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Search results 1 to 100 out of 530 for Irf1

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Hits by Category

Hits by Strain

Type Details Score
Gene
3659 | IRF1
Type: gene
Organism: human
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Gene
448320 | irf1
Type: gene
Organism: frog, western clawed
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Gene
107974852 | IRF1
Type: gene
Organism: chimpanzee
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Gene
24508 | Irf1
Type: gene
Organism: rat
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Gene
789216 | IRF1
Type: gene
Organism: cattle
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Gene
100855872 | IRF1
Type: gene
Organism: dog, domestic
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Gene
396384 | IRF1
Type: gene
Organism: chicken
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Gene
707788 | IRF1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR031215 | IRF1
Type: Family
Description: Interferon regulatory factor 1 (IRF1) is a transcriptional regulator involved in the regulation of several cellular responses, such as regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage [, , , , , ].
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Protein Coding Gene
MGI:96590 | Irf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11244049 | J:183979
 
First Author: Taniguchi T
Year: 2001
Journal: Annu Rev Immunol
Title: IRF family of transcription factors as regulators of host defense.
Volume: 19
Pages: 623-55
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Publication
36736301 | J:336125
First Author: Rosain J
Year: 2023
Journal: Cell
Title: Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.
Volume: 186
Issue: 3
Pages: 621-645.e33
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Gene
441108 | CARINH
Type: gene
Organism: human
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Publication
35852463 | J:328947
First Author: Romeike M
Year: 2022
Journal: EMBO Rep
Title: Transient upregulation of IRF1 during exit from naive pluripotency confers viral protection.
Volume: 23
Issue: 9
Pages: e55375
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Publication
24973819 | J:259007
First Author: Végran F
Year: 2014
Journal: Nat Immunol
Title: The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.
Volume: 15
Issue: 8
Pages: 758-66
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Publication
37889967 | J:342211
First Author: Rundberg Nilsson AJS
Year: 2023
Journal: Sci Adv
Title: IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance.
Volume: 9
Issue: 43
Pages: eadg5391
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Publication
28166218 | J:259571
First Author: Karwacz K
Year: 2017
Journal: Nat Immunol
Title: Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.
Volume: 18
Issue: 4
Pages: 412-421
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Publication
26318672 | J:330978
First Author: Masuda T
Year: 2015
Journal: J Pharmacol Sci
Title: Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia.
Volume: 128
Issue: 4
Pages: 216-20
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Publication
24464131 | J:209440
First Author: Harikumar KB
Year: 2014
Journal: Nat Immunol
Title: K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Volume: 15
Issue: 3
Pages: 231-8
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Publication
31619669 | J:281676
First Author: Wang P
Year: 2019
Journal: Nat Commun
Title: IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners.
Volume: 10
Issue: 1
Pages: 4700
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Publication
28497800 | J:249546
 
First Author: Campos Carrascosa L
Year: 2017
Journal: Nat Commun
Title: Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.
Volume: 8
Pages: 15366
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Publication
26158850 | J:228771
First Author: Mould AW
Year: 2015
Journal: PLoS Genet
Title: Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation.
Volume: 11
Issue: 7
Pages: e1005375
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Publication
23623383 | J:203156
First Author: Venkatesh D
Year: 2013
Journal: Immunity
Title: Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-β autocrine signaling to promote monocyte recruitment.
Volume: 38
Issue: 5
Pages: 1025-37
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Publication
23657854 | J:345267
First Author: Winterberg PD
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI.
Volume: 305
Issue: 2
Pages: F164-72
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Publication
38833371 | J:352683
First Author: Purbey PK
Year: 2024
Journal: Cell Rep
Title: Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity.
Volume: 43
Issue: 6
Pages: 114289
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Publication
25774715 | J:231714
First Author: Man SM
Year: 2015
Journal: Nat Immunol
Title: The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
Volume: 16
Issue: 5
Pages: 467-75
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Publication
11846974 | -
First Author: Romeo G
Year: 2002
Journal: J Interferon Cytokine Res
Title: IRF-1 as a negative regulator of cell proliferation.
Volume: 22
Issue: 1
Pages: 39-47
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Publication
15226432 | -
First Author: Oshima S
Year: 2004
Journal: Mol Cell Biol
Title: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.
Volume: 24
Issue: 14
Pages: 6298-310
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Publication
22200613 | -
First Author: Armstrong MJ
Year: 2012
Journal: Cancer Lett
Title: Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.
Volume: 319
Issue: 1
Pages: 56-65
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Publication
19851330 | -
First Author: Gao J
Year: 2010
Journal: Cell Death Differ
Title: IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells.
Volume: 17
Issue: 4
Pages: 699-709
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Publication
15509808 | -
First Author: Dornan D
Year: 2004
Journal: Mol Cell Biol
Title: Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.
Volume: 24
Issue: 22
Pages: 10083-98
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Publication
24214980 | J:207189
First Author: Yang H
Year: 2013
Journal: J Biol Chem
Title: Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.
Volume: 288
Issue: 52
Pages: 37256-66
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Publication
34244313 | J:345013
 
First Author: Ghislat G
Year: 2021
Journal: Sci Immunol
Title: NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity.
Volume: 6
Issue: 61
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GXD Expression
GXD Expression
     
Probe: MGI:6175580
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190621
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Irf1
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6175580
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190621
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Irf1
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6175580
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190621
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Irf1
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6175580
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190621
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Irf1
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6175580
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190621
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Irf1
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:6175580
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190621
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Irf1
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6175580
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190621
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Irf1
Detected: false
Specimen Num: 5
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Publication
29321274 | J:258250
First Author: Kuriakose T
Year: 2018
Journal: J Immunol
Title: IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection.
Volume: 200
Issue: 4
Pages: 1489-1495
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Protein
P15314
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
Q3U5M1
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
Q5SX13
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
Q4FK18
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Publication
17293456 | J:125899
First Author: Ramsauer K
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene.
Volume: 104
Issue: 8
Pages: 2849-54
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Publication
18059273 | J:130476
First Author: Kano S
Year: 2008
Journal: Nat Immunol
Title: The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells.
Volume: 9
Issue: 1
Pages: 34-41
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Protein
A8Y5B9
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Protein
D6RH71
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: false
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Protein
Q5SX16
Organism: Mus musculus/domesticus
Length: 62  
Fragment?: true
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Protein
Q5SX14
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
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Protein
Q5SX15
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Publication
19720760 | J:154191
First Author: Fortier A
Year: 2009
Journal: Infect Immun
Title: Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.
Volume: 77
Issue: 11
Pages: 4794-805
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Publication
9144426 | J:39666
First Author: Nozaki T
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Abrogation of G1 arrest after DNA damage is associated with constitutive overexpression of Mdm2, Cdk4, and Irf1 mRNAs in the BALB/c 3T3 A31 variant 1-1 clone.
Volume: 233
Issue: 1
Pages: 216-20
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Publication
22229156 | J:179655
First Author: Burocchi A
Year: 2011
Journal: Eur J Immunol
Title: Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells.
Volume: 41
Issue: 12
Pages: 3615-26
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Publication
31471108 | J:283546
First Author: Forero A
Year: 2019
Journal: Immunity
Title: Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons.
Volume: 51
Issue: 3
Pages: 451-464.e6
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Publication
- | J:267677
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Longs_peak.
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Publication
- | J:267675
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for endeka2.
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Publication
24954358 | J:233228
First Author: Salem S
Year: 2014
Journal: J Cell Mol Med
Title: A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism.
Volume: 18
Issue: 8
Pages: 1588-98
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Publication
19429811 | J:151107
First Author: Yu Q
Year: 2009
Journal: Am J Physiol Heart Circ Physiol
Title: IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice.
Volume: 297
Issue: 1
Pages: H76-85
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Publication
28975621 | J:248000
     
First Author: Buccione C
Year: 2017
Journal: Int J Cancer
Title: Role of interferon regulatory factor 1 in governing Treg depletion, Th1 polarization, inflammasome activation and antitumor efficacy of cyclophosphamide.
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Publication
31827213 | J:297850
First Author: Jeyakumar T
Year: 2019
Journal: Sci Rep
Title: Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer.
Volume: 9
Issue: 1
Pages: 18897
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Publication
24130180 | J:215143
First Author: Yoon GS
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Interferon regulatory factor-1 in flagellin-induced reprogramming: potential protective role of CXCL10 in cornea innate defense against Pseudomonas aeruginosa infection.
Volume: 54
Issue: 12
Pages: 7510-21
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Publication
32087218 | J:288279
 
First Author: Peng K
Year: 2020
Journal: J Mol Cell Cardiol
Title: IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium.
Volume: 140
Pages: 30-41
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Publication
28196914 | J:258541
First Author: Hazra B
Year: 2017
Journal: Sci Signal
Title: The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection.
Volume: 10
Issue: 466
Pages: eaaf5185
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Publication
32554929 | J:296303
 
First Author: Karki R
Year: 2020
Journal: JCI Insight
Title: Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.
Volume: 5
Issue: 12
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Publication
32938919 | J:297027
First Author: Huang Y
Year: 2020
Journal: Nat Commun
Title: IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4.
Volume: 11
Issue: 1
Pages: 4664
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Publication
17018642 | J:115304
First Author: Negishi H
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.
Volume: 103
Issue: 41
Pages: 15136-41
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Publication
25280793 | J:222327
First Author: Maruyama S
Year: 2015
Journal: Int Immunol
Title: A novel function of interferon regulatory factor-1: inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection.
Volume: 27
Issue: 3
Pages: 143-52
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Publication
30348900 | J:272880
First Author: Rani R
Year: 2018
Journal: J Biol Chem
Title: Mechanisms of concanavalin A-induced cytokine synthesis by hepatic stellate cells: Distinct roles of interferon regulatory factor-1 in liver injury.
Volume: 293
Issue: 48
Pages: 18466-18476
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Publication
20083668 | J:159478
First Author: Molle C
Year: 2010
Journal: J Immunol
Title: Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process.
Volume: 184
Issue: 4
Pages: 1784-92
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Publication
28970238 | J:251008
First Author: Sun L
Year: 2017
Journal: J Exp Med
Title: HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.
Volume: 214
Issue: 11
Pages: 3263-3277
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Publication
22252317 | J:183707
First Author: Farlik M
Year: 2012
Journal: Mol Cell Biol
Title: Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.
Volume: 32
Issue: 6
Pages: 1032-43
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Publication
20451243 | J:167950
First Author: Dixit E
Year: 2010
Journal: Cell
Title: Peroxisomes are signaling platforms for antiviral innate immunity.
Volume: 141
Issue: 4
Pages: 668-81
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Publication
37001504 | J:334891
First Author: Gungabeesoon J
Year: 2023
Journal: Cell
Title: A neutrophil response linked to tumor control in immunotherapy.
Volume: 186
Issue: 7
Pages: 1448-1464.e20
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Publication
33137133 | J:296973
First Author: Yan B
Year: 2020
Journal: PLoS One
Title: Interferon Regulatory Factor-1 (IRF1) activates autophagy to promote liver ischemia/reperfusion injury by inhibiting β-catenin in mice.
Volume: 15
Issue: 11
Pages: e0239119
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Publication
28062696 | J:247731
First Author: Hooper KM
Year: 2017
Journal: J Immunol
Title: Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1.
Volume: 198
Issue: 4
Pages: 1521-1530
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Publication
23975864 | J:205843
First Author: Sjöstrand M
Year: 2013
Journal: J Immunol
Title: Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.
Volume: 191
Issue: 7
Pages: 3753-63
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Publication
22464096 | J:184869
First Author: Korhonen R
Year: 2012
Journal: Mol Immunol
Title: The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
Volume: 51
Issue: 2
Pages: 219-26
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Publication
38660315 | J:349239
 
First Author: Loftus SN
Year: 2024
Journal: Front Immunol
Title: Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1.
Volume: 15
Pages: 1384606
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Publication
26254356 | J:316830
First Author: Hayashi T
Year: 2015
Journal: Anticancer Res
Title: Uterine Leiomyosarcoma Tumorigenesis in Lmp2-deficient Mice: Involvement of Impaired Anti-oncogenic Factor IRF1.
Volume: 35
Issue: 9
Pages: 4665-79
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Publication
22962685 | J:190532
First Author: Parker D
Year: 2012
Journal: J Immunol
Title: Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9.
Volume: 189
Issue: 8
Pages: 4040-6
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Publication
31235522 | J:281282
First Author: Liang S
Year: 2019
Journal: J Biol Chem
Title: Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.
Volume: 294
Issue: 33
Pages: 12359-12369
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Publication
31301160 | J:279773
First Author: Gao T
Year: 2019
Journal: Glia
Title: Transcriptional regulation of homeostatic and disease-associated-microglial genes by IRF1, LXRβ, and CEBPα.
Volume: 67
Issue: 10
Pages: 1958-1975
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Publication
15860458 | J:133228
First Author: Liu J
Year: 2005
Journal: J Biol Chem
Title: Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages.
Volume: 280
Issue: 26
Pages: 24347-55
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Publication
31367250 | J:295871
First Author: Du M
Year: 2019
Journal: Theranostics
Title: Absence of Interferon Regulatory Factor 1 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice.
Volume: 9
Issue: 16
Pages: 4688-4703
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Publication
23853600 | J:213363
First Author: Berghout J
Year: 2013
Journal: PLoS Pathog
Title: Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.
Volume: 9
Issue: 7
Pages: e1003491
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Publication
22777843 | J:188005
First Author: Biondo C
Year: 2012
Journal: Eur J Immunol
Title: Recognition of fungal RNA by TLR7 has a nonredundant role in host defense against experimental candidiasis.
Volume: 42
Issue: 10
Pages: 2632-43
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Publication
21282509 | J:169378
First Author: Bourgeois C
Year: 2011
Journal: J Immunol
Title: Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling.
Volume: 186
Issue: 5
Pages: 3104-12
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Publication
22896628 | J:189947
First Author: Weiss G
Year: 2012
Journal: J Immunol
Title: MyD88 drives the IFN-β response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7.
Volume: 189
Issue: 6
Pages: 2860-8
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Publication
27001747 | J:233076
First Author: Langlais D
Year: 2016
Journal: J Exp Med
Title: The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.
Volume: 213
Issue: 4
Pages: 585-603
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Protein Coding Gene
MGP_CAROLIEiJ_G0016346 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018273 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018243 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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