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Search results 1 to 100 out of 271 for Itk

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Type Details Score
Gene
3702 | ITK
Type: gene
Organism: human
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Gene
522311 | ITK
Type: gene
Organism: cattle
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Gene
416247 | ITK
Type: gene
Organism: chicken
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Gene
798906 | itk
Type: gene
Organism: zebrafish
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Gene
715471 | ITK
Type: gene
Organism: macaque, rhesus
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Gene
100492561 | itk
Type: gene
Organism: frog, western clawed
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Gene
363577 | Itk
Type: gene
Organism: rat
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Gene
489159 | ITK
Type: gene
Organism: dog, domestic
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Gene
735556 | ITK
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:96621 | Itk
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17412921 | J:121632
First Author: Huang YH
Year: 2007
Journal: Science
Title: Positive regulation of Itk PH domain function by soluble IP4.
Volume: 316
Issue: 5826
Pages: 886-9
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Publication
24270545 | J:206884
First Author: Jain N
Year: 2013
Journal: Nat Med
Title: CD28 and ITK signals regulate autoreactive T cell trafficking.
Volume: 19
Issue: 12
Pages: 1632-7
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Publication
21971040 | J:259096
First Author: Singleton KL
Year: 2011
Journal: Sci Signal
Title: Itk controls the spatiotemporal organization of T cell activation.
Volume: 4
Issue: 193
Pages: ra66
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Publication
9396778 | J:44879
First Author: Liao XC
Year: 1997
Journal: J Exp Med
Title: Itk and Fyn make independent contributions to T cell activation.
Volume: 186
Issue: 12
Pages: 2069-73
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Publication
25568116 | J:217732
First Author: Kannan AK
Year: 2015
Journal: J Neurosci
Title: Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.
Volume: 35
Issue: 1
Pages: 221-33
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Publication
26936133 | J:236343
 
First Author: Gomez-Rodriguez J
Year: 2016
Journal: Nat Commun
Title: Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Volume: 7
Pages: 10857
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Publication
18322190 | J:132902
First Author: Sahu N
Year: 2008
Journal: J Immunol
Title: Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration.
Volume: 180
Issue: 6
Pages: 3833-8
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Publication
22289921 | J:188974
First Author: Linka RM
Year: 2012
Journal: Leukemia
Title: Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases.
Volume: 26
Issue: 5
Pages: 963-71
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Publication
25989458 | J:229743
First Author: Kannan A
Year: 2015
Journal: Eur J Immunol
Title: Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, and iNKT-cell cytokine production.
Volume: 45
Issue: 8
Pages: 2276-85
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Publication
20237289 | J:159872
First Author: Min L
Year: 2010
Journal: J Immunol
Title: Disrupting the intermolecular self-association of Itk enhances T cell signaling.
Volume: 184
Issue: 8
Pages: 4228-35
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Publication
18453573 | J:134960
First Author: Hu J
Year: 2008
Journal: J Immunol
Title: Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development.
Volume: 180
Issue: 10
Pages: 6544-52
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Publication
16880398 | J:111786
First Author: Dubois S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: ITK and IL-15 support two distinct subsets of CD8+ T cells.
Volume: 103
Issue: 32
Pages: 12075-80
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Publication
25250764 | J:222505
First Author: Deakin A
Year: 2014
Journal: PLoS One
Title: Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.
Volume: 9
Issue: 9
Pages: e107490
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Publication
18941202 | J:140737
First Author: Sahu N
Year: 2008
Journal: J Immunol
Title: Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
Volume: 181
Issue: 9
Pages: 6125-31
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Publication
35210549 | J:336970
First Author: Elmore J
Year: 2022
Journal: Commun Biol
Title: ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation.
Volume: 5
Issue: 1
Pages: 162
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Publication
20126642 | J:157617
First Author: Hu J
Year: 2010
Journal: PLoS One
Title: Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells.
Volume: 5
Issue: 1
Pages: e8891
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Publication
17579028 | J:143156
First Author: Au-Yeung BB
Year: 2007
Journal: J Immunol
Title: A key role for Itk in both IFN gamma and IL-4 production by NKT cells.
Volume: 179
Issue: 1
Pages: 111-9
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Publication
18292523 | J:131540
First Author: Felices M
Year: 2008
Journal: J Immunol
Title: The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
Volume: 180
Issue: 5
Pages: 3007-18
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Publication
12055226 | J:123795
First Author: Lucas JA
Year: 2002
Journal: J Immunol
Title: The absence of Itk inhibits positive selection without changing lineage commitment.
Volume: 168
Issue: 12
Pages: 6142-51
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Publication
34566971 | J:311199
 
First Author: Thelen F
Year: 2021
Journal: Front Immunol
Title: The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis.
Volume: 12
Pages: 716405
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Publication
28635957 | J:250332
 
First Author: Huang W
Year: 2017
Journal: Nat Commun
Title: ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.
Volume: 8
Pages: 15871
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Publication
15814667 | J:98162
First Author: Li CR
Year: 2005
Journal: J Immunol
Title: Itk is not essential for CD28 signaling in naive T cells.
Volume: 174
Issue: 8
Pages: 4475-9
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Publication
19955438 | J:248271
First Author: Min L
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
Volume: 106
Issue: 50
Pages: 21143-8
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Publication
15345221 | J:93606
First Author: Miller AT
Year: 2004
Journal: Immunity
Title: Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet.
Volume: 21
Issue: 1
Pages: 67-80
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Publication
10213685 | J:54449
First Author: Schaeffer EM
Year: 1999
Journal: Science
Title: Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Volume: 284
Issue: 5414
Pages: 638-41
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Publication
19416854 | J:148531
First Author: Felices M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo.
Volume: 106
Issue: 20
Pages: 8308-13
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Publication
12193707 | J:120689
First Author: Gadue P
Year: 2002
Journal: J Immunol
Title: NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation.
Volume: 169
Issue: 5
Pages: 2397-406
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Publication
12842872 | J:85663
First Author: Wilcox HM
Year: 2003
Journal: J Biol Chem
Title: Itk phosphorylation sites are required for functional activity in primary T cells.
Volume: 278
Issue: 39
Pages: 37112-21
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Publication
16860760 | J:113409
First Author: Broussard C
Year: 2006
Journal: Immunity
Title: Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.
Volume: 25
Issue: 1
Pages: 93-104
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Publication
22403441 | J:184083
First Author: Qi Q
Year: 2012
Journal: J Immunol
Title: A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.
Volume: 188
Issue: 8
Pages: 3611-9
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Publication
16860759 | J:113408
First Author: Atherly LO
Year: 2006
Journal: Immunity
Title: The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.
Volume: 25
Issue: 1
Pages: 79-91
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Publication
30770814 | J:275414
First Author: Cho HS
Year: 2019
Journal: Nat Commun
Title: The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine.
Volume: 10
Issue: 1
Pages: 784
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Publication
16631752 | J:127466
First Author: Hao S
Year: 2006
Journal: FEBS Lett
Title: A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation.
Volume: 580
Issue: 11
Pages: 2691-7
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Publication
19443662 | J:150752
First Author: Qi Q
Year: 2009
Journal: Blood
Title: Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production.
Volume: 114
Issue: 3
Pages: 564-71
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Publication
23378428 | J:193616
First Author: Yin CC
Year: 2013
Journal: J Immunol
Title: The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells.
Volume: 190
Issue: 6
Pages: 2659-69
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Publication
26581914 | J:329775
First Author: Huang W
Year: 2016
Journal: J Allergy Clin Immunol
Title: Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide.
Volume: 137
Issue: 4
Pages: 1197-1205
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Publication
24620029 | J:212002
First Author: Huang W
Year: 2014
Journal: J Leukoc Biol
Title: ITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner.
Volume: 96
Issue: 1
Pages: 55-63
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Publication
16424186 | J:126428
First Author: Atherly LO
Year: 2006
Journal: J Immunol
Title: Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.
Volume: 176
Issue: 3
Pages: 1571-81
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Publication
25097034 | J:259505
First Author: Wang X
Year: 2014
Journal: Sci Signal
Title: Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
Volume: 7
Issue: 337
Pages: ra74
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Publication
32493815 | J:291694
First Author: Conley JM
Year: 2020
Journal: J Immunol
Title: Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength.
Volume: 205
Issue: 2
Pages: 335-345
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Publication
23011795 | J:190333
First Author: Nayar R
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
Volume: 109
Issue: 41
Pages: E2794-802
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Publication
26628680 | J:259522
First Author: Sun Y
Year: 2015
Journal: Sci Signal
Title: Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Volume: 8
Issue: 405
Pages: ra122
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Publication
7829087 | J:20150
First Author: Janis EM
Year: 1994
Journal: Genomics
Title: Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.
Volume: 23
Issue: 1
Pages: 269-71
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Publication
24610010 | J:210245
First Author: Huang W
Year: 2014
Journal: J Immunol
Title: Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation.
Volume: 192
Issue: 7
Pages: 3435-3441
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Publication
25492967 | J:260191
First Author: Granum S
Year: 2014
Journal: Sci Signal
Title: The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Volume: 7
Issue: 355
Pages: ra118
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Publication
20305788 | J:158899
First Author: Berge T
Year: 2010
Journal: PLoS One
Title: T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
Volume: 5
Issue: 3
Pages: e9761
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Publication
15123627 | J:91612
First Author: Fischer AM
Year: 2004
Journal: J Biol Chem
Title: Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.
Volume: 279
Issue: 28
Pages: 29816-20
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Publication
9311799 | J:42955
First Author: Bachmann MF
Year: 1997
Journal: J Virol
Title: Antiviral immune responses in Itk-deficient mice.
Volume: 71
Issue: 10
Pages: 7253-7
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Publication
12734350 | J:83276
First Author: Mueller C
Year: 2003
Journal: J Immunol
Title: Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK.
Volume: 170
Issue: 10
Pages: 5056-63
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Publication
10549622 | J:109489
First Author: Fowell DJ
Year: 1999
Journal: Immunity
Title: Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.
Volume: 11
Issue: 4
Pages: 399-409
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Publication
11702066 | J:72934
First Author: Schaeffer EM
Year: 2001
Journal: Nat Immunol
Title: Mutation of Tec family kinases alters T helper cell differentiation.
Volume: 2
Issue: 12
Pages: 1183-8
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Publication
8777721 | J:31230
First Author: Liao XC
Year: 1995
Journal: Immunity
Title: Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.
Volume: 3
Issue: 6
Pages: 757-69
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Publication
15778496 | J:110944
First Author: Forssell J
Year: 2005
Journal: Am J Respir Cell Mol Biol
Title: Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses.
Volume: 32
Issue: 6
Pages: 511-20
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Publication
21036902 | J:167539
First Author: Qi Q
Year: 2011
Journal: J Biol Chem
Title: Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell.
Volume: 286
Issue: 1
Pages: 138-46
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Publication
16237085 | J:119338
First Author: Finkelstein LD
Year: 2005
Journal: J Immunol
Title: Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion.
Volume: 175
Issue: 9
Pages: 5923-30
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Publication
18424706 | J:134319
First Author: Lutsiak ME
Year: 2008
Journal: J Immunol
Title: Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells.
Volume: 180
Issue: 9
Pages: 5871-81
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Publication
28213500 | J:247667
First Author: Kapnick SM
Year: 2017
Journal: J Immunol
Title: Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.
Volume: 198
Issue: 7
Pages: 2699-2711
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Publication
8893810 | J:36084
First Author: Tate G
Year: 1996
Journal: Cytogenet Cell Genet
Title: Localization of the human IL-2-inducible T-cell kinase gene (ITK) to chromosome band 5q34 and the mouse gene (Itk) to chromosome 15 by fluorescence in situ hybridization.
Volume: 74
Issue: 1-2
Pages: 96-8
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Publication
18031697 | J:127611
First Author: Horai R
Year: 2007
Journal: Immunity
Title: Requirements for selection of conventional and innate T lymphocyte lineages.
Volume: 27
Issue: 5
Pages: 775-85
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Publication
20483745 | J:161148
First Author: Xia M
Year: 2010
Journal: J Immunol
Title: Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.
Volume: 184
Issue: 12
Pages: 6807-14
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Publication
25063868 | J:273489
First Author: Huang W
Year: 2014
Journal: J Immunol
Title: IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.
Volume: 193
Issue: 5
Pages: 2267-72
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Publication
10562318 | J:58493
First Author: Sommers CL
Year: 1999
Journal: J Exp Med
Title: A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection.
Volume: 190
Issue: 10
Pages: 1427-38
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Publication
16547221 | J:129883
First Author: Au-Yeung BB
Year: 2006
Journal: J Immunol
Title: Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function.
Volume: 176
Issue: 7
Pages: 3895-9
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Publication
19818650 | J:153810
First Author: Gomez-Rodriguez J
Year: 2009
Journal: Immunity
Title: Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Volume: 31
Issue: 4
Pages: 587-97
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Publication
17724684 | J:125268
First Author: Hu J
Year: 2007
Journal: Eur J Immunol
Title: Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk.
Volume: 37
Issue: 10
Pages: 2892-9
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Publication
24534190 | J:210475
First Author: Gomez-Rodriguez J
Year: 2014
Journal: J Exp Med
Title: Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.
Volume: 211
Issue: 3
Pages: 529-43
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Publication
20596543 | J:162005
First Author: Sahu N
Year: 2010
Journal: PLoS One
Title: Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk.
Volume: 5
Issue: 6
Pages: e11348
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Publication
19009524 | J:141390
First Author: Raberger J
Year: 2008
Journal: Eur J Immunol
Title: Impaired T-cell development in the absence of Vav1 and Itk.
Volume: 38
Issue: 12
Pages: 3530-42
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Publication
28406139 | J:275129
 
First Author: Kannan AK
Year: 2017
Journal: Sci Rep
Title: T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.
Volume: 7
Pages: 45935
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Publication
33324410 | J:335606
 
First Author: Mammadli M
Year: 2020
Journal: Front Immunol
Title: Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT.
Volume: 11
Pages: 593863
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Publication
18523250 | J:137249
First Author: Iyer AS
Year: 2008
Journal: J Immunol
Title: The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses.
Volume: 180
Issue: 12
Pages: 7869-77
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Publication
10556826 | J:243546
First Author: Su YW
Year: 1999
Journal: Eur J Immunol
Title: Interaction of SLP adaptors with the SH2 domain of Tec family kinases.
Volume: 29
Issue: 11
Pages: 3702-11
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11015440 | J:115113
First Author: Schaeffer EM
Year: 2000
Journal: J Exp Med
Title: Tec family kinases modulate thresholds for thymocyte development and selection.
Volume: 192
Issue: 7
Pages: 987-1000
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9584150 | J:48231
First Author: Liu KQ
Year: 1998
Journal: J Exp Med
Title: T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells.
Volume: 187
Issue: 10
Pages: 1721-7
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Publication
25271622 | J:217616
First Author: Dubovsky JA
Year: 2014
Journal: J Clin Invest
Title: Ibrutinib treatment ameliorates murine chronic graft-versus-host disease.
Volume: 124
Issue: 11
Pages: 4867-76
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Publication
32038633 | J:298408
 
First Author: Huang L
Year: 2019
Journal: Front Immunol
Title: Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection.
Volume: 10
Pages: 3103
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Publication
34452995 | J:309571
 
First Author: Gallagher MP
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK.
Volume: 118
Issue: 35
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Publication
31663508 | J:281553
   
First Author: Clark DJ
Year: 2019
Journal: Elife
Title: Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion.
Volume: 8
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Publication
11859102 | J:74774
First Author: Miller AT
Year: 2002
Journal: J Immunol
Title: Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase.
Volume: 168
Issue: 5
Pages: 2163-72
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Publication
18025201 | J:154808
First Author: Lucas JA
Year: 2007
Journal: J Immunol
Title: Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk.
Volume: 179
Issue: 11
Pages: 7561-7
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Publication
19701889 | J:152151
First Author: Sacristán C
Year: 2009
Journal: Eur J Immunol
Title: Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.
Volume: 39
Issue: 9
Pages: 2584-95
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Publication
25548254 | J:242685
First Author: Sakaguchi S
Year: 2015
Journal: J Leukoc Biol
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