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Search results 1 to 100 out of 1235 for Ins1

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0.036s
Type Details Score
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
GXD Expression  
Probe: MGI:3826505
Assay Type: RNA in situ
Annotation Date: 2009-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826657
Age: embryonic day 14.5
Image: 2 Ins1
Detected: true
Specimen Num: 1
Publication
First Author: Hasegawa Y
Year: 2016
Journal: Exp Anim
Title: Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice.
Volume: 65
Issue: 3
Pages: 319-27
Publication
First Author: Abdellatif AM
Year: 2016
Journal: PLoS One
Title: β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Volume: 11
Issue: 2
Pages: e0150010
Publication
First Author: Thorens B
Year: 2015
Journal: Diabetologia
Title: Ins1(Cre) knock-in mice for beta cell-specific gene recombination.
Volume: 58
Issue: 3
Pages: 558-65
Publication  
First Author: Mosleh E
Year: 2020
Journal: Endocrinology
Title: Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation.
Volume: 161
Issue: 8
Publication
First Author: Hennings TG
Year: 2018
Journal: Endocrinology
Title: In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption.
Volume: 159
Issue: 9
Pages: 3245-3256
Publication
First Author: Nguyen-Tu MS
Year: 2018
Journal: J Biol Chem
Title: Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion.
Volume: 293
Issue: 36
Pages: 14178-14189
Publication  
First Author: Carrat GR
Year: 2020
Journal: Mol Metab
Title: The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
Volume: 40
Pages: 101015
Publication
First Author: D'souza AM
Year: 2017
Journal: Mol Metab
Title: Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia.
Volume: 6
Issue: 6
Pages: 585-593
Publication
First Author: Marquard J
Year: 2015
Journal: Nat Med
Title: Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
Volume: 21
Issue: 4
Pages: 363-72
Publication
First Author: Shirakawa J
Year: 2017
Journal: Cell Metab
Title: Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.
Volume: 25
Issue: 4
Pages: 868-882.e5
Publication
First Author: Patel D
Year: 2015
Journal: Mol Metab
Title: Clic4, a novel protein that sensitizes β-cells to apoptosis.
Volume: 4
Issue: 4
Pages: 253-64
Publication
First Author: Cane MC
Year: 2016
Journal: Cell Calcium
Title: The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.
Volume: 59
Issue: 1
Pages: 32-40
Publication
First Author: Yang Y
Year: 2017
Journal: Endocrinology
Title: Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function.
Volume: 158
Issue: 1
Pages: 9-20
Publication
First Author: Sabatini PV
Year: 2018
Journal: Cell Rep
Title: Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells.
Volume: 22
Issue: 1
Pages: 163-174
Publication
First Author: Mitchell RK
Year: 2016
Journal: Mol Endocrinol
Title: Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.
Volume: 30
Issue: 1
Pages: 77-91
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication
First Author: Spaeth JM
Year: 2019
Journal: Diabetes
Title: The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function.
Volume: 68
Issue: 9
Pages: 1806-1818
Publication
First Author: Danilova T
Year: 2019
Journal: Diabetes
Title: MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice.
Volume: 68
Issue: 1
Pages: 66-80
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication  
First Author: Kragl M
Year: 2016
Journal: Nat Commun
Title: The biomechanical properties of an epithelial tissue determine the location of its vasculature.
Volume: 7
Pages: 13560
Publication
First Author: Carrat GR
Year: 2017
Journal: Am J Hum Genet
Title: Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
Volume: 100
Issue: 2
Pages: 238-256
Publication
First Author: Corsa CAS
Year: 2019
Journal: J Biol Chem
Title: The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic β cells and adipocytes.
Volume: 294
Issue: 18
Pages: 7296-7307
Publication
First Author: Hughes JW
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Primary cilia control glucose homeostasis via islet paracrine interactions.
Volume: 117
Issue: 16
Pages: 8912-8923
Publication
First Author: Millership SJ
Year: 2018
Journal: J Clin Invest
Title: Neuronatin regulates pancreatic β cell insulin content and secretion.
Volume: 128
Issue: 8
Pages: 3369-3381
Publication
First Author: Modi H
Year: 2015
Journal: Diabetes
Title: Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.
Volume: 64
Issue: 12
Pages: 4148-57
Publication
First Author: Wong C
Year: 2020
Journal: Cell Death Differ
Title: Two well-differentiated pancreatic neuroendocrine tumor mouse models.
Volume: 27
Issue: 1
Pages: 269-283
Publication
First Author: Marasco MR
Year: 2018
Journal: Diabetes
Title: Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response.
Volume: 67
Issue: 8
Pages: 1576-1588
Publication  
First Author: Berdous D
Year: 2020
Journal: Mol Metab
Title: A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion.
Volume: 37
Pages: 100993
Publication  
First Author: Navarro G
Year: 2018
Journal: JCI Insight
Title: Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.
Volume: 3
Issue: 12
Publication
First Author: Zhang M
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes.
Volume: 113
Issue: 3
Pages: 650-5
Publication  
First Author: Stefan-Lifshitz M
Year: 2019
Journal: JCI Insight
Title: Epigenetic modulation of β cells by interferon-α via PNPT1/mir-26a/TET2 triggers autoimmune diabetes.
Volume: 4
Issue: 5
Publication
First Author: Kone M
Year: 2014
Journal: FASEB J
Title: LKB1 and AMPK differentially regulate pancreatic β-cell identity.
Volume: 28
Issue: 11
Pages: 4972-85
Publication  
First Author: Xiafukaiti G
Year: 2019
Journal: Mol Cell Biol
Title: MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition.
Volume: 39
Issue: 17
Publication
First Author: Navarro G
Year: 2016
Journal: Cell Metab
Title: Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.
Volume: 23
Issue: 5
Pages: 837-51
Publication
First Author: Tamarina NA
Year: 2014
Journal: Islets
Title: Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic β-cells.
Volume: 6
Issue: 1
Pages: e27685
Publication
First Author: Deltour L
Year: 2004
Journal: Gene Expr Patterns
Title: Differential expression and imprinting status of Ins1 and Ins2 genes in extraembryonic tissues of laboratory mice.
Volume: 5
Issue: 2
Pages: 297-300
Publication  
First Author: Leroux L
Year: 2001
Journal: Diabetes
Title: Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.
Volume: 50 Suppl 1
Pages: S150-3
Publication
First Author: Cheng Y
Year: 2015
Journal: Endocrinology
Title: Generation and Characterization of Transgenic Mice Expressing Mouse Ins1 Promoter for Pancreatic β-Cell-Specific Gene Overexpression and Knockout.
Volume: 156
Issue: 7
Pages: 2724-31
Publication
First Author: Babaya N
Year: 2006
Journal: Diabetologia
Title: A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2.
Volume: 49
Issue: 6
Pages: 1222-8
Allele
Name: transgene insertion 16.7, Mouse Clinical Institute
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Publication
First Author: Hasegawa Y
Year: 2014
Journal: Exp Anim
Title: Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP recombination.
Volume: 63
Issue: 2
Pages: 183-91
Allele
Name: transgene insertion 25, Ken-ichi Yagami
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication
First Author: Piccand J
Year: 2014
Journal: Cell Rep
Title: Rfx6 maintains the functional identity of adult pancreatic β cells.
Volume: 9
Issue: 6
Pages: 2219-32
Publication      
First Author: Pavlovic G
Year: 2013
Journal: MGI Direct Data Submission
Title: Data submissions from the Mouse Clinical Institute (ICS)
Strain
Attribute String: mutant strain, coisogenic, transgenic
Strain
Attribute String: congenic, targeted mutation, transgenic
Strain
Attribute String: transgenic, targeted mutation, coisogenic
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Ins1-cre)25Utr/?
Background: B6.Cg-Gt(ROSA)26Sor Tg(Ins1-cre)25Utr
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Ins1-cre)25Utr/?
Background: C57BL/6N-Gt(ROSA)26Sor Tg(Ins1-cre)25Utr
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Mitchell RK
Year: 2015
Journal: Hum Mol Genet
Title: Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.
Volume: 24
Issue: 5
Pages: 1390-9
Publication
First Author: Mehta ZB
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.
Volume: 311
Issue: 2
Pages: E488-507
Publication
First Author: Hasegawa Y
Year: 2013
Journal: Exp Anim
Title: Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination.
Volume: 62
Issue: 4
Pages: 295-304
Publication
First Author: Yagishita Y
Year: 2017
Journal: Cell Rep
Title: Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress.
Volume: 18
Issue: 8
Pages: 2030-2044
Publication
First Author: Kaihara KA
Year: 2015
Journal: Diabetes
Title: PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control.
Volume: 64
Issue: 5
Pages: 1688-97
Publication
First Author: Wicksteed B
Year: 2010
Journal: Diabetes
Title: Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
Volume: 59
Issue: 12
Pages: 3090-8
Publication
First Author: Malenczyk K
Year: 2017
Journal: EMBO J
Title: A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.
Volume: 36
Issue: 14
Pages: 2107-2125
Publication
First Author: Ussher JR
Year: 2018
Journal: Cell Metab
Title: Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.
Volume: 27
Issue: 2
Pages: 450-460.e6
Publication
First Author: Quarta C
Year: 2017
Journal: Cell Metab
Title: Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.
Volume: 26
Issue: 4
Pages: 620-632.e6
Publication
First Author: Oakie A
Year: 2019
Journal: Diabetologia
Title: Long-term c-Kit overexpression in beta cells compromises their function in ageing mice.
Volume: 62
Issue: 8
Pages: 1430-1444
Publication  
First Author: Oakie A
Year: 2020
Journal: Mol Cell Endocrinol
Title: Postnatal knockout of beta cell insulin receptor impaired insulin secretion in male mice exposed to high-fat diet stress.
Volume: 499
Pages: 110588
Publication
First Author: Magnuson MA
Year: 2013
Journal: Cell Metab
Title: Pancreas-specific Cre driver lines and considerations for their prudent use.
Volume: 18
Issue: 1
Pages: 9-20
Publication
First Author: Swisa A
Year: 2017
Journal: J Clin Invest
Title: PAX6 maintains β cell identity by repressing genes of alternative islet cell types.
Volume: 127
Issue: 1
Pages: 230-243
Publication
First Author: Ediger BN
Year: 2017
Journal: J Clin Invest
Title: LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.
Volume: 127
Issue: 1
Pages: 215-229
Publication
First Author: van der Meulen T
Year: 2017
Journal: Cell Metab
Title: Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.
Volume: 25
Issue: 4
Pages: 911-926.e6
Publication
First Author: Bartolome A
Year: 2019
Journal: J Clin Invest
Title: Notch signaling dynamically regulates adult β cell proliferation and maturity.
Volume: 129
Issue: 1
Pages: 268-280
Publication
First Author: Kim K
Year: 2015
Journal: Endocrinology
Title: Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.
Volume: 156
Issue: 2
Pages: 444-52
Publication
First Author: Liu G
Year: 2015
Journal: Hum Mol Genet
Title: Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.
Volume: 24
Issue: 18
Pages: 5299-312
Publication
First Author: Oropeza D
Year: 2015
Journal: Diabetes
Title: Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.
Volume: 64
Issue: 11
Pages: 3798-807
Publication  
First Author: Blandino-Rosano M
Year: 2017
Journal: Nat Commun
Title: Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Volume: 8
Pages: 16014
Publication  
First Author: Levasseur EM
Year: 2019
Journal: Sci Signal
Title: Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Volume: 12
Issue: 610
Allele
Name: insulin I; targeted mutation 1.1, Bernard Thorens
Allele Type: Targeted
Attribute String: Null/knockout, Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: targeted mutation, mutant strain
Strain
Attribute String: mutant strain, targeted mutation, congenic
Strain
Attribute String: mutant strain, targeted mutation
Allele
Name: insulin I; targeted mutation 2.1, Bernard Thorens
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: targeted mutation, mutant strain
Allele
Name: insulin I; targeted mutation 2, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Inducible, Recombinase, Reporter
Publication categories: ProxyCollection
Strain
Attribute String: targeted mutation, mutant strain, coisogenic
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Allele
Name: insulin I; targeted mutation 1, Guy Rutter
Allele Type: Targeted
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication      
First Author: National Laboratory Animal Center, National Applied Research Laboratories
Year: 2013
Journal: MGI Direct Data Submission
Title: Transgene insertion mice at National Laboratory Animal Center, National Applied Research Laboratories
Publication
First Author: Campbell JE
Year: 2016
Journal: Nat Med
Title: TCF1 links GIPR signaling to the control of beta cell function and survival.
Volume: 22
Issue: 1
Pages: 84-90
Allele
Name: insulin I; endonuclease-mediated mutation 1, Ken-ichi Yagami
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
Publication
First Author: Blanchet E
Year: 2015
Journal: Cell Rep
Title: Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance.
Volume: 10
Issue: 7
Pages: 1149-57
Publication
First Author: Alejandro EU
Year: 2015
Journal: Cell Rep
Title: Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.
Volume: 13
Issue: 11
Pages: 2527-2538
Publication
First Author: Zhao S
Year: 2014
Journal: Cell Metab
Title: α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion.
Volume: 19
Issue: 6
Pages: 993-1007
Publication
First Author: Attané C
Year: 2016
Journal: Diabetologia
Title: A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice.
Volume: 59
Issue: 12
Pages: 2654-2663
Publication
First Author: Smith EP
Year: 2014
Journal: Cell Metab
Title: The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.
Volume: 19
Issue: 6
Pages: 1050-7
Publication
First Author: Zhu K
Year: 2020
Journal: Nat Commun
Title: Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice.
Volume: 11
Issue: 1
Pages: 484
Publication
First Author: Kim H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Ectopic serotonin production in β-cell specific transgenic mice.
Volume: 495
Issue: 2
Pages: 1986-1991
Publication
First Author: Loyd C
Year: 2017
Journal: Endocrinology
Title: LDB1 Regulates Energy Homeostasis During Diet-Induced Obesity.
Volume: 158
Issue: 5
Pages: 1289-1297
Publication
First Author: Qin K
Year: 2018
Journal: Diabetologia
Title: SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Volume: 61
Issue: 4
Pages: 906-918
Publication
First Author: Kaihara KA
Year: 2013
Journal: Diabetes
Title: β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.
Volume: 62
Issue: 5
Pages: 1527-36
Publication
First Author: Dadi PK
Year: 2014
Journal: Endocrinology
Title: Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.
Volume: 155
Issue: 10
Pages: 3757-68
Publication
First Author: Xiong X
Year: 2016
Journal: Diabetologia
Title: Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells.
Volume: 59
Issue: 1
Pages: 151-60
Publication
First Author: Bergeron V
Year: 2018
Journal: Diabetes
Title: Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.
Volume: 67
Issue: 1
Pages: 71-77