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Search results 1 to 100 out of 482 for Irs1

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Type Details Score
Gene
3667 | IRS1
Type: gene
Organism: human
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Gene
538598 | IRS1
Type: gene
Organism: cattle
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Gene
559281 | irs1
Type: gene
Organism: zebrafish
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Gene
707870 | IRS1
Type: gene
Organism: macaque, rhesus
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Gene
100495320 | irs1
Type: gene
Organism: frog, western clawed
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Gene
25467 | Irs1
Type: gene
Organism: rat
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Gene
486148 | IRS1
Type: gene
Organism: dog, domestic
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Gene
459985 | IRS1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:99454 | Irs1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20074531 | J:156999
First Author: Copps KD
Year: 2010
Journal: Cell Metab
Title: Irs1 serine 307 promotes insulin sensitivity in mice.
Volume: 11
Issue: 1
Pages: 84-92
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Publication
30679431 | J:271266
First Author: Hwang JH
Year: 2019
Journal: Nat Commun
Title: TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression.
Volume: 10
Issue: 1
Pages: 421
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Publication
20837540 | J:164568
First Author: Westrick RJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.
Volume: 107
Issue: 39
Pages: 16904-9
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Publication
31515271 | J:282843
First Author: Frendo-Cumbo S
Year: 2019
Journal: J Biol Chem
Title: Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.
Volume: 294
Issue: 44
Pages: 16172-16185
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Publication
32051546 | J:291410
First Author: Cong XX
Year: 2020
Journal: Cell Death Differ
Title: Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration.
Volume: 27
Issue: 8
Pages: 2344-2362
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Publication
19596788 | J:152605
First Author: Guo S
Year: 2009
Journal: Mol Cell Biol
Title: The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.
Volume: 29
Issue: 18
Pages: 5070-83
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Publication
16374520 | J:105361
First Author: Dong X
Year: 2006
Journal: J Clin Invest
Title: Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.
Volume: 116
Issue: 1
Pages: 101-14
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Publication
20032200 | J:163661
First Author: DeMambro VE
Year: 2010
Journal: J Endocrinol
Title: A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis.
Volume: 204
Issue: 3
Pages: 241-53
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Publication
20351777 | J:158727
First Author: Kim K
Year: 2010
Journal: PLoS One
Title: Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3.
Volume: 5
Issue: 3
Pages: e8649
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Publication
24159000 | J:209017
First Author: Qi Y
Year: 2013
Journal: Diabetes
Title: Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.
Volume: 62
Issue: 11
Pages: 3887-900
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Publication
19587264 | J:169581
First Author: Wang Y
Year: 2009
Journal: J Endocrinol
Title: Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng.
Volume: 203
Issue: 1
Pages: 65-74
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Publication
21135130 | J:170424
First Author: Long YC
Year: 2011
Journal: Mol Cell Biol
Title: Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.
Volume: 31
Issue: 3
Pages: 430-41
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Publication
26888756 | J:250858
 
First Author: Groeneveld MP
Year: 2016
Journal: Sci Rep
Title: Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production.
Volume: 6
Pages: 21105
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Publication
22859932 | J:189684
First Author: Wang Z
Year: 2012
Journal: PLoS One
Title: The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models.
Volume: 7
Issue: 7
Pages: e36961
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Publication
20009030 | J:162899
First Author: Westergren R
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo.
Volume: 298
Issue: 3
Pages: E548-54
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Publication
- | J:148382
     
First Author: Ginsburg D
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of a knock-in mutation of Irs1
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Publication
26433160 | J:227278
First Author: Chung W
Year: 2016
Journal: Cancer Lett
Title: Activation of signal transduction pathways during hepatic oncogenesis.
Volume: 370
Issue: 1
Pages: 1-9
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Publication
18633112 | J:142011
First Author: Morino K
Year: 2008
Journal: Diabetes
Title: Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.
Volume: 57
Issue: 10
Pages: 2644-51
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Publication
- | J:267532
     
First Author: Turer E
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for runt2.
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Publication
16127460 | J:100915
First Author: Banks AS
Year: 2005
Journal: J Clin Invest
Title: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.
Volume: 115
Issue: 9
Pages: 2462-71
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Publication
36812323 | J:341595
First Author: Baghdadi M
Year: 2023
Journal: Sci Adv
Title: Reduced insulin signaling in neurons induces sex-specific health benefits.
Volume: 9
Issue: 8
Pages: eade8137
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Publication
18590692 | J:137846
First Author: Kubota N
Year: 2008
Journal: Cell Metab
Title: Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Volume: 8
Issue: 1
Pages: 49-64
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Publication
27452396 | J:251842
 
First Author: Essers P
Year: 2016
Journal: Sci Rep
Title: Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.
Volume: 6
Pages: 30290
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Publication
22955994 | J:194564
First Author: Nakamura A
Year: 2012
Journal: Diabetologia
Title: Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance.
Volume: 55
Issue: 12
Pages: 3382-91
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Publication
21283571 | J:169458
First Author: Selman C
Year: 2011
Journal: PLoS One
Title: Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.
Volume: 6
Issue: 1
Pages: e16144
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Publication
33761350 | J:304286
First Author: Stöhr O
Year: 2021
Journal: Cell Rep
Title: FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.
Volume: 34
Issue: 12
Pages: 108893
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Publication
18590693 | J:137845
First Author: Dong XC
Year: 2008
Journal: Cell Metab
Title: Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.
Volume: 8
Issue: 1
Pages: 65-76
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Publication
23354051 | J:194550
First Author: Song R
Year: 2013
Journal: Nature
Title: Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.
Volume: 494
Issue: 7437
Pages: 375-9
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Publication
24333417 | J:211864
First Author: Herrema H
Year: 2014
Journal: Biochem Biophys Res Commun
Title: IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance.
Volume: 443
Issue: 2
Pages: 689-93
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Publication
27452800 | J:248863
 
First Author: Moon MK
Year: 2016
Journal: Mol Cell Endocrinol
Title: Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression.
Volume: 436
Pages: 50-8
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Publication
27568561 | J:239020
First Author: Forand A
Year: 2016
Journal: Cell Rep
Title: Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction.
Volume: 16
Issue: 10
Pages: 2736-2748
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Publication
17928362 | J:134916
First Author: Selman C
Year: 2008
Journal: FASEB J
Title: Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
Volume: 22
Issue: 3
Pages: 807-18
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Publication
25002528 | J:224354
First Author: Riehle C
Year: 2014
Journal: Mol Cell Biol
Title: Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.
Volume: 34
Issue: 18
Pages: 3450-60
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Publication
33839150 | J:306699
   
First Author: Takatani T
Year: 2021
Journal: J Biol Chem
Title: Insulin receptor substrate 1 (IRS1), but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.
Pages: 100646
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Publication
27708333 | J:242357
 
First Author: Kubota N
Year: 2016
Journal: Nat Commun
Title: Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.
Volume: 7
Pages: 12977
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Publication
18755774 | J:138784
First Author: Parathath SR
Year: 2008
Journal: Development
Title: Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.
Volume: 135
Issue: 19
Pages: 3291-300
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Publication
20028942 | J:164152
First Author: González-Rodríguez A
Year: 2010
Journal: Diabetes
Title: Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.
Volume: 59
Issue: 3
Pages: 588-99
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Publication
23741292 | J:200785
First Author: Griffeth RJ
Year: 2013
Journal: PLoS One
Title: Insulin receptor substrate 2 is required for testicular development.
Volume: 8
Issue: 5
Pages: e62103
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Publication
24177427 | J:207702
First Author: Riehle C
Year: 2013
Journal: J Clin Invest
Title: Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
Volume: 123
Issue: 12
Pages: 5319-33
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Publication
32213702 | J:330771
 
First Author: Riehle C
Year: 2020
Journal: JCI Insight
Title: Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling.
Volume: 5
Issue: 6
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Publication
33634126 | J:315748
 
First Author: Kapetanou M
Year: 2021
Journal: Front Cell Dev Biol
Title: FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity.
Volume: 9
Pages: 625715
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Publication
29269414 | J:258439
First Author: Sun S
Year: 2018
Journal: J Biol Chem
Title: Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes.
Volume: 293
Issue: 7
Pages: 2383-2394
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Publication
17641282 | J:123293
First Author: Hadsell DL
Year: 2007
Journal: J Endocrinol
Title: Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.
Volume: 194
Issue: 2
Pages: 327-36
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Publication
36125265 | J:330376
First Author: Riehle C
Year: 2022
Journal: Mol Cell Biol
Title: Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart.
Volume: 42
Issue: 10
Pages: e0016322
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Publication
20947509 | J:167586
First Author: Xuan S
Year: 2010
Journal: J Biol Chem
Title: Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.
Volume: 285
Issue: 52
Pages: 41044-50
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Publication
26846849 | J:342709
First Author: Copps KD
Year: 2016
Journal: J Biol Chem
Title: Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
Volume: 291
Issue: 16
Pages: 8602-17
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Publication
30578299 | J:275335
First Author: Xi G
Year: 2019
Journal: J Biol Chem
Title: Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization.
Volume: 294
Issue: 7
Pages: 2407-2421
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Publication
28322786 | J:251423
First Author: Zhao J
Year: 2017
Journal: Biochem Biophys Res Commun
Title: ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.
Volume: 486
Issue: 4
Pages: 865-871
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Publication
30770439 | J:273466
     
First Author: Besse-Patin A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.
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Publication
28710407 | J:250196
First Author: Sakurai Y
Year: 2017
Journal: Sci Rep
Title: Role of insulin receptor substrates in the progression of hepatocellular carcinoma.
Volume: 7
Issue: 1
Pages: 5387
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Publication
24677713 | J:229791
First Author: Fu Q
Year: 2014
Journal: Diabetes
Title: Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.
Volume: 63
Issue: 8
Pages: 2676-89
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Publication
22210743 | J:182437
First Author: Burgos-Ramos E
Year: 2012
Journal: Endocrinology
Title: Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.
Volume: 153
Issue: 3
Pages: 1129-40
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Publication
33270683 | J:299235
First Author: Hashimoto S
Year: 2020
Journal: PLoS One
Title: Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.
Volume: 15
Issue: 12
Pages: e0242332
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Protein Coding Gene
MGP_CAROLIEiJ_G0014324 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016196 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016153 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016151 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015981 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016604 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016059 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016079 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015353 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027562 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015130 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8167159 | J:17970
First Author: Araki E
Year: 1994
Journal: Biochim Biophys Acta
Title: Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.
Volume: 1221
Issue: 3
Pages: 353-6
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Publication
10749573 | J:61479
First Author: Ogata N
Year: 2000
Journal: J Clin Invest
Title: Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover.
Volume: 105
Issue: 7
Pages: 935-43
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Publication
9348224 | J:43854
First Author: Sciacchitano S
Year: 1997
Journal: Endocrinology
Title: Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene.
Volume: 138
Issue: 11
Pages: 4931-40
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Publication
29045833 | J:254199
First Author: Bolukbasi E
Year: 2017
Journal: Cell Rep
Title: Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity.
Volume: 21
Issue: 3
Pages: 641-653
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Publication
26997483 | J:234411
First Author: Okin D
Year: 2016
Journal: Cell
Title: The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia.
Volume: 165
Issue: 2
Pages: 343-56
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Publication
23160735 | J:318815
First Author: Zemva J
Year: 2013
Journal: Age (Dordr)
Title: Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging.
Volume: 35
Issue: 5
Pages: 1881-97
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Publication
17030605 | J:117024
First Author: Ma Z
Year: 2006
Journal: Mol Cell Biol
Title: Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.
Volume: 26
Issue: 24
Pages: 9338-51
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Publication
- | J:267531
     
First Author: Turer E
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for runt.
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Publication
7969452 | J:21373
First Author: Tamemoto H
Year: 1994
Journal: Nature
Title: Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
Volume: 372
Issue: 6502
Pages: 182-6
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Publication
14969391 | J:111230
First Author: Hoshi K
Year: 2004
Journal: J Bone Miner Res
Title: Deficiency of insulin receptor substrate-1 impairs skeletal growth through early closure of epiphyseal cartilage.
Volume: 19
Issue: 2
Pages: 214-23
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Publication
10811851 | J:62262
First Author: Ueki K
Year: 2000
Journal: J Clin Invest
Title: Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy.
Volume: 105
Issue: 10
Pages: 1437-45
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Publication
9541510 | J:47029
First Author: Abe H
Year: 1998
Journal: J Clin Invest
Title: Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
Volume: 101
Issue: 8
Pages: 1784-8
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Publication
24624118 | J:312013
 
First Author: Ozoe A
Year: 2014
Journal: Front Endocrinol (Lausanne)
Title: Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.
Volume: 5
Pages: 24
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Publication
32721050 | J:344673
First Author: Man XF
Year: 2020
Journal: FASEB J
Title: Insulin receptor substrate-1 inhibits high-fat diet-induced obesity by browning of white adipose tissue through miR-503.
Volume: 34
Issue: 9
Pages: 12308-12323
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Publication
7526222 | J:21374
First Author: Araki E
Year: 1994
Journal: Nature
Title: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
Volume: 372
Issue: 6502
Pages: 186-90
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Publication
11753753 | J:120555
First Author: Dumke CL
Year: 2001
Journal: Horm Metab Res
Title: Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle.
Volume: 33
Issue: 12
Pages: 696-700
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Publication
10512356 | J:57862
First Author: Gazdag AC
Year: 1999
Journal: Diabetes
Title: Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice.
Volume: 48
Issue: 10
Pages: 1930-6
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Publication
17823215 | J:126952
First Author: Simmons JG
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth.
Volume: 293
Issue: 5
Pages: G995-1003
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Publication
24186867 | J:209003
First Author: Isganaitis E
Year: 2014
Journal: Diabetes
Title: Developmental programming by maternal insulin resistance: hyperinsulinemia, glucose intolerance, and dysregulated lipid metabolism in male offspring of insulin-resistant mice.
Volume: 63
Issue: 2
Pages: 688-700
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