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Search results 1 to 92 out of 92 for Iqsec2

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
23096 | IQSEC2
Type: gene
Organism: human
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Gene
100485600 | iqsec2
Type: gene
Organism: frog, western clawed
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Gene
491895 | IQSEC2
Type: gene
Organism: dog, domestic
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Gene
685244 | Iqsec2
Type: gene
Organism: rat
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Gene
465972 | IQSEC2
Type: gene
Organism: chimpanzee
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Gene
517311 | IQSEC2
Type: gene
Organism: cattle
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Gene
702562 | IQSEC2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:3528396 | Iqsec2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31978606 | J:284762
 
First Author: Sah M
Year: 2020
Journal: Neurobiol Dis
Title: Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease.
Volume: 137
Pages: 104758
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Publication
33753721 | J:350901
First Author: Lichtman D
Year: 2021
Journal: Transl Psychiatry
Title: Structural and functional brain-wide alterations in A350V Iqsec2 mutant mice displaying autistic-like behavior.
Volume: 11
Issue: 1
Pages: 181
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Publication
30842726 | J:280198
 
First Author: Rogers EJ
Year: 2019
Journal: Front Mol Neurosci
Title: An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors.
Volume: 12
Pages: 43
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Publication
33888678 | J:350904
First Author: Jabarin R
Year: 2021
Journal: Transl Psychiatry
Title: Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation.
Volume: 11
Issue: 1
Pages: 234
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Publication
34685703 | J:350905
 
First Author: Mehta A
Year: 2021
Journal: Cells
Title: IQSEC2 Deficiency Results in Abnormal Social Behaviors Relevant to Autism by Affecting Functions of Neural Circuits in the Medial Prefrontal Cortex.
Volume: 10
Issue: 10
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Publication
36835332 | J:334657
 
First Author: Jada R
Year: 2023
Journal: Int J Mol Sci
Title: Daily Brief Heat Therapy Reduces Seizures in A350V IQSEC2 Mice and Is Associated with Correction of AMPA Receptor-Mediated Synaptic Dysfunction.
Volume: 24
Issue: 4
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Publication
37787765 | J:350906
 
First Author: Bai G
Year: 2023
Journal: J Cell Biol
Title: Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under physiological and pathological conditions.
Volume: 222
Issue: 12
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Publication
28463240 | J:284763
First Author: Hinze SJ
Year: 2017
Journal: Transl Psychiatry
Title: Incorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis.
Volume: 7
Issue: 5
Pages: e1110
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Publication
31439632 | J:284750
 
First Author: Jackson MR
Year: 2019
Journal: Life Sci Alliance
Title: Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females.
Volume: 2
Issue: 4
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Protein Coding Gene
MGP_CAROLIEiJ_G0033499 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0036183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0036159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0036085 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0036150 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3528396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036675 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0035149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035835 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0036084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036710 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034843 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0032038 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034669 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6390612
Assay Type: RT-PCR
Annotation Date: 2020-02-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6390964
Age: postnatal day 1
Image: S8
Specimen Label: P1 brain
Detected: true
Specimen Num: 3
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Publication
19811534 | J:263480
First Author: Katsumata O
Year: 2009
Journal: Eur J Neurosci
Title: IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina.
Volume: 30
Issue: 8
Pages: 1509-16
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Publication
15197169 | J:95647
First Author: Tsuchiya KD
Year: 2004
Journal: Genome Res
Title: Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse.
Volume: 14
Issue: 7
Pages: 1275-84
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Publication
19083995 | J:147794
 
First Author: Sanda M
Year: 2009
Journal: Brain Res
Title: The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence.
Volume: 1251
Pages: 7-15
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Publication
18164504 | J:131067
First Author: Sakagami H
Year: 2008
Journal: Neurosci Res
Title: IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses.
Volume: 60
Issue: 2
Pages: 199-212
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Publication
26884337 | J:233724
First Author: Elagabani MN
Year: 2016
Journal: J Biol Chem
Title: Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
Volume: 291
Issue: 17
Pages: 9105-18
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Publication
15669143 | J:95807
First Author: Filippova GN
Year: 2005
Journal: Dev Cell
Title: Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.
Volume: 8
Issue: 1
Pages: 31-42
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Publication
20547133 | J:163183
First Author: Scholz R
Year: 2010
Journal: Neuron
Title: AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.
Volume: 66
Issue: 5
Pages: 768-80
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Publication
30674481 | J:272623
 
First Author: Kinoshita-Kawada M
Year: 2019
Journal: Development
Title: A crucial role for Arf6 in the response of commissural axons to Slit.
Volume: 146
Issue: 3
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Iqsec2<em1Alev> | MGI:6393275
Name: IQ motif and Sec7 domain 2; endonuclease-mediated mutation 1, Andrew P Levy
Allele Type: Endonuclease-mediated
Attribute String: Constitutively active, Humanized sequence
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Publication
21686261 | -
First Author: Shoubridge C
Year: 2010
Journal: Small GTPases
Title: Subtle functional defects in the Arf-specific guanine nucleotide exchange factor IQSEC2 cause non-syndromic X-linked intellectual disability.
Volume: 1
Issue: 2
Pages: 98-103
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DO Term
DOID:0112038 | non-syndromic X-linked intellectual disability 1
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Publication
22886754 | J:263581
First Author: Sakagami H
Year: 2013
Journal: J Comp Neurol
Title: Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina.
Volume: 521
Issue: 4
Pages: 860-76
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Publication
21198641 | J:170549
First Author: Fukaya M
Year: 2011
Journal: J Neurochem
Title: SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses.
Volume: 116
Issue: 6
Pages: 1122-37
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Publication
24058294 | -
First Author: Aizel K
Year: 2013
Journal: PLoS Biol
Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.
Volume: 11
Issue: 9
Pages: e1001652
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Protein Domain
IPR033742 | IQSEC_PH
Type: Domain
Description: The IQSEC (IQ motif and SEC7 domain-containing protein), also called BRAG (Brefeldin A-resistant Arf-gunanine nucleotide exchange factor) family are a subset of Arf GEFs that have been shown to activate Arf6, which acts in the endocytic pathway to control the trafficking of a subset of cargo proteins including integrins. IQSEC family also have key roles in the function and organization of distinct excitatory and inhibitory synapses in the retina [, ]. The family consists of 3 members: IQSEC1 (also called BRAG2/GEP100), IQSEC2 (also called BRAG1), and IQSEC3 (also called SynArfGEF, BRAG3, or KIAA1110). IQSEC1 interacts with clathrin and modulates cell adhesion by regulating integrin surface expression and in addition to Arf6, it also activates the class II Arfs, Arf4 and Arf5 []. Mutations in IQSEC2 cause non-syndromic X-linked intellectual disability as well as reduced activation of Arf substrates (Arf1, Arf6) []. IQSEC3 regulates Arf6 at inhibitory synapses and associates with the dystrophin-associated glycoprotein complex and S-SCAM [].These IQSEC family members contain a IQ domain that may bind calmodulin, a PH domain that is thought to mediate membrane localization, and a SEC7 domain that can promote GEF activity on ARF []. The PH domain of BRAG2 has been shown to potentiate nucleotide exchange by binding to polyanionic membranes without marked phosphoinositides preference [].
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Publication
16461286 | -
First Author: Dunphy JL
Year: 2006
Journal: Curr Biol
Title: The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins.
Volume: 16
Issue: 3
Pages: 315-20
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Publication
22815487 | -
First Author: Moravec R
Year: 2012
Journal: J Biol Chem
Title: BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
Volume: 287
Issue: 37
Pages: 31138-47
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Publication
17850229 | -
First Author: Casanova JE
Year: 2007
Journal: Traffic
Title: Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.
Volume: 8
Issue: 11
Pages: 1476-85
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Publication
33125726 | J:323480
First Author: Briševac D
Year: 2021
Journal: J Neurochem
Title: The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome.
Volume: 157
Issue: 3
Pages: 666-683
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Publication
18971342 | J:143260
First Author: Li N
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Escape from X chromosome inactivation is an intrinsic property of the Jarid1c locus.
Volume: 105
Issue: 44
Pages: 17055-60
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Protein
Q3TES0
Organism: Mus musculus/domesticus
Length: 1195  
Fragment?: false
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Protein
Q8R0S2
Organism: Mus musculus/domesticus
Length: 961  
Fragment?: false
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Protein
A4GZ26
Organism: Mus musculus/domesticus
Length: 1479  
Fragment?: false
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Protein
E9PUA3
Organism: Mus musculus/domesticus
Length: 1099  
Fragment?: false
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Protein
A0A1D5RM83
Organism: Mus musculus/domesticus
Length: 1051  
Fragment?: false
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Protein
Q3UHJ6
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
A0A5F8MPT9
Organism: Mus musculus/domesticus
Length: 788  
Fragment?: true
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Protein
Q5DU25
Organism: Mus musculus/domesticus
Length: 1478  
Fragment?: false
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Protein
D3Z6V7
Organism: Mus musculus/domesticus
Length: 949  
Fragment?: false
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Protein
D3Z5I6
Organism: Mus musculus/domesticus
Length: 1154  
Fragment?: false
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Protein
E9QAD8
Organism: Mus musculus/domesticus
Length: 1488  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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