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Search results 1 to 69 out of 69 for Impg2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Interphotoreceptor matrix proteoglycan 2 (IMPG2, also known as SPACRCAN) is a interphotoreceptor matrix proteoglycan that binds to chondroitin sulfate and hyaluronan. It may be involved in organisation of the insoluble interphotoreceptor matrix [, ]. Mutations in the IMPG2 gene cause retinitis pigmentosa 56 (RP56) []and vitelliform macular dystrophy 5 (VMD5) [].
Publication
First Author: Salido EM
Year: 2020
Journal: J Neurosci
Title: Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
Volume: 40
Issue: 20
Pages: 4059-4072
Publication
First Author: Xu H
Year: 2020
Journal: Hum Mol Genet
Title: Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice.
Volume: 29
Issue: 10
Pages: 1624-1634
Publication
First Author: Meunier I
Year: 2014
Journal: Ophthalmology
Title: Frequency and clinical pattern of vitelliform macular dystrophy caused by mutations of interphotoreceptor matrix IMPG1 and IMPG2 genes.
Volume: 121
Issue: 12
Pages: 2406-14
Protein
Organism: Mus musculus
Length: 128  
Fragment?: false
Publication
First Author: Bandah-Rozenfeld D
Year: 2010
Journal: Am J Hum Genet
Title: Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal-recessive retinitis pigmentosa.
Volume: 87
Issue: 2
Pages: 199-208
Publication  
First Author: Castberg T
Year: 1976
Journal: Acta Med Scand Suppl
Title: Complications from the pacemaker pocket. Prophylaxis, treatment and results.
Volume: 596
Pages: 51-4
Protein
Organism: Mus musculus
Length: 1243  
Fragment?: false
Allele
Name: interphotoreceptor matrix proteoglycan 2; endonuclease-mediated mutation 2, Xianjun Zhu
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication categories: ProxyCollection
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Chen Q
Year: 2003
Journal: Exp Eye Res
Title: SPACRCAN in the interphotoreceptor matrix of the mouse retina: molecular, developmental and promoter analysis.
Volume: 76
Issue: 1
Pages: 1-14
Publication
First Author: Chen Q
Year: 2004
Journal: J Biol Chem
Title: Spacrcan binding to hyaluronan and other glycosaminoglycans. Molecular and biochemical studies.
Volume: 279
Issue: 22
Pages: 23142-50
GXD Expression    
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585432
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585432
Age: embryonic day 16.0
Note: Expression was widespread.
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3585432
Age: embryonic day 18.0
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585432
Age: postnatal day 0-1
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585432
Age: postnatal day 2-3
Note: Expression was detected in the vitreal outer neuroblastic layer.
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585432
Age: postnatal day 4-5
Note: Expression was detected in the vitreal outer neuroblastic layer.
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585432
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3585432
Age: embryonic day 16.0
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 1
Publication
First Author: Zamfirescu RC
Year: 2021
Journal: Am J Physiol Cell Physiol
Title: mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition.
Volume: 320
Issue: 1
Pages: C30-C44
Allele
Name: interphotoreceptor matrix proteoglycan 2; endonuclease-mediated mutation 1, Xianjun Zhu
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication categories: ProxyCollection
Publication
First Author: Ghai R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Volume: 110
Issue: 8
Pages: E643-52
Publication
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Genotype
Symbol: Impg2/Impg2
Background: C57BL/6J-Impg2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Impg2/Impg2
Background: C57BL/6J-Impg2
Zygosity: hm
Has Mutant Allele: true
DO Term
Publication
First Author: Manes G
Year: 2013
Journal: Am J Hum Genet
Title: Mutations in IMPG1 cause vitelliform macular dystrophies.
Volume: 93
Issue: 3
Pages: 571-8
Protein Domain
Type: Family
Description: Interphotoreceptor matrix proteoglycan 2 (IMPG2, also known as SPACRCAN) is a interphotoreceptor matrix proteoglycan that binds to chondroitin sulfate and hyaluronan. It may be involved in organisation of the insoluble interphotoreceptor matrix [, ]. Mutations in the IMPG2 gene cause retinitis pigmentosa 56 (RP56) []and vitelliform macular dystrophy 5 (VMD5) [].This entry includes interphotoreceptor matrix proteoglycans 1 and 2.IMPG1, also known as SPACR, is a sialoprotein associated with photoreceptor cones and rods protein. It is a secreted glycoprotein containing a central mucin-like domain and an EGF-like domain in the C-terminal region. It also contains two SEA domains (after sea urchin sperm protein, enterokinase, and agrin), a highly conserved structure composed of four anti-parallel beta sheets surrounded by alpha helices in an O-linked glycosylation-rich environment. IMPG1 has been linked to vitelliform macular dystrophies [].
Publication  
First Author: Escher P
Year: 2008
Journal: Mol Vis
Title: Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice.
Volume: 14
Pages: 2126-35
Protein
Organism: Mus musculus
Length: 798  
Fragment?: false
Protein
Organism: Mus musculus
Length: 215  
Fragment?: true