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Search results 1 to 100 out of 233 for Insl3

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0.05s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: pig, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Insulin-like 3 (INSL3) is a secreted protein produced by testicular Leydig cells and in lower amounts by ovarian follicular theca interna cells and the corpus luteum []. It acts as a theca cell-derived growth factor for preantral follicle and its action is mediated by growth differentiation factor 9 []. Signaling through INSL3 and its cognate G protein-coupled receptor RXFP2 is important for testicular descent. It seems to be dispensable for spermatogenesis and fertility in adult males [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Huang Z
Year: 2012
Journal: Biol Reprod
Title: Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice.
Volume: 87
Issue: 6
Pages: 143
Publication
First Author: Hombach-Klonisch S
Year: 2010
Journal: Int J Cancer
Title: INSL3 has tumor-promoting activity in thyroid cancer.
Volume: 127
Issue: 3
Pages: 521-31
Publication
First Author: Adham IM
Year: 2002
Journal: Mol Endocrinol
Title: The overexpression of the insl3 in female mice causes descent of the ovaries.
Volume: 16
Issue: 2
Pages: 244-52
Publication
First Author: Li Y
Year: 2018
Journal: Genes Cells
Title: FEAT enhances INSL3 expression in testicular Leydig cells.
Volume: 23
Issue: 11
Pages: 952-962
Publication
First Author: Zimmermann S
Year: 1999
Journal: Mol Endocrinol
Title: Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.
Volume: 13
Issue: 5
Pages: 681-91
Publication
First Author: Adham IM
Year: 2000
Journal: Mol Cell Endocrinol
Title: The role of the testicular factor INSL3 in establishing the gonadal position.
Volume: 160
Issue: 1-2
Pages: 11-6
Publication
First Author: Laguë E
Year: 2008
Journal: Endocrinology
Title: Antagonistic effects of testosterone and the endocrine disruptor mono-(2-ethylhexyl) phthalate on INSL3 transcription in Leydig cells.
Volume: 149
Issue: 9
Pages: 4688-94
Publication
First Author: Mendoza-Villarroel RE
Year: 2014
Journal: J Mol Endocrinol
Title: The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells.
Volume: 53
Issue: 1
Pages: 43-55
Publication
First Author: Bathgate R
Year: 1996
Journal: Biol Reprod
Title: Relaxin-like factor gene is highly expressed in the bovine ovary of the cycle and pregnancy: sequence and messenger ribonucleic acid analysis.
Volume: 55
Issue: 6
Pages: 1452-7
Publication
First Author: Xue K
Year: 2014
Journal: Endocrinology
Title: Insulin-like 3-induced rat preantral follicular growth is mediated by growth differentiation factor 9.
Volume: 155
Issue: 1
Pages: 156-67
Protein
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
Publication
First Author: Nef S
Year: 1999
Journal: Nat Genet
Title: Cryptorchidism in mice mutant for Insl3.
Volume: 22
Issue: 3
Pages: 295-9
Publication
First Author: Kubota Y
Year: 2001
Journal: J Urol
Title: Leydig insulin-like hormone, gubernacular development and testicular descent.
Volume: 165
Issue: 5
Pages: 1673-5
Publication
First Author: Kamat AA
Year: 2004
Journal: Endocrinology
Title: Genetic targeting of relaxin and insulin-like factor 3 receptors in mice.
Volume: 145
Issue: 10
Pages: 4712-20
Publication
First Author: Feng S
Year: 2006
Journal: Endocrinology
Title: Endocrine effects of relaxin overexpression in mice.
Volume: 147
Issue: 1
Pages: 407-14
GXD Expression      
Probe: MGI:6390150
Assay Type: Northern blot
Annotation Date: 2020-02-14
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6390151
Age: postnatal
Specimen Label: Insl3 -/-
Detected: true
Specimen Num: 3
Publication
First Author: Koskimies P
Year: 2003
Journal: Mol Cell Endocrinol
Title: Female mice carrying a ubiquitin promoter-Insl3 transgene have descended ovaries and inguinal hernias but normal fertility.
Volume: 206
Issue: 1-2
Pages: 159-66
Publication
First Author: Spanel-Borowski K
Year: 2001
Journal: Mol Reprod Dev
Title: Increase in final stages of follicular atresia and premature decay of corpora lutea in Insl3-deficient mice.
Volume: 58
Issue: 3
Pages: 281-6
Publication
First Author: Bogatcheva NV
Year: 2003
Journal: Mol Endocrinol
Title: GREAT/LGR8 is the only receptor for insulin-like 3 peptide.
Volume: 17
Issue: 12
Pages: 2639-46
Publication
First Author: Emmen JM
Year: 2000
Journal: Endocrinology
Title: Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism.
Volume: 141
Issue: 2
Pages: 846-9
Publication
First Author: Robert NM
Year: 2006
Journal: Biol Reprod
Title: The orphan nuclear receptor NR4A1 regulates insulin-like 3 gene transcription in Leydig cells.
Volume: 74
Issue: 2
Pages: 322-30
Publication  
First Author: Schillebeeckx M
Year: 2015
Journal: Mol Cell Endocrinol
Title: Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.
Volume: 399
Pages: 122-30
Publication
First Author: Warr N
Year: 2009
Journal: Dev Biol
Title: Sfrp1 and Sfrp2 are required for normal male sexual development in mice.
Volume: 326
Issue: 2
Pages: 273-84
Publication
First Author: Kaftanovskaya EM
Year: 2011
Journal: Mol Endocrinol
Title: Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development.
Volume: 25
Issue: 1
Pages: 170-83
Publication
First Author: Val P
Year: 2006
Journal: Dev Biol
Title: Identification of a novel population of adrenal-like cells in the mammalian testis.
Volume: 299
Issue: 1
Pages: 250-6
Publication
First Author: Kothandapani A
Year: 2020
Journal: PLoS Genet
Title: GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.
Volume: 16
Issue: 6
Pages: e1008810
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Pusch W
Year: 1996
Journal: Endocrinology
Title: Molecular cloning and expression of the relaxin-like factor from the mouse testis.
Volume: 137
Issue: 7
Pages: 3009-13
Publication
First Author: Spiess AN
Year: 1999
Journal: Mol Reprod Dev
Title: Structure and expression of the rat relaxin-like factor (RLF) gene.
Volume: 54
Issue: 4
Pages: 319-25
Publication
First Author: Zimmermann S
Year: 1997
Journal: Mol Reprod Dev
Title: Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development.
Volume: 47
Issue: 1
Pages: 30-8
GXD Expression      
Probe: MGI:2663989
Assay Type: RNase protection
Annotation Date: 2003-06-27
Strength: Present
Sex: Male
Emaps: EMAPS:1797224
Stage: TS24
Assay Id: MGI:2664057
Age: embryonic day 16.5
Specimen Label: E16 Ctr
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2663989
Assay Type: RNase protection
Annotation Date: 2003-06-27
Strength: Present
Sex: Male
Emaps: EMAPS:1797226
Stage: TS26
Assay Id: MGI:2664057
Age: embryonic day 18.5
Specimen Label: E18 Ctr
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: K
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: B
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: Li
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: Lu
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: T
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: S
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: H
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: M
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: P
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762573
Age: postnatal adult
Image: 4
Specimen Label: O
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762579
Age: postnatal adult
Image: 4
Specimen Label: T
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:5762579
Age: postnatal adult
Image: 4
Specimen Label: P
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762579
Age: postnatal adult
Image: 4
Specimen Label: O
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762580
Age: postnatal adult
Image: 4
Specimen Label: W
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762639
Age: postnatal day 5
Image: 6
Specimen Label: 5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762639
Age: postnatal day 10
Image: 6
Specimen Label: 10
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762639
Age: postnatal day 15
Image: 6
Specimen Label: 15
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762639
Age: postnatal day 20
Image: 6
Specimen Label: 20
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762639
Age: postnatal day 25
Image: 6
Specimen Label: 25
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762639
Age: postnatal day 30
Image: 6
Specimen Label: 30
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762639
Age: postnatal day 40
Image: 6
Specimen Label: 40
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5762639
Age: postnatal day 60
Image: 6
Specimen Label: 60
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Female
Emaps: EMAPS:1796227
Stage: TS27
Assay Id: MGI:5762640
Age: postnatal day 3
Image: 6
Specimen Label: 3
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762640
Age: postnatal day 4
Image: 6
Specimen Label: 4
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762640
Age: postnatal day 5
Image: 6
Specimen Label: 5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762640
Age: postnatal day 6
Image: 6
Specimen Label: 6
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762640
Age: postnatal day 10
Image: 6
Specimen Label: 10
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762640
Age: postnatal day 15
Image: 6
Specimen Label: 15
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762640
Age: postnatal day 20
Image: 6
Specimen Label: 20
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 0.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 1.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 2.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 3.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 4.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 5.5
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 6.5
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 7.5
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 8.5
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 9.5
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:36437
Assay Type: Northern blot
Annotation Date: 2016-04-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5762641
Age: postnatal adult
Image: 7
Specimen Label: 10.5
Detected: true
Specimen Num: 11