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Search results 1 to 87 out of 87 for Iqsec2

0.043s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Sah M
Year: 2020
Journal: Neurobiol Dis
Title: Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease.
Volume: 137
Pages: 104758
Publication  
First Author: Rogers EJ
Year: 2019
Journal: Front Mol Neurosci
Title: An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors.
Volume: 12
Pages: 43
Publication  
First Author: Jada R
Year: 2023
Journal: Int J Mol Sci
Title: Daily Brief Heat Therapy Reduces Seizures in A350V IQSEC2 Mice and Is Associated with Correction of AMPA Receptor-Mediated Synaptic Dysfunction.
Volume: 24
Issue: 4
Publication
First Author: Hinze SJ
Year: 2017
Journal: Transl Psychiatry
Title: Incorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis.
Volume: 7
Issue: 5
Pages: e1110
Publication  
First Author: Jackson MR
Year: 2019
Journal: Life Sci Alliance
Title: Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females.
Volume: 2
Issue: 4
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:6390612
Assay Type: RT-PCR
Annotation Date: 2020-02-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6390964
Age: postnatal day 1
Image: S8
Specimen Label: P1 brain
Detected: true
Specimen Num: 3
Publication
First Author: Katsumata O
Year: 2009
Journal: Eur J Neurosci
Title: IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina.
Volume: 30
Issue: 8
Pages: 1509-16
Publication
First Author: Tsuchiya KD
Year: 2004
Journal: Genome Res
Title: Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse.
Volume: 14
Issue: 7
Pages: 1275-84
Publication  
First Author: Sanda M
Year: 2009
Journal: Brain Res
Title: The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence.
Volume: 1251
Pages: 7-15
Publication
First Author: Sakagami H
Year: 2008
Journal: Neurosci Res
Title: IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses.
Volume: 60
Issue: 2
Pages: 199-212
Publication
First Author: Elagabani MN
Year: 2016
Journal: J Biol Chem
Title: Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
Volume: 291
Issue: 17
Pages: 9105-18
Publication
First Author: Filippova GN
Year: 2005
Journal: Dev Cell
Title: Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.
Volume: 8
Issue: 1
Pages: 31-42
Publication
First Author: Scholz R
Year: 2010
Journal: Neuron
Title: AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.
Volume: 66
Issue: 5
Pages: 768-80
Publication  
First Author: Kinoshita-Kawada M
Year: 2019
Journal: Development
Title: A crucial role for Arf6 in the response of commissural axons to Slit.
Volume: 146
Issue: 3
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Allele
Name: IQ motif and Sec7 domain 2; endonuclease-mediated mutation 1, Andrew P Levy
Allele Type: Endonuclease-mediated
Attribute String: Constitutively active, Humanized sequence
Publication
First Author: Shoubridge C
Year: 2010
Journal: Small GTPases
Title: Subtle functional defects in the Arf-specific guanine nucleotide exchange factor IQSEC2 cause non-syndromic X-linked intellectual disability.
Volume: 1
Issue: 2
Pages: 98-103
DO Term
Publication
First Author: Sakagami H
Year: 2013
Journal: J Comp Neurol
Title: Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina.
Volume: 521
Issue: 4
Pages: 860-76
Publication
First Author: Fukaya M
Year: 2011
Journal: J Neurochem
Title: SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses.
Volume: 116
Issue: 6
Pages: 1122-37
Publication
First Author: Aizel K
Year: 2013
Journal: PLoS Biol
Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.
Volume: 11
Issue: 9
Pages: e1001652
Protein Domain
Type: Domain
Description: The IQSEC (IQ motif and SEC7 domain-containing protein), also called BRAG (Brefeldin A-resistant Arf-gunanine nucleotide exchange factor) family are a subset of Arf GEFs that have been shown to activate Arf6, which acts in the endocytic pathway to control the trafficking of a subset of cargo proteins including integrins. IQSEC family also have key roles in the function and organization of distinct excitatory and inhibitory synapses in the retina [, ]. The family consists of 3 members: IQSEC1 (also called BRAG2/GEP100), IQSEC2 (also called BRAG1), and IQSEC3 (also called SynArfGEF, BRAG3, or KIAA1110). IQSEC1 interacts with clathrin and modulates cell adhesion by regulating integrin surface expression and in addition to Arf6, it also activates the class II Arfs, Arf4 and Arf5 []. Mutations in IQSEC2 cause non-syndromic X-linked intellectual disability as well as reduced activation of Arf substrates (Arf1, Arf6) []. IQSEC3 regulates Arf6 at inhibitory synapses and associates with the dystrophin-associated glycoprotein complex and S-SCAM [].These IQSEC family members contain a IQ domain that may bind calmodulin, a PH domain that is thought to mediate membrane localization, and a SEC7 domain that can promote GEF activity on ARF []. The PH domain of BRAG2 has been shown to potentiate nucleotide exchange by binding to polyanionic membranes without marked phosphoinositides preference [].
Publication
First Author: Dunphy JL
Year: 2006
Journal: Curr Biol
Title: The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins.
Volume: 16
Issue: 3
Pages: 315-20
Publication
First Author: Moravec R
Year: 2012
Journal: J Biol Chem
Title: BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
Volume: 287
Issue: 37
Pages: 31138-47
Publication
First Author: Casanova JE
Year: 2007
Journal: Traffic
Title: Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.
Volume: 8
Issue: 11
Pages: 1476-85
Publication
First Author: Briševac D
Year: 2021
Journal: J Neurochem
Title: The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome.
Volume: 157
Issue: 3
Pages: 666-683
Publication
First Author: Li N
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Escape from X chromosome inactivation is an intrinsic property of the Jarid1c locus.
Volume: 105
Issue: 44
Pages: 17055-60
Protein
Organism: Mus musculus/domesticus
Length: 1195  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 961  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1479  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1099  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1051  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 788  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1478  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 949  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1154  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1488  
Fragment?: false