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Search results 1 to 100 out of 11341 for Impact

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 10  
Fragment?: true
Publication
First Author: Okamura K
Year: 2000
Journal: Genome Res
Title: Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting.
Volume: 10
Issue: 12
Pages: 1878-89
Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
GXD Expression      
Probe: MGI:3618792
Assay Type: RT-PCR
Annotation Date: 2006-04-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Stage: TS28
Assay Id: MGI:3618805
Age: postnatal adult
Specimen Label: Impact
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3618776
Assay Type: RNA in situ
Annotation Date: 2006-04-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753626
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:3618787
Age: embryonic day 18.5
Note: Expression is in the acruate nucleus.
Specimen Label: Impact
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
Gene
Type: gene
Organism: human
Publication
First Author: Hagiwara Y
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18.
Volume: 94
Issue: 17
Pages: 9249-54
Gene
Type: gene
Organism: human
Publication
First Author: Cambiaghi TD
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Volume: 443
Issue: 2
Pages: 592-7
Publication
First Author: Roffé M
Year: 2013
Journal: J Biol Chem
Title: IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.
Volume: 288
Issue: 15
Pages: 10860-9
Publication
First Author: Pereira CM
Year: 2005
Journal: J Biol Chem
Title: IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.
Volume: 280
Issue: 31
Pages: 28316-23
Publication
First Author: Waller T
Year: 2012
Journal: FEBS J
Title: Evidence that Yih1 resides in a complex with ribosomes.
Volume: 279
Issue: 10
Pages: 1761-76
Publication
First Author: Okamura K
Year: 2008
Journal: Genome Biol
Title: Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting.
Volume: 9
Issue: 11
Pages: R160
Publication
First Author: Pereira CM
Year: 2019
Journal: PLoS One
Title: The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.
Volume: 14
Issue: 6
Pages: e0217287
Publication
First Author: Kosaki K
Year: 2001
Journal: Mol Psychiatry
Title: Human homolog of the mouse imprinted gene Impact resides at the pericentric region of chromosome 18 within the critical region for bipolar affective disorder.
Volume: 6
Issue: 1
Pages: 87-91
Publication
First Author: Okamura K
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact.
Volume: 329
Issue: 3
Pages: 824-30
UniProt Feature
Begin: 1
Description: Protein IMPACT
Type: chain
End: 318
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:4878852
Age: embryonic day 10.5
Specimen Label: Embryo
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:4878852
Age: embryonic day 10.5
Specimen Label: Placenta
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604217
Stage: TS17
Assay Id: MGI:4878852
Age: embryonic day 10.5
Specimen Label: Umbilical cord
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608517
Stage: TS17
Assay Id: MGI:4878852
Age: embryonic day 10.5
Specimen Label: Yolk sac
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:4878950
Age: embryonic day 14.5
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Male
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:4878950
Age: embryonic day 14.5
Specimen Label: Heart
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Male
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:4878950
Age: embryonic day 14.5
Specimen Label: Liver
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Male
Emaps: EMAPS:1604222
Stage: TS22
Assay Id: MGI:4878950
Age: embryonic day 14.5
Specimen Label: Trophectoderm
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Male
Emaps: EMAPS:1604222
Stage: TS22
Assay Id: MGI:4878950
Age: embryonic day 14.5
Specimen Label: Umbilical cord
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Female
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:4878978
Age: embryonic day 14.5
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Female
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:4878978
Age: embryonic day 14.5
Specimen Label: Gonads
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Female
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:4878978
Age: embryonic day 14.5
Specimen Label: Liver
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Female
Emaps: EMAPS:1604222
Stage: TS22
Assay Id: MGI:4878978
Age: embryonic day 14.5
Specimen Label: Trophectoderm
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4868799
Assay Type: RT-PCR
Annotation Date: 2011-01-25
Strength: Present
Sex: Female
Emaps: EMAPS:1604222
Stage: TS22
Assay Id: MGI:4878978
Age: embryonic day 14.5
Specimen Label: Umbilical cord
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:6113944
Age: embryonic day 7.0
Image: 4
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:6113944
Age: embryonic day 11.0
Image: 4
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:6113944
Age: embryonic day 17.0
Image: 4
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6113945
Age: postnatal adult
Image: 4
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6113945
Age: postnatal adult
Image: 4
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6113945
Age: postnatal adult
Image: 4
Specimen Label: 3
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6113945
Age: postnatal adult
Image: 4
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6113945
Age: postnatal adult
Image: 4
Specimen Label: 5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6113945
Age: postnatal adult
Image: 4
Specimen Label: 6
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6113945
Age: postnatal adult
Image: 4
Specimen Label: 7
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6113945
Age: postnatal adult
Image: 4
Specimen Label: 8
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6113943
Assay Type: Northern blot
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:6113944
Age: embryonic day 15.0
Image: 4
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672826
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Lung
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Heart
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876826
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Thymus
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Liver
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876726
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Spleen
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Pancreas
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702126
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Stomach
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Intestine
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6436590
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:6436595
Age: embryonic day 18.5
Image: S1
Specimen Label: Kidney
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B middle
Specimen Label: 4B middle
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3605128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B middle
Specimen Label: 4B middle
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B top
Specimen Label: 4B top
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1903728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B middle
Specimen Label: 4B middle
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B middle
Specimen Label: 4B middle
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B top
Specimen Label: 4B top
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B middle
Specimen Label: 4B middle
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B middle
Specimen Label: 4B middle
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3522328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B bottom right
Specimen Label: 4B bottom right
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6113943
Assay Type: RNA in situ
Annotation Date: 2018-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6113946
Age: postnatal adult
Image: 4B bottom left
Specimen Label: 4B bottom left
Detected: true
Specimen Num: 3
Publication
First Author: Yamazaki H
Year: 2020
Journal: PLoS Genet
Title: Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
Volume: 16
Issue: 4
Pages: e1008693
Publication
First Author: Ciccone DN
Year: 2009
Journal: Nature
Title: KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints.
Volume: 461
Issue: 7262
Pages: 415-8