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Search results 1 to 100 out of 2174 for Ins2

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Type Details Score
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication      
First Author: King A
Year: 2020
Journal: MGI Direct Data Submission
Title: Ins2 Kings allele
Publication  
First Author: Li L
Year: 2016
Journal: Sci Rep
Title: Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons.
Volume: 6
Pages: 20438
GXD Expression  
Probe: MGI:3820901
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825694
Age: embryonic day 14.5
Image: 5 Ins2
Detected: true
Specimen Num: 1
Allele
Name: insulin II; KCL Ins2 G32S
Allele Type: Spontaneous
Attribute String: Not Specified
Publication categories: ProxyCollection
Publication
First Author: Fan Y
Year: 2009
Journal: EMBO J
Title: Thymus-specific deletion of insulin induces autoimmune diabetes.
Volume: 28
Issue: 18
Pages: 2812-24
Publication
First Author: Matsuda T
Year: 2010
Journal: J Clin Invest
Title: Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.
Volume: 120
Issue: 1
Pages: 115-26
Publication
First Author: Nakamura K
Year: 2011
Journal: Biomed Res
Title: Pancreatic β-cells are generated by neogenesis from non-β-cells after birth.
Volume: 32
Issue: 2
Pages: 167-74
GXD Expression  
Probe: MGI:3820901
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825694
Age: embryonic day 14.5
Image: Additional file 4 Ins2
Detected: true
Specimen Num: 2
Publication    
First Author: Riahi Y
Year: 2018
Journal: Elife
Title: Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse.
Volume: 7
Publication
First Author: Winnay JN
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis.
Volume: 111
Issue: 3
Pages: 1192-7
Publication
First Author: Lee AH
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.
Volume: 108
Issue: 21
Pages: 8885-90
Publication  
First Author: Blum B
Year: 2014
Journal: Elife
Title: Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.
Volume: 3
Pages: e02809
Publication
First Author: Dahan T
Year: 2017
Journal: Diabetes
Title: Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.
Volume: 66
Issue: 2
Pages: 426-436
Publication  
First Author: Wu X
Year: 2014
Journal: Physiol Rep
Title: Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.
Volume: 2
Issue: 11
Publication
First Author: Magnuson MA
Year: 2013
Journal: Cell Metab
Title: Pancreas-specific Cre driver lines and considerations for their prudent use.
Volume: 18
Issue: 1
Pages: 9-20
Publication
First Author: Schaffer AE
Year: 2013
Journal: PLoS Genet
Title: Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
Volume: 9
Issue: 1
Pages: e1003274
Publication
First Author: Talchai C
Year: 2012
Journal: Cell
Title: Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.
Volume: 150
Issue: 6
Pages: 1223-34
Publication
First Author: Kesavan G
Year: 2014
Journal: Development
Title: Cdc42/N-WASP signaling links actin dynamics to pancreatic β cell delamination and differentiation.
Volume: 141
Issue: 3
Pages: 685-96
Publication
First Author: Gannon M
Year: 2008
Journal: Dev Biol
Title: pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.
Volume: 314
Issue: 2
Pages: 406-17
Publication
First Author: Talchai SC
Year: 2015
Journal: Diabetes
Title: Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.
Volume: 64
Issue: 8
Pages: 2868-79
Publication
First Author: Pan FC
Year: 2015
Journal: Development
Title: Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.
Volume: 142
Issue: 21
Pages: 3637-48
Publication
First Author: Martín J
Year: 2003
Journal: Oncogene
Title: Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
Volume: 22
Issue: 34
Pages: 5261-9
Publication
First Author: Paul L
Year: 2016
Journal: Diabetes
Title: Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.
Volume: 65
Issue: 3
Pages: 687-98
Publication
First Author: Alejandro EU
Year: 2011
Journal: FASEB J
Title: Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription.
Volume: 25
Issue: 11
Pages: 3884-95
Publication
First Author: Xue J
Year: 2019
Journal: Cell Rep
Title: CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.
Volume: 28
Issue: 11
Pages: 2892-2904.e7
Publication
First Author: Wang S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.
Volume: 106
Issue: 24
Pages: 9715-20
Publication
First Author: Bonnavion R
Year: 2015
Journal: Mol Cell Biol
Title: Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors.
Volume: 35
Issue: 19
Pages: 3274-83
Publication
First Author: Yang YP
Year: 2017
Journal: Development
Title: The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation.
Volume: 144
Issue: 2
Pages: 248-257
Publication
First Author: Kon N
Year: 2012
Journal: J Biol Chem
Title: Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.
Volume: 287
Issue: 7
Pages: 5102-11
Publication
First Author: Edfalk S
Year: 2008
Journal: Diabetes
Title: Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.
Volume: 57
Issue: 9
Pages: 2280-7
Publication
First Author: Goulley J
Year: 2007
Journal: Cell Metab
Title: BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Volume: 5
Issue: 3
Pages: 207-19
Publication
First Author: Yang Y
Year: 2017
Journal: Endocrinology
Title: Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function.
Volume: 158
Issue: 1
Pages: 9-20
Publication
First Author: Chamberlain CE
Year: 2014
Journal: J Clin Invest
Title: Menin determines K-RAS proliferative outputs in endocrine cells.
Volume: 124
Issue: 9
Pages: 4093-101
Publication
First Author: Nir T
Year: 2007
Journal: J Clin Invest
Title: Recovery from diabetes in mice by beta cell regeneration.
Volume: 117
Issue: 9
Pages: 2553-61
Publication
First Author: Romer AI
Year: 2019
Journal: Diabetes
Title: Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1.
Volume: 68
Issue: 12
Pages: 2259-2271
Publication
First Author: Wei FY
Year: 2011
Journal: J Clin Invest
Title: Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice.
Volume: 121
Issue: 9
Pages: 3598-608
Publication
First Author: Wakae-Takada N
Year: 2013
Journal: Diabetologia
Title: Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin.
Volume: 56
Issue: 4
Pages: 856-66
Publication
First Author: Boj SF
Year: 2012
Journal: Cell
Title: Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Volume: 151
Issue: 7
Pages: 1595-607
Publication  
First Author: Kim-Muller JY
Year: 2016
Journal: Nat Commun
Title: Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.
Volume: 7
Pages: 12631
Publication
First Author: Moon JH
Year: 2020
Journal: Diabetes
Title: Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.
Volume: 69
Issue: 2
Pages: 205-214
Publication
First Author: Shi JH
Year: 2020
Journal: Diabetes
Title: Liver ChREBP Protects Against Fructose-Induced Glycogenic Hepatotoxicity by Regulating L-Type Pyruvate Kinase.
Volume: 69
Issue: 4
Pages: 591-602
Publication
First Author: Diaferia GR
Year: 2013
Journal: Development
Title: β1 integrin is a crucial regulator of pancreatic β-cell expansion.
Volume: 140
Issue: 16
Pages: 3360-72
Publication
First Author: Stiles BL
Year: 2006
Journal: Mol Cell Biol
Title: Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
Volume: 26
Issue: 7
Pages: 2772-81
Publication
First Author: Gu Y
Year: 2011
Journal: Diabetes
Title: Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.
Volume: 60
Issue: 3
Pages: 827-37
Publication
First Author: Tsai MJ
Year: 2014
Journal: Endocrinology
Title: TCTP is essential for β-cell proliferation and mass expansion during development and β-cell adaptation in response to insulin resistance.
Volume: 155
Issue: 2
Pages: 392-404
Publication
First Author: Pomplun D
Year: 2007
Journal: Horm Metab Res
Title: Alterations of pancreatic beta-cell mass and islet number due to Ins2-controlled expression of Cre recombinase: RIP-Cre revisited; part 2.
Volume: 39
Issue: 5
Pages: 336-40
Publication
First Author: Cui Y
Year: 2004
Journal: Mol Cell Biol
Title: Essential role of STAT3 in body weight and glucose homeostasis.
Volume: 24
Issue: 1
Pages: 258-69
Publication
First Author: Brissova M
Year: 2006
Journal: Diabetes
Title: Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.
Volume: 55
Issue: 11
Pages: 2974-85
Publication
First Author: Valtat B
Year: 2011
Journal: Diabetologia
Title: Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice.
Volume: 54
Issue: 2
Pages: 350-9
Publication
First Author: Lu J
Year: 2010
Journal: Gastroenterology
Title: Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.
Volume: 138
Issue: 5
Pages: 1954-65
Publication
First Author: Li F
Year: 2015
Journal: Endocrinology
Title: Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.
Volume: 156
Issue: 1
Pages: 48-57
Publication
First Author: Lu J
Year: 2012
Journal: Oncogene
Title: Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.
Volume: 31
Issue: 31
Pages: 3647-54
Publication
First Author: van Arensbergen J
Year: 2013
Journal: Genes Dev
Title: Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells.
Volume: 27
Issue: 1
Pages: 52-63
Publication
First Author: Tsuchiya Y
Year: 2018
Journal: J Cell Biol
Title: IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.
Volume: 217
Issue: 4
Pages: 1287-1301
Publication
First Author: Back SH
Year: 2009
Journal: Cell Metab
Title: Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
Volume: 10
Issue: 1
Pages: 13-26
Publication
First Author: Jarchum I
Year: 2010
Journal: J Immunol
Title: Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.
Volume: 184
Issue: 2
Pages: 658-65
Publication
First Author: Gastinger MJ
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice.
Volume: 49
Issue: 6
Pages: 2635-42
Publication
First Author: Duvillié B
Year: 1998
Journal: Genomics
Title: Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.
Volume: 47
Issue: 1
Pages: 52-7
Publication
First Author: Deltour L
Year: 2004
Journal: Gene Expr Patterns
Title: Differential expression and imprinting status of Ins1 and Ins2 genes in extraembryonic tissues of laboratory mice.
Volume: 5
Issue: 2
Pages: 297-300
Publication
First Author: Fang F
Year: 2015
Journal: Diabetologia
Title: Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse.
Volume: 58
Issue: 7
Pages: 1668-78
Publication
First Author: Lamotte L
Year: 2004
Journal: Transgenic Res
Title: Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
Volume: 13
Issue: 5
Pages: 463-73
Publication  
First Author: Francis AW
Year: 2018
Journal: J Ophthalmol
Title: Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography.
Volume: 2018
Pages: 7253498
Publication
First Author: Pearce RB
Year: 1996
Journal: Mamm Genome
Title: Clarification of the Ins2 gene sequence: relevance to glucose intolerance in NON/Lt mice.
Volume: 7
Issue: 2
Pages: 143-4
Publication
First Author: Lefebvre L
Year: 2009
Journal: Hum Mol Genet
Title: The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.
Volume: 18
Issue: 22
Pages: 4255-67
Publication
First Author: Herbach N
Year: 2007
Journal: Diabetes
Title: Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.
Volume: 56
Issue: 5
Pages: 1268-76
Publication
First Author: de Preux Charles AS
Year: 2010
Journal: PLoS One
Title: Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.
Volume: 5
Issue: 5
Pages: e10832
Publication
First Author: Templeman NM
Year: 2016
Journal: PLoS One
Title: Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility.
Volume: 11
Issue: 4
Pages: e0153280
Publication
First Author: Pearson T
Year: 2008
Journal: Diabetologia
Title: A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Volume: 51
Issue: 8
Pages: 1449-56
Allele
Name: insulin II; targeted mutation 1, Susumu Seino
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Genotype
Symbol: Ins2/Ins2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Wicksteed B
Year: 2010
Journal: Diabetes
Title: Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
Volume: 59
Issue: 12
Pages: 3090-8
Genotype
Symbol: Cebpb/Cebpb Ins2/Ins2 Tg(Ins2-cre)23Herr/?
Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Nozaki Ji
Year: 2004
Journal: Genes Cells
Title: The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.
Volume: 9
Issue: 3
Pages: 261-70
Publication
First Author: Schoeller EL
Year: 2012
Journal: Diabetes
Title: Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary-gonadal axis in Akita diabetic mice and restores male fertility.
Volume: 61
Issue: 7
Pages: 1869-78
Publication
First Author: Takeshita S
Year: 2012
Journal: Genes Genet Syst
Title: Diabetic modifier QTL, Dbm4, affecting elevated fasting blood glucose concentrations in congenic mice.
Volume: 87
Issue: 5
Pages: 341-6
Publication
First Author: Yeh CK
Year: 2012
Journal: Lab Invest
Title: Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice.
Volume: 92
Issue: 6
Pages: 868-82
Publication
First Author: Kakoki M
Year: 2006
Journal: J Clin Invest
Title: Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.
Volume: 116
Issue: 5
Pages: 1302-9
Publication
First Author: Vashistha H
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.
Volume: 303
Issue: 12
Pages: F1629-40
Publication
First Author: Jun JY
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Spontaneously diabetic Ins2(+/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis.
Volume: 301
Issue: 1
Pages: E145-54
Publication
First Author: Takeshita S
Year: 2006
Journal: Mamm Genome
Title: Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice.
Volume: 17
Issue: 9
Pages: 927-40
Publication
First Author: Han J
Year: 2013
Journal: Nat Cell Biol
Title: ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.
Volume: 15
Issue: 5
Pages: 481-90
Publication  
First Author: Wang B
Year: 2018
Journal: EMBO Rep
Title: Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system.
Volume: 19
Issue: 4
Publication  
First Author: Yu J
Year: 2013
Journal: Sci Rep
Title: Metabolic characterization of a Sirt5 deficient mouse model.
Volume: 3
Pages: 2806
Publication
First Author: Prevost G
Year: 2013
Journal: Endocrinology
Title: The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human β-cells and its targeted inactivation impairs glucose tolerance.
Volume: 154
Issue: 10
Pages: 3796-806
Publication
First Author: Cape A
Year: 2012
Journal: Cell Mol Life Sci
Title: Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.
Volume: 69
Issue: 8
Pages: 1305-17
Publication
First Author: Lee J
Year: 2013
Journal: Mol Cell Biol
Title: Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice.
Volume: 33
Issue: 11
Pages: 2327-38
Publication
First Author: Zhang Q
Year: 2014
Journal: J Physiol
Title: Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.
Volume: 592
Issue: 21
Pages: 4677-96
Publication
First Author: Srinivasan M
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion.
Volume: 299
Issue: 6
Pages: E910-7
Publication
First Author: Smemo S
Year: 2014
Journal: Nature
Title: Obesity-associated variants within FTO form long-range functional connections with IRX3.
Volume: 507
Issue: 7492
Pages: 371-5
Publication
First Author: Sund NJ
Year: 2001
Journal: Genes Dev
Title: Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.
Volume: 15
Issue: 13
Pages: 1706-15
Publication
First Author: Liang T
Year: 2017
Journal: J Biol Chem
Title: New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment.
Volume: 292
Issue: 6
Pages: 2203-2216
Publication
First Author: Pearson ER
Year: 2007
Journal: PLoS Med
Title: Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.
Volume: 4
Issue: 4
Pages: e118
Publication
First Author: Tanabe K
Year: 2008
Journal: PLoS Biol
Title: Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
Volume: 6
Issue: 2
Pages: e37
Publication
First Author: Postic C
Year: 1999
Journal: J Biol Chem
Title: Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
Volume: 274
Issue: 1
Pages: 305-15
Publication
First Author: Gautam D
Year: 2006
Journal: Cell Metab
Title: A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.
Volume: 3
Issue: 6
Pages: 449-61
Publication
First Author: Gupta RK
Year: 2005
Journal: J Clin Invest
Title: The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
Volume: 115
Issue: 4
Pages: 1006-15
Publication  
First Author: Switon K
Year: 2017
Journal: Neuroscience
Title: Molecular neurobiology of mTOR.
Volume: 341
Pages: 112-153
Publication
First Author: Xie L
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.
Volume: 108
Issue: 24
Pages: 9939-44