Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
409
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Rai P |
Year: |
2021 |
Journal: |
Nat Immunol |
Title: |
IRGM1 links mitochondrial quality control to autoimmunity. |
Volume: |
22 |
Issue: |
3 |
Pages: |
312-321 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2020 |
Journal: |
Int Immunopharmacol |
Title: |
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice. |
Volume: |
84 |
|
Pages: |
106515 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henry SC |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). |
Volume: |
179 |
Issue: |
10 |
Pages: |
6963-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
King KY |
Year: |
2011 |
Journal: |
Blood |
Title: |
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. |
Volume: |
118 |
Issue: |
6 |
Pages: |
1525-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang S |
Year: |
2016 |
Journal: |
Atherosclerosis |
Title: |
Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development. |
Volume: |
251 |
|
Pages: |
282-290 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia F |
Year: |
2013 |
Journal: |
Sci Rep |
Title: |
IRGM1 regulates oxidized LDL uptake by macrophage via actin-dependent receptor internalization during atherosclerosis. |
Volume: |
3 |
|
Pages: |
1867 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao YO |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells. |
Volume: |
5 |
Issue: |
1 |
Pages: |
e8648 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan Y |
Year: |
2022 |
Journal: |
Cell Death Differ |
Title: |
Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis. |
Volume: |
29 |
Issue: |
9 |
Pages: |
1673-1688 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu Y |
Year: |
2017 |
Journal: |
J Leukoc Biol |
Title: |
Irgm1 is required for the inflammatory function of M1 macrophage in early experimental autoimmune encephalomyelitis. |
Volume: |
101 |
Issue: |
2 |
Pages: |
507-517 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu H |
Year: |
2010 |
Journal: |
FASEB J |
Title: |
Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. |
Volume: |
24 |
Issue: |
5 |
Pages: |
1583-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng CG |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. |
Volume: |
9 |
Issue: |
11 |
Pages: |
1279-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tiwari S |
Year: |
2009 |
Journal: |
Nat Immunol |
Title: |
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. |
Volume: |
10 |
Issue: |
8 |
Pages: |
907-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Springer HM |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells. |
Volume: |
191 |
Issue: |
4 |
Pages: |
1765-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang C |
Year: |
2013 |
Journal: |
Mol Immunol |
Title: |
Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier. |
Volume: |
53 |
Issue: |
1-2 |
Pages: |
43-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh SB |
Year: |
2006 |
Journal: |
Science |
Title: |
Human IRGM induces autophagy to eliminate intracellular mycobacteria. |
Volume: |
313 |
Issue: |
5792 |
Pages: |
1438-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haldar AK |
Year: |
2013 |
Journal: |
PLoS Pathog |
Title: |
IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. |
Volume: |
9 |
Issue: |
6 |
Pages: |
e1003414 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chauhan NR |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Transgenic mouse models support a protective role of type I IFN response in SARS-CoV-2 infection-related lung immunopathology and neuroinvasion. |
Volume: |
42 |
Issue: |
11 |
Pages: |
113275 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mehto S |
Year: |
2022 |
Journal: |
EMBO J |
Title: |
Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection. |
Volume: |
41 |
Issue: |
23 |
Pages: |
e111289 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuzawa T |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
IFN-γ elicits macrophage autophagy via the p38 MAPK signaling pathway. |
Volume: |
189 |
Issue: |
2 |
Pages: |
813-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henry SC |
Year: |
2010 |
Journal: |
J Leukoc Biol |
Title: |
Regulation of macrophage motility by Irgm1. |
Volume: |
87 |
Issue: |
2 |
Pages: |
333-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang CP |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption. |
Volume: |
6 |
Issue: |
12 |
Pages: |
e28323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo J |
Year: |
2015 |
Journal: |
Infect Immun |
Title: |
IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. |
Volume: |
83 |
Issue: |
4 |
Pages: |
1406-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coers J |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. |
Volume: |
180 |
Issue: |
9 |
Pages: |
6237-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Finethy R |
Year: |
2020 |
Journal: |
EMBO Rep |
Title: |
Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. |
Volume: |
21 |
Issue: |
11 |
Pages: |
e50830 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmidt EA |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. |
Volume: |
292 |
Issue: |
11 |
Pages: |
4651-4662 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henry SC |
Year: |
2009 |
Journal: |
J Leukoc Biol |
Title: |
Balance of Irgm protein activities determines IFN-gamma-induced host defense. |
Volume: |
85 |
Issue: |
5 |
Pages: |
877-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dockterman J |
Year: |
2021 |
Journal: |
Infect Immun |
Title: |
Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii. |
Volume: |
89 |
Issue: |
11 |
Pages: |
e0020221 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu B |
Year: |
2013 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation. |
Volume: |
305 |
Issue: |
8 |
Pages: |
G573-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taylor GA |
Year: |
2020 |
Journal: |
PLoS Pathog |
Title: |
Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium. |
Volume: |
16 |
Issue: |
5 |
Pages: |
e1008553 |
|
•
•
•
•
•
|
Publication |
First Author: |
He S |
Year: |
2012 |
Journal: |
Autophagy |
Title: |
Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke. |
Volume: |
8 |
Issue: |
11 |
Pages: |
1621-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nath P |
Year: |
2021 |
Journal: |
EMBO Rep |
Title: |
Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. |
Volume: |
22 |
Issue: |
11 |
Pages: |
e52948 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pradipta A |
Year: |
2021 |
Journal: |
Life Sci Alliance |
Title: |
Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization. |
Volume: |
4 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Traver MK |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. |
Volume: |
286 |
Issue: |
35 |
Pages: |
30471-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou RX |
Year: |
2020 |
Journal: |
CNS Neurosci Ther |
Title: |
Regulation of hippocampal neuronal apoptosis and autophagy in mice with sepsis-associated encephalopathy by immunity-related GTPase M1. |
Volume: |
26 |
Issue: |
2 |
Pages: |
177-188 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun S |
Year: |
2023 |
Journal: |
Biomed Pharmacother |
Title: |
IRGM/Irgm1 deficiency inhibits neutrophil-platelet interactions and thrombosis in experimental atherosclerosis and arterial injury. |
Volume: |
158 |
|
Pages: |
114152 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogala AR |
Year: |
2017 |
Journal: |
Dis Model Mech |
Title: |
Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Henry SC |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission. |
Volume: |
9 |
Issue: |
4 |
Pages: |
e95021 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maric-Biresev J |
Year: |
2016 |
Journal: |
BMC Biol |
Title: |
Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection. |
Volume: |
14 |
|
Pages: |
33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Trost M |
Year: |
2009 |
Journal: |
Immunity |
Title: |
The phagosomal proteome in interferon-gamma-activated macrophages. |
Volume: |
30 |
Issue: |
1 |
Pages: |
143-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martens S |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosis. |
Volume: |
173 |
Issue: |
4 |
Pages: |
2594-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hunn JP |
Year: |
2008 |
Journal: |
EMBO J |
Title: |
Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii. |
Volume: |
27 |
Issue: |
19 |
Pages: |
2495-509 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sorace JM |
Year: |
1995 |
Journal: |
J Leukoc Biol |
Title: |
Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family. |
Volume: |
58 |
Issue: |
4 |
Pages: |
477-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Collazo CM |
Year: |
2001 |
Journal: |
J Exp Med |
Title: |
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. |
Volume: |
194 |
Issue: |
2 |
Pages: |
181-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng CG |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. |
Volume: |
172 |
Issue: |
2 |
Pages: |
1163-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Butcher BA |
Year: |
2005 |
Journal: |
Infect Immun |
Title: |
p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. |
Volume: |
73 |
Issue: |
6 |
Pages: |
3278-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santiago HC |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. |
Volume: |
175 |
Issue: |
12 |
Pages: |
8165-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bafica A |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. |
Volume: |
179 |
Issue: |
8 |
Pages: |
5514-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coers J |
Year: |
2011 |
Journal: |
PLoS Pathog |
Title: |
Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. |
Volume: |
7 |
Issue: |
6 |
Pages: |
e1001346 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berghout J |
Year: |
2013 |
Journal: |
PLoS Pathog |
Title: |
Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria. |
Volume: |
9 |
Issue: |
7 |
Pages: |
e1003491 |
|
•
•
•
•
•
|
Publication |
First Author: |
Christgen S |
Year: |
2022 |
Journal: |
Eur J Immunol |
Title: |
The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice. |
Volume: |
52 |
Issue: |
2 |
Pages: |
285-296 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhar N |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice. |
Volume: |
107 |
Issue: |
27 |
Pages: |
12275-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Bargen K |
Year: |
2011 |
Journal: |
Infect Immun |
Title: |
Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron. |
Volume: |
79 |
Issue: |
5 |
Pages: |
2098-111 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Budry L |
Year: |
2012 |
Journal: |
Genes Dev |
Title: |
The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. |
Volume: |
26 |
Issue: |
20 |
Pages: |
2299-310 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pilla DM |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. |
Volume: |
111 |
Issue: |
16 |
Pages: |
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