Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Not Specified |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
95
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1314839 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-11-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1638615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:5810202 |
Age: |
embryonic day 9.5 |
Image: |
1B Isl1 |
Note: |
Expression in core mesodermal nuclei. |
Specimen Label: |
1B Isl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhuang S |
Year: |
2013 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of Isl1 during mouse development. |
Volume: |
13 |
Issue: |
8 |
Pages: |
407-12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Isl1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271020 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Isl1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266524 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
There is very strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences. |
Specimen Label: |
Isl1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Isl1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Isl1 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271124 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Isl1 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271220 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Isl1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271222 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Isl1 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271224 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Isl1 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754320 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Isl1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754322 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Isl1 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754324 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Isl1 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753720 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
There is strong staining in the mantle zone of the dorsal and ventral POAs, the VMH and ARH nuclei and anterior and posterior IDs. Staining is either absent or ubiquitous in the mantle zone of the PVH nucleus and the AVH. |
Specimen Label: |
Isl1 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753722 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
There is strong staining in the mantle zone of the AVH and VMH and ARH nuclei and moderate staining in the dorsal and ventral POAs. Staining is either absent or ubiquitous in the mantle zone of the PVH nucleus and anterior and posterior IDs. |
Specimen Label: |
Isl1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753724 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
Staining is strong in the MZ of the AVH, DAH & PH, strong & scattered in the DMH, VMH & ARH nuclei, moderate in the dorsal POA & weak & scattered in the ventral POA. Staining is either absent or ubiquitous in the MZ of the PVH & SCH nuclei. |
Specimen Label: |
Isl1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691319 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 11.5 |
Image: |
Isl1 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex and the ganglionic eminences. |
Specimen Label: |
Isl1 - E11.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271820 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
There is strong staining in the mantle zone of the premam zone and the TT. Staining is either absent or ubiquitous in the mantle zone of the mam and supramam zone. |
Specimen Label: |
Isl1 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271822 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
There is strong staining in the mantle zone of the premam zone and the TT. Staining is either absent or ubiquitous in the mantle zone of the mam and supramam zone. |
Specimen Label: |
Isl1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271824 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
There is strong staining in the mantle zone of the premam zone. Staining is either absent or ubiquitous in the mantle zone of the mam and supramam zones. |
Specimen Label: |
Isl1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750321 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6449817 |
Age: |
embryonic day 13.5 |
Image: |
S1 E13.5 Isl1 |
Note: |
Expression overlaps with that of Myt1. |
Specimen Label: |
S1 E13.5 Isl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690819 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 11.5 |
Image: |
Isl1 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus, the prethalamus, dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH, the anterior and posterior IDs, the premam, mam and supramam zones and the TT. |
Specimen Label: |
Isl1 - E11.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753922 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
There is strong staining in the ventricular zone of the anterior and posterior IDs. Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei and the AVH. |
Specimen Label: |
Isl1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753924 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH. |
Specimen Label: |
Isl1 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724315 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-15 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3565022 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3826212 |
Age: |
embryonic day 14.5 |
Image: |
Additional file 4 Isl1 |
|
Specimen Label: |
Additional file 4 Isl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691119 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 11.5 |
Image: |
Isl1 - E11.5 |
Note: |
There is very strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex. |
Specimen Label: |
Isl1 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Isl1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Isl1 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754724 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Isl1 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1314839 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-11-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1638615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:5810202 |
Age: |
embryonic day 9.5 |
Image: |
1D Isl1 Tbx1+/- |
Note: |
Expression in core mesodermal nuclei. |
Specimen Label: |
1D Isl1 Tbx1+/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1314839 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-11-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1638615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:5810202 |
Age: |
embryonic day 9.5 |
Image: |
1D Isl1 Tbx1-/- |
Note: |
Expression in core mesodermal nuclei. |
Specimen Label: |
1D Isl1 Tbx1-/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3292723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6449817 |
Age: |
embryonic day 15.5 |
Image: |
S1 E15.5 Isl1 |
Note: |
Expression overlaps with that of Myt1. |
Specimen Label: |
S1 E15.5 Isl1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271022 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Isl1 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271024 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones. |
Specimen Label: |
Isl1 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266520 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
There is strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences. |
Specimen Label: |
Isl1 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266522 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
There is very strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences. |
Specimen Label: |
Isl1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690619 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 11.5 |
Image: |
Isl1 - E11.5 |
Note: |
Staining is very strong in the MZ of the prethalamus & dorsal & ventral POAs, strong in anterior & posterior IDs, VMH & ARH nuclei, premam zone & TT & either absent or ubiquitous in the dorsal thalamus, PVH nucleus, AVH & mam & supramam zones. |
Specimen Label: |
Isl1 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754120 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 12.5 |
Image: |
Isl1 - E12.5 |
Note: |
There is very strong staining in the mantle zone of the prethalamus. Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus. |
Specimen Label: |
Isl1 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754122 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 14.5 |
Image: |
Isl1 - E14.5 |
Note: |
There is very strong staining in the mantle zone of the prethalamus. Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus. |
Specimen Label: |
Isl1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442684 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754124 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450710 |
Age: |
embryonic day 16.5 |
Image: |
Isl1 - E16.5 |
Note: |
There is very strong staining in the mantle zone of the prethalamus. Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus. |
Specimen Label: |
Isl1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6383136 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3673011 |
Pattern: |
Regionally restricted |
Stage: |
TS11 |
Assay Id: |
MGI:6383156 |
Age: |
embryonic day 7.5 |
Image: |
4 Isl1 E7.5 G4+/+ G6-/- |
Note: |
Predominantly expressed in progenitor cells within the second heart field. Most abundant in two lateral domains of mesoderm that mark cardiac progenitors. |
Specimen Label: |
4 Isl1 E7.5 G4+/+ G6-/- |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6383136 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3673011 |
Pattern: |
Regionally restricted |
Stage: |
TS11 |
Assay Id: |
MGI:6383156 |
Age: |
embryonic day 7.5 |
Image: |
4 Isl1 E7.5 G4-/- G6-/- |
Note: |
Predominantly expressed in progenitor cells within the second heart field. Most abundant in two lateral domains of mesoderm that mark cardiac progenitors. |
Specimen Label: |
4 Isl1 E7.5 G4-/- G6-/- |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6383136 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3673013 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6383156 |
Age: |
embryonic day 8.5 |
Image: |
4 Isl1 E8.5 ventral view G4+/+ G6+/+ |
Note: |
Predominantly expressed in progenitor cells within the second heart field. Most abundant in two lateral domains of mesoderm that mark cardiac progenitors. |
Specimen Label: |
4 Isl1 E8.5 ventral view G4+/+ G6+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6383136 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3673013 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6383156 |
Age: |
embryonic day 8.5 |
Image: |
4 Isl1 E8.5 ventral view G4-/- G6-/- |
Note: |
Predominantly expressed in progenitor cells within the second heart field. Most abundant in two lateral domains of mesoderm that mark cardiac progenitors. |
Specimen Label: |
4 Isl1 E8.5 ventral view G4-/- G6-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6383136 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3673013 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6383156 |
Age: |
embryonic day 8.5 |
Image: |
4 Isl1 E8.5 (section) G4+/+ G6+/+ |
Note: |
Predominantly expressed in progenitor cells within the second heart field. Most abundant in two lateral domains of mesoderm that mark cardiac progenitors. |
Specimen Label: |
4 Isl1 E8.5 (section) G4+/+ G6+/+ |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6383136 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3673013 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6383156 |
Age: |
embryonic day 8.5 |
Image: |
4 Isl1 E8.5 (section) G4-/- G6-/- |
Note: |
Predominantly expressed in progenitor cells within the second heart field. Most abundant in two lateral domains of mesoderm that mark cardiac progenitors. |
Specimen Label: |
4 Isl1 E8.5 (section) G4-/- G6-/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su T |
Year: |
2019 |
Journal: |
Cell Death Dis |
Title: |
LIM homeodomain transcription factor Isl1 affects urethral epithelium differentiation and apoptosis via Shh. |
Volume: |
10 |
Issue: |
10 |
Pages: |
713 |
|
•
•
•
•
•
|
Publication |
First Author: |
Galang G |
Year: |
2020 |
Journal: |
Circ Res |
Title: |
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function. |
Volume: |
127 |
Issue: |
12 |
Pages: |
1502-1518 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kappen C |
Year: |
2009 |
Journal: |
Int J Dev Biol |
Title: |
Identification of regulatory elements in the Isl1 gene locus. |
Volume: |
53 |
Issue: |
7 |
Pages: |
935-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dorn T |
Year: |
2015 |
Journal: |
Stem Cells |
Title: |
Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity. |
Volume: |
33 |
Issue: |
4 |
Pages: |
1113-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hilton JM |
Year: |
2011 |
Journal: |
Genome Biol |
Title: |
Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice. |
Volume: |
12 |
Issue: |
9 |
Pages: |
R90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2014 |
Journal: |
BMC Biol |
Title: |
LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3. |
Volume: |
12 |
|
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang J |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Isl1 is a direct transcriptional target of Forkhead transcription factors in second-heart-field-derived mesoderm. |
Volume: |
334 |
Issue: |
2 |
Pages: |
513-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang X |
Year: |
2011 |
Journal: |
Mol Cell Neurosci |
Title: |
Isl1 is required for multiple aspects of motor neuron development. |
Volume: |
47 |
Issue: |
3 |
Pages: |
215-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keeley PW |
Year: |
2023 |
Journal: |
Development |
Title: |
Neurog2 regulates Isl1 to modulate horizontal cell number. |
Volume: |
150 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ahlgren U |
Year: |
1997 |
Journal: |
Nature |
Title: |
Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. |
Volume: |
385 |
Issue: |
6613 |
Pages: |
257-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whitney IE |
Year: |
2015 |
Journal: |
Mol Cell Neurosci |
Title: |
Alternative splicing of the LIM-homeodomain transcription factor Isl1 in the mouse retina. |
Volume: |
65 |
|
Pages: |
102-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang X |
Year: |
2015 |
Journal: |
J Clin Invest |
Title: |
Transcription factor ISL1 is essential for pacemaker development and function. |
Volume: |
125 |
Issue: |
8 |
Pages: |
3256-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang R |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
ISL1 is a major susceptibility gene for classic bladder exstrophy and a regulator of urinary tract development. |
Volume: |
7 |
|
Pages: |
42170 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang R |
Year: |
2023 |
Journal: |
J Biol Chem |
Title: |
ISL1 regulates lung branching morphogenesis via Shh signaling pathway. |
Volume: |
299 |
Issue: |
8 |
Pages: |
105034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bohuslavova R |
Year: |
2023 |
Journal: |
Cell Biosci |
Title: |
ISL1 controls pancreatic alpha cell fate and beta cell maturation. |
Volume: |
13 |
Issue: |
1 |
Pages: |
53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castinetti F |
Year: |
2015 |
Journal: |
Mol Endocrinol |
Title: |
ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism. |
Volume: |
29 |
Issue: |
10 |
Pages: |
1510-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pfaff SL |
Year: |
1996 |
Journal: |
Cell |
Title: |
Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. |
Volume: |
84 |
Issue: |
2 |
Pages: |
309-20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724315 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270422 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4354740 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Table S5 - Isl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724315 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:4354740 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression is present in the upper, but not the lower, cortical plate. |
Specimen Label: |
Table S5 - Isl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7596113 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-02-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1609215 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7596124 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
6H +/- Isl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7596113 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-02-22 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:1609215 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7596124 |
Age: |
embryonic day 9.5 |
|
Note: |
Authors report severe reduction in expression in motor neurons. |
Specimen Label: |
6H -/- Isl1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724315 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4354740 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Table S5 - Isl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang C |
Year: |
2025 |
Journal: |
FEBS J |
Title: |
Transcriptional factor ISL1 regulates palate development by tuning the SHH cascade. |
Volume: |
292 |
Issue: |
4 |
Pages: |
851-863 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elshatory Y |
Year: |
2007 |
Journal: |
J Comp Neurol |
Title: |
Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. |
Volume: |
503 |
Issue: |
1 |
Pages: |
182-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naveau A |
Year: |
2017 |
Journal: |
J Bone Miner Res |
Title: |
Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. |
Volume: |
32 |
Issue: |
11 |
Pages: |
2219-2231 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Q |
Year: |
2018 |
Journal: |
Cell Death Dis |
Title: |
Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. |
Volume: |
9 |
Issue: |
2 |
Pages: |
247 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ching ST |
Year: |
2018 |
Journal: |
Hum Mol Genet |
Title: |
Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a. |
Volume: |
27 |
Issue: |
1 |
Pages: |
107-119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao R |
Year: |
2019 |
Journal: |
Cell Res |
Title: |
Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. |
Volume: |
29 |
Issue: |
6 |
Pages: |
486-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee B |
Year: |
2016 |
Journal: |
Development |
Title: |
The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons. |
Volume: |
143 |
Issue: |
20 |
Pages: |
3763-3773 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim N |
Year: |
2015 |
Journal: |
PLoS Genet |
Title: |
Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution. |
Volume: |
11 |
Issue: |
10 |
Pages: |
e1005560 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taroc EZM |
Year: |
2020 |
Journal: |
Front Physiol |
Title: |
Identifying Isl1 Genetic Lineage in the Developing Olfactory System and in GnRH-1 Neurons. |
Volume: |
11 |
|
Pages: |
601923 |
|
•
•
•
•
•
|
Publication |
First Author: |
Filova I |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization. |
Volume: |
119 |
Issue: |
37 |
Pages: |
e2207433119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho HH |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. |
Volume: |
10 |
Issue: |
4 |
Pages: |
e1004280 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin L |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. |
Volume: |
295 |
Issue: |
2 |
Pages: |
756-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li R |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. |
Volume: |
9 |
Issue: |
3 |
Pages: |
e92105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2016 |
Journal: |
Nucleic Acids Res |
Title: |
ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. |
Volume: |
44 |
Issue: |
14 |
Pages: |
6741-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Q |
Year: |
2008 |
Journal: |
Dev Biol |
Title: |
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. |
Volume: |
323 |
Issue: |
1 |
Pages: |
98-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pan L |
Year: |
2008 |
Journal: |
Development |
Title: |
ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. |
Volume: |
135 |
Issue: |
11 |
Pages: |
1981-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brinkmeier ML |
Year: |
2020 |
Journal: |
J Clin Invest |
Title: |
Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors. |
Volume: |
130 |
Issue: |
8 |
Pages: |
4501-4515 |
|
•
•
•
•
•
|