Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The CDK2-associated cyclin A1 is essential for spermatogenesis, and contributes to leukemogenesis, but its detailed molecular functions are unclear. Several novel cyclin A1/CDK2 interaction partners have been identified by means of a yeast triple-hybrid approach, including INCA1, KARCA1 and PROCA1. These proteins link the cyclin A1-CDK2 complex to diverse cellular processes, such as DNA repair, signalling and splicing [].One of the new genes has been cloned and characterised, and named INCA1 (inhibitor of CDK interacting with cyclin A1). The nuclear INCA1 protein is evolutionarily conserved but shares no similarity with any known gene. This novel protein and two other interacting partners serve as substrates for the cyclin A1-CDK2 kinase complex []. |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
231
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Diederichs S |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. |
Volume: |
279 |
Issue: |
32 |
Pages: |
33727-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang F |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. |
Volume: |
6 |
Issue: |
7 |
Pages: |
e21505 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bäumer N |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. |
Volume: |
286 |
Issue: |
32 |
Pages: |
28210-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bäumer N |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1. |
Volume: |
9 |
Issue: |
12 |
Pages: |
e115578 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1737921 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13140 |
|
Specimen Label: |
GUDMAP:13140 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796521 |
Pattern: |
Spotted |
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
Note: |
graded expression |
Specimen Label: |
GUDMAP:13142 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1737321 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13139 |
|
Specimen Label: |
GUDMAP:13139 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1795921 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
|
Specimen Label: |
GUDMAP:13142 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Ambiguous |
Sex: |
Female |
Emaps: |
EMAPS:2888021 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
|
Specimen Label: |
GUDMAP:13142 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2888821 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
|
Specimen Label: |
GUDMAP:13142 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1795021 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13139 |
|
Specimen Label: |
GUDMAP:13139 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2890921 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
|
Specimen Label: |
GUDMAP:13142 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2913821 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13141 |
|
Specimen Label: |
GUDMAP:13141 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:3090121 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13140 |
|
Specimen Label: |
GUDMAP:13140 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2918521 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13141 |
|
Specimen Label: |
GUDMAP:13141 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796321 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
|
Specimen Label: |
GUDMAP:13142 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797221 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13141 |
|
Specimen Label: |
GUDMAP:13141 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2894021 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
|
Specimen Label: |
GUDMAP:13142 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2917321 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13141 |
|
Specimen Label: |
GUDMAP:13141 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:3087021 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13140 |
|
Specimen Label: |
GUDMAP:13140 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2894521 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
|
Specimen Label: |
GUDMAP:13142 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796221 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:5541975 |
Age: |
embryonic day 13.5 |
Image: |
GUDMAP:13142 |
|
Specimen Label: |
GUDMAP:13142 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Protein INCA1 |
Type: |
chain |
End: |
231 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
196
 |
Fragment?: |
false |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
117 |
Description: |
Essential for interaction with INCA1 |
Type: |
site |
End: |
117 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
119 |
Description: |
Essential for interaction with INCA1 |
Type: |
site |
End: |
119 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE54418 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Heck MV |
Year: |
2014 |
Journal: |
Neurogenetics |
Title: |
Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue. |
Volume: |
15 |
Issue: |
2 |
Pages: |
135-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|