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Search results 1 to 100 out of 538 for Jak1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
3716 | JAK1
Type: gene
Organism: human
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Gene
100038172 | jak1
Type: gene
Organism: frog, western clawed
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Gene
84598 | Jak1
Type: gene
Organism: rat
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Gene
743373 | JAK1
Type: gene
Organism: chimpanzee
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Gene
442952 | JAK1
Type: gene
Organism: dog, domestic
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Gene
537201 | JAK1
Type: gene
Organism: cattle
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Gene
395681 | JAK1
Type: gene
Organism: chicken
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Gene
30280 | jak1
Type: gene
Organism: zebrafish
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Gene
677689 | JAK1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:96628 | Jak1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8331382 | J:13250
First Author: Yang X
Year: 1993
Journal: J Neurosci
Title: Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system.
Volume: 13
Issue: 7
Pages: 3006-17
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Publication
30671064 | J:273156
 
First Author: Witalisz-Siepracka A
Year: 2018
Journal: Front Immunol
Title: Loss of JAK1 Drives Innate Immune Deficiency.
Volume: 9
Pages: 3108
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Publication
18362173 | J:133976
First Author: Flex E
Year: 2008
Journal: J Exp Med
Title: Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.
Volume: 205
Issue: 4
Pages: 751-8
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Publication
27111231 | J:237080
First Author: Yasuda T
Year: 2016
Journal: J Clin Invest
Title: Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.
Volume: 126
Issue: 6
Pages: 2064-76
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Publication
24048415 | J:205415
First Author: Bellanger D
Year: 2014
Journal: Leukemia
Title: Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia.
Volume: 28
Issue: 2
Pages: 417-9
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Publication
33475190 | J:324471
First Author: Daryadel A
Year: 2021
Journal: FASEB J
Title: Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage.
Volume: 35
Issue: 2
Pages: e21302
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Publication
35046931 | J:318756
 
First Author: Takeichi T
Year: 2021
Journal: Front Immunol
Title: Autoinflammatory Keratinization Disease With Hepatitis and Autism Reveals Roles for JAK1 Kinase Hyperactivity in Autoinflammation.
Volume: 12
Pages: 737747
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Publication
17928529 | J:130084
First Author: Lee Y
Year: 2008
Journal: Blood
Title: The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-beta-induced inhibitory signaling.
Volume: 111
Issue: 2
Pages: 885-93
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Publication
23791841 | J:199153
First Author: Sabrautzki S
Year: 2013
Journal: Am J Pathol
Title: An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease.
Volume: 183
Issue: 2
Pages: 352-68
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Publication
34118090 | J:342929
First Author: Fuente R
Year: 2021
Journal: FASEB J
Title: Systemic Jak1 activation causes extrarenal calcitriol production and skeletal alterations provoking stunted growth.
Volume: 35
Issue: 7
Pages: e21721
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Publication
35196494 | J:328350
First Author: Vogel A
Year: 2022
Journal: Cell Rep
Title: JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Volume: 38
Issue: 8
Pages: 110420
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Publication
28965767 | J:253956
First Author: Kleppe M
Year: 2017
Journal: Cell Stem Cell
Title: Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.
Volume: 21
Issue: 4
Pages: 489-501.e7
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Publication
27088444 | J:236888
 
First Author: O'Leary CE
Year: 2016
Journal: Nat Commun
Title: Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Volume: 7
Pages: 11226
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Publication
9590172 | J:47300
First Author: Rodig SJ
Year: 1998
Journal: Cell
Title: Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses.
Volume: 93
Issue: 3
Pages: 373-83
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Publication
18178840 | J:130947
First Author: Haan S
Year: 2008
Journal: J Immunol
Title: Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation.
Volume: 180
Issue: 2
Pages: 998-1007
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Publication
25113558 | J:224338
First Author: Meares GP
Year: 2014
Journal: Mol Cell Biol
Title: PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.
Volume: 34
Issue: 20
Pages: 3911-25
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Publication
1848670 | J:14190
First Author: Wilks AF
Year: 1991
Journal: Mol Cell Biol
Title: Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.
Volume: 11
Issue: 4
Pages: 2057-65
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Publication
20974963 | J:167374
First Author: Rochman Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Volume: 107
Issue: 45
Pages: 19455-60
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Publication
2466296 | J:42354
First Author: Wilks AF
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.
Volume: 86
Issue: 5
Pages: 1603-7
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Publication
29668931 | J:263510
First Author: Kimura M
Year: 2018
Journal: Int Immunol
Title: TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction.
Volume: 30
Issue: 7
Pages: 291-299
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Publication
7929391 | J:21848
First Author: Yin T
Year: 1994
Journal: J Biol Chem
Title: JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes.
Volume: 269
Issue: 43
Pages: 26614-7
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Publication
9553136 | J:47131
First Author: Zhu MH
Year: 1998
Journal: J Biol Chem
Title: Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.
Volume: 273
Issue: 17
Pages: 10719-25
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Publication
7579387 | J:29195
First Author: Novak U
Year: 1995
Journal: Blood
Title: Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts.
Volume: 86
Issue: 8
Pages: 2948-56
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Publication
12738762 | J:84709
First Author: Taler M
Year: 2003
Journal: Mol Endocrinol
Title: Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells.
Volume: 17
Issue: 8
Pages: 1580-92
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Ontology Term
- | Inhibition of host JAK1 by virus
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Publication
2482828 | J:22689
First Author: Wilks AF
Year: 1989
Journal: Gene
Title: The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.
Volume: 85
Issue: 1
Pages: 67-74
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Publication
32750333 | -
First Author: Gruber CN
Year: 2020
Journal: Immunity
Title: Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function.
Volume: 53
Issue: 3
Pages: 672-684.e11
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Publication
16239216 | -
First Author: Staerk J
Year: 2005
Journal: J Biol Chem
Title: JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
Volume: 280
Issue: 51
Pages: 41893-9
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Publication
30463015 | J:270675
First Author: Wehde BL
Year: 2018
Journal: Cell Rep
Title: Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression.
Volume: 25
Issue: 8
Pages: 2192-2207.e5
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Publication
10502458 | J:156077
First Author: Hellgren G
Year: 1999
Journal: Growth Horm IGF Res
Title: The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.
Volume: 9
Issue: 3
Pages: 212-8
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Publication
8514334 | J:4976
First Author: Harpur AG
Year: 1993
Journal: Immunol Lett
Title: A prominent natural H-2 Kd ligand is derived from protein tyrosine kinase JAK1.
Volume: 35
Issue: 3
Pages: 235-7
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Publication
7613027 | J:24373
First Author: Gough NM
Year: 1995
Journal: Mamm Genome
Title: Localization of genes for two members of the JAK family of protein tyrosine kinases to murine chromosomes 4 and 19.
Volume: 6
Issue: 4
Pages: 247-8
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Publication
8378315 | J:15255
First Author: Silvennoinen O
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
Volume: 90
Issue: 18
Pages: 8429-33
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Publication
27671227 | J:235355
First Author: Sakamoto K
Year: 2016
Journal: Genesis
Title: Generation of Janus kinase 1 (JAK1) conditional knockout mice.
Volume: 54
Issue: 11
Pages: 582-588
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Publication
31556112 | J:299896
First Author: Fang H
Year: 2020
Journal: J Cell Physiol
Title: PRR34-AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1-dependent JAK-STAT signaling pathway.
Volume: 235
Issue: 3
Pages: 2545-2556
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Publication
15526032 | J:115464
First Author: Durán A
Year: 2004
Journal: EMBO J
Title: Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.
Volume: 23
Issue: 23
Pages: 4595-605
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Publication
24169825 | J:207710
First Author: Keil E
Year: 2014
Journal: Blood
Title: Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.
Volume: 123
Issue: 4
Pages: 520-9
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Publication
8934548 | J:36866
First Author: Kumar A
Year: 1996
Journal: Oncogene
Title: Structural organization and chromosomal mapping of JAK3 locus.
Volume: 13
Issue: 9
Pages: 2009-14
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Publication
38733583 | J:349756
First Author: Shrestha H
Year: 2024
Journal: Cell Rep
Title: The Janus kinase 1 is critical for pancreatic cancer initiation and progression.
Volume: 43
Issue: 5
Pages: 114202
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Publication
19620279 | J:152602
First Author: Diao Y
Year: 2009
Journal: Mol Cell Biol
Title: SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
Volume: 29
Issue: 18
Pages: 5084-93
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Publication
27044867 | J:235354
First Author: Sakamoto K
Year: 2016
Journal: Mol Cell Biol
Title: Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.
Volume: 36
Issue: 11
Pages: 1673-90
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Publication
16280321 | J:107465
First Author: Shang L
Year: 2006
Journal: J Biol Chem
Title: The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.
Volume: 281
Issue: 4
Pages: 1876-84
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Publication
10374907 | J:55343
First Author: Aringer M
Year: 1999
Journal: Life Sci
Title: Janus kinases and their role in growth and disease.
Volume: 64
Issue: 24
Pages: 2173-86
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Publication
25959715 | J:229755
First Author: Dong G
Year: 2015
Journal: Eur J Immunol
Title: STS-1 promotes IFN-α induced autophagy by activating the JAK1-STAT1 signaling pathway in B cells.
Volume: 45
Issue: 8
Pages: 2377-88
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Publication
21383241 | J:170459
First Author: Ghoreschi K
Year: 2011
Journal: J Immunol
Title: Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).
Volume: 186
Issue: 7
Pages: 4234-43
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Publication
34675248 | J:311967
First Author: Rädler PD
Year: 2021
Journal: Sci Rep
Title: Dual recombinase action in the normal and neoplastic mammary gland epithelium.
Volume: 11
Issue: 1
Pages: 20775
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Publication
18451094 | J:136972
First Author: Takahashi Y
Year: 2008
Journal: Mol Endocrinol
Title: Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway.
Volume: 22
Issue: 7
Pages: 1673-81
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Publication
27919027 | J:260305
First Author: Rutherford C
Year: 2016
Journal: Sci Signal
Title: Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.
Volume: 9
Issue: 453
Pages: ra109
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Publication
21155952 | J:186969
First Author: Motegi H
Year: 2011
Journal: Genes Cells
Title: TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling.
Volume: 16
Issue: 2
Pages: 179-89
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Publication
16737695 | J:111382
First Author: Rajasingh J
Year: 2006
Journal: Exp Cell Res
Title: 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells.
Volume: 312
Issue: 13
Pages: 2538-46
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Publication
23526587 | J:201029
First Author: Pérez-Rivero G
Year: 2013
Journal: Eur J Immunol
Title: Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing.
Volume: 43
Issue: 7
Pages: 1745-57
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Publication
17550976 | J:125399
First Author: Neilson LM
Year: 2007
Journal: Mol Endocrinol
Title: Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
Volume: 21
Issue: 9
Pages: 2218-32
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Publication
15456882 | J:93318
First Author: Vuong BQ
Year: 2004
Journal: Mol Cell Biol
Title: SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.
Volume: 24
Issue: 20
Pages: 9092-101
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Publication
21160051 | J:168764
First Author: Wang H
Year: 2011
Journal: J Immunol
Title: The role of glycogen synthase kinase 3 in regulating IFN-β-mediated IL-10 production.
Volume: 186
Issue: 2
Pages: 675-84
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Publication
15659653 | J:99220
First Author: Hao A
Year: 2005
Journal: Mol Biol Cell
Title: The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.
Volume: 16
Issue: 4
Pages: 1569-83
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Publication
7544789 | J:29002
First Author: Yin T
Year: 1995
Journal: J Biol Chem
Title: Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases.
Volume: 270
Issue: 35
Pages: 20497-502
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GO Term
GO:0039576 | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
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Protein
Q8CFX4
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: true
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Protein Coding Gene
MGP_CAROLIEiJ_G0026203 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028491 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028401 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028185 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96628 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028911 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027625 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028154 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028404 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028299 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027350 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028540 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027172 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
36639058 | J:349251
First Author: Iino Y
Year: 2023
Journal: J Lipid Res
Title: Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1.
Volume: 64
Issue: 2
Pages: 100329
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Publication
7589562 | J:29670
First Author: Domanski P
Year: 1995
Journal: FEBS Lett
Title: Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.
Volume: 374
Issue: 3
Pages: 317-22
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GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 7
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•
GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1204405
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1204407
Age: postnatal week 6-8
Image: st96_149
Specimen Label: None
Detected: true
Specimen Num: 11
•
•
•
•
•




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