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Search results 1 to 100 out of 646 for Irf8

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
3394 | IRF8
Type: gene
Organism: human
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Gene
100496217 | irf8
Type: gene
Organism: frog, western clawed
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Gene
292060 | Irf8
Type: gene
Organism: rat
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Gene
489673 | IRF8
Type: gene
Organism: dog, domestic
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Gene
454294 | IRF8
Type: gene
Organism: chimpanzee
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Gene
614909 | IRF8
Type: gene
Organism: cattle
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Gene
396385 | IRF8
Type: gene
Organism: chicken
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Gene
436895 | irf8
Type: gene
Organism: zebrafish
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Gene
693933 | IRF8
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR044400 | IRF8
Type: Family
Description: This family represents the Interferon regulatory factor 8 (IRF8) which plays essential roles in host defense, hematopoietic differentiation, and immune response. It is a transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) []. It may act as a transcriptional activator or repressor and may play a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. It may be required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. It also positively regulates macroautophagy in dendritic cells [].This entry also includes some uncharacterised virus proteins that contain the IRF tryptophan pentad repeat, which is a DNA-binding domain.
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Protein Coding Gene
MGI:96395 | Irf8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
36990511 | J:355425
First Author: Liu TT
Year: 2023
Journal: Genes Dev
Title: Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation.
Volume: 37
Issue: 7-8
Pages: 291-302
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Publication
31406378 | J:279982
First Author: Durai V
Year: 2019
Journal: Nat Immunol
Title: Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Volume: 20
Issue: 9
Pages: 1161-1173
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Publication
31406377 | J:279983
First Author: Bagadia P
Year: 2019
Journal: Nat Immunol
Title: An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.
Volume: 20
Issue: 9
Pages: 1174-1185
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Publication
18799728 | J:142750
First Author: Wang H
Year: 2008
Journal: Blood
Title: IRF8 regulates B-cell lineage specification, commitment, and differentiation.
Volume: 112
Issue: 10
Pages: 4028-38
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Publication
24218455 | J:207133
First Author: Pathak S
Year: 2013
Journal: J Immunol
Title: A role for IRF8 in B cell anergy.
Volume: 191
Issue: 12
Pages: 6222-30
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Publication
29576451 | J:262477
First Author: Karki R
Year: 2018
Journal: Cell
Title: IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Volume: 173
Issue: 4
Pages: 920-933.e13
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Publication
23251709 | J:195660
First Author: Li HS
Year: 2012
Journal: PLoS One
Title: miR-22 controls Irf8 mRNA abundance and murine dendritic cell development.
Volume: 7
Issue: 12
Pages: e52341
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Publication
24526256 | J:206811
 
First Author: Jiang DS
Year: 2014
Journal: Nat Commun
Title: IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling.
Volume: 5
Pages: 3303
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Publication
32205422 | J:289674
First Author: Karki R
Year: 2020
Journal: J Immunol
Title: IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death.
Volume: 204
Issue: 9
Pages: 2514-2522
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Publication
29434592 | -
 
First Author: Agod Z
Year: 2018
Journal: Front Immunol
Title: Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8.
Volume: 9
Pages: 62
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Publication
25122610 | -
First Author: Salem S
Year: 2014
Journal: Blood
Title: Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation.
Volume: 124
Issue: 12
Pages: 1894-904
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Publication
29858012 | J:272417
First Author: Adams NM
Year: 2018
Journal: Immunity
Title: Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response.
Volume: 48
Issue: 6
Pages: 1172-1182.e6
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Publication
26932576 | J:231921
First Author: Pang SH
Year: 2016
Journal: Leukemia
Title: PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.
Volume: 30
Issue: 6
Pages: 1375-87
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Publication
25775030 | J:221880
 
First Author: Gupta M
Year: 2015
Journal: Nat Commun
Title: IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes.
Volume: 6
Pages: 6379
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Publication
21949018 | J:179444
First Author: Yang J
Year: 2011
Journal: J Immunol
Title: Cutting edge: IRF8 regulates Bax transcription in vivo in primary myeloid cells.
Volume: 187
Issue: 9
Pages: 4426-30
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Protein
Q3TZQ3
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Publication
38420590 | J:345602
First Author: Tzetzo SL
Year: 2024
Journal: iScience
Title: Downregulation of IRF8 in alveolar macrophages by G-CSF promotes metastatic tumor progression.
Volume: 27
Issue: 3
Pages: 109187
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Publication
32049023 | J:288070
First Author: Zhang Y
Year: 2020
Journal: Cell Rep
Title: SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes.
Volume: 30
Issue: 6
Pages: 1951-1963.e4
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Publication
27893462 | J:239741
First Author: Mace EM
Year: 2017
Journal: J Clin Invest
Title: Biallelic mutations in IRF8 impair human NK cell maturation and function.
Volume: 127
Issue: 1
Pages: 306-320
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Protein
E0CZE4
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
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Publication
36288724 | J:331110
First Author: Nixon BG
Year: 2022
Journal: Immunity
Title: Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
Volume: 55
Issue: 11
Pages: 2044-2058.e5
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Publication
21587231 | J:205655
 
First Author: Ouyang X
Year: 2011
Journal: Nat Commun
Title: Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation.
Volume: 2
Pages: 314
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Protein
P23611
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q544J7
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q3U068
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q3U0X4
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q3UCV9
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
F7C1A3
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Protein
Q3U075
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q3U6F0
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Publication
24485804 | J:209803
First Author: Yoshida Y
Year: 2014
Journal: Immunity
Title: The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.
Volume: 40
Issue: 2
Pages: 187-98
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Publication
27067057 | J:257991
First Author: Luda KM
Year: 2016
Journal: Immunity
Title: IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis.
Volume: 44
Issue: 4
Pages: 860-74
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Publication
22832225 | J:196019
First Author: Masuda T
Year: 2012
Journal: Cell Rep
Title: IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.
Volume: 1
Issue: 4
Pages: 334-340
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Publication
18055870 | J:131318
First Author: Tailor P
Year: 2008
Journal: Blood
Title: The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse.
Volume: 111
Issue: 4
Pages: 1942-5
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Publication
33603226 | J:305266
First Author: Murakami K
Year: 2021
Journal: Nat Immunol
Title: A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.
Volume: 22
Issue: 3
Pages: 301-311
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Publication
22610140 | J:187656
First Author: Xu H
Year: 2012
Journal: Nat Immunol
Title: Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Volume: 13
Issue: 7
Pages: 642-50
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Publication
30484118 | J:272708
First Author: Zhou N
Year: 2019
Journal: Protein Cell
Title: Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition.
Volume: 10
Issue: 2
Pages: 87-103
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Publication
25288399 | J:218674
First Author: Carotta S
Year: 2014
Journal: J Exp Med
Title: The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation.
Volume: 211
Issue: 11
Pages: 2169-81
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Publication
21487040 | J:170975
First Author: Hu X
Year: 2011
Journal: Cancer Res
Title: IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.
Volume: 71
Issue: 8
Pages: 2882-91
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Publication
30241692 | J:329865
 
First Author: Zhang R
Year: 2019
Journal: J Autoimmun
Title: T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.
Volume: 96
Pages: 113-122
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Publication
30266821 | J:321180
First Author: Gaillard C
Year: 2018
Journal: Blood Adv
Title: Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia.
Volume: 2
Issue: 19
Pages: 2462-2466
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Publication
30840779 | J:277621
First Author: Thumbigere-Math V
Year: 2019
Journal: J Bone Miner Res
Title: Inactivating Mutation in IRF8 Promotes Osteoclast Transcriptional Programs and Increases Susceptibility to Tooth Root Resorption.
Volume: 34
Issue: 6
Pages: 1155-1168
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Publication
36916882 | J:345390
   
First Author: Xu H
Year: 2023
Journal: Elife
Title: A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation.
Volume: 12
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Publication
30796024 | J:275482
First Author: Kurotaki D
Year: 2019
Journal: Blood
Title: Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.
Volume: 133
Issue: 17
Pages: 1803-1813
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Publication
25597637 | J:221913
First Author: Yáñez A
Year: 2015
Journal: Blood
Title: IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Volume: 125
Issue: 9
Pages: 1452-9
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Publication
25024380 | J:218664
First Author: Wang H
Year: 2014
Journal: J Immunol
Title: A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.
Volume: 193
Issue: 4
Pages: 1766-77
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Publication
23623495 | J:323537
First Author: Schönheit J
Year: 2013
Journal: Cell Rep
Title: PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment.
Volume: 3
Issue: 5
Pages: 1617-28
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Publication
32375053 | J:354459
First Author: McDaniel MM
Year: 2020
Journal: Cell Rep
Title: Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming.
Volume: 31
Issue: 5
Pages: 107604
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Publication
32795402 | J:305829
First Author: Kim S
Year: 2020
Journal: Immunity
Title: High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.
Volume: 53
Issue: 4
Pages: 759-774.e9
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Publication
24101380 | J:204584
First Author: Scheller M
Year: 2013
Journal: J Exp Med
Title: Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.
Volume: 210
Issue: 11
Pages: 2239-56
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Publication
39313544 | J:359214
First Author: Saeki K
Year: 2024
Journal: Nat Immunol
Title: IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs.
Volume: 25
Issue: 10
Pages: 1928-1942
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Publication
35830859 | J:351519
First Author: Lança T
Year: 2022
Journal: Immunity
Title: IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage.
Volume: 55
Issue: 8
Pages: 1431-1447.e11
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Publication
39043941 | J:352131
First Author: Yamasaki A
Year: 2024
Journal: Commun Biol
Title: IRF8 and MAFB drive distinct transcriptional machineries in different resident macrophages of the central nervous system.
Volume: 7
Issue: 1
Pages: 896
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Publication
33705797 | J:325753
First Author: Ototake Y
Year: 2021
Journal: J Invest Dermatol
Title: Downregulated IRF8 in Monocytes and Macrophages of Patients with Systemic Sclerosis May Aggravate the Fibrotic Phenotype.
Volume: 141
Issue: 8
Pages: 1954-1963
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Publication
30540937 | J:271529
First Author: Ibrahim ML
Year: 2018
Journal: Cell Rep
Title: Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.
Volume: 25
Issue: 11
Pages: 3036-3046.e6
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Publication
27637148 | J:240512
First Author: Sichien D
Year: 2016
Journal: Immunity
Title: IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively.
Volume: 45
Issue: 3
Pages: 626-640
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Publication
26054719 | J:232963
First Author: Grajales-Reyes GE
Year: 2015
Journal: Nat Immunol
Title: Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Volume: 16
Issue: 7
Pages: 708-17
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Publication
22003407 | J:179608
First Author: Yamamoto M
Year: 2011
Journal: PLoS One
Title: Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development.
Volume: 6
Issue: 10
Pages: e25812
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Publication
26746189 | J:337380
First Author: Bajaña S
Year: 2016
Journal: J Immunol
Title: IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells.
Volume: 196
Issue: 4
Pages: 1666-77
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Publication
26843324 | J:331034
First Author: Yan M
Year: 2016
Journal: J Immunol
Title: Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection.
Volume: 196
Issue: 5
Pages: 1999-2003
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Publication
27412700 | J:235152
First Author: Hagemeyer N
Year: 2016
Journal: EMBO J
Title: Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
Volume: 35
Issue: 16
Pages: 1730-44
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Publication
25398936 | J:220775
First Author: Sasaki H
Year: 2015
Journal: Blood
Title: Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.
Volume: 125
Issue: 2
Pages: 358-69
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Publication
23382217 | J:194543
First Author: Baccala R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.
Volume: 110
Issue: 8
Pages: 2940-5
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Publication
29514092 | J:271151
First Author: Kurotaki D
Year: 2018
Journal: Cell Rep
Title: Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.
Volume: 22
Issue: 10
Pages: 2628-2641
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Publication
28650480 | J:354456
First Author: Lee J
Year: 2017
Journal: Nat Immunol
Title: Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors.
Volume: 18
Issue: 8
Pages: 877-888
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Publication
22096565 | J:180972
First Author: Shin DM
Year: 2011
Journal: PLoS One
Title: IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells.
Volume: 6
Issue: 11
Pages: e27384
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Publication
31000603 | J:275800
First Author: Wang H
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.
Volume: 116
Issue: 19
Pages: 9511-9520
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Publication
19720760 | J:154191
First Author: Fortier A
Year: 2009
Journal: Infect Immun
Title: Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.
Volume: 77
Issue: 11
Pages: 4794-805
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Publication
32213561 | J:288497
First Author: Pearl D
Year: 2020
Journal: J Immunol
Title: 4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response.
Volume: 204
Issue: 9
Pages: 2392-2400
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Publication
34867997 | J:329862
 
First Author: Das A
Year: 2021
Journal: Front Immunol
Title: Mutation in Irf8 Gene (Irf8R294C ) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs.
Volume: 12
Pages: 758190
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Publication
- | J:274937
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for gemini2.
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Publication
34958351 | J:329864
 
First Author: Anderson DA
Year: 2022
Journal: J Exp Med
Title: Transition from cMyc to L-Myc during dendritic cell development coordinated by rising levels of IRF8.
Volume: 219
Issue: 2
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Publication
35732734 | J:334296
First Author: Liu TT
Year: 2022
Journal: Nature
Title: Ablation of cDC2 development by triple mutations within the Zeb2 enhancer.
Volume: 607
Issue: 7917
Pages: 142-148
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Publication
22783014 | J:186474
First Author: Miyagawa F
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells.
Volume: 109
Issue: 30
Pages: 12123-8
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Publication
31106270 | J:287600
First Author: Kobayakawa K
Year: 2019
Journal: Sci Adv
Title: Macrophage centripetal migration drives spontaneous healing process after spinal cord injury.
Volume: 5
Issue: 5
Pages: eaav5086
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Publication
28120198 | J:315602
First Author: Cheng J
Year: 2017
Journal: Inflammation
Title: miRNA-451a Targets IFN Regulatory Factor 8 for the Progression of Systemic Lupus Erythematosus.
Volume: 40
Issue: 2
Pages: 676-687
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Publication
29233972 | J:259796
First Author: Humblin E
Year: 2017
Journal: Nat Commun
Title: IRF8-dependent molecular complexes control the Th9 transcriptional program.
Volume: 8
Issue: 1
Pages: 2085
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Publication
28356386 | J:247808
First Author: Netherby CS
Year: 2017
Journal: J Immunol
Title: The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Volume: 198
Issue: 10
Pages: 4129-4139
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Publication
19718038 | J:154322
First Author: Zhao B
Year: 2009
Journal: Nat Med
Title: Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis.
Volume: 15
Issue: 9
Pages: 1066-71
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Publication
23319570 | J:195891
First Author: Kurotaki D
Year: 2013
Journal: Blood
Title: Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.
Volume: 121
Issue: 10
Pages: 1839-49
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Publication
24528256 | J:211584
First Author: Xiang M
Year: 2014
Journal: J Neurochem
Title: Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury.
Volume: 129
Issue: 6
Pages: 988-1001
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Publication
23166780 | J:194791
First Author: Minten C
Year: 2012
Journal: PLoS One
Title: IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS.
Volume: 7
Issue: 11
Pages: e49851
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Publication
19648273 | J:151868
First Author: Zhou JX
Year: 2009
Journal: J Immunol
Title: IFN regulatory factor 8 regulates MDM2 in germinal center B cells.
Volume: 183
Issue: 5
Pages: 3188-94
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Publication
32535543 | J:299394
 
First Author: Qiu Z
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First Author: Li N
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Journal: Front Immunol
Title: IRF8-Dependent Type I Conventional Dendritic Cells (cDC1s) Control Post-Ischemic Inflammation and Mildly Protect Against Post-Ischemic Acute Kidney Injury and Disease.
Volume: 12
Pages: 685559
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Journal: Cells
Title: Maternal High-Fat Diet Promotes Abdominal Aortic Aneurysm Expansion in Adult Offspring by Epigenetic Regulation of IRF8-Mediated Osteoclast-like Macrophage Differentiation.
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Title: TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.
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Journal: J Pharmacol Sci
Title: Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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