
|
Pages: |
636198 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tachdjian R |
Year: |
2010 |
Journal: |
J Allergy Clin Immunol |
Title: |
In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. |
Volume: |
125 |
Issue: |
5 |
Pages: |
1128-1136.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duan L |
Year: |
2021 |
Journal: |
Immunity |
Title: |
Follicular dendritic cells restrict interleukin-4 availability in germinal centers and foster memory B cell generation. |
Volume: |
54 |
Issue: |
10 |
Pages: |
2256-2272.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
You D |
Year: |
2013 |
Journal: |
J Leukoc Biol |
Title: |
IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates. |
Volume: |
93 |
Issue: |
6 |
Pages: |
933-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao W |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. |
Volume: |
9 |
Issue: |
11 |
Pages: |
1288-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mathias CB |
Year: |
2011 |
Journal: |
J Allergy Clin Immunol |
Title: |
IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. |
Volume: |
127 |
Issue: |
3 |
Pages: |
795-805.e1-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Waddell A |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
IL-33 Induces Murine Intestinal Goblet Cell Differentiation Indirectly via Innate Lymphoid Cell IL-13 Secretion. |
Volume: |
202 |
Issue: |
2 |
Pages: |
598-607 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pelly VS |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths. |
Volume: |
214 |
Issue: |
6 |
Pages: |
1809-1826 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Genetic dissection of the Canq1 locus governing variation in extent of the collateral circulation. |
Volume: |
7 |
Issue: |
3 |
Pages: |
e31910 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koller FL |
Year: |
2010 |
Journal: |
Carcinogenesis |
Title: |
Epithelial interleukin-4 receptor expression promotes colon tumor growth. |
Volume: |
31 |
Issue: |
6 |
Pages: |
1010-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harris AJ |
Year: |
2019 |
Journal: |
Am J Respir Crit Care Med |
Title: |
IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo. |
Volume: |
200 |
Issue: |
2 |
Pages: |
235-246 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noval Rivas M |
Year: |
2016 |
Journal: |
J Allergy Clin Immunol |
Title: |
IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. |
Volume: |
138 |
Issue: |
3 |
Pages: |
801-811.e9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hilton DJ |
Year: |
1996 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. |
Volume: |
93 |
Issue: |
1 |
Pages: |
497-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdel-Gadir A |
Year: |
2019 |
Journal: |
Nat Med |
Title: |
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy. |
Volume: |
25 |
Issue: |
7 |
Pages: |
1164-1174 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burton OT |
Year: |
2014 |
Journal: |
Immunity |
Title: |
Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. |
Volume: |
41 |
Issue: |
1 |
Pages: |
141-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noval Rivas M |
Year: |
2015 |
Journal: |
Immunity |
Title: |
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. |
Volume: |
42 |
Issue: |
3 |
Pages: |
512-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Massoud AH |
Year: |
2016 |
Journal: |
Nat Med |
Title: |
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells. |
Volume: |
22 |
Issue: |
9 |
Pages: |
1013-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Turner JA |
Year: |
2020 |
Journal: |
Immunity |
Title: |
Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. |
Volume: |
53 |
Issue: |
6 |
Pages: |
1202-1214.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herbert DR |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. |
Volume: |
184 |
Issue: |
11 |
Pages: |
6438-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee CG |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. |
Volume: |
277 |
Issue: |
38 |
Pages: |
35466-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mosley B |
Year: |
1989 |
Journal: |
Cell |
Title: |
The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. |
Volume: |
59 |
Issue: |
2 |
Pages: |
335-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harada N |
Year: |
1990 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding. |
Volume: |
87 |
Issue: |
3 |
Pages: |
857-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wrighton N |
Year: |
1992 |
Journal: |
Growth Factors |
Title: |
The murine interleukin-4 receptor gene: genomic structure, expression and potential for alternative splicing. |
Volume: |
6 |
Issue: |
2 |
Pages: |
103-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schulte T |
Year: |
1997 |
Journal: |
J Exp Med |
Title: |
Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes. |
Volume: |
186 |
Issue: |
9 |
Pages: |
1419-29 |
|
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•
•
•
•
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Publication |
First Author: |
Seki Y |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. |
Volume: |
99 |
Issue: |
20 |
Pages: |
13003-8 |
|
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•
•
•
•
|
Publication |
First Author: |
Blum H |
Year: |
1996 |
Journal: |
J Immunol |
Title: |
Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor. |
Volume: |
157 |
Issue: |
5 |
Pages: |
1846-53 |
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•
•
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Publication |
First Author: |
Moshkovits I |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CD300f associates with IL-4 receptor α and amplifies IL-4-induced immune cell responses. |
Volume: |
112 |
Issue: |
28 |
Pages: |
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Publication |
First Author: |
Sintes J |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells. |
Volume: |
190 |
Issue: |
1 |
Pages: |
21-6 |
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•
•
•
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Publication |
First Author: |
Guimarães MJ |
Year: |
1996 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? |
Volume: |
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Issue: |
26 |
Pages: |
15086-91 |
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•
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Publication |
First Author: |
Seki Y |
Year: |
2003 |
Journal: |
Nat Med |
Title: |
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. |
Volume: |
9 |
Issue: |
8 |
Pages: |
1047-54 |
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Publication |
First Author: |
Ghai R |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. |
Volume: |
110 |
Issue: |
8 |
Pages: |
E643-52 |
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•
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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•
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Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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•
•
•
•
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Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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•
•
•
•
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Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
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First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Cyagen Biosciences Inc. |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
Chen YT |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. |
Volume: |
175 |
Issue: |
10 |
Pages: |
6537-50 |
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Publication |
First Author: |
Kurey I |
Year: |
2009 |
Journal: |
Immunogenetics |
Title: |
Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. |
Volume: |
61 |
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9 |
Pages: |
619-33 |
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Publication |
First Author: |
Kosiewicz MM |
Year: |
2004 |
Journal: |
Int Immunol |
Title: |
Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand. |
Volume: |
16 |
Issue: |
5 |
Pages: |
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Year: |
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Nature |
Title: |
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. |
Volume: |
529 |
Issue: |
7585 |
Pages: |
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Year: |
2021 |
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Mucosal Immunol |
Title: |
CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone. |
Volume: |
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6 |
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Year: |
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Immunity |
Title: |
Innate type 2 immunity controls hair follicle commensalism by Demodex mites. |
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Issue: |
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Pages: |
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Journal: |
J Immunol |
Title: |
IL-4 exacerbates anaphylaxis. |
Volume: |
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J Clin Invest |
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Year: |
2023 |
Journal: |
J Immunol |
Title: |
HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection. |
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Database (Oxford) |
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CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. |
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Alaeddine M |
Year: |
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Cancer Immunol Res |
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IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells. |
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