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Search results 1 to 100 out of 1072 for Jak2

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Type Details Score
Gene
3717 | JAK2
Type: gene
Organism: human
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Gene
525246 | JAK2
Type: gene
Organism: cattle
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Gene
374199 | JAK2
Type: gene
Organism: chicken
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Gene
694184 | JAK2
Type: gene
Organism: macaque, rhesus
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Gene
100036599 | jak2
Type: gene
Organism: frog, western clawed
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Gene
24514 | Jak2
Type: gene
Organism: rat
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Gene
484185 | JAK2
Type: gene
Organism: dog, domestic
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Gene
464979 | JAK2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:96629 | Jak2
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:7528852
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Present
Sex: Female
Emaps: EMAPS:3102527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7528866
Age: postnatal day 1
Image: 1D 1 dpp JAK2
Note: Expression colocalized with Ddx4 mainly in oocyte cytoplasm.
Specimen Label: 1D 1 dpp JAK2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7528852
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7528866
Age: postnatal day 1
Image: S1A 1 dpp JAK2
Note: Expression not co-localized with Foxl2.
Specimen Label: S1A 1 dpp JAK2
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:7528852
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Present
Sex: Female
Emaps: EMAPS:3562727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7528866
Age: postnatal day 3
Image: 1D 3 dpp JAK2
Note: Expression in cytoplasm of cuboidal granulosa cells in growing follicles.
Specimen Label: 1D 3 dpp JAK2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7528852
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Present
Sex: Female
Emaps: EMAPS:3102525
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:7528866
Age: embryonic day 17.5
Image: 1D 17.5 dpc JAK2
Note: Expression colocalized with Ddx4 mainly in oocyte cytoplasm.
Specimen Label: 1D 17.5 dpc JAK2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7528852
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Present
Sex: Female
Emaps: EMAPS:3102527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7528866
Age: postnatal day 3
Image: 1D 3 dpp JAK2
Note: Expression colocalized with Ddx4 mainly in oocyte cytoplasm.
Specimen Label: 1D 3 dpp JAK2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7528852
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796225
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:7528866
Age: embryonic day 17.5
Image: S1A 17.5 dpc JAK2
Note: Expression not co-localized with Foxl2.
Specimen Label: S1A 17.5 dpc JAK2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7528852
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7528866
Age: postnatal day 3
Image: S1A 3 dpp JAK2
Note: Expression not co-localized with Foxl2.
Specimen Label: S1A 3 dpp JAK2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:7528852
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Present
Sex: Female
Emaps: EMAPS:3562727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7528866
Age: postnatal day 3
Image: S1A 3 dpp JAK2
Note: Expression in cytoplasm of cuboidal granulosa cells in growing follicles.
Specimen Label: S1A 3 dpp JAK2
Detected: true
Specimen Num: 6
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Publication
9590174 | J:47298
First Author: Neubauer H
Year: 1998
Journal: Cell
Title: Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.
Volume: 93
Issue: 3
Pages: 397-409
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Publication
20304997 | J:161170
First Author: Argetsinger LS
Year: 2010
Journal: Mol Endocrinol
Title: Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.
Volume: 24
Issue: 5
Pages: 1062-76
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Publication
8378315 | J:15255
First Author: Silvennoinen O
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
Volume: 90
Issue: 18
Pages: 8429-33
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Publication
8343951 | J:40444
First Author: Witthuhn BA
Year: 1993
Journal: Cell
Title: JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.
Volume: 74
Issue: 2
Pages: 227-36
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Publication
9590173 | J:47299
First Author: Parganas E
Year: 1998
Journal: Cell
Title: Jak2 is essential for signaling through a variety of cytokine receptors.
Volume: 93
Issue: 3
Pages: 385-95
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Publication
21423214 | J:190278
First Author: Jäkel H
Year: 2011
Journal: Oncogene
Title: Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.
Volume: 30
Issue: 32
Pages: 3502-12
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Publication
7775438 | J:25950
First Author: Zhao Y
Year: 1995
Journal: J Biol Chem
Title: The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.
Volume: 270
Issue: 23
Pages: 13814-8
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Publication
21362419 | J:200500
First Author: Zou H
Year: 2011
Journal: FEBS Lett
Title: Differential biological activity of disease-associated JAK2 mutants.
Volume: 585
Issue: 7
Pages: 1007-13
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Publication
19293402 | J:149617
First Author: Gery S
Year: 2009
Journal: J Leukoc Biol
Title: Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F.
Volume: 85
Issue: 6
Pages: 957-65
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Publication
17024180 | J:200427
First Author: Funakoshi-Tago M
Year: 2006
Journal: EMBO J
Title: Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2.
Volume: 25
Issue: 20
Pages: 4763-72
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Publication
18033315 | J:130189
First Author: Shide K
Year: 2008
Journal: Leukemia
Title: Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F.
Volume: 22
Issue: 1
Pages: 87-95
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Publication
29907650 | J:272585
First Author: Kim SK
Year: 2018
Journal: Genes Dev
Title: JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias.
Volume: 32
Issue: 11-12
Pages: 849-864
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Publication
28194444 | J:290762
First Author: Corbit KC
Year: 2017
Journal: JCI Insight
Title: Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance.
Volume: 2
Issue: 3
Pages: e91001
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Publication
28724798 | J:288058
 
First Author: Sivasubramaniyam T
Year: 2017
Journal: JCI Insight
Title: Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.
Volume: 2
Issue: 14
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Publication
28794431 | J:287516
First Author: Desai HR
Year: 2017
Journal: Sci Rep
Title: Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.
Volume: 7
Issue: 1
Pages: 7653
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Publication
31393852 | J:286888
   
First Author: Corbit KC
Year: 2019
Journal: JCI Insight
Title: Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma.
Volume: 5
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Publication
21209203 | J:167849
First Author: Wu S
Year: 2011
Journal: J Neurosci
Title: Jak2 is necessary for neuroendocrine control of female reproduction.
Volume: 31
Issue: 1
Pages: 184-92
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Publication
35169231 | J:321610
First Author: Dotan I
Year: 2022
Journal: Commun Biol
Title: Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.
Volume: 5
Issue: 1
Pages: 132
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Publication
9154835 | J:40355
First Author: Jaster R
Year: 1997
Journal: Mol Cell Biol
Title: JAK2 is required for induction of the murine DUB-1 gene.
Volume: 17
Issue: 6
Pages: 3364-72
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Publication
22281400 | J:181262
First Author: Smith JK
Year: 2012
Journal: Free Radic Biol Med
Title: Identification of a redox-sensitive switch within the JAK2 catalytic domain.
Volume: 52
Issue: 6
Pages: 1101-10
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Publication
27288519 | J:236259
First Author: Grisouard J
Year: 2016
Journal: Blood
Title: JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis.
Volume: 128
Issue: 6
Pages: 839-51
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Publication
30571460 | J:292272
First Author: Wang W
Year: 2018
Journal: Circ Res
Title: Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice.
Volume: 123
Issue: 11
Pages: e35-e47
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Publication
15121872 | J:200316
First Author: Kurzer JH
Year: 2004
Journal: Mol Cell Biol
Title: Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
Volume: 24
Issue: 10
Pages: 4557-70
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Publication
16887119 | J:112700
First Author: Frenzel K
Year: 2006
Journal: Exp Cell Res
Title: A functional Jak2 tyrosine kinase domain is essential for mouse development.
Volume: 312
Issue: 15
Pages: 2735-44
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Publication
1848670 | J:14190
First Author: Wilks AF
Year: 1991
Journal: Mol Cell Biol
Title: Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.
Volume: 11
Issue: 4
Pages: 2057-65
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Publication
22378845 | J:184997
First Author: Pecquet C
Year: 2012
Journal: Blood
Title: Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.
Volume: 119
Issue: 20
Pages: 4625-35
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Publication
18636744 | J:139801
First Author: McDoom I
Year: 2008
Journal: Biochemistry
Title: Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation.
Volume: 47
Issue: 32
Pages: 8326-34
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Publication
20489053 | J:164539
First Author: Li J
Year: 2010
Journal: Blood
Title: JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.
Volume: 116
Issue: 9
Pages: 1528-38
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Publication
24086539 | J:207740
First Author: Anderson NM
Year: 2013
Journal: PLoS One
Title: Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.
Volume: 8
Issue: 9
Pages: e75472
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Publication
25115888 | J:218722
First Author: Meyer SC
Year: 2014
Journal: Blood
Title: Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.
Volume: 124
Issue: 14
Pages: 2280-4
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Publication
23544085 | J:199896
First Author: Park SO
Year: 2013
Journal: PLoS One
Title: Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans.
Volume: 8
Issue: 3
Pages: e59675
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Publication
37611729 | J:342495
     
First Author: Fisher DAC
Year: 2023
Journal: Exp Hematol
Title: Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice.
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Publication
15705783 | J:107464
First Author: Tong W
Year: 2005
Journal: Blood
Title: Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.
Volume: 105
Issue: 12
Pages: 4604-12
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Publication
17183644 | J:223643
 
First Author: Zaleskas VM
Year: 2006
Journal: PLoS One
Title: Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.
Volume: 1
Pages: e18
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Publication
28383049 | J:274603
 
First Author: Kim WS
Year: 2017
Journal: Sci Rep
Title: Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity.
Volume: 7
Pages: 46153
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Publication
16847321 | J:111417
First Author: Nilsson J
Year: 2006
Journal: Mol Cell Biol
Title: Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells.
Volume: 26
Issue: 15
Pages: 5663-74
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Publication
29382747 | J:259828
First Author: Betts BC
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.
Volume: 115
Issue: 7
Pages: 1582-1587
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Publication
21420414 | J:173798
First Author: Kirabo A
Year: 2011
Journal: J Mol Cell Cardiol
Title: Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.
Volume: 50
Issue: 6
Pages: 1026-34
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Publication
11875116 | J:75082
First Author: Shillingford JM
Year: 2002
Journal: Mol Endocrinol
Title: Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium.
Volume: 16
Issue: 3
Pages: 563-70
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Publication
24480985 | J:212503
First Author: Akada H
Year: 2014
Journal: Leukemia
Title: Loss of wild-type Jak2 allele enhances myeloid cell expansion and accelerates myelofibrosis in Jak2V617F knock-in mice.
Volume: 28
Issue: 8
Pages: 1627-35
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Publication
24237791 | J:205523
First Author: Bartalucci N
Year: 2013
Journal: J Cell Mol Med
Title: Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms.
Volume: 17
Issue: 11
Pages: 1385-96
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Publication
21354995 | J:191633
First Author: Kirabo A
Year: 2011
Journal: Cardiovasc Res
Title: Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species.
Volume: 91
Issue: 1
Pages: 171-9
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Publication
24677703 | J:216787
First Author: Akada H
Year: 2014
Journal: Stem Cells
Title: Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.
Volume: 32
Issue: 7
Pages: 1878-89
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Publication
23747947 | J:198722
First Author: Yang P
Year: 2013
Journal: Am J Pathol
Title: Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.
Volume: 183
Issue: 2
Pages: 617-25
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Publication
26864339 | J:232800
First Author: Mascarenhas MI
Year: 2016
Journal: Blood
Title: Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.
Volume: 127
Issue: 19
Pages: 2298-309
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Publication
11821424 | J:76057
First Author: Xie J
Year: 2002
Journal: J Biol Chem
Title: Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells.
Volume: 277
Issue: 16
Pages: 14020-30
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Publication
9111318 | J:266146
First Author: Feng J
Year: 1997
Journal: Mol Cell Biol
Title: Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.
Volume: 17
Issue: 5
Pages: 2497-501
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Publication
10600756 | J:172914
First Author: Cruz MT
Year: 1999
Journal: Am J Physiol
Title: Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells.
Volume: 277
Issue: 6 Pt 1
Pages: C1050-7
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Publication
18515659 | J:138414
First Author: Plo I
Year: 2008
Journal: Blood
Title: JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.
Volume: 112
Issue: 4
Pages: 1402-12
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Publication
19638629 | J:155509
First Author: Zhao L
Year: 2009
Journal: J Biol Chem
Title: A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.
Volume: 284
Issue: 39
Pages: 26988-98
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Publication
21557940 | J:173249
First Author: Sumi K
Year: 2011
Journal: FEBS Lett
Title: Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells.
Volume: 585
Issue: 12
Pages: 1884-90
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Publication
23782652 | J:221230
First Author: Nordstrom SM
Year: 2013
Journal: Mol Endocrinol
Title: Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.
Volume: 27
Issue: 8
Pages: 1333-42
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Publication
22740348 | J:190584
First Author: Zhou C
Year: 2013
Journal: J Cell Physiol
Title: JAK2 mediates the acute response to decreased cell volume in mouse preimplantation embryos by activating NHE1.
Volume: 228
Issue: 2
Pages: 428-38
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Publication
15169911 | J:90883
First Author: Wagner KU
Year: 2004
Journal: Mol Cell Biol
Title: Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice.
Volume: 24
Issue: 12
Pages: 5510-20
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Publication
24211109 | J:206169
First Author: Huang Z
Year: 2014
Journal: Am J Pathol
Title: Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice.
Volume: 184
Issue: 1
Pages: 122-32
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Publication
26227742 | J:232260
First Author: Jones RS
Year: 2015
Journal: Neurobiol Aging
Title: Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice.
Volume: 36
Issue: 10
Pages: 2716-24
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Publication
7889566 | J:23805
First Author: Klingmüller U
Year: 1995
Journal: Cell
Title: Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
Volume: 80
Issue: 5
Pages: 729-38
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Publication
7499280 | J:29835
First Author: Wang XY
Year: 1995
Journal: J Biol Chem
Title: Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.
Volume: 270
Issue: 47
Pages: 27999-8002
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Publication
20028972 | J:159894
First Author: Funakoshi-Tago M
Year: 2010
Journal: J Biol Chem
Title: STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant.
Volume: 285
Issue: 8
Pages: 5296-307
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Publication
8943354 | J:36542
First Author: Jiao H
Year: 1996
Journal: Mol Cell Biol
Title: Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1.
Volume: 16
Issue: 12
Pages: 6985-92
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Publication
26175413 | J:222995
First Author: Meyer SC
Year: 2015
Journal: Cancer Cell
Title: CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.
Volume: 28
Issue: 1
Pages: 15-28
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Publication
19287004 | J:149742
First Author: Yu L
Year: 2009
Journal: J Biol Chem
Title: JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1.
Volume: 284
Issue: 20
Pages: 13481-8
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Publication
30755420 | J:275430
First Author: Donaghy R
Year: 2019
Journal: Blood
Title: The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.
Volume: 133
Issue: 14
Pages: 1560-1571
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Publication
24169825 | J:207710
First Author: Keil E
Year: 2014
Journal: Blood
Title: Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.
Volume: 123
Issue: 4
Pages: 520-9
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Publication
29203511 | J:258057
First Author: Corbit KC
Year: 2018
Journal: Diabetes
Title: Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.
Volume: 67
Issue: 2
Pages: 208-221
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Publication
31943454 | J:290381
First Author: Zhang L
Year: 2020
Journal: Cell Prolif
Title: Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation.
Volume: 53
Issue: 2
Pages: e12742
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Publication
22051730 | J:180613
First Author: Hoermann G
Year: 2012
Journal: FASEB J
Title: Identification of oncostatin M as a JAK2 V617F-dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms.
Volume: 26
Issue: 2
Pages: 894-906
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22131881 | J:315088
First Author: Kirabo A
Year: 2011
Journal: Neoplasia
Title: The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.
Volume: 13
Issue: 11
Pages: 1058-68
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Publication
25969154 | J:317265
First Author: Burgos-Ojeda D
Year: 2015
Journal: Mol Cancer Ther
Title: CD24+ Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis.
Volume: 14
Issue: 7
Pages: 1717-27
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Publication
34808021 | J:320104
First Author: Takei H
Year: 2022
Journal: Cancer Sci
Title: Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms.
Volume: 113
Issue: 2
Pages: 597-608
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Publication
17128263 | J:200422
First Author: Choi JH
Year: 2006
Journal: Nat Cell Biol
Title: Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B.
Volume: 8
Issue: 12
Pages: 1389-97
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2466296 | J:42354
First Author: Wilks AF
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.
Volume: 86
Issue: 5
Pages: 1603-7
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Publication
28611190 | J:243931
First Author: Lv K
Year: 2017
Journal: Genes Dev
Title: CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies.
Volume: 31
Issue: 10
Pages: 1007-1023
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Publication
26515423 | J:232364
First Author: Shi SY
Year: 2016
Journal: Diabetologia
Title: JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.
Volume: 59
Issue: 1
Pages: 187-96
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Publication
26575024 | J:280480
First Author: Mace TA
Year: 2015
Journal: Oncotarget
Title: Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.
Volume: 6
Issue: 42
Pages: 44509-22
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Publication
20231889 | J:158917
First Author: Zhong J
Year: 2010
Journal: PLoS One
Title: Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock.
Volume: 5
Issue: 3
Pages: e9593
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Publication
11980901 | J:77620
First Author: Drachman JG
Year: 2002
Journal: J Biol Chem
Title: Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation.
Volume: 277
Issue: 26
Pages: 23544-53
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Publication
30242073 | J:267000
First Author: Iamsawat S
Year: 2018
Journal: J Immunol
Title: Stabilization of Foxp3 by Targeting JAK2 Enhances Efficacy of CD8 Induced Regulatory T Cells in the Prevention of Graft-versus-Host Disease.
Volume: 201
Issue: 9
Pages: 2812-2823
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Publication
20974963 | J:167374
First Author: Rochman Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Volume: 107
Issue: 45
Pages: 19455-60
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Publication
21941370 | J:203080
First Author: Caffarel MM
Year: 2012
Journal: Cell Death Differ
Title: Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death, and contributes to tumourigenesis.
Volume: 19
Issue: 3
Pages: 511-22
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Publication
17404288 | J:145281
First Author: Waiboci LW
Year: 2007
Journal: J Immunol
Title: Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist.
Volume: 178
Issue: 8
Pages: 5058-68
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15640156 | J:98046
First Author: Ferrand A
Year: 2005
Journal: J Biol Chem
Title: A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.
Volume: 280
Issue: 11
Pages: 10710-5
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Publication
8923468 | J:143702
First Author: Yi W
Year: 1996
Journal: Mol Endocrinol
Title: Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.
Volume: 10
Issue: 11
Pages: 1425-43
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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