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Search results 1 to 100 out of 315 for Irak1

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
3654 | IRAK1
Type: gene
Organism: human
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Gene
533953 | IRAK1
Type: gene
Organism: cattle
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Gene
569226 | irak1
Type: gene
Organism: zebrafish
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Gene
699919 | IRAK1
Type: gene
Organism: macaque, rhesus
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Gene
448357 | irak1
Type: gene
Organism: frog, western clawed
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Gene
363520 | Irak1
Type: gene
Organism: rat
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Gene
492247 | IRAK1
Type: gene
Organism: dog, domestic
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Gene
465935 | IRAK1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR035536 | IRAK1
Type: Family
Description: Interleukin-1 receptor-associated kinases (IRAKs) are essential components of innate immunity and inflammation in mammals and other vertebrates. They are involved in signal transduction pathways involving IL-1 and IL-18 receptors, Toll-like receptors, nuclear factor-kappaB (NF-kB), and mitogen-activated protein kinases (MAPKs). IRAKs contain an N-terminal death domain (DD) and a C-terminal kinase domain [, , , ].IRAK1 is an active kinase and also plays adaptor functions. It binds to the MyD88-IRAK4 complex via its DD, which facilitates its phosphorylation by IRAK4, activating it for further auto-phosphorylation []. Hyper-phosphorylated IRAK1 forms a cytosolic complex with TRAF6, leading to the activation of NF-kB and MAPK pathways. IRAK1 is involved in autoimmunity and may be associated with lupus pathogenesis [].
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Protein Coding Gene
MGI:107420 | Irak1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99J34
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Publication
35801586 | J:343378
 
First Author: Hoyler T
Year: 2022
Journal: JCI Insight
Title: Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.
Volume: 7
Issue: 13
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Publication
18438411 | J:136290
First Author: Kawagoe T
Year: 2008
Journal: Nat Immunol
Title: Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
Volume: 9
Issue: 6
Pages: 684-91
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Publication
29038250 | J:251197
First Author: Kong F
Year: 2017
Journal: J Immunol
Title: Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages.
Volume: 199
Issue: 10
Pages: 3654-3667
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Publication
12860565 | J:84829
First Author: Thomas JA
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction.
Volume: 285
Issue: 2
Pages: H597-606
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Publication
24043892 | J:206268
First Author: Fernandes-Alnemri T
Year: 2013
Journal: J Immunol
Title: Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
Volume: 191
Issue: 8
Pages: 3995-9
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Publication
23404570 | J:195046
First Author: Sandig H
Year: 2013
Journal: Eur J Immunol
Title: IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.
Volume: 43
Issue: 4
Pages: 979-88
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Publication
23918981 | J:205798
First Author: Pauls E
Year: 2013
Journal: J Immunol
Title: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.
Volume: 191
Issue: 5
Pages: 2717-30
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Publication
24193737 | J:211506
First Author: Chandra R
Year: 2014
Journal: J Leukoc Biol
Title: Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis.
Volume: 95
Issue: 3
Pages: 497-507
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Publication
22227568 | J:181218
First Author: Liu YC
Year: 2012
Journal: J Immunol
Title: TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9.
Volume: 188
Issue: 3
Pages: 1019-26
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Publication
37311534 | J:338880
First Author: Zhang L
Year: 2023
Journal: J Biol Chem
Title: Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.
Volume: 299
Issue: 7
Pages: 104911
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Publication
19329491 | J:147757
First Author: Jacob CO
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.
Volume: 106
Issue: 15
Pages: 6256-61
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Publication
27807192 | J:269079
First Author: Nanda SK
Year: 2016
Journal: J Immunol
Title: Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1.
Volume: 197
Issue: 11
Pages: 4266-4273
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Protein
B1AUV9
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
Q8K4N5
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
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Publication
17890055 | -
First Author: Gottipati S
Year: 2008
Journal: Cell Signal
Title: IRAK1: a critical signaling mediator of innate immunity.
Volume: 20
Issue: 2
Pages: 269-76
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Publication
17276401 | -
First Author: Neumann D
Year: 2007
Journal: Biochem Biophys Res Commun
Title: The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.
Volume: 354
Issue: 4
Pages: 1089-94
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Protein
Q62406
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Publication
16212909 | -
First Author: Huang YS
Year: 2005
Journal: Cell Mol Immunol
Title: Novel role and regulation of the interleukin-1 receptor associated kinase (IRAK) family proteins.
Volume: 2
Issue: 1
Pages: 36-9
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Publication
17172653 | -
First Author: Gan L
Year: 2006
Journal: Immunol Res
Title: Regulations and roles of the interleukin-1 receptor associated kinases (IRAKs) in innate and adaptive immunity.
Volume: 35
Issue: 3
Pages: 295-302
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Publication
18249132 | -
First Author: Ringwood L
Year: 2008
Journal: Cytokine
Title: The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation.
Volume: 42
Issue: 1
Pages: 1-7
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Protein
Q8K4N7
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
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Protein
F7CUT1
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Publication
12620219 | -
First Author: Janssens S
Year: 2003
Journal: Mol Cell
Title: Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members.
Volume: 11
Issue: 2
Pages: 293-302
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Protein
F7ANU5
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Protein
F6ZGQ1
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Protein
B1AUW1
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
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Protein
F6TQF4
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
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Protein
Q8K4N8
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
Q8BR10
Organism: Mus musculus/domesticus
Length: 711  
Fragment?: false
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Protein
B1AUW9
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: false
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Protein
Q540G0
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Protein
B1AUW8
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
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Protein
B1AUW6
Organism: Mus musculus/domesticus
Length: 750  
Fragment?: false
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Protein
F6THK7
Organism: Mus musculus/domesticus
Length: 383  
Fragment?: true
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Publication
12566447 | J:113963
First Author: Takatsuna H
Year: 2003
Journal: J Biol Chem
Title: Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling.
Volume: 278
Issue: 14
Pages: 12144-50
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Publication
12626533 | J:82302
First Author: Deng C
Year: 2003
Journal: J Immunol
Title: IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity.
Volume: 170
Issue: 6
Pages: 2833-42
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Publication
28572512 | J:246809
First Author: Sun XJ
Year: 2017
Journal: J Biol Chem
Title: Deletion of interleukin 1 receptor-associated kinase 1 (Irak1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle.
Volume: 292
Issue: 29
Pages: 12339-12350
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Publication
33203828 | J:341766
 
First Author: Lei Y
Year: 2020
Journal: Med Sci Monit
Title: Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout.
Volume: 26
Pages: e926187
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Publication
21743479 | J:174420
First Author: Tun-Kyi A
Year: 2011
Journal: Nat Immunol
Title: Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity.
Volume: 12
Issue: 8
Pages: 733-41
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Publication
17379480 | J:148060
First Author: Su J
Year: 2007
Journal: Cell Signal
Title: Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling.
Volume: 19
Issue: 7
Pages: 1596-601
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Publication
34636324 | J:316931
   
First Author: Akaki K
Year: 2021
Journal: Elife
Title: IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay.
Volume: 10
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Publication
28882891 | J:246096
First Author: Tanishima M
Year: 2017
Journal: J Biol Chem
Title: Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.
Volume: 292
Issue: 42
Pages: 17250-17257
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Publication
26732763 | J:260310
First Author: Sun J
Year: 2016
Journal: Sci Signal
Title: Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
Volume: 9
Issue: 409
Pages: ra3
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Publication
23396947 | J:193597
First Author: Bruni D
Year: 2013
Journal: J Immunol
Title: A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3.
Volume: 190
Issue: 6
Pages: 2844-56
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Publication
21435586 | J:169840
First Author: Saitoh T
Year: 2011
Journal: Immunity
Title: Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Volume: 34
Issue: 3
Pages: 352-63
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Publication
31883536 | J:292505
First Author: Liu X
Year: 2019
Journal: J Neuroinflammation
Title: BAP31 regulates IRAK1-dependent neuroinflammation in microglia.
Volume: 16
Issue: 1
Pages: 281
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Publication
22007846 | J:179219
First Author: Goh ET
Year: 2012
Journal: Biochem J
Title: Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.
Volume: 441
Issue: 1
Pages: 339-46
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Publication
17785432 | J:129077
First Author: Zhande R
Year: 2007
Journal: Mol Cell Biol
Title: FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction.
Volume: 27
Issue: 21
Pages: 7394-404
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Publication
24706909 | J:208867
First Author: Inoue M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.
Volume: 111
Issue: 14
Pages: 5295-300
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Protein Coding Gene
MGP_CAROLIEiJ_G0033169 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035829 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035810 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035735 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035795 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035500 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107420 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036325 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034791 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035475 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035632 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035576 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035614 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036347 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034490 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034932 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031712 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034324 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8663605 | J:34345
First Author: Trofimova M
Year: 1996
Journal: J Biol Chem
Title: Developmental and tissue-specific expression of mouse pelle-like protein kinase.
Volume: 271
Issue: 30
Pages: 17609-12
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Publication
10190904 | J:54308
First Author: Kanakaraj P
Year: 1999
Journal: J Exp Med
Title: Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice.
Volume: 189
Issue: 7
Pages: 1129-38
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Publication
22364946 | J:182739
First Author: Singh N
Year: 2012
Journal: Mol Immunol
Title: Reduced oxidative tissue damage during endotoxemia in IRAK-1 deficient mice.
Volume: 50
Issue: 4
Pages: 244-52
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Publication
10754329 | J:61586
First Author: Swantek JL
Year: 2000
Journal: J Immunol
Title: IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.
Volume: 164
Issue: 8
Pages: 4301-6
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Publication
19540456 | J:151411
First Author: Berglund M
Year: 2009
Journal: Cell Immunol
Title: Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis.
Volume: 259
Issue: 1
Pages: 27-32
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Publication
8905588 | J:36653
First Author: Manning KL
Year: 1996
Journal: Lab Anim Sci
Title: Successful determination of platelet lifespan in C3H mice by in vivo biotinylation.
Volume: 46
Issue: 5
Pages: 545-8
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GXD Expression
GXD Expression
   
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2655758
Age: embryonic day 7.0
Image: 3
Specimen Label: d7
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2655758
Age: embryonic day 11.0
Image: 3
Specimen Label: d11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2655758
Age: embryonic day 15.0
Image: 3
Specimen Label: d15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2655758
Age: embryonic day 17.0
Image: 3
Specimen Label: d17
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2655759
Age: postnatal adult
Image: 3
Specimen Label: heart
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2655759
Age: postnatal adult
Image: 3
Specimen Label: brain
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2655759
Age: postnatal adult
Image: 3
Specimen Label: spleen
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2655759
Age: postnatal adult
Image: 3
Specimen Label: lung
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2655759
Age: postnatal adult
Image: 3
Specimen Label: liver
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2655759
Age: postnatal adult
Image: 3
Specimen Label: sk. muscle
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2655759
Age: postnatal adult
Image: 3
Specimen Label: kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:2655757
Assay Type: Northern blot
Annotation Date: 2003-04-29
Strength: Not Specified
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2655759
Age: postnatal adult
Image: 3
Specimen Label: testis
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:6887418
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6887635
Age: embryonic day 13.0
Image: 2
Specimen Label: E13
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6887418
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:6887635
Age: embryonic day 14.0
Image: 2
Specimen Label: E14
Detected: true
Specimen Num: 2
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•
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GXD Expression
GXD Expression
   
Probe: MGI:6887418
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:6887635
Age: embryonic day 15.0
Image: 2
Specimen Label: E15
Detected: true
Specimen Num: 3
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