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Search results 1 to 100 out of 115 for Kash5

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Hits by Category

Hits by Strain

Type Details Score
Gene
147872 | KASH5
Type: gene
Organism: human
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Protein Domain
IPR028170 | KASH5
Type: Family
Description: KASH5 (also known as CCDC155) is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton []. KASH5 interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localisation [].
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Gene
308581 | Kash5
Type: gene
Organism: rat
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Gene
456203 | KASH5
Type: gene
Organism: chimpanzee
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Gene
617651 | KASH5
Type: gene
Organism: cattle
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Gene
100855738 | KASH5
Type: gene
Organism: dog, domestic
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Gene
719163 | KASH5
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2687329 | Kash5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22826121 | J:190404
First Author: Morimoto A
Year: 2012
Journal: J Cell Biol
Title: A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
Volume: 198
Issue: 2
Pages: 165-72
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Publication
26842404 | J:231308
 
First Author: Luo Y
Year: 2016
Journal: Sci Rep
Title: Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes.
Volume: 6
Pages: 20408
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Protein
Q80VJ8
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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GXD Expression
GXD Expression
Probe: MGI:6694250
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6715979
Age: postnatal day 16
Image: 6c Meioc-/-
Note: Kash5 staining was observed at telomeric sites in mutant spermatocytes. However, in approximately half of the zygotene-like cells, Kash5 foci remained clustered indicating an arrest at the so-called 'bouquet' stage.
Specimen Label: 6c Meioc-/-
Detected: true
Specimen Num: 2
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Publication
24062341 | J:201813
First Author: Horn HF
Year: 2013
Journal: J Cell Biol
Title: A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton.
Volume: 202
Issue: 7
Pages: 1023-39
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Publication
25892231 | J:228378
First Author: Lee CY
Year: 2015
Journal: Cell Rep
Title: Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes.
Volume: 11
Issue: 4
Pages: 551-63
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Publication
25380821 | J:218218
First Author: Viera A
Year: 2015
Journal: J Cell Sci
Title: CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.
Volume: 128
Issue: 1
Pages: 88-99
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Protein Coding Gene
MGP_CAROLIEiJ_G0029705 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032208 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032187 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032123 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032199 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2687329 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032691 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031243 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032037 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031988 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032025 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032707 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012930 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030803 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7560687
Assay Type: Western blot
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:7561474
Age: postnatal
Image: 1
Specimen Label: -
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal
Image: 1
Specimen Label: Brain
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal
Image: 1
Specimen Label: Thymus
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal
Image: 1
Specimen Label: Heart
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal
Image: 1
Specimen Label: Liver
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal
Image: 1
Specimen Label: Spleen
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal
Image: 1
Specimen Label: Kidney
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal
Image: 1
Specimen Label: Small Intestine
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal
Image: 1
Specimen Label: Testis
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796226
Stage: TS26
Assay Id: MGI:7561487
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:7561487
Age: postnatal week 4
Image: 1
Specimen Label: 4 wk
Detected: false
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:7561488
Age: postnatal
Image: 1
Specimen Label: Testis
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:7561488
Age: embryonic day 14.0
Image: 1
Specimen Label: E14
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:7561488
Age: embryonic day 15.0
Image: 1
Specimen Label: E15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796224
Stage: TS24
Assay Id: MGI:7561488
Age: embryonic day 16.0
Image: 1
Specimen Label: E16
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796225
Stage: TS25
Assay Id: MGI:7561488
Age: embryonic day 17.0
Image: 1
Specimen Label: E17
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7561475
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796226
Stage: TS26
Assay Id: MGI:7561488
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:7560687
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:3570728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7561492
Age: postnatal
Image: S2A top
Note: Expression is at the ends of chromosomes in leptotene and throughout pachytene until the diplotene stage and then becomes undetectable in metaphase I.
Specimen Label: S2A top
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7560687
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:3570728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7561492
Age: postnatal
Image: S2A bottom
Note: Expression is at the ends of chromosomes in leptotene and throughout pachytene until the diplotene stage and then becomes undetectable in metaphase I.
Specimen Label: S2A bottom
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6694250
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6715979
Age: postnatal day 16
Image: 6c Meioc+/+
Specimen Label: 6c Meioc+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7560687
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3148628
Stage: TS28
Assay Id: MGI:7561492
Age: postnatal
Image: S2A bottom
Specimen Label: S2A bottom
Detected: false
Specimen Num: 2
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein KASH5
Type: chain
End: 648
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Publication
26742488 | J:231231
 
First Author: Abby E
Year: 2016
Journal: Nat Commun
Title: Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.
Volume: 7
Pages: 10324
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Publication
38485951 | J:346053
First Author: Zhang J
Year: 2024
Journal: Nat Commun
Title: Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.
Volume: 15
Issue: 1
Pages: 2315
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Publication
- | J:66661
       
First Author: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Year: 2001
Title: GenBank Record Derived Information
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
35703493 | J:326432
   
First Author: Agrawal R
Year: 2022
Journal: Elife
Title: The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor.
Volume: 11
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Publication
24586178 | J:211008
First Author: Link J
Year: 2014
Journal: PLoS Genet
Title: Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.
Volume: 10
Issue: 2
Pages: e1004099
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DO Term
DOID:0070587 | spermatogenic failure 88
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Protein Domain
IPR028168 | KASH5_coiled-coil
Type: Domain
Description: This is the central coiled-coil region of the protein KASH5 (also known as CCDC155). KASH5 may be involved in meiotic chromosome dynamics and homologue pairing []. The domain also appears to be present in a number of other proteins.
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Publication
22542100 | -
First Author: Lindeman RE
Year: 2012
Journal: Curr Biol
Title: Localized products of futile cycle/lrmp promote centrosome-nucleus attachment in the zebrafish zygote.
Volume: 22
Issue: 10
Pages: 843-51
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Protein Domain
IPR039508 | KASH5_EF-hand-like_dom
Type: Domain
Description: This entry represents the EF-hand-like domain found in protein KASH5. KASH5 is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton []. It interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localisation []. Proteins containing this domain also include lrmp from Zebra fish. It is a maternally expressed membrane and cytoskeletal linker protein, which is essential for attachment of the centrosome to the male pronucleus [].
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Publication
34039995 | J:340384
First Author: Chen Y
Year: 2021
Journal: Nat Commun
Title: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Volume: 12
Issue: 1
Pages: 3176
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Protein Domain
IPR018539 | SUN1
Type: Family
Description: SUN domain-containing protein 1 is a nuclear inner membrane protein and a component of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [].SUN1 contains a conserved Sad1p/UNC-84 (SUN)-domain at its C terminus that can associate with Klarsicht/ANC-1/Syne homology (KASH)-domain proteins []. The structure of the LINC complex has been solved []. In mammals, SUN1 is widely expressed and can bind to all four Nesprins (KASH-domain containing proteins) []. Sun1 and KASH5 are essential factors which mediate meiotic resumption and spindle formation [].
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Protein
D3Z0L7
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: true
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Publication
22632968 | -
First Author: Sosa BA
Year: 2012
Journal: Cell
Title: LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.
Volume: 149
Issue: 5
Pages: 1035-47
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Protein
Q3TSM1
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
E9LV88
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
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Protein
E9LV94
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
F6XYA0
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: true
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Protein
F7BX07
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Protein
D3Z1X3
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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