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Search results 1 to 100 out of 687 for Irf3

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Type Details Score
Gene
3661 | IRF3
Type: gene
Organism: human
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Gene
516979 | IRF3
Type: gene
Organism: cattle
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Gene
564854 | irf3
Type: gene
Organism: zebrafish
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Gene
718970 | IRF3
Type: gene
Organism: macaque, rhesus
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Gene
101734275 | irf3
Type: gene
Organism: frog, western clawed
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Gene
292892 | Irf3
Type: gene
Organism: rat
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Gene
476412 | IRF3
Type: gene
Organism: dog, domestic
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Gene
747565 | IRF3
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1859179 | Irf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33571167 | J:304593
 
First Author: Yan S
Year: 2021
Journal: J Clin Invest
Title: IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis.
Volume: 131
Issue: 7
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Publication
27400129 | J:237123
First Author: Kumari M
Year: 2016
Journal: J Clin Invest
Title: IRF3 promotes adipose inflammation and insulin resistance and represses browning.
Volume: 126
Issue: 8
Pages: 2839-54
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Publication
29339449 | J:257695
First Author: Jiao S
Year: 2018
Journal: J Exp Med
Title: Targeting IRF3 as a YAP agonist therapy against gastric cancer.
Volume: 215
Issue: 2
Pages: 699-718
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Publication
28951494 | J:251372
First Author: Warner JD
Year: 2017
Journal: J Exp Med
Title: STING-associated vasculopathy develops independently of IRF3 in mice.
Volume: 214
Issue: 11
Pages: 3279-3292
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Publication
28763789 | J:257308
 
First Author: Ni G
Year: 2017
Journal: Sci Immunol
Title: Ubiquitination of STING at lysine 224 controls IRF3 activation.
Volume: 2
Issue: 11
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Publication
30932349 | J:294253
First Author: Simons KH
Year: 2019
Journal: J Cell Mol Med
Title: IRF3 and IRF7 mediate neovascularization via inflammatory cytokines.
Volume: 23
Issue: 6
Pages: 3888-3896
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Publication
25811886 | J:246456
First Author: Majumdar T
Year: 2015
Journal: PLoS Pathog
Title: Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii.
Volume: 11
Issue: 3
Pages: e1004779
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Publication
22285490 | J:181915
First Author: Zhao W
Year: 2012
Journal: FEBS Lett
Title: LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism.
Volume: 586
Issue: 6
Pages: 705-10
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Publication
31213650 | J:293325
First Author: Zhou Y
Year: 2019
Journal: Cell Res
Title: Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation.
Volume: 29
Issue: 8
Pages: 641-654
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Publication
33188184 | J:297899
First Author: Tian M
Year: 2020
Journal: Nat Commun
Title: IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin.
Volume: 11
Issue: 1
Pages: 5762
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Publication
23892079 | J:200923
First Author: Moore TC
Year: 2013
Journal: FEBS Lett
Title: IRF3 and ERK MAP-kinases control nitric oxide production from macrophages in response to poly-I:C.
Volume: 587
Issue: 18
Pages: 3014-20
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Publication
29106401 | J:251813
First Author: King KR
Year: 2017
Journal: Nat Med
Title: IRF3 and type I interferons fuel a fatal response to myocardial infarction.
Volume: 23
Issue: 12
Pages: 1481-1487
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Publication
24244017 | J:207113
First Author: Munitic I
Year: 2013
Journal: J Immunol
Title: Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.
Volume: 191
Issue: 12
Pages: 6231-40
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Publication
26900919 | J:247225
First Author: Chen W
Year: 2016
Journal: PLoS Pathog
Title: ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs.
Volume: 12
Issue: 2
Pages: e1005462
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Publication
36417850 | J:334284
First Author: Wang S
Year: 2022
Journal: Cell Rep
Title: LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.
Volume: 41
Issue: 8
Pages: 111661
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Publication
32130408 | J:289863
 
First Author: Cai Z
Year: 2020
Journal: J Exp Med
Title: USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Volume: 217
Issue: 5
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Publication
23770239 | J:199310
First Author: Di Paolo NC
Year: 2013
Journal: Cell Rep
Title: The transcription factor IRF3 triggers "defensive suicide" necrosis in response to viral and bacterial pathogens.
Volume: 3
Issue: 6
Pages: 1840-6
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Publication
23048204 | J:191102
First Author: Walker WE
Year: 2012
Journal: J Leukoc Biol
Title: IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model.
Volume: 92
Issue: 6
Pages: 1261-8
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Publication
28904192 | J:253347
 
First Author: Manivanh R
Year: 2017
Journal: J Virol
Title: Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling.
Volume: 91
Issue: 23
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Publication
32393626 | J:288594
First Author: Luther J
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation.
Volume: 117
Issue: 21
Pages: 11667-11673
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Publication
21266535 | J:172781
First Author: Tsushima K
Year: 2011
Journal: FASEB J
Title: IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension.
Volume: 25
Issue: 5
Pages: 1531-43
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Publication
23213237 | J:193098
First Author: Negishi H
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction.
Volume: 109
Issue: 51
Pages: 21016-21
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Publication
17360955 | J:122339
First Author: Trumstedt C
Year: 2007
Journal: J Leukoc Biol
Title: Role of IRAK4 and IRF3 in the control of intracellular infection with Chlamydia pneumoniae.
Volume: 81
Issue: 6
Pages: 1591-8
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Publication
28159912 | J:246386
First Author: Bakshi S
Year: 2017
Journal: Biochem J
Title: Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
Volume: 474
Issue: 7
Pages: 1163-1174
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Publication
28939760 | J:251075
First Author: Fang R
Year: 2017
Journal: J Immunol
Title: NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway.
Volume: 199
Issue: 9
Pages: 3222-3233
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Publication
30842273 | J:274373
First Author: Luo F
Year: 2019
Journal: J Immunol
Title: Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production.
Volume: 202
Issue: 8
Pages: 2254-2265
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Publication
16840729 | J:140456
First Author: Bozza S
Year: 2006
Journal: Blood
Title: Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation.
Volume: 108
Issue: 10
Pages: 3387-96
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Publication
19617565 | J:150948
First Author: Nakajima A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene.
Volume: 106
Issue: 30
Pages: 12448-52
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Publication
29712834 | J:267354
First Author: Yanai H
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.
Volume: 115
Issue: 20
Pages: 5253-5258
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Publication
18818394 | J:144249
First Author: Liu X
Year: 2008
Journal: Blood
Title: CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.
Volume: 112
Issue: 13
Pages: 4961-70
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Publication
37733807 | J:341613
First Author: Bourdon M
Year: 2023
Journal: PLoS Pathog
Title: Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo.
Volume: 19
Issue: 9
Pages: e1011446
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GO Term
GO:0039548 | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
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Publication
9803267 | J:62618
First Author: Bellingham J
Year: 1998
Journal: Ann Hum Genet
Title: Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
Volume: 62
Issue: Pt 3
Pages: 231-4
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Publication
24368188 | J:208168
First Author: Moore TC
Year: 2014
Journal: Cancer Lett
Title: Interferon response factor 3 is crucial to poly-I:C induced NK cell activity and control of B16 melanoma growth.
Volume: 346
Issue: 1
Pages: 122-8
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Publication
34731629 | J:328540
First Author: Xu J
Year: 2021
Journal: Cell Rep
Title: IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation.
Volume: 37
Issue: 5
Pages: 109926
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Publication
17074929 | J:124623
First Author: Chow EK
Year: 2006
Journal: J Exp Med
Title: A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections.
Volume: 203
Issue: 12
Pages: 2589-602
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Publication
29429998 | J:287040
First Author: Liu Y
Year: 2018
Journal: Cell Mol Immunol
Title: ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.
Volume: 15
Issue: 10
Pages: 907-916
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Publication
23918362 | J:200677
First Author: Ysebrant de Lendonck L
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes.
Volume: 110
Issue: 34
Pages: E3189-97
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Publication
29101251 | J:251909
First Author: Wang C
Year: 2017
Journal: J Exp Med
Title: The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3.
Volume: 214
Issue: 12
Pages: 3597-3610
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Publication
27546168 | J:246178
First Author: Janss T
Year: 2016
Journal: Eur J Immunol
Title: Interferon response factor-3 promotes the pro-Th2 activity of mouse lung CD11b+ conventional dendritic cells in response to house dust mite allergens.
Volume: 46
Issue: 11
Pages: 2614-2628
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Publication
23307144 | J:319021
First Author: Lu J
Year: 2013
Journal: Basic Res Cardiol
Title: Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy.
Volume: 108
Issue: 2
Pages: 326
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Publication
31281243 | J:281010
 
First Author: Zhang X
Year: 2019
Journal: Front Cell Neurosci
Title: Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice.
Volume: 13
Pages: 272
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Publication
28363903 | J:247796
First Author: Ishii T
Year: 2017
Journal: J Immunol
Title: IFN Regulatory Factor 3 Potentiates Emphysematous Aggravation by Lipopolysaccharide.
Volume: 198
Issue: 9
Pages: 3637-3649
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Publication
35471821 | J:336121
First Author: Foss MH
Year: 2022
Journal: ACS Chem Biol
Title: Identification and Characterization of Small-Molecule IRF3-Dependent Immune Activators for Pharmaceutical Development.
Volume: 17
Issue: 5
Pages: 1073-1081
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Publication
34091599 | J:312859
First Author: Tang P
Year: 2021
Journal: Cell Death Differ
Title: Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3.
Volume: 28
Issue: 11
Pages: 3022-3035
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Publication
22610141 | J:187655
First Author: Negishi H
Year: 2012
Journal: Nat Immunol
Title: Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses.
Volume: 13
Issue: 7
Pages: 659-66
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Publication
16699525 | J:112672
First Author: Saitoh T
Year: 2006
Journal: Nat Immunol
Title: Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.
Volume: 7
Issue: 6
Pages: 598-605
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Publication
26692175 | J:260236
First Author: Li S
Year: 2016
Journal: Nat Immunol
Title: The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Volume: 17
Issue: 3
Pages: 241-9
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Publication
25763818 | J:245855
First Author: Wang P
Year: 2015
Journal: PLoS Pathog
Title: TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3.
Volume: 11
Issue: 3
Pages: e1004726
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Publication
22379081 | J:186100
First Author: Ishibashi D
Year: 2012
Journal: J Virol
Title: Protective role of interferon regulatory factor 3-mediated signaling against prion infection.
Volume: 86
Issue: 9
Pages: 4947-55
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Publication
20886096 | J:167920
First Author: Fischer H
Year: 2010
Journal: PLoS Pathog
Title: Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.
Volume: 6
Issue: 9
Pages: e1001109
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Ontology Term
- | Inhibition of host IRF3 by virus
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Publication
30878284 | J:274136
First Author: Ning X
Year: 2019
Journal: Mol Cell
Title: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3.
Volume: 74
Issue: 1
Pages: 19-31.e7
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Publication
17548596 | J:148591
First Author: Molle C
Year: 2007
Journal: J Immunol
Title: IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3.
Volume: 178
Issue: 12
Pages: 7607-15
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Publication
30842237 | J:275220
First Author: Huai W
Year: 2019
Journal: J Exp Med
Title: KAT8 selectively inhibits antiviral immunity by acetylating IRF3.
Volume: 216
Issue: 4
Pages: 772-785
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Publication
25526531 | J:219762
First Author: Xu P
Year: 2014
Journal: Mol Cell
Title: Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling.
Volume: 56
Issue: 6
Pages: 723-37
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Publication
14679297 | J:87323
First Author: McWhirter SM
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Volume: 101
Issue: 1
Pages: 233-8
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Publication
28302626 | J:263664
First Author: Mao Y
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity.
Volume: 37
Issue: 5
Pages: 920-929
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Publication
20720199 | J:163545
First Author: Carrigan SO
Year: 2010
Journal: J Immunol
Title: IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice.
Volume: 185
Issue: 6
Pages: 3602-9
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Publication
21653850 | J:310784
First Author: Stevens SL
Year: 2011
Journal: J Neurosci
Title: Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury.
Volume: 31
Issue: 23
Pages: 8456-63
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Publication
27122612 | J:249562
First Author: Puthia M
Year: 2016
Journal: Sci Transl Med
Title: IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections.
Volume: 8
Issue: 336
Pages: 336ra59
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Publication
19657036 | J:151462
First Author: Marsh B
Year: 2009
Journal: J Neurosci
Title: Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: a critical role for IRF3.
Volume: 29
Issue: 31
Pages: 9839-49
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Publication
15585867 | J:94858
First Author: Stockinger S
Year: 2004
Journal: J Immunol
Title: IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.
Volume: 173
Issue: 12
Pages: 7416-25
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Publication
16394098 | J:111745
First Author: Yang K
Year: 2006
Journal: Mol Biol Cell
Title: Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells.
Volume: 17
Issue: 3
Pages: 1461-71
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Publication
27742471 | J:251241
First Author: Cao Y
Year: 2016
Journal: Biochim Biophys Acta
Title: Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
Volume: 1863
Issue: 12
Pages: 3148-3159
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Publication
32907941 | J:296365
First Author: Liu W
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity.
Volume: 117
Issue: 38
Pages: 23695-23706
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Publication
24185615 | J:209010
First Author: You F
Year: 2013
Journal: Nat Immunol
Title: ELF4 is critical for induction of type I interferon and the host antiviral response.
Volume: 14
Issue: 12
Pages: 1237-46
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Publication
30683688 | J:286517
 
First Author: Imanishi T
Year: 2019
Journal: Life Sci Alliance
Title: Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.
Volume: 2
Issue: 1
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Publication
27565347 | J:234468
First Author: Yockey LJ
Year: 2016
Journal: Cell
Title: Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection.
Volume: 166
Issue: 5
Pages: 1247-1256.e4
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Publication
16286919 | J:112953
First Author: Ishii KJ
Year: 2006
Journal: Nat Immunol
Title: A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Volume: 7
Issue: 1
Pages: 40-8
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Publication
23770228 | J:207582
First Author: del Fresno C
Year: 2013
Journal: Immunity
Title: Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.
Volume: 38
Issue: 6
Pages: 1176-86
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Publication
24391507 | J:246031
First Author: Archer KA
Year: 2014
Journal: PLoS Pathog
Title: STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes.
Volume: 10
Issue: 1
Pages: e1003861
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Publication
17925397 | J:130096
First Author: Oganesyan G
Year: 2008
Journal: J Biol Chem
Title: IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production.
Volume: 283
Issue: 2
Pages: 802-8
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Publication
16670275 | J:131688
First Author: Chiang E
Year: 2006
Journal: J Immunol
Title: Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide.
Volume: 176
Issue: 10
Pages: 5720-4
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Publication
23160154 | J:191073
First Author: Hasan M
Year: 2013
Journal: Nat Immunol
Title: Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Volume: 14
Issue: 1
Pages: 61-71
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Publication
17618271 | J:123411
First Author: Takaoka A
Year: 2007
Journal: Nature
Title: DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Volume: 448
Issue: 7152
Pages: 501-5
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Publication
29053748 | J:248204
First Author: Egarnes B
Year: 2017
Journal: PLoS One
Title: Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice.
Volume: 12
Issue: 10
Pages: e0186639
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Publication
37737190 | J:340751
First Author: Weichert L
Year: 2023
Journal: J Neuroinflammation
Title: Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection.
Volume: 20
Issue: 1
Pages: 213
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Publication
27859049 | J:246564
First Author: Klaska IP
Year: 2017
Journal: Immunology
Title: Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms.
Volume: 150
Issue: 3
Pages: 364-377
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Publication
23555875 | J:276271
First Author: Tang CK
Year: 2013
Journal: PLoS One
Title: The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant.
Volume: 8
Issue: 3
Pages: e60038
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Publication
29321276 | J:274261
First Author: James KR
Year: 2018
Journal: J Immunol
Title: IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection.
Volume: 200
Issue: 4
Pages: 1443-1456
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Publication
22514347 | J:303149
First Author: Christensen JE
Year: 2012
Journal: J Virol
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