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Search results 1 to 100 out of 141 for Irak3

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
11213 | IRAK3
Type: gene
Organism: human
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Gene
314870 | Irak3
Type: gene
Organism: rat
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Gene
481150 | IRAK3
Type: gene
Organism: dog, domestic
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Gene
467058 | IRAK3
Type: gene
Organism: chimpanzee
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Gene
510342 | IRAK3
Type: gene
Organism: cattle
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Gene
567444 | irak3
Type: gene
Organism: zebrafish
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Gene
717845 | IRAK3
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033610 | IRAK3
Type: Family
Description: Interleukin-1 receptor-associated kinase 3 (IRAK3/IRAK-M) is a negative regulator of MyD88-dependent Toll-like receptor (TLR) signalling []. It is expressed in monocytes/macrophages and lung epithelial cells. Structurally, IRAK3 consists of a kinase domain (KD) flanked by an N-terminal death domain (DD) involved in binding to other IRAK family members and an unstructured C-terminal domain. The kinase domain lacks the critical active site aspartate residue and IRAK-M appears devoid of kinase activity [, ]. IRAK-M may inhibit inflammation through several mechanisms, including stabilization of MKP-1 []and down-regulation of the non-canonical NFkB pathway []. It can also induce NFkB activation to produce inhibitory molecules as a negative feedback for the pathway [].
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Protein Coding Gene
MGI:1921164 | Irak3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12150927 | J:78189
First Author: Kobayashi K
Year: 2002
Journal: Cell
Title: IRAK-M is a negative regulator of Toll-like receptor signaling.
Volume: 110
Issue: 2
Pages: 191-202
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Publication
17379480 | J:148060
First Author: Su J
Year: 2007
Journal: Cell Signal
Title: Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling.
Volume: 19
Issue: 7
Pages: 1596-601
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Publication
23376919 | J:206904
First Author: Zhou H
Year: 2013
Journal: EMBO J
Title: IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production.
Volume: 32
Issue: 4
Pages: 583-96
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Publication
19809574 | -
First Author: Su J
Year: 2009
Journal: J Innate Immun
Title: The interleukin-1 receptor-associated kinase M selectively inhibits the alternative, instead of the classical NFkappaB pathway.
Volume: 1
Issue: 2
Pages: 164-74
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Publication
10383454 | -
First Author: Wesche H
Year: 1999
Journal: J Biol Chem
Title: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.
Volume: 274
Issue: 27
Pages: 19403-10
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Publication
20599782 | -
First Author: Flannery S
Year: 2010
Journal: Biochem Pharmacol
Title: The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.
Volume: 80
Issue: 12
Pages: 1981-91
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Protein
D3Z007
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
Q8K4B2
Organism: Mus musculus/domesticus
Length: 609  
Fragment?: false
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Protein
Q0VB14
Organism: Mus musculus/domesticus
Length: 609  
Fragment?: false
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Protein
D6RCU1
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Publication
19414798 | J:148320
First Author: Zacharioudaki V
Year: 2009
Journal: J Immunol
Title: Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression.
Volume: 182
Issue: 10
Pages: 6444-51
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Publication
37402858 | J:337904
First Author: Thiel FG
Year: 2023
Journal: Sci Rep
Title: IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis.
Volume: 13
Issue: 1
Pages: 10833
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Publication
36757800 | J:353318
 
First Author: Tunalı G
Year: 2023
Journal: J Clin Invest
Title: IL-1 receptor-associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy.
Volume: 133
Issue: 7
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Publication
30622459 | J:275801
 
First Author: Lyu C
Year: 2018
Journal: Front Cell Neurosci
Title: IRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice.
Volume: 12
Pages: 504
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Protein Coding Gene
MGP_CAROLIEiJ_G0015847 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017710 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1921164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018166 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017504 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017610 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017605 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017684 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017634 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018207 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016880 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031240 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016671 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
20042589 | J:159499
First Author: Seki M
Year: 2010
Journal: J Immunol
Title: Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia.
Volume: 184
Issue: 3
Pages: 1410-8
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Publication
20817880 | J:164297
First Author: Turnis ME
Year: 2010
Journal: J Immunol
Title: IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity.
Volume: 185
Issue: 7
Pages: 4223-32
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Publication
37481199 | J:348834
 
First Author: Lin C
Year: 2023
Journal: Eur J Pharmacol
Title: Ketogenic diet and β-Hydroxybutyrate alleviate ischemic brain injury in mice via an IRAKM-dependent pathway.
Volume: 955
Pages: 175933
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Publication
25585690 | J:219732
 
First Author: Miyata M
Year: 2015
Journal: Nat Commun
Title: Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.
Volume: 6
Pages: 6062
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Publication
31607540 | J:316155
First Author: Zhang Y
Year: 2020
Journal: Mol Ther
Title: Neutrophils Deficient in Innate Suppressor IRAK-M Enhances Anti-tumor Immune Responses.
Volume: 28
Issue: 1
Pages: 89-99
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Publication
22661086 | J:188940
First Author: Ballinger MN
Year: 2012
Journal: J Immunol
Title: TLR signaling prevents hyperoxia-induced lung injury by protecting the alveolar epithelium from oxidant-mediated death.
Volume: 189
Issue: 1
Pages: 356-64
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Publication
28665693 | J:266799
First Author: Zhang M
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Critical Role of IRAK-M in Regulating Antigen-Induced Airway Inflammation.
Volume: 57
Issue: 5
Pages: 547-559
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Publication
20585389 | J:162015
First Author: Lyn-Kew K
Year: 2010
Journal: PLoS One
Title: IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis.
Volume: 5
Issue: 6
Pages: e11145
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Publication
28701510 | J:251378
First Author: Steiger S
Year: 2017
Journal: J Immunol
Title: Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis.
Volume: 199
Issue: 4
Pages: 1440-1452
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Publication
26542797 | J:251450
First Author: Saxena A
Year: 2015
Journal: J Mol Cell Cardiol
Title: The role of Interleukin Receptor Associated Kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction.
Volume: 89
Issue: Pt B
Pages: 223-31
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Publication
23567778 | J:316431
First Author: Klimesova K
Year: 2013
Journal: Inflamm Bowel Dis
Title: Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.
Volume: 19
Issue: 6
Pages: 1266-77
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Publication
15809356 | J:98035
First Author: Li H
Year: 2005
Journal: J Exp Med
Title: IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation.
Volume: 201
Issue: 7
Pages: 1169-77
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Publication
23437317 | J:197190
First Author: Wang Y
Year: 2013
Journal: PLoS One
Title: Role of IRAK-M in alcohol induced liver injury.
Volume: 8
Issue: 2
Pages: e57085
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Publication
20439918 | J:161218
First Author: Hubbard LL
Year: 2010
Journal: J Immunol
Title: A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.
Volume: 184
Issue: 11
Pages: 6299-308
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Publication
24696448 | J:229884
First Author: Tan Q
Year: 2014
Journal: Diabetes
Title: IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice.
Volume: 63
Issue: 8
Pages: 2761-75
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Publication
26140693 | J:233059
First Author: Srivastav S
Year: 2015
Journal: Eur J Immunol
Title: IRAK-M regulates the inhibition of TLR-mediated macrophage immune response during late in vitro Leishmania donovani infection.
Volume: 45
Issue: 10
Pages: 2787-97
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Publication
28011933 | J:247804
First Author: Lyroni K
Year: 2017
Journal: J Immunol
Title: Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages.
Volume: 198
Issue: 3
Pages: 1297-1307
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Publication
31036429 | J:295508
 
First Author: Liu B
Year: 2019
Journal: J Autoimmun
Title: Interleukin-1 receptor associated kinase (IRAK)-M -mediated type 2 microglia polarization ameliorates the severity of experimental autoimmune encephalomyelitis (EAE).
Volume: 102
Pages: 77-88
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Publication
25603827 | J:315011
First Author: Shiu J
Year: 2015
Journal: Mucosal Immunol
Title: Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth.
Volume: 8
Issue: 5
Pages: 1047-59
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Publication
22472665 | J:318125
First Author: Cole TS
Year: 2012
Journal: Immunol Lett
Title: IRAK-M modulates expression of IL-10 and cell surface markers CD80 and MHC II after bacterial re-stimulation of tolerized dendritic cells.
Volume: 144
Issue: 1-2
Pages: 49-59
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Publication
27939424 | J:317883
 
First Author: Rothschild DE
Year: 2017
Journal: EBioMedicine
Title: Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M.
Volume: 15
Pages: 36-47
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Publication
37984750 | J:343743
 
First Author: Liu H
Year: 2024
Journal: Free Radic Biol Med
Title: Protectin D1 inhibits TLR4 signaling pathway to alleviate non-alcoholic steatohepatitis via upregulating IRAK-M.
Volume: 210
Pages: 42-53
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Publication
29686383 | J:304047
First Author: Nechama M
Year: 2018
Journal: Nat Commun
Title: The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.
Volume: 9
Issue: 1
Pages: 1603
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Publication
11960013 | J:76299
First Author: Li S
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
Volume: 99
Issue: 8
Pages: 5567-72
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Publication
28120642 | J:256180
First Author: Jiang D
Year: 2017
Journal: Innate Immun
Title: A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection.
Volume: 23
Issue: 2
Pages: 206-215
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Publication
27628766 | J:359636
First Author: Zhou H
Year: 2016
Journal: Hepatology
Title: IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease.
Volume: 64
Issue: 6
Pages: 1978-1993
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Publication
19596984 | J:151586
First Author: Lagler H
Year: 2009
Journal: J Immunol
Title: TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.
Volume: 183
Issue: 3
Pages: 2027-36
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Publication
12054681 | J:77382
First Author: Rosati O
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of murine IRAK-M.
Volume: 293
Issue: 5
Pages: 1472-7
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Publication
27824038 | J:242723
 
First Author: Geng S
Year: 2016
Journal: Nat Commun
Title: The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis.
Volume: 7
Pages: 13436
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Publication
32253243 | J:288499
First Author: Reader BF
Year: 2020
Journal: J Immunol
Title: IRAK-M Regulates Monocyte Trafficking to the Lungs in Response to Bleomycin Challenge.
Volume: 204
Issue: 10
Pages: 2661-2670
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Publication
16917541 | J:114453
First Author: Deng JC
Year: 2006
Journal: J Clin Invest
Title: Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M.
Volume: 116
Issue: 9
Pages: 2532-42
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Publication
17477969 | J:123571
First Author: Xie Q
Year: 2007
Journal: Mol Immunol
Title: Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth.
Volume: 44
Issue: 14
Pages: 3453-61
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Publication
19251253 | J:148550
First Author: Hassan F
Year: 2009
Journal: Cell Immunol
Title: Involvement of interleukin-1 receptor-associated kinase (IRAK)-M in toll-like receptor (TLR) 7-mediated tolerance in RAW 264.7 macrophage-like cells.
Volume: 256
Issue: 1-2
Pages: 99-103
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Publication
30372424 | J:271280
First Author: Zhang CJ
Year: 2018
Journal: J Clin Invest
Title: TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
Volume: 128
Issue: 12
Pages: 5399-5412
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Publication
24172845 | J:336624
First Author: Jeyanathan M
Year: 2014
Journal: Mucosal Immunol
Title: Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells.
Volume: 7
Issue: 3
Pages: 670-83
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Publication
32154744 | J:296815
First Author: Poblete JMS
Year: 2020
Journal: Am J Physiol Endocrinol Metab
Title: Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M.
Volume: 318
Issue: 5
Pages: E689-E700
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Publication
23776703 | J:203342
First Author: Shiu J
Year: 2013
Journal: PLoS One
Title: IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori.
Volume: 8
Issue: 6
Pages: e66914
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Publication
23117655 | J:216920
First Author: Maitra U
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin.
Volume: 33
Issue: 1
Pages: 24-33
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Publication
21098228 | J:168006
First Author: Kobayashi H
Year: 2011
Journal: J Immunol
Title: Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M.
Volume: 186
Issue: 1
Pages: 403-10
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Publication
21257958 | J:168989
First Author: Sumpter TL
Year: 2011
Journal: J Immunol
Title: DAP12 promotes IRAK-M expression and IL-10 production by liver myeloid dendritic cells and restrains their T cell allostimulatory ability.
Volume: 186
Issue: 4
Pages: 1970-80
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Publication
18336909 | J:134468
First Author: Arranz A
Year: 2008
Journal: Mol Immunol
Title: Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide.
Volume: 45
Issue: 10
Pages: 2970-80
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Publication
27150039 | J:231897
First Author: Kesselring R
Year: 2016
Journal: Cancer Cell
Title: IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3.
Volume: 29
Issue: 5
Pages: 684-696
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Publication
21182089 | J:174655
First Author: Biswas A
Year: 2011
Journal: Eur J Immunol
Title: Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine.
Volume: 41
Issue: 1
Pages: 182-94
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Publication
21690387 | J:174298
First Author: Norton JT
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates.
Volume: 108
Issue: 27
Pages: 11163-8
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Publication
29636416 | J:263882
First Author: Griffin C
Year: 2018
Journal: J Biol Chem
Title: TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice.
Volume: 293
Issue: 23
Pages: 8775-8786
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Publication
18378686 | J:137555
First Author: Kim YI
Year: 2008
Journal: J Biol Chem
Title: CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases.
Volume: 283
Issue: 22
Pages: 15258-70
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Publication
12819136 | J:84168
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
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Publication
15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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