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Search results 1 to 83 out of 83 for Isg20

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
3669 | ISG20
Type: gene
Organism: human
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Gene
293052 | Isg20
Type: gene
Organism: rat
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Gene
488729 | ISG20
Type: gene
Organism: dog, domestic
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Gene
744472 | ISG20
Type: gene
Organism: chimpanzee
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Gene
506604 | ISG20
Type: gene
Organism: cattle
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Gene
100534720 | isg20
Type: gene
Organism: zebrafish
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Gene
698376 | ISG20
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1928895 | Isg20
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30232164 | J:266377
 
First Author: Weiss CM
Year: 2018
Journal: mSphere
Title: The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.
Volume: 3
Issue: 5
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Publication
37452495 | J:343183
First Author: Jia M
Year: 2023
Journal: Mol Ther
Title: Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury.
Volume: 31
Issue: 10
Pages: 3034-3051
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Protein Coding Gene
MGP_CAROLIEiJ_G0029873 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032361 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032297 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032373 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1928895 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032865 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031414 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032052 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032207 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032199 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032883 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031134 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031532 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013095 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030975 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:947711
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825628
Age: embryonic day 14.5
Image: euxassay_001454_01
Specimen Label: euxassay_001454_01
Detected: true
Specimen Num: 1
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Publication
- | J:66671
   
First Author: Ramirez MH
Year: 2000
Journal: GenBank Submission
Title: Mus musculus DnaQL mRNA, complete cds
Pages: AF217484
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q4FK39
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Publication
16033969 | -
First Author: Espert L
Year: 2005
Journal: J Gen Virol
Title: Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.
Volume: 86
Issue: Pt 8
Pages: 2221-9
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Protein
Q9JL16
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
Q9JL16-2
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Allele
Tg(CAG-Otx2,-GFP)21Asim | MGI:4887448
Name: transgene insertion 21, Antonio Simeone
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5560656 | STOCK Tg(CAG-Otx2,-GFP)21Asim/Cnrm
Attribute String: transgenic, mutant stock
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Publication
24384227 | J:207997
 
First Author: Tripathi PP
Year: 2014
Journal: Neuroscience
Title: Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: effects on locomotor behavior and seizure susceptibility.
Volume: 261
Pages: 173-83
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Publication
18820178 | J:143341
First Author: Omodei D
Year: 2008
Journal: Development
Title: Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon.
Volume: 135
Issue: 20
Pages: 3459-70
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Publication
23117062 | J:192282
First Author: Di Giovannantonio LG
Year: 2013
Journal: Dev Biol
Title: Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability.
Volume: 373
Issue: 1
Pages: 176-83
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Slc6a3/Slc6a3<+> Tg(CAG-Otx2,-GFP)21Asim/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
15527770 | -
First Author: Horio T
Year: 2004
Journal: FEBS Lett
Title: Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.
Volume: 577
Issue: 1-2
Pages: 111-6
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Publication
17445960 | -
First Author: Degols G
Year: 2007
Journal: Biochimie
Title: ISG20, an actor of the innate immune response.
Volume: 89
Issue: 6-7
Pages: 831-5
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Publication
9569007 | -
First Author: Pentecost BT
Year: 1998
Journal: J Steroid Biochem Mol Biol
Title: Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus.
Volume: 64
Issue: 1-2
Pages: 25-33
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Protein Domain
IPR037433 | ISG20_DEDDh
Type: Domain
Description: Interferon (IFN) Stimulated Gene product of 20kDa (ISG20) is an IFN-induced antiviral exonuclease with a strong preference for single-stranded RNA and minor activity towards single-stranded DNA []. It was also independently identified by its response to estrogen and was called HEM45 (human estrogen regulated transcript) []. ISG20 may be a major effector of innate immunity against pathogens including viruses, bacteria, and parasites. It is located in promyelocytic leukemia (PML) nuclear bodies, sites for oncogenic DNA viral transcription and replication. It may carry out its function by degrading viral RNAs as part of the IFN-regulated antiviral response [].ISG20 is a DEDDh-type DnaQ-like 3'-5' exonuclease containing three conserved sequence motifs termed ExoI, ExoII and ExoIII with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis [].
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Publication
17686841 | J:127942
First Author: Zhang Y
Year: 2007
Journal: J Virol
Title: Identification and characterization of interferon-induced proteins that inhibit alphavirus replication.
Volume: 81
Issue: 20
Pages: 11246-55
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Publication
37483625 | J:338524
 
First Author: Huang Z
Year: 2023
Journal: Front Immunol
Title: Integrated analyses of single-cell transcriptomics identify metastasis-associated myeloid subpopulations in breast cancer lung metastasis.
Volume: 14
Pages: 1180402
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Publication
21057506 | J:166896
First Author: Di Salvio M
Year: 2010
Journal: Nat Neurosci
Title: Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.
Volume: 13
Issue: 12
Pages: 1481-8
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Protein
Q3U1G5
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Protein
A0A0R4J0R3
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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