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Search results 1 to 97 out of 97 for Ints1

0.063s

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Hits by Strain

Type Details Score
Gene
26173 | INTS1
Type: gene
Organism: human
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Gene
100380131 | ints1
Type: gene
Organism: frog, western clawed
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Gene
107975668 | INTS1
Type: gene
Organism: chimpanzee
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Gene
288514 | Ints1
Type: gene
Organism: rat
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Gene
790146 | INTS1
Type: gene
Organism: cattle
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Gene
100685475 | INTS1
Type: gene
Organism: dog, domestic
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Gene
416461 | INTS1
Type: gene
Organism: chicken
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Gene
562131 | ints1
Type: gene
Organism: zebrafish
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Gene
711947 | INTS1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1915760 | Ints1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR038902 | INTS1
Type: Family
Description: INTS1 is a component of the Integrator (INT) complex. INT consists of at least 14 subunits and associates with the C-terminal domain of the largest subunit of the RNA polymerase II (RNAPII) and has a role in the regulation of gene expression and RNA processing. Besides mediating the co-transcriptional 3'-end processing of the U-rich small nuclear RNAs (UsnRNAs), INT also functions in RNAPII promoter proximal pause-release and in the processing of enhancer RNAs. Mutations in the INTS1 gene cause a severe neurodevelopmental syndrome [].
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Protein
A0A0G2JFR3
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
Q0KK53
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: true
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Protein
Q3U1N8
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q6P4S8
Organism: Mus musculus/domesticus
Length: 2195  
Fragment?: false
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Protein
A0A0G2JH17
Organism: Mus musculus/domesticus
Length: 2222  
Fragment?: false
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Protein
K3W4P2
Organism: Mus musculus/domesticus
Length: 2193  
Fragment?: false
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Publication
28542170 | -
First Author: Oegema R
Year: 2017
Journal: PLoS Genet
Title: Human mutations in integrator complex subunits link transcriptome integrity to brain development.
Volume: 13
Issue: 5
Pages: e1006809
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Protein Coding Gene
MGP_CAROLIEiJ_G0027938 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
ENSMUSG00200039809 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00195039781 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00220020156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00180031425 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00175044392 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1915760 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00215035627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSTCUG00005034306 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00210023307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00185051367 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00205035221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00230046464 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSUMUG00000050577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00190029650 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00225022328 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSLUMG00010017797 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSIUOG00005033028 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024510 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
ENSMSPG00010028842 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:4442074
Assay Type: RT-PCR
Annotation Date: 2010-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:4442235
Age: embryonic day 0.5
Specimen Label: 1-cell
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4442074
Assay Type: RT-PCR
Annotation Date: 2010-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:4442235
Age: embryonic day 3.5
Specimen Label: Blastocyst
Detected: true
Specimen Num: 2
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Publication
- | J:76284
   
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, clone IMAGE: 3601115, mRNA, partial cds
Pages: BC010333
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Publication
16807365 | J:111319
First Author: Nakayama M
Year: 2006
Journal: FASEB J
Title: A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.
Volume: 20
Issue: 10
Pages: 1718-20
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Publication
17544522 | J:124808
First Author: Hata T
Year: 2007
Journal: Biochim Biophys Acta
Title: Targeted disruption of the murine large nuclear KIAA1440/Ints1 protein causes growth arrest in early blastocyst stage embryos and eventual apoptotic cell death.
Volume: 1773
Issue: 7
Pages: 1039-51
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Publication
- | J:175597
     
First Author: Overbeek PA
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Overbeek Lentiviral Transgenic Lines
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:389486
     
First Author: Mouse Genome Informatics and Ensembl Genome Database Project
Year: 2026
Journal: Database Release
Title: MGI Strain Genome Feature and Gene Model Load from Ensembl.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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DO Term
DOID:0070346 | neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies
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Publication
12529635 | -
First Author: Kamath RS
Year: 2003
Journal: Nature
Title: Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
Volume: 421
Issue: 6920
Pages: 231-7
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Publication
15716491 | -
First Author: Gross JM
Year: 2005
Journal: Genetics
Title: Identification of zebrafish insertional mutants with defects in visual system development and function.
Volume: 170
Issue: 1
Pages: 245-61
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Publication
19326441 | -
First Author: Rutkowski RJ
Year: 2009
Journal: Dev Dyn
Title: Phenotypic analysis of deflated/Ints7 function in Drosophila development.
Volume: 238
Issue: 5
Pages: 1131-9
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Protein Domain
IPR054519 | INTS7_C
Type: Domain
Description: This entry represents the C-terminal domain of the Integrator complex subunit 7 (INTS7).Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the largest subunit of RNA-polymerase II to promote 3'-snRNA processing []. INTS7 interacts with INTS1 and INTS2 making extensive contacts with each other, nucleating the assembly of the whole INTAC complex []. In zebrafish, C. elegans and Drosophila, INTS7 has been found to be essential for normal development [, , , ].
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Protein Domain
IPR056517 | INTS7_HB
Type: Domain
Description: This entry represents the helical bundle (HB) of INTS7, localised between the superhelical ��-solenoid () and the C-terminal ��-sandwich () [].Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the largest subunit of RNA-polymerase II to promote 3'-snRNA processing []. INTS7 interacts with INTS1 and INTS2 making extensive contacts with each other, nucleating the assembly of the whole INTAC complex []. In zebrafish, C. elegans and Drosophila, INTS7 has been found to be essential for normal development[, , , ].
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Protein Domain
IPR056516 | INTS7_N
Type: Domain
Description: This entry represents the superhelical ��-solenoid found at the N-terminal of INTS7.Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the largest subunit of RNA-polymerase II to promote 3'-snRNA processing []. INTS7 interacts with INTS1 and INTS2 making extensive contacts with each other, nucleating the assembly of the whole INTAC complex []. In zebrafish, C. elegans and Drosophila, INTS7 has been found to be essential for normal development [, , , ].
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Protein Domain
IPR033060 | INTS7
Type: Family
Description: Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the largest subunit of RNA-polymerase II to promote 3'-snRNA processing []. INTS7 interacts with INTS1 and INTS2 making extensive contacts with each other, nucleating the assembly of the whole INTAC complex []. In zebrafish, C. elegans and Drosophila, INTS7 has been found to be essential for normal development [, , , ].
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Protein Domain
IPR053964 | INT1_R3
Type: Domain
Description: Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both protein-coding genes and noncoding elements []. Integrator also associates with protein phosphatase 2A (PP2A) core enzyme to form the INTAC complex []which regulates transcription through dephosphorylation of Pol II CTD.This entry includes the Integrator complex subunit 1 (INTS1), which forms the backbone module of the complex (it consists of four modules: backbone, shoulder, phosphatase and endonuclease) through the association with INTS2 and INTS7 to form a rigid scaffold. The backbone and shoulder modules form a central cruciform scaffold. INTS1 contains four repetitive helix hairpin domains towards the C-terminal (R1-R4); this entry represents the R3 domain [].
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Protein Domain
IPR053965 | INTS1_R4
Type: Domain
Description: Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both protein-coding genes and noncoding elements []. Integrator also associates with protein phosphatase 2A (PP2A) core enzyme to form the INTAC complex []which regulates transcription through dephosphorylation of Pol II CTD.This entry includes the Integrator complex subunit 1 (INTS1) which forms the backbone module of the complex (it consists of four modules: backbone, shoulder, phosphatase and endonuclease) through the association with INTS2 and INTS7 to form a rigid scaffold. The backbone and shoulder modules form a central cruciform scaffold. INTS1 contains four repetitive helix hairpin domains towards the C-terminal (R1-R4); this entry represents R4 domain [].
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Publication
34762484 | -
First Author: Fianu I
Year: 2021
Journal: Science
Title: Structural basis of Integrator-mediated transcription regulation.
Volume: 374
Issue: 6569
Pages: 883-887
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Protein
Q7TQK1
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
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Protein
A0A0R4J0E4
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
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Publication
27427483 | -
First Author: Rienzo M
Year: 2016
Journal: Biochim Biophys Acta
Title: Integrator complex and transcription regulation: Recent findings and pathophysiology.
Volume: 1859
Issue: 10
Pages: 1269-80
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Protein Domain
IPR053966 | INTS1_INTS2-bd
Type: Domain
Description: Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both protein-coding genes and noncoding elements [, ]. Integrator also associates with protein phosphatase 2A (PP2A) core enzyme to form the INTAC complex []which regulates transcription through dephosphorylation of Pol II CTD.This entry includes the Integrator complex subunit 1 (INTS1) which forms the backbone module of the complex (it consists of four modules: backbone, shoulder, phosphatase and endonuclease) through the association with INTS2 and INTS7 to form a rigid scaffold. The backbone and shoulder modules form a central cruciform scaffold. INTS1 is an all-�� helical protein with four repetitive helix hairpin domains towards the C-terminal (R1-R4) []. This entry represents a domain found in the middle region of INTS1, after , which interacts with the INTS2 subunit [].
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Protein Domain
IPR022145 | INTS1_RPB2-bd
Type: Domain
Description: Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing []. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both protein-coding genes and noncoding elements [, ]. Integrator also associates with protein phosphatase 2A (PP2A) core enzyme to form the INTAC complex [, ]which regulates transcription through dephosphorylation of Pol II CTD. The complex consists of four modules: the backbone, the shoulder, the phosphatase and the endonuclease, formed by different integrator components.This entry includes the Integrator complex subunit 1 (INTS1) which forms the backbone module of the complex through the association with INTS2 and INTS7 to form a rigid scaffold. The backbone and shoulder modules form a central cruciform scaffold. INTS1 is an all-�� helical protein with four repetitive helix hairpin domains towards the C-terminal (R1-R4) [, ]. This entry represents a domain found towards the N-terminal region, which interacts with Pol II subunit RPB2 and form interface A [].
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Publication
33243860 | -
 
First Author: Zheng H
Year: 2020
Journal: Science
Title: Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Volume: 370
Issue: 6520
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Publication
12006978 | -
First Author: Golling G
Year: 2002
Journal: Nat Genet
Title: Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development.
Volume: 31
Issue: 2
Pages: 135-40
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Publication
16239144 | -
First Author: Baillat D
Year: 2005
Journal: Cell
Title: Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
Volume: 123
Issue: 2
Pages: 265-76
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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