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Search results 1 to 100 out of 539 for Irf8

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: This family represents the Interferon regulatory factor 8 (IRF8) which plays essential roles in host defense, hematopoietic differentiation, and immune response. It is a transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) []. It may act as a transcriptional activator or repressor and may play a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. It may be required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. It also positively regulates macroautophagy in dendritic cells [].This entry also includes some uncharacterised virus proteins that contain the IRF tryptophan pentad repeat, which is a DNA-binding domain.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Durai V
Year: 2019
Journal: Nat Immunol
Title: Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Volume: 20
Issue: 9
Pages: 1161-1173
Publication
First Author: Bagadia P
Year: 2019
Journal: Nat Immunol
Title: An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.
Volume: 20
Issue: 9
Pages: 1174-1185
Publication
First Author: Wang H
Year: 2008
Journal: Blood
Title: IRF8 regulates B-cell lineage specification, commitment, and differentiation.
Volume: 112
Issue: 10
Pages: 4028-38
Publication
First Author: Pathak S
Year: 2013
Journal: J Immunol
Title: A role for IRF8 in B cell anergy.
Volume: 191
Issue: 12
Pages: 6222-30
Publication
First Author: Karki R
Year: 2018
Journal: Cell
Title: IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Volume: 173
Issue: 4
Pages: 920-933.e13
Publication
First Author: Li HS
Year: 2012
Journal: PLoS One
Title: miR-22 controls Irf8 mRNA abundance and murine dendritic cell development.
Volume: 7
Issue: 12
Pages: e52341
Publication  
First Author: Jiang DS
Year: 2014
Journal: Nat Commun
Title: IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling.
Volume: 5
Pages: 3303
Publication
First Author: Karki R
Year: 2020
Journal: J Immunol
Title: IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death.
Volume: 204
Issue: 9
Pages: 2514-2522
Publication
First Author: Adams NM
Year: 2018
Journal: Immunity
Title: Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response.
Volume: 48
Issue: 6
Pages: 1172-1182.e6
Publication
First Author: Pang SH
Year: 2016
Journal: Leukemia
Title: PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.
Volume: 30
Issue: 6
Pages: 1375-87
Publication
First Author: Yang J
Year: 2011
Journal: J Immunol
Title: Cutting edge: IRF8 regulates Bax transcription in vivo in primary myeloid cells.
Volume: 187
Issue: 9
Pages: 4426-30
Publication  
First Author: Gupta M
Year: 2015
Journal: Nat Commun
Title: IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes.
Volume: 6
Pages: 6379
Publication
First Author: Zhang Y
Year: 2020
Journal: Cell Rep
Title: SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes.
Volume: 30
Issue: 6
Pages: 1951-1963.e4
Publication
First Author: Mace EM
Year: 2017
Journal: J Clin Invest
Title: Biallelic mutations in IRF8 impair human NK cell maturation and function.
Volume: 127
Issue: 1
Pages: 306-320
Publication  
First Author: Agod Z
Year: 2018
Journal: Front Immunol
Title: Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8.
Volume: 9
Pages: 62
Publication
First Author: Salem S
Year: 2014
Journal: Blood
Title: Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation.
Volume: 124
Issue: 12
Pages: 1894-904
Publication  
First Author: Ouyang X
Year: 2011
Journal: Nat Commun
Title: Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation.
Volume: 2
Pages: 314
Publication
First Author: Yoshida Y
Year: 2014
Journal: Immunity
Title: The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.
Volume: 40
Issue: 2
Pages: 187-98
Publication
First Author: Luda KM
Year: 2016
Journal: Immunity
Title: IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis.
Volume: 44
Issue: 4
Pages: 860-74
Publication
First Author: Tailor P
Year: 2008
Journal: Blood
Title: The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse.
Volume: 111
Issue: 4
Pages: 1942-5
Publication
First Author: Masuda T
Year: 2012
Journal: Cell Rep
Title: IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.
Volume: 1
Issue: 4
Pages: 334-340
Publication
First Author: Murakami K
Year: 2021
Journal: Nat Immunol
Title: A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.
Volume: 22
Issue: 3
Pages: 301-311
Publication
First Author: Carotta S
Year: 2014
Journal: J Exp Med
Title: The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation.
Volume: 211
Issue: 11
Pages: 2169-81
Publication
First Author: Zhou N
Year: 2019
Journal: Protein Cell
Title: Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition.
Volume: 10
Issue: 2
Pages: 87-103
Publication
First Author: Xu H
Year: 2012
Journal: Nat Immunol
Title: Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Volume: 13
Issue: 7
Pages: 642-50
Publication
First Author: Hu X
Year: 2011
Journal: Cancer Res
Title: IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.
Volume: 71
Issue: 8
Pages: 2882-91
Publication
First Author: Thumbigere-Math V
Year: 2019
Journal: J Bone Miner Res
Title: Inactivating Mutation in IRF8 Promotes Osteoclast Transcriptional Programs and Increases Susceptibility to Tooth Root Resorption.
Volume: 34
Issue: 6
Pages: 1155-1168
Publication
First Author: Yáñez A
Year: 2015
Journal: Blood
Title: IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Volume: 125
Issue: 9
Pages: 1452-9
Publication
First Author: Kurotaki D
Year: 2019
Journal: Blood
Title: Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.
Volume: 133
Issue: 17
Pages: 1803-1813
Publication
First Author: Wang H
Year: 2014
Journal: J Immunol
Title: A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.
Volume: 193
Issue: 4
Pages: 1766-77
Publication
First Author: Scheller M
Year: 2013
Journal: J Exp Med
Title: Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.
Volume: 210
Issue: 11
Pages: 2239-56
Publication
First Author: Ibrahim ML
Year: 2018
Journal: Cell Rep
Title: Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.
Volume: 25
Issue: 11
Pages: 3036-3046.e6
Protein
Organism: Mus musculus
Length: 295  
Fragment?: false
Publication
First Author: Sichien D
Year: 2016
Journal: Immunity
Title: IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively.
Volume: 45
Issue: 3
Pages: 626-640
Publication
First Author: Grajales-Reyes GE
Year: 2015
Journal: Nat Immunol
Title: Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Volume: 16
Issue: 7
Pages: 708-17
Publication
First Author: Yamamoto M
Year: 2011
Journal: PLoS One
Title: Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development.
Volume: 6
Issue: 10
Pages: e25812
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus
Length: 151  
Fragment?: true
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Publication
First Author: Kim S
Year: 2020
Journal: Immunity
Title: High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.
Volume: 53
Issue: 4
Pages: 759-774.e9
Publication
First Author: Hagemeyer N
Year: 2016
Journal: EMBO J
Title: Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
Volume: 35
Issue: 16
Pages: 1730-44
Publication
First Author: Sasaki H
Year: 2015
Journal: Blood
Title: Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.
Volume: 125
Issue: 2
Pages: 358-69
Publication
First Author: Baccala R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.
Volume: 110
Issue: 8
Pages: 2940-5
Publication
First Author: Kurotaki D
Year: 2018
Journal: Cell Rep
Title: Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.
Volume: 22
Issue: 10
Pages: 2628-2641
Publication
First Author: Shin DM
Year: 2011
Journal: PLoS One
Title: IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells.
Volume: 6
Issue: 11
Pages: e27384
Publication
First Author: Wang H
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.
Volume: 116
Issue: 19
Pages: 9511-9520
Publication
First Author: Fortier A
Year: 2009
Journal: Infect Immun
Title: Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.
Volume: 77
Issue: 11
Pages: 4794-805
Publication
First Author: Pearl D
Year: 2020
Journal: J Immunol
Title: 4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response.
Volume: 204
Issue: 9
Pages: 2392-2400
Publication      
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for gemini2.
Allele
Name: interferon regulatory factor 8; endonuclease-mediated mutation 1, Kenneth Murphy
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Publication categories: ProxyCollection
Allele
Name: interferon regulatory factor 8; endonuclease-medited mutation 2, Kenneth Murphy
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Publication categories: ProxyCollection
Publication
First Author: Miyagawa F
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells.
Volume: 109
Issue: 30
Pages: 12123-8
Publication
First Author: Kobayakawa K
Year: 2019
Journal: Sci Adv
Title: Macrophage centripetal migration drives spontaneous healing process after spinal cord injury.
Volume: 5
Issue: 5
Pages: eaav5086
Publication
First Author: Humblin E
Year: 2017
Journal: Nat Commun
Title: IRF8-dependent molecular complexes control the Th9 transcriptional program.
Volume: 8
Issue: 1
Pages: 2085
Publication
First Author: de Mingo Pulido Á
Year: 2018
Journal: Cancer Cell
Title: TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.
Volume: 33
Issue: 1
Pages: 60-74.e6
Publication
First Author: Minten C
Year: 2012
Journal: PLoS One
Title: IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS.
Volume: 7
Issue: 11
Pages: e49851
Publication
First Author: Zhao B
Year: 2009
Journal: Nat Med
Title: Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis.
Volume: 15
Issue: 9
Pages: 1066-71
Publication
First Author: Netherby CS
Year: 2017
Journal: J Immunol
Title: The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Volume: 198
Issue: 10
Pages: 4129-4139
Publication
First Author: Kurotaki D
Year: 2013
Journal: Blood
Title: Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.
Volume: 121
Issue: 10
Pages: 1839-49
Publication
First Author: Xiang M
Year: 2014
Journal: J Neurochem
Title: Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury.
Volume: 129
Issue: 6
Pages: 988-1001
Publication
First Author: Zhou JX
Year: 2009
Journal: J Immunol
Title: IFN regulatory factor 8 regulates MDM2 in germinal center B cells.
Volume: 183
Issue: 5
Pages: 3188-94
Publication  
First Author: Qiu Z
Year: 2020
Journal: Cancer Genet
Title: Generation and characterization of the Eµ-Irf8 mouse model.
Volume: 245
Pages: 6-16
Publication
First Author: Tailor P
Year: 2007
Journal: Immunity
Title: The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.
Volume: 27
Issue: 2
Pages: 228-39
Publication
First Author: Valanparambil RM
Year: 2017
Journal: PLoS Pathog
Title: IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.
Volume: 13
Issue: 10
Pages: e1006647
Publication
First Author: Xu H
Year: 2015
Journal: Nat Immunol
Title: Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8.
Volume: 16
Issue: 12
Pages: 1274-81
Publication
First Author: Cohen SB
Year: 2015
Journal: J Immunol
Title: Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.
Volume: 194
Issue: 1
Pages: 210-22
Publication
First Author: Feng J
Year: 2011
Journal: J Immunol
Title: IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools.
Volume: 186
Issue: 3
Pages: 1458-66
Publication
First Author: Kinder M
Year: 2010
Journal: Exp Hematol
Title: Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling.
Volume: 38
Issue: 11
Pages: 1036-1046.e1-4
Publication
First Author: Van Hove H
Year: 2019
Journal: Nat Neurosci
Title: A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Volume: 22
Issue: 6
Pages: 1021-1035
Publication
First Author: Cougnoux A
Year: 2018
Journal: Hum Mol Genet
Title: Microglia activation in Niemann-Pick disease, type C1 is amendable to therapeutic intervention.
Volume: 27
Issue: 12
Pages: 2076-2089
Publication
First Author: Schwieger M
Year: 2009
Journal: Blood
Title: Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C.
Volume: 114
Issue: 12
Pages: 2476-88
Publication
First Author: Hu L
Year: 2013
Journal: J Clin Invest
Title: Increased Fanconi C expression contributes to the emergency granulopoiesis response.
Volume: 123
Issue: 9
Pages: 3952-66
Publication
First Author: Lee CH
Year: 2006
Journal: J Exp Med
Title: Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein.
Volume: 203
Issue: 1
Pages: 63-72
Publication
First Author: Yang D
Year: 2007
Journal: J Immunol
Title: IFN regulatory factor 8 mediates apoptosis in nonhemopoietic tumor cells via regulation of Fas expression.
Volume: 179
Issue: 7
Pages: 4775-82
Publication
First Author: Tussiwand R
Year: 2012
Journal: Nature
Title: Compensatory dendritic cell development mediated by BATF-IRF interactions.
Volume: 490
Issue: 7421
Pages: 502-7
Publication
First Author: Hérault A
Year: 2017
Journal: Nature
Title: Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Volume: 544
Issue: 7648
Pages: 53-58
Publication
First Author: Seillet C
Year: 2013
Journal: Blood
Title: CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3.
Volume: 121
Issue: 9
Pages: 1574-83
Publication  
First Author: Morita M
Year: 2016
Journal: Sci Rep
Title: Smad4 is required to inhibit osteoclastogenesis and maintain bone mass.
Volume: 6
Pages: 35221
Publication
First Author: Ma S
Year: 2006
Journal: J Immunol
Title: IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development.
Volume: 177
Issue: 11
Pages: 7898-904
Publication
First Author: Redd PS
Year: 2017
Journal: Cancer Res
Title: SETD1B Activates iNOS Expression in Myeloid-Derived Suppressor Cells.
Volume: 77
Issue: 11
Pages: 2834-2843
Publication
First Author: Zhang SM
Year: 2014
Journal: Mol Cell Biol
Title: Interferon regulatory factor 8 modulates phenotypic switching of smooth muscle cells by regulating the activity of myocardin.
Volume: 34
Issue: 3
Pages: 400-14
Publication
First Author: Klement JD
Year: 2018
Journal: J Clin Invest
Title: An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.
Volume: 128
Issue: 12
Pages: 5549-5560
Publication
First Author: Sun L
Year: 2016
Journal: PLoS One
Title: Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells.
Volume: 11
Issue: 5
Pages: e0155420
Publication
First Author: Sjöstrand M
Year: 2013
Journal: J Immunol
Title: Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.
Volume: 191
Issue: 7
Pages: 3753-63
Publication
First Author: Chang TH
Year: 2012
Journal: J Immunol
Title: The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation.
Volume: 189
Issue: 7
Pages: 3548-56
Publication
First Author: Laricchia-Robbio L
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages.
Volume: 102
Issue: 40
Pages: 14368-73
Publication
First Author: Jaiswal H
Year: 2013
Journal: J Immunol
Title: Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development.
Volume: 191
Issue: 12
Pages: 5993-6001
Publication
First Author: Ayithan N
Year: 2015
Journal: PLoS One
Title: Virus-like particles activate type I interferon pathways to facilitate post-exposure protection against Ebola virus infection.
Volume: 10
Issue: 2
Pages: e0118345
Publication
First Author: Yoon J
Year: 2014
Journal: J Biol Chem
Title: Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR.
Volume: 289
Issue: 49
Pages: 34250-7