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Search results 1 to 100 out of 244 for Itk

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Huang YH
Year: 2007
Journal: Science
Title: Positive regulation of Itk PH domain function by soluble IP4.
Volume: 316
Issue: 5826
Pages: 886-9
Publication
First Author: Jain N
Year: 2013
Journal: Nat Med
Title: CD28 and ITK signals regulate autoreactive T cell trafficking.
Volume: 19
Issue: 12
Pages: 1632-7
Publication
First Author: Singleton KL
Year: 2011
Journal: Sci Signal
Title: Itk controls the spatiotemporal organization of T cell activation.
Volume: 4
Issue: 193
Pages: ra66
Publication
First Author: Liao XC
Year: 1997
Journal: J Exp Med
Title: Itk and Fyn make independent contributions to T cell activation.
Volume: 186
Issue: 12
Pages: 2069-73
Publication
First Author: Kannan AK
Year: 2015
Journal: J Neurosci
Title: Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.
Volume: 35
Issue: 1
Pages: 221-33
Publication  
First Author: Gomez-Rodriguez J
Year: 2016
Journal: Nat Commun
Title: Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Volume: 7
Pages: 10857
Publication
First Author: Sahu N
Year: 2008
Journal: J Immunol
Title: Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration.
Volume: 180
Issue: 6
Pages: 3833-8
Publication
First Author: Linka RM
Year: 2012
Journal: Leukemia
Title: Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases.
Volume: 26
Issue: 5
Pages: 963-71
Publication
First Author: Kannan A
Year: 2015
Journal: Eur J Immunol
Title: Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, and iNKT-cell cytokine production.
Volume: 45
Issue: 8
Pages: 2276-85
Publication
First Author: Min L
Year: 2010
Journal: J Immunol
Title: Disrupting the intermolecular self-association of Itk enhances T cell signaling.
Volume: 184
Issue: 8
Pages: 4228-35
Publication
First Author: Hu J
Year: 2008
Journal: J Immunol
Title: Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development.
Volume: 180
Issue: 10
Pages: 6544-52
Publication
First Author: Dubois S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: ITK and IL-15 support two distinct subsets of CD8+ T cells.
Volume: 103
Issue: 32
Pages: 12075-80
Publication
First Author: Deakin A
Year: 2014
Journal: PLoS One
Title: Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.
Volume: 9
Issue: 9
Pages: e107490
Publication
First Author: Hu J
Year: 2010
Journal: PLoS One
Title: Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells.
Volume: 5
Issue: 1
Pages: e8891
Publication
First Author: Sahu N
Year: 2008
Journal: J Immunol
Title: Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
Volume: 181
Issue: 9
Pages: 6125-31
Publication
First Author: Au-Yeung BB
Year: 2007
Journal: J Immunol
Title: A key role for Itk in both IFN gamma and IL-4 production by NKT cells.
Volume: 179
Issue: 1
Pages: 111-9
Publication
First Author: Felices M
Year: 2008
Journal: J Immunol
Title: The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
Volume: 180
Issue: 5
Pages: 3007-18
Publication
First Author: Lucas JA
Year: 2002
Journal: J Immunol
Title: The absence of Itk inhibits positive selection without changing lineage commitment.
Volume: 168
Issue: 12
Pages: 6142-51
Publication  
First Author: Huang W
Year: 2017
Journal: Nat Commun
Title: ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.
Volume: 8
Pages: 15871
Publication
First Author: Li CR
Year: 2005
Journal: J Immunol
Title: Itk is not essential for CD28 signaling in naive T cells.
Volume: 174
Issue: 8
Pages: 4475-9
Publication
First Author: Min L
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
Volume: 106
Issue: 50
Pages: 21143-8
Publication
First Author: Miller AT
Year: 2004
Journal: Immunity
Title: Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet.
Volume: 21
Issue: 1
Pages: 67-80
Publication
First Author: Schaeffer EM
Year: 1999
Journal: Science
Title: Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Volume: 284
Issue: 5414
Pages: 638-41
Publication
First Author: Felices M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo.
Volume: 106
Issue: 20
Pages: 8308-13
Publication
First Author: Gadue P
Year: 2002
Journal: J Immunol
Title: NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation.
Volume: 169
Issue: 5
Pages: 2397-406
Publication
First Author: Wilcox HM
Year: 2003
Journal: J Biol Chem
Title: Itk phosphorylation sites are required for functional activity in primary T cells.
Volume: 278
Issue: 39
Pages: 37112-21
Publication
First Author: Broussard C
Year: 2006
Journal: Immunity
Title: Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.
Volume: 25
Issue: 1
Pages: 93-104
Publication
First Author: Qi Q
Year: 2012
Journal: J Immunol
Title: A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.
Volume: 188
Issue: 8
Pages: 3611-9
Publication
First Author: Atherly LO
Year: 2006
Journal: Immunity
Title: The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.
Volume: 25
Issue: 1
Pages: 79-91
Publication
First Author: Cho HS
Year: 2019
Journal: Nat Commun
Title: The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine.
Volume: 10
Issue: 1
Pages: 784
Publication
First Author: Hao S
Year: 2006
Journal: FEBS Lett
Title: A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation.
Volume: 580
Issue: 11
Pages: 2691-7
Publication
First Author: Qi Q
Year: 2009
Journal: Blood
Title: Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production.
Volume: 114
Issue: 3
Pages: 564-71
Publication
First Author: Yin CC
Year: 2013
Journal: J Immunol
Title: The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells.
Volume: 190
Issue: 6
Pages: 2659-69
Publication
First Author: Huang W
Year: 2014
Journal: J Leukoc Biol
Title: ITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner.
Volume: 96
Issue: 1
Pages: 55-63
Publication
First Author: Atherly LO
Year: 2006
Journal: J Immunol
Title: Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.
Volume: 176
Issue: 3
Pages: 1571-81
Publication
First Author: Wang X
Year: 2014
Journal: Sci Signal
Title: Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
Volume: 7
Issue: 337
Pages: ra74
Publication
First Author: Conley JM
Year: 2020
Journal: J Immunol
Title: Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength.
Volume: 205
Issue: 2
Pages: 335-345
Publication
First Author: Nayar R
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
Volume: 109
Issue: 41
Pages: E2794-802
Publication
First Author: Sun Y
Year: 2015
Journal: Sci Signal
Title: Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Volume: 8
Issue: 405
Pages: ra122
Publication
First Author: Janis EM
Year: 1994
Journal: Genomics
Title: Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.
Volume: 23
Issue: 1
Pages: 269-71
Publication
First Author: Huang W
Year: 2014
Journal: J Immunol
Title: Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation.
Volume: 192
Issue: 7
Pages: 3435-3441
Publication
First Author: Granum S
Year: 2014
Journal: Sci Signal
Title: The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Volume: 7
Issue: 355
Pages: ra118
Publication
First Author: Berge T
Year: 2010
Journal: PLoS One
Title: T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
Volume: 5
Issue: 3
Pages: e9761
Publication
First Author: Fischer AM
Year: 2004
Journal: J Biol Chem
Title: Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.
Volume: 279
Issue: 28
Pages: 29816-20
Publication
First Author: Bachmann MF
Year: 1997
Journal: J Virol
Title: Antiviral immune responses in Itk-deficient mice.
Volume: 71
Issue: 10
Pages: 7253-7
Publication
First Author: Mueller C
Year: 2003
Journal: J Immunol
Title: Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK.
Volume: 170
Issue: 10
Pages: 5056-63
Publication
First Author: Fowell DJ
Year: 1999
Journal: Immunity
Title: Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.
Volume: 11
Issue: 4
Pages: 399-409
Publication
First Author: Schaeffer EM
Year: 2001
Journal: Nat Immunol
Title: Mutation of Tec family kinases alters T helper cell differentiation.
Volume: 2
Issue: 12
Pages: 1183-8
Publication
First Author: Liao XC
Year: 1995
Journal: Immunity
Title: Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.
Volume: 3
Issue: 6
Pages: 757-69
Publication
First Author: Forssell J
Year: 2005
Journal: Am J Respir Cell Mol Biol
Title: Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses.
Volume: 32
Issue: 6
Pages: 511-20
Publication
First Author: Qi Q
Year: 2011
Journal: J Biol Chem
Title: Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell.
Volume: 286
Issue: 1
Pages: 138-46
Publication
First Author: Finkelstein LD
Year: 2005
Journal: J Immunol
Title: Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion.
Volume: 175
Issue: 9
Pages: 5923-30
Publication
First Author: Lutsiak ME
Year: 2008
Journal: J Immunol
Title: Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells.
Volume: 180
Issue: 9
Pages: 5871-81
Publication
First Author: Kapnick SM
Year: 2017
Journal: J Immunol
Title: Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.
Volume: 198
Issue: 7
Pages: 2699-2711
Publication
First Author: Tate G
Year: 1996
Journal: Cytogenet Cell Genet
Title: Localization of the human IL-2-inducible T-cell kinase gene (ITK) to chromosome band 5q34 and the mouse gene (Itk) to chromosome 15 by fluorescence in situ hybridization.
Volume: 74
Issue: 1-2
Pages: 96-8
Publication
First Author: Horai R
Year: 2007
Journal: Immunity
Title: Requirements for selection of conventional and innate T lymphocyte lineages.
Volume: 27
Issue: 5
Pages: 775-85
Publication
First Author: Xia M
Year: 2010
Journal: J Immunol
Title: Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.
Volume: 184
Issue: 12
Pages: 6807-14
Publication
First Author: Huang W
Year: 2014
Journal: J Immunol
Title: IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.
Volume: 193
Issue: 5
Pages: 2267-72
Publication
First Author: Sommers CL
Year: 1999
Journal: J Exp Med
Title: A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection.
Volume: 190
Issue: 10
Pages: 1427-38
Publication
First Author: Au-Yeung BB
Year: 2006
Journal: J Immunol
Title: Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function.
Volume: 176
Issue: 7
Pages: 3895-9
Publication
First Author: Gomez-Rodriguez J
Year: 2009
Journal: Immunity
Title: Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Volume: 31
Issue: 4
Pages: 587-97
Publication
First Author: Hu J
Year: 2007
Journal: Eur J Immunol
Title: Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk.
Volume: 37
Issue: 10
Pages: 2892-9
Publication
First Author: Gomez-Rodriguez J
Year: 2014
Journal: J Exp Med
Title: Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.
Volume: 211
Issue: 3
Pages: 529-43
Publication
First Author: Sahu N
Year: 2010
Journal: PLoS One
Title: Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk.
Volume: 5
Issue: 6
Pages: e11348
Publication
First Author: Raberger J
Year: 2008
Journal: Eur J Immunol
Title: Impaired T-cell development in the absence of Vav1 and Itk.
Volume: 38
Issue: 12
Pages: 3530-42
Publication  
First Author: Kannan AK
Year: 2017
Journal: Sci Rep
Title: T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.
Volume: 7
Pages: 45935
Publication
First Author: Iyer AS
Year: 2008
Journal: J Immunol
Title: The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses.
Volume: 180
Issue: 12
Pages: 7869-77
Publication
First Author: Su YW
Year: 1999
Journal: Eur J Immunol
Title: Interaction of SLP adaptors with the SH2 domain of Tec family kinases.
Volume: 29
Issue: 11
Pages: 3702-11
Publication
First Author: Cho HS
Year: 2020
Journal: Immunohorizons
Title: CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.
Volume: 4
Issue: 2
Pages: 57-71
Publication
First Author: Schaeffer EM
Year: 2000
Journal: J Exp Med
Title: Tec family kinases modulate thresholds for thymocyte development and selection.
Volume: 192
Issue: 7
Pages: 987-1000
Publication
First Author: Liu KQ
Year: 1998
Journal: J Exp Med
Title: T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells.
Volume: 187
Issue: 10
Pages: 1721-7
Publication
First Author: Dubovsky JA
Year: 2014
Journal: J Clin Invest
Title: Ibrutinib treatment ameliorates murine chronic graft-versus-host disease.
Volume: 124
Issue: 11
Pages: 4867-76
Publication  
First Author: Huang L
Year: 2019
Journal: Front Immunol
Title: Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection.
Volume: 10
Pages: 3103
Publication    
First Author: Clark DJ
Year: 2019
Journal: Elife
Title: Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion.
Volume: 8
Publication
First Author: Miller AT
Year: 2002
Journal: J Immunol
Title: Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase.
Volume: 168
Issue: 5
Pages: 2163-72
Publication
First Author: Lucas JA
Year: 2007
Journal: J Immunol
Title: Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk.
Volume: 179
Issue: 11
Pages: 7561-7
Publication
First Author: Sacristán C
Year: 2009
Journal: Eur J Immunol
Title: Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.
Volume: 39
Issue: 9
Pages: 2584-95
Publication
First Author: Sakaguchi S
Year: 2015
Journal: J Leukoc Biol
Title: A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Volume: 97
Issue: 4
Pages: 635-44
Publication
First Author: Siliciano JD
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.
Volume: 89
Issue: 23
Pages: 11194-8
Publication
First Author: Carrizosa E
Year: 2009
Journal: J Immunol
Title: Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.
Volume: 183
Issue: 11
Pages: 7352-61
Publication
First Author: Jordan MS
Year: 2008
Journal: Immunity
Title: Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.
Volume: 28
Issue: 3
Pages: 359-69
Publication
First Author: Tomlinson MG
Year: 2004
Journal: Mol Cell Biol
Title: Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.
Volume: 24
Issue: 6
Pages: 2455-66
Publication
First Author: Iyer AS
Year: 2011
Journal: J Biol Chem
Title: Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses.
Volume: 286
Issue: 11
Pages: 9503-13
Publication
First Author: Joseph RE
Year: 2013
Journal: Sci Signal
Title: Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.
Volume: 6
Issue: 290
Pages: ra76
Publication
First Author: Xie Q
Year: 2013
Journal: J Mol Biol
Title: Substrate recognition of PLCγ1 via a specific docking surface on Itk.
Volume: 425
Issue: 4
Pages: 683-96
Publication
First Author: Clarke RL
Year: 2009
Journal: Eur J Immunol
Title: A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
Volume: 39
Issue: 6
Pages: 1619-31
Publication
First Author: Dervovic DD
Year: 2013
Journal: J Immunol
Title: Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch.
Volume: 191
Issue: 4
Pages: 1704-15
Publication
First Author: Rochman Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Volume: 107
Issue: 45
Pages: 19455-60
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus