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Search results 1 to 96 out of 96 for Jmy

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Hits by Category

Type Details Score
Gene
133746 | JMY
Type: gene
Organism: human
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Gene
683593 | Jmy
Type: gene
Organism: rat
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Gene
528498 | JMY
Type: gene
Organism: cattle
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Gene
427182 | JMY
Type: gene
Organism: chicken
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Gene
406556 | jmy
Type: gene
Organism: zebrafish
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Gene
709502 | JMY
Type: gene
Organism: macaque, rhesus
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Gene
100127594 | jmy
Type: gene
Organism: frog, western clawed
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Gene
610323 | JMY
Type: gene
Organism: dog, domestic
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Gene
461784 | JMY
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1913096 | Jmy
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR033324 | Jmy
Type: Family
Description: Junction-mediating and regulatory protein (JMY) is a vertebrate protein that was first identified as a transcriptional co-activator of p53 []. It is a regulator of both transcription and actin filament assembly [, , ]. In the nucleus it acts as a transcriptional coactivator and promotes programmed cell death in response to DNA damage [], whereas in the cytoplasm it promotes actin filament assembly []. JMY can either initiate actin filament formation by binding and activating the Arp2/3 complex or nucleate filaments directly in a SPIRE-like fashion [, ]. In both cases, the JMY's actin-regulatory activity relies on a cluster of three actin-binding WH2 domains at its C terminus [].
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Publication
19287377 | J:156038
First Author: Zuchero JB
Year: 2009
Journal: Nat Cell Biol
Title: p53-cofactor JMY is a multifunctional actin nucleation factor.
Volume: 11
Issue: 4
Pages: 451-9
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Publication
17170761 | J:148063
First Author: Coutts AS
Year: 2007
Journal: EMBO Rep
Title: Mdm2 targets the p53 transcription cofactor JMY for degradation.
Volume: 8
Issue: 1
Pages: 84-90
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Publication
10518217 | J:64939
First Author: Shikama N
Year: 1999
Journal: Mol Cell
Title: A novel cofactor for p300 that regulates the p53 response.
Volume: 4
Issue: 3
Pages: 365-76
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Publication
22262458 | J:197007
First Author: Zuchero JB
Year: 2012
Journal: Mol Biol Cell
Title: Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY.
Volume: 23
Issue: 5
Pages: 853-63
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Publication
32279424 | J:307721
First Author: Liu Y
Year: 2020
Journal: FEBS J
Title: JMY expression by Sertoli cells contributes to mediating spermatogenesis in mice.
Volume: 287
Issue: 24
Pages: 5478-5497
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Publication
25279558 | -
First Author: Lin Z
Year: 2014
Journal: PLoS One
Title: JMY functions as actin nucleation-promoting factor and mediator for p53-mediated DNA damage in porcine oocytes.
Volume: 9
Issue: 10
Pages: e109385
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Protein
A0A1Y7VLC3
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q9QXM1
Organism: Mus musculus/domesticus
Length: 983  
Fragment?: false
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Protein
A0A0R4J0V4
Organism: Mus musculus/domesticus
Length: 983  
Fragment?: false
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Publication
20237478 | -
First Author: Campellone KG
Year: 2010
Journal: Nat Rev Mol Cell Biol
Title: A nucleator arms race: cellular control of actin assembly.
Volume: 11
Issue: 4
Pages: 237-51
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Publication
23272233 | J:195643
First Author: Liu J
Year: 2012
Journal: PLoS One
Title: Nucleation promoting factors regulate the expression and localization of Arp2/3 complex during meiosis of mouse oocytes.
Volume: 7
Issue: 12
Pages: e52277
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Protein Coding Gene
MGP_CAROLIEiJ_G0018779 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020825 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020752 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020569 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1913096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021212 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020528 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020653 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020633 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019840 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020145 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015858 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019664 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:5817978
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818010
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5817978
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818010
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5817978
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818019
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5+/+;E2F1-/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5817978
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818019
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5-/-;E2F1-/-
Detected: true
Specimen Num: 2
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Publication
11511361 | J:314962
First Author: Demonacos C
Year: 2001
Journal: Mol Cell
Title: A TPR motif cofactor contributes to p300 activity in the p53 response.
Volume: 8
Issue: 1
Pages: 71-84
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Publication
25940086 | J:227534
First Author: Gong W
Year: 2015
Journal: J Biol Chem
Title: Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
Volume: 290
Issue: 24
Pages: 15350-61
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Author
Ng JMY
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Author
How JMY
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Author
Teves JMY
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Publication
30420355 | J:314387
First Author: Hu X
Year: 2019
Journal: J Cell Biol
Title: LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.
Volume: 218
Issue: 1
Pages: 251-266
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Publication
25015719 | -
First Author: Schlüter K
Year: 2014
Journal: Eur J Cell Biol
Title: JMY is involved in anterograde vesicle trafficking from the trans-Golgi network.
Volume: 93
Issue: 5-6
Pages: 194-204
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Interaction Experiment
Coutts AS (2007)
Description: Mdm2 targets the p53 transcription cofactor JMY for degradation.
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Publication
28977603 | J:247249
First Author: Davey RA
Year: 2017
Journal: Endocrinology
Title: Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice.
Volume: 158
Issue: 10
Pages: 3684-3695
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Publication
33649536 | J:303972
First Author: Fan Q
Year: 2021
Journal: Oncogene
Title: Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.
Volume: 40
Issue: 12
Pages: 2258-2272
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Publication
31300449 | J:294670
First Author: Du F
Year: 2019
Journal: Clin Cancer Res
Title: Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Volume: 25
Issue: 21
Pages: 6475-6486
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Publication
28986380 | J:252299
First Author: Liu Y
Year: 2017
Journal: Cancer Res
Title: Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion.
Volume: 77
Issue: 23
Pages: 6692-6703
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Protein Domain
IPR031738 | JMY/WHAMM
Type: Domain
Description: JMY (junction-mediating and -regulatory protein) []and WHAMM (WASP homologue-associated protein with actin, membranes and microtubules) []are two nucleation-promoting factors (NPFs) with similar domain architecture. JMY was originally identified as a transcriptional co-factor in the p53-response to DNA damage. Aside from this nuclear function, JMY is involved in cytoskeleton remodelling and trans-Golgi transport []. WHAMM binds microtubules and is involved in ER to cis-Golgi transport []. JMY and WHAMM show similar localisation and could be involved in similar processes []. This middle domain is the coiled-coil region that putatively binds microtubules to the scaffold. This ability to interact with microtubules plays a role in membrane tubulation.
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Publication
26096974 | -
First Author: Kast DJ
Year: 2015
Journal: Curr Biol
Title: WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism.
Volume: 25
Issue: 13
Pages: 1791-7
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Publication
37436997 | -
First Author: Pikkupeura LM
Year: 2023
Journal: Sci Adv
Title: Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation.
Volume: 9
Issue: 28
Pages: eadf9460
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Protein
A0A140LI61
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Publication
18614018 | J:212803
First Author: Campellone KG
Year: 2008
Journal: Cell
Title: WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport.
Volume: 134
Issue: 1
Pages: 148-61
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Protein Domain
IPR031808 | JMY/WHAMM_N
Type: Domain
Description: This is the N-terminal domain of WHAMM (WASP homologue-associated protein with actin, membranes and microtubules) and JMY (junction-mediating and -regulatory protein), two nucleation-promoting factors (NPFs) with similar domain architecture []. The function of this conserved region is not known; there are two highly conserved tryptophan residues.
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Protein
Q571B6
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Publication
22362889 | J:182131
First Author: Adams CJ
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
Volume: 109
Issue: 10
Pages: 3778-83
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Publication
32196488 | J:289916
First Author: Kabrawala S
Year: 2020
Journal: PLoS Genet
Title: WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility.
Volume: 16
Issue: 3
Pages: e1008694
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom