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Search results 1 to 83 out of 83 for Impg2

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Hits by Category

Hits by Strain

Type Details Score
Gene
50939 | IMPG2
Type: gene
Organism: human
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Gene
101731798 | impg2
Type: gene
Organism: frog, western clawed
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Gene
245919 | Impg2
Type: gene
Organism: rat
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Gene
608491 | IMPG2
Type: gene
Organism: dog, domestic
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Gene
460558 | IMPG2
Type: gene
Organism: chimpanzee
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Gene
517845 | IMPG2
Type: gene
Organism: cattle
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Gene
418393 | IMPG2
Type: gene
Organism: chicken
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Gene
701319 | IMPG2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:3044955 | Impg2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR032975 | IMPG2
Type: Family
Description: Interphotoreceptor matrix proteoglycan 2 (IMPG2, also known as SPACRCAN) is a interphotoreceptor matrix proteoglycan that binds to chondroitin sulfate and hyaluronan. It may be involved in organisation of the insoluble interphotoreceptor matrix [, ]. Mutations in the IMPG2 gene cause retinitis pigmentosa 56 (RP56) []and vitelliform macular dystrophy 5 (VMD5) [].
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Publication
32265257 | J:288311
First Author: Salido EM
Year: 2020
Journal: J Neurosci
Title: Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
Volume: 40
Issue: 20
Pages: 4059-4072
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Publication
25085631 | -
First Author: Meunier I
Year: 2014
Journal: Ophthalmology
Title: Frequency and clinical pattern of vitelliform macular dystrophy caused by mutations of interphotoreceptor matrix IMPG1 and IMPG2 genes.
Volume: 121
Issue: 12
Pages: 2406-14
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Publication
37975905 | J:346749
First Author: Williams BN
Year: 2024
Journal: Hum Mol Genet
Title: Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.
Volume: 33
Issue: 5
Pages: 448-464
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Publication
32242237 | J:295355
First Author: Xu H
Year: 2020
Journal: Hum Mol Genet
Title: Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice.
Volume: 29
Issue: 10
Pages: 1624-1634
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Publication
36109576 | J:334833
First Author: Mitchell B
Year: 2022
Journal: Sci Rep
Title: Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze in the SEA domain and reveal localization mutual dependency.
Volume: 12
Issue: 1
Pages: 15535
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Protein
Q8C8X6
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Publication
20673862 | -
First Author: Bandah-Rozenfeld D
Year: 2010
Journal: Am J Hum Genet
Title: Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal-recessive retinitis pigmentosa.
Volume: 87
Issue: 2
Pages: 199-208
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Publication
1070225 | -
 
First Author: Castberg T
Year: 1976
Journal: Acta Med Scand Suppl
Title: Complications from the pacemaker pocket. Prophylaxis, treatment and results.
Volume: 596
Pages: 51-4
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Protein
Q80XH2
Organism: Mus musculus/domesticus
Length: 1243  
Fragment?: false
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Allele
Impg2<em2Xjz> | MGI:6466713
Name: interphotoreceptor matrix proteoglycan 2; endonuclease-mediated mutation 2, Xianjun Zhu
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein Coding Gene
MGP_CAROLIEiJ_G0020814 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022888 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022827 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022618 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3044955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022145 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022698 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022790 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022716 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023318 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021884 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022189 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016514 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021714 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12589770 | J:90863
First Author: Chen Q
Year: 2003
Journal: Exp Eye Res
Title: SPACRCAN in the interphotoreceptor matrix of the mouse retina: molecular, developmental and promoter analysis.
Volume: 76
Issue: 1
Pages: 1-14
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Publication
15044457 | J:90670
First Author: Chen Q
Year: 2004
Journal: J Biol Chem
Title: Spacrcan binding to hyaluronan and other glycosaminoglycans. Molecular and biochemical studies.
Volume: 279
Issue: 22
Pages: 23142-50
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GXD Expression
GXD Expression
   
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585432
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585432
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3585432
Age: embryonic day 18.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585432
Age: postnatal day 0-1
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585432
Age: postnatal day 2-3
Note: Expression was detected in the vitreal outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585432
Age: postnatal day 4-5
Note: Expression was detected in the vitreal outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585432
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3584881
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3585432
Age: embryonic day 16.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 1
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Allele
Impg2<em1Xjz> | MGI:6466711
Name: interphotoreceptor matrix proteoglycan 2; endonuclease-mediated mutation 1, Xianjun Zhu
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
33052068 | J:304555
First Author: Zamfirescu RC
Year: 2021
Journal: Am J Physiol Cell Physiol
Title: mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition.
Volume: 320
Issue: 1
Pages: C30-C44
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Publication
23382219 | J:194542
First Author: Ghai R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Volume: 110
Issue: 8
Pages: E643-52
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Allele
Impg2<em1Smoc> | MGI:7290544
Name: interphotoreceptor matrix proteoglycan 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7718112 | C57BL/6JSmoc-Impg2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Impg2/Impg2
Background: C57BL/6J-Impg2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Impg2/Impg2
Background: C57BL/6J-Impg2
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110371 | retinitis pigmentosa 56
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Publication
23993198 | -
First Author: Manes G
Year: 2013
Journal: Am J Hum Genet
Title: Mutations in IMPG1 cause vitelliform macular dystrophies.
Volume: 93
Issue: 3
Pages: 571-8
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Protein Domain
IPR039861 | IMPG
Type: Family
Description: This entry includes interphotoreceptor matrix proteoglycans 1 and 2.IMPG1, also known as SPACR, is a sialoprotein associated with photoreceptor cones and rods protein. It is a secreted glycoprotein containing a central mucin-like domain and an EGF-like domain in the C-terminal region. It also contains two SEA domains (after sea urchin sperm protein, enterokinase, and agrin), a highly conserved structure composed of four anti-parallel beta sheets surrounded by alpha helices in an O-linked glycosylation-rich environment. IMPG1 has been linked to vitelliform macular dystrophies [].Interphotoreceptor matrix proteoglycan 2 (IMPG2, also known as SPACRCAN) is a interphotoreceptor matrix proteoglycan that binds to chondroitin sulfate and hyaluronan. It may be involved in organisation of the insoluble interphotoreceptor matrix [, ]. Mutations in the IMPG2 gene cause retinitis pigmentosa 56 (RP56) []and vitelliform macular dystrophy 5 (VMD5) [].
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Publication
19050768 | J:142700
 
First Author: Escher P
Year: 2008
Journal: Mol Vis
Title: Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice.
Volume: 14
Pages: 2126-35
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Protein
Q8R1W8
Organism: Mus musculus/domesticus
Length: 798  
Fragment?: false
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Protein
A0A140T8V8
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
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