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Search results 1 to 100 out of 391 for Irs2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Taguchi A
Year: 2007
Journal: Science
Title: Brain IRS2 signaling coordinates life span and nutrient homeostasis.
Volume: 317
Issue: 5836
Pages: 369-72
Publication
First Author: Ren D
Year: 2014
Journal: Diabetes
Title: BH3-only molecule Bim mediates β-cell death in IRS2 deficiency.
Volume: 63
Issue: 10
Pages: 3378-87
Publication
First Author: Li D
Year: 2008
Journal: Diabetes
Title: The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis.
Volume: 57
Issue: 3
Pages: 635-44
Publication
First Author: Kushner JA
Year: 2002
Journal: J Clin Invest
Title: Pdx1 restores beta cell function in Irs2 knockout mice.
Volume: 109
Issue: 9
Pages: 1193-201
Publication
First Author: Szabolcs M
Year: 2009
Journal: Am J Pathol
Title: Irs2 inactivation suppresses tumor progression in Pten+/- mice.
Volume: 174
Issue: 1
Pages: 276-86
Publication
First Author: Sadagurski M
Year: 2011
Journal: J Clin Invest
Title: IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease.
Volume: 121
Issue: 10
Pages: 4070-81
Publication
First Author: Killick R
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.
Volume: 386
Issue: 1
Pages: 257-62
Publication
First Author: Mohanty S
Year: 2005
Journal: Exp Cell Res
Title: Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.
Volume: 303
Issue: 1
Pages: 68-78
Publication
First Author: Kushner JA
Year: 2004
Journal: Diabetes
Title: Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
Volume: 53
Issue: 1
Pages: 61-6
Publication
First Author: Sadagurski M
Year: 2012
Journal: Cell Metab
Title: IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.
Volume: 15
Issue: 5
Pages: 703-12
Publication
First Author: Sadagurski M
Year: 2014
Journal: Mol Metab
Title: Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.
Volume: 3
Issue: 1
Pages: 55-63
Publication
First Author: Kubota T
Year: 2018
Journal: Nat Commun
Title: Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity.
Volume: 9
Issue: 1
Pages: 4863
Publication  
First Author: Carew RM
Year: 2010
Journal: BMC Dev Biol
Title: Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta?
Volume: 10
Pages: 73
Publication
First Author: Santamaria B
Year: 2015
Journal: Biochim Biophys Acta
Title: IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.
Volume: 1853
Issue: 12
Pages: 3224-34
Publication
First Author: Dong X
Year: 2006
Journal: J Clin Invest
Title: Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.
Volume: 116
Issue: 1
Pages: 101-14
Publication
First Author: Agarwal P
Year: 2013
Journal: Biochim Biophys Acta
Title: miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle.
Volume: 1832
Issue: 8
Pages: 1294-303
Publication
First Author: Guo S
Year: 2006
Journal: Mol Endocrinol
Title: The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
Volume: 20
Issue: 12
Pages: 3389-99
Publication
First Author: Chirivella L
Year: 2012
Journal: Eur J Neurosci
Title: IRS2 signalling is required for the development of a subset of sensory spinal neurons.
Volume: 35
Issue: 3
Pages: 341-52
Publication
First Author: Qi Y
Year: 2013
Journal: Diabetes
Title: Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.
Volume: 62
Issue: 11
Pages: 3887-900
Publication  
First Author: Gonzalez-Navarro H
Year: 2007
Journal: Front Biosci
Title: Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice.
Volume: 12
Pages: 2291-8
Publication  
First Author: Rached MT
Year: 2019
Journal: Mol Metab
Title: Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity.
Volume: 20
Pages: 38-50
Publication
First Author: Long YC
Year: 2011
Journal: Mol Cell Biol
Title: Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.
Volume: 31
Issue: 3
Pages: 430-41
Publication
First Author: Neukamm SS
Year: 2013
Journal: J Biol Chem
Title: Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation.
Volume: 288
Issue: 23
Pages: 16403-15
Publication
First Author: Park K
Year: 2013
Journal: Mol Cell Biol
Title: Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Volume: 33
Issue: 16
Pages: 3227-41
Publication
First Author: Hennige AM
Year: 2003
Journal: J Clin Invest
Title: Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
Volume: 112
Issue: 10
Pages: 1521-32
Publication
First Author: Norquay LD
Year: 2009
Journal: Endocrinology
Title: Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice.
Volume: 150
Issue: 10
Pages: 4531-40
Publication
First Author: Roncero I
Year: 2013
Journal: PLoS One
Title: Insulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liver.
Volume: 8
Issue: 4
Pages: e58797
Publication      
First Author: Turer E
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Dum_dum.
Publication
First Author: Yi X
Year: 2005
Journal: J Neurosci
Title: Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.
Volume: 25
Issue: 5
Pages: 1240-8
Publication
First Author: Wu J
Year: 2008
Journal: Nat Struct Mol Biol
Title: Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
Volume: 15
Issue: 3
Pages: 251-8
Publication
First Author: Baquedano E
Year: 2016
Journal: Dis Model Mech
Title: Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.
Volume: 9
Issue: 5
Pages: 573-83
Publication
First Author: Martín ED
Year: 2012
Journal: Cereb Cortex
Title: IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation.
Volume: 22
Issue: 8
Pages: 1717-27
Publication
First Author: Dasgupta P
Year: 2016
Journal: Sci Signal
Title: The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation.
Volume: 9
Issue: 433
Pages: ra63
Publication
First Author: Catalano-Iniesta L
Year: 2018
Journal: J Physiol Biochem
Title: Variations in adrenal gland medulla and dopamine effects induced by the lack of Irs2.
Volume: 74
Issue: 4
Pages: 667-677
Publication
First Author: Oliveira JM
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Tungstate promotes β-cell survival in Irs2-/- mice.
Volume: 306
Issue: 1
Pages: E36-47
Publication
First Author: González-Navarro H
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling.
Volume: 28
Issue: 12
Pages: 2187-94
Publication
First Author: Simmgen M
Year: 2006
Journal: Diabetologia
Title: Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.
Volume: 49
Issue: 3
Pages: 552-61
Publication  
First Author: Mercado-Matos J
Year: 2018
Journal: Mol Cell Biol
Title: Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2.
Volume: 38
Issue: 14
Publication  
First Author: Villar-Lorenzo A
Year: 2019
Journal: Dis Model Mech
Title: Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury.
Volume: 12
Issue: 7
Publication
First Author: Garcia-Barrado MJ
Year: 2011
Journal: Biochem Pharmacol
Title: Differential sensitivity to adrenergic stimulation underlies the sexual dimorphism in the development of diabetes caused by Irs-2 deficiency.
Volume: 81
Issue: 2
Pages: 279-88
Publication
First Author: Jain S
Year: 2013
Journal: J Clin Invest
Title: Chronic activation of a designer G(q)-coupled receptor improves β cell function.
Volume: 123
Issue: 4
Pages: 1750-62
Publication  
First Author: Albert-Fort M
Year: 2014
Journal: Exp Eye Res
Title: Retinal neurodegenerative changes in the adult insulin receptor substrate-2 deficient mouse.
Volume: 124
Pages: 1-10
Publication
First Author: Stamateris RE
Year: 2016
Journal: Diabetes
Title: Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor.
Volume: 65
Issue: 4
Pages: 981-95
Publication
First Author: Iglesias-Osma MC
Year: 2019
Journal: Sci Rep
Title: The influence of the lack of insulin receptor substrate 2 (IRS2) on the thyroid gland.
Volume: 9
Issue: 1
Pages: 5673
Publication
First Author: do Carmo JM
Year: 2016
Journal: Hypertension
Title: Regulation of Blood Pressure, Appetite, and Glucose by Leptin After Inactivation of Insulin Receptor Substrate 2 Signaling in the Entire Brain or in Proopiomelanocortin Neurons.
Volume: 67
Issue: 2
Pages: 378-86
Publication
First Author: Choudhury AI
Year: 2005
Journal: J Clin Invest
Title: The role of insulin receptor substrate 2 in hypothalamic and beta cell function.
Volume: 115
Issue: 4
Pages: 940-50
Publication
First Author: Irvine EE
Year: 2011
Journal: Learn Mem
Title: Insulin receptor substrate 2 is a negative regulator of memory formation.
Volume: 18
Issue: 6
Pages: 375-83
Publication
First Author: Kubota N
Year: 2004
Journal: J Clin Invest
Title: Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
Volume: 114
Issue: 7
Pages: 917-27
Publication
First Author: Hashimoto S
Year: 2015
Journal: Diabetes
Title: Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion.
Volume: 64
Issue: 3
Pages: 876-86
Publication
First Author: Isaac R
Year: 2017
Journal: Diabetes
Title: Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo.
Volume: 66
Issue: 7
Pages: 1879-1889
Publication
First Author: Kubota N
Year: 2008
Journal: Cell Metab
Title: Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Volume: 8
Issue: 1
Pages: 49-64
Publication
First Author: Kubota T
Year: 2011
Journal: Cell Metab
Title: Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.
Volume: 13
Issue: 3
Pages: 294-307
Publication
First Author: Lin X
Year: 2004
Journal: J Clin Invest
Title: Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.
Volume: 114
Issue: 7
Pages: 908-16
Publication
First Author: Copps KD
Year: 2010
Journal: Cell Metab
Title: Irs1 serine 307 promotes insulin sensitivity in mice.
Volume: 11
Issue: 1
Pages: 84-92
Publication
First Author: Alvarez-Perez JC
Year: 2014
Journal: Mol Endocrinol
Title: Hepatocyte growth factor ameliorates hyperglycemia and corrects β-cell mass in IRS2-deficient mice.
Volume: 28
Issue: 12
Pages: 2038-48
Publication  
First Author: Turaihi AH
Year: 2018
Journal: Front Physiol
Title: Insulin Receptor Substrate 2 Controls Insulin-Mediated Vasoreactivity and Perivascular Adipose Tissue Function in Muscle.
Volume: 9
Pages: 245
Publication
First Author: Cantley J
Year: 2007
Journal: Diabetologia
Title: Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.
Volume: 50
Issue: 6
Pages: 1248-56
Publication
First Author: Dong XC
Year: 2008
Journal: Cell Metab
Title: Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.
Volume: 8
Issue: 1
Pages: 65-76
Publication
First Author: Sato K
Year: 2012
Journal: Endocrinology
Title: Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and β-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet.
Volume: 153
Issue: 3
Pages: 1093-102
Publication
First Author: Kushner JA
Year: 2005
Journal: J Biol Chem
Title: Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis.
Volume: 280
Issue: 47
Pages: 39388-93
Publication
First Author: Nakamura A
Year: 2012
Journal: Diabetologia
Title: Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions.
Volume: 55
Issue: 6
Pages: 1745-54
Publication
First Author: Kim JJ
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2.
Volume: 292
Issue: 6
Pages: E1694-701
Publication  
First Author: Kubota N
Year: 2016
Journal: Nat Commun
Title: Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.
Volume: 7
Pages: 12977
Publication
First Author: Guo S
Year: 2009
Journal: Mol Cell Biol
Title: The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.
Volume: 29
Issue: 18
Pages: 5070-83
Publication
First Author: Riehle C
Year: 2014
Journal: Mol Cell Biol
Title: Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.
Volume: 34
Issue: 18
Pages: 3450-60
Publication
First Author: Mao N
Year: 2020
Journal: Cancer Res
Title: Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2.
Volume: 80
Issue: 7
Pages: 1428-1437
Publication
First Author: Griffeth RJ
Year: 2013
Journal: PLoS One
Title: Insulin receptor substrate 2 is required for testicular development.
Volume: 8
Issue: 5
Pages: e62103
Publication
First Author: González-Rodríguez A
Year: 2010
Journal: Diabetes
Title: Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.
Volume: 59
Issue: 3
Pages: 588-99
Publication
First Author: Neganova I
Year: 2007
Journal: Biol Reprod
Title: Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse.
Volume: 76
Issue: 6
Pages: 1045-53
Publication
First Author: Terauchi Y
Year: 2007
Journal: J Clin Invest
Title: Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
Volume: 117
Issue: 1
Pages: 246-57
Publication
First Author: Riehle C
Year: 2013
Journal: J Clin Invest
Title: Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
Volume: 123
Issue: 12
Pages: 5319-33
Publication
First Author: Wei K
Year: 2013
Journal: Nat Med
Title: A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Volume: 19
Issue: 10
Pages: 1331-1337
Publication
First Author: Schubert M
Year: 2003
Journal: J Neurosci
Title: Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation.
Volume: 23
Issue: 18
Pages: 7084-92
Publication
First Author: Vinué Á
Year: 2017
Journal: Diabetologia
Title: The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype.
Volume: 60
Issue: 9
Pages: 1801-1812
Publication
First Author: Hadsell DL
Year: 2007
Journal: J Endocrinol
Title: Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.
Volume: 194
Issue: 2
Pages: 327-36
Publication
First Author: Xuan S
Year: 2010
Journal: J Biol Chem
Title: Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.
Volume: 285
Issue: 52
Pages: 41044-50
Publication
First Author: Buzzi F
Year: 2010
Journal: Mol Cell Biol
Title: Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.
Volume: 30
Issue: 3
Pages: 601-12
Publication      
First Author: Besse-Patin A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.
Publication
First Author: Blandino-Rosano M
Year: 2016
Journal: Diabetes
Title: 4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.
Volume: 65
Issue: 8
Pages: 2235-48
Publication  
First Author: Groeneveld MP
Year: 2016
Journal: Sci Rep
Title: Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production.
Volume: 6
Pages: 21105
Publication
First Author: Tao R
Year: 2018
Journal: Nat Med
Title: Inactivating hepatic follistatin alleviates hyperglycemia.
Volume: 24
Issue: 7
Pages: 1058-1069
Publication
First Author: Jeong SH
Year: 2018
Journal: J Clin Invest
Title: Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer.
Volume: 128
Issue: 3
Pages: 1010-1025
Publication
First Author: Martínez-Hervás S
Year: 2014
Journal: Cardiovasc Res
Title: Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis.
Volume: 103
Issue: 2
Pages: 324-36
Publication
First Author: Lagarrigue S
Year: 2016
Journal: J Clin Invest
Title: CDK4 is an essential insulin effector in adipocytes.
Volume: 126
Issue: 1
Pages: 335-48
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus