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Search results 1 to 100 out of 187 for Irf2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Protein Domain
Type: Family
Description: Interferon regulatory factor 2 (IRF2) is a multifunctional transcription factor that plays a pivotal role in regulation of apoptosis and cell cycle control [, , ]. It also plays an important role in modulating cellular responses to interferon (IFN) and viral infection []. It has an antagonistic role to IRF1 in transcriptional regulation of IFN and ISG genes []. While IRF1 acts as a positive regulator, IRF2 is known to repress IFN-mediated gene expression.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication  
First Author: Kayagaki N
Year: 2019
Journal: Sci Signal
Title: IRF2 transcriptionally induces GSDMD expression for pyroptosis.
Volume: 12
Issue: 582
Publication
First Author: Lukhele S
Year: 2022
Journal: Immunity
Title: The transcription factor IRF2 drives interferon-mediated CD8(+) T cell exhaustion to restrict anti-tumor immunity.
Volume: 55
Issue: 12
Pages: 2369-2385.e10
Publication
First Author: Minamide K
Year: 2020
Journal: Sci Rep
Title: IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon.
Volume: 10
Issue: 1
Pages: 14639
Publication
First Author: Gu M
Year: 2015
Journal: Dev Comp Immunol
Title: Ctenopharyngodon idella IRF2 plays an antagonistic role to IRF1 in transcriptional regulation of IFN and ISG genes.
Volume: 49
Issue: 1
Pages: 103-12
Publication
First Author: Mizutani T
Year: 2008
Journal: Exp Hematol
Title: Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling.
Volume: 36
Issue: 3
Pages: 255-64
GXD Expression      
Probe: MGI:6175581
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190622
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Irf2
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6175581
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190622
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Irf2
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6175581
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190622
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Irf2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6175581
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190622
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Irf2
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6175581
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190622
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Irf2
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:6175581
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190622
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Irf2
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6175581
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190622
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Irf2
Detected: false
Specimen Num: 6
Publication
First Author: Mukherjee RM
Year: 2012
Journal: J Clin Exp Hepatol
Title: Human Interferon Regulatory Factor 2 Gene Expression is Induced in Chronic Hepatitis C Virus Infection-A Possible Mode of Viral Persistence.
Volume: 2
Issue: 1
Pages: 27-34
Publication
First Author: Harada H
Year: 1993
Journal: Science
Title: Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2.
Volume: 259
Issue: 5097
Pages: 971-4
Publication
First Author: Masumi A
Year: 2003
Journal: J Biol Chem
Title: Interferon regulatory factor-2 regulates cell growth through its acetylation.
Volume: 278
Issue: 28
Pages: 25401-7
Publication
First Author: Taniguchi T
Year: 1995
Journal: Indian J Biochem Biophys
Title: IRF-1 and IRF-2 as regulators of the interferon system and cell growth.
Volume: 32
Issue: 5
Pages: 235-9
Protein
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 41  
Fragment?: false
Publication
First Author: Klune JR
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury.
Volume: 303
Issue: 5
Pages: G666-73
Publication
First Author: Cui H
Year: 2018
Journal: J Immunol
Title: IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages.
Volume: 200
Issue: 9
Pages: 3218-3230
Publication
First Author: Mashima H
Year: 2011
Journal: Gastroenterology
Title: Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells.
Volume: 141
Issue: 3
Pages: 1102-1113.e1-8
Publication
First Author: Liao W
Year: 2019
Journal: Cancer Cell
Title: KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Volume: 35
Issue: 4
Pages: 559-572.e7
Publication
First Author: Sun L
Year: 2017
Journal: J Exp Med
Title: HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.
Volume: 214
Issue: 11
Pages: 3263-3277
Publication
First Author: Sato T
Year: 2020
Journal: Nat Cell Biol
Title: Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages.
Volume: 22
Issue: 8
Pages: 919-926
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Li MM
Year: 2016
Journal: J Exp Med
Title: Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion.
Volume: 213
Issue: 13
Pages: 2931-2947
Publication
First Author: Xi H
Year: 2001
Journal: Oncogene
Title: Impaired class II transactivator expression in mice lacking interferon regulatory factor-2.
Volume: 20
Issue: 31
Pages: 4219-27
Publication
First Author: Minamino K
Year: 2012
Journal: Int Immunol
Title: IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms.
Volume: 24
Issue: 9
Pages: 573-81
Publication
First Author: Cuesta N
Year: 2007
Journal: J Immunol
Title: IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism.
Volume: 178
Issue: 6
Pages: 3602-11
Publication
First Author: Cuesta N
Year: 2003
Journal: J Immunol
Title: Regulation of lipopolysaccharide sensitivity by IFN regulatory factor-2.
Volume: 170
Issue: 11
Pages: 5739-47
Publication
First Author: Uegaki K
Year: 1993
Journal: Protein Eng
Title: Characterization of the DNA binding domain of the mouse IRF-2 protein.
Volume: 6
Issue: 2
Pages: 195-200
Publication
First Author: Vaughan PS
Year: 1998
Journal: J Biol Chem
Title: Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2.
Volume: 273
Issue: 1
Pages: 194-9
Publication
First Author: Masumi A
Year: 2009
Journal: FEBS Lett
Title: Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells.
Volume: 583
Issue: 21
Pages: 3493-500
GXD Expression    
Probe: MGI:1339129
Assay Type: RT-PCR
Annotation Date: 1999-07-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:1339237
Age: postnatal week 6
Image: 2
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1339148
Assay Type: Western blot
Annotation Date: 1999-07-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:1339258
Age: postnatal week 6
Image: 2
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4845632
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4849106
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4845632
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4849106
Age: embryonic day 11.5
Note: Staining is present in the posterior-distal region of the limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:1339148
Assay Type: Immunohistochemistry
Annotation Date: 2008-04-01
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1783925
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3775665
Age: embryonic day 17.0
Image: 3e
Note: Very little expression was detectable in the anterior epithelia.
Specimen Label: 3e
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:1339148
Assay Type: Immunohistochemistry
Annotation Date: 2008-04-01
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1783925
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3775665
Age: embryonic day 17.0
Image: 3f
Note: Very little expression was detectable in the anterior epithelia.
Specimen Label: 3f
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4845632
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4849106
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2854023
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4845632
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1636717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4849106
Age: embryonic day 10.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:1339148
Assay Type: Immunohistochemistry
Annotation Date: 2008-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3775665
Age: embryonic day 17.0
Image: 3e
Note: Expression was present in the cytoplasm of fiber cells.
Specimen Label: 3e
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:1339148
Assay Type: Immunohistochemistry
Annotation Date: 2008-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3775665
Age: embryonic day 17.0
Image: 3f
Note: Expression was present in the cytoplasm of fiber cells.
Specimen Label: 3f
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5597
Specimen Label: GUDMAP:5597
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4879837
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541066
Age: embryonic day 15.5
Image: GUDMAP:5596
Specimen Label: GUDMAP:5596
Detected: true
Specimen Num: 1