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Search results 1 to 100 out of 838 for Kat8

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
84148 | KAT8
Type: gene
Organism: human
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Gene
548988 | kat8
Type: gene
Organism: frog, western clawed
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Gene
121108154 | KAT8
Type: gene
Organism: chicken
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Gene
310194 | Kat8
Type: gene
Organism: rat
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Gene
479777 | KAT8
Type: gene
Organism: dog, domestic
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Gene
468102 | KAT8
Type: gene
Organism: chimpanzee
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Gene
100125883 | KAT8
Type: gene
Organism: cattle
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Gene
100003790 | kat8
Type: gene
Organism: zebrafish
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Gene
713117 | KAT8
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR037906 | KAT8
Type: Family
Description: Histone acetyltransferase KAT8 () has activity directed towards histones H3, H2A and H4 []and is the active component of the MSL and NSL complexes []. KAT8 autoacetylates itself on Lys-274 which is a requirement for binding to histone H4 []. In Drosophila melanogaster this protein is known as 'males-absent on the first protein' (MOF) [].The male-specific lethal (MSL) complex is a histone acetyltransferase with specificity for histone H4 'lysine-16' in chromatin. The complex consists of MOF, MSL1, MSL2, and MSL3 []. The complex was first identified in Drosophila.
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Protein Coding Gene
MGI:1915023 | Kat8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9D1P2
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
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Publication
10786633 | -
First Author: Neal KC
Year: 2000
Journal: Biochim Biophys Acta
Title: A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.
Volume: 1490
Issue: 1-2
Pages: 170-4
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Publication
22547026 | -
First Author: Huang J
Year: 2012
Journal: Cell Res
Title: Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex.
Volume: 22
Issue: 6
Pages: 1078-81
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Publication
22020126 | -
First Author: Yuan H
Year: 2012
Journal: EMBO J
Title: MYST protein acetyltransferase activity requires active site lysine autoacetylation.
Volume: 31
Issue: 1
Pages: 58-70
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Publication
30842237 | J:275220
First Author: Huai W
Year: 2019
Journal: J Exp Med
Title: KAT8 selectively inhibits antiviral immunity by acetylating IRF3.
Volume: 216
Issue: 4
Pages: 772-785
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Publication
20620954 | -
First Author: Raja SJ
Year: 2010
Journal: Mol Cell
Title: The nonspecific lethal complex is a transcriptional regulator in Drosophila.
Volume: 38
Issue: 6
Pages: 827-41
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Publication
16227571 | -
First Author: Smith ER
Year: 2005
Journal: Mol Cell Biol
Title: A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.
Volume: 25
Issue: 21
Pages: 9175-88
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Protein
A0A0U1RNW7
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Publication
28506985 | J:242000
First Author: Yin S
Year: 2017
Journal: Development
Title: Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels.
Volume: 144
Issue: 12
Pages: 2165-2174
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Protein
Q3V268
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
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Publication
31794431 | J:297798
First Author: Li L
Year: 2020
Journal: J Clin Invest
Title: Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability.
Volume: 130
Issue: 3
Pages: 1431-1445
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Publication
32671208 | J:292072
First Author: Pessoa Rodrigues C
Year: 2020
Journal: Sci Adv
Title: Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Volume: 6
Issue: 21
Pages: eaaz4815
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Gene
284058 | KANSL1
Type: gene
Organism: human
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Gene
55683 | KANSL3
Type: gene
Organism: human
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Gene
54934 | KANSL2
Type: gene
Organism: human
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Gene
151050 | KANSL1L
Type: gene
Organism: human
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Publication
32541879 | J:291094
First Author: Sheikh BN
Year: 2020
Journal: Nat Cell Biol
Title: Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature.
Volume: 22
Issue: 7
Pages: 828-841
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Publication
31576060 | J:282942
First Author: Karoutas A
Year: 2019
Journal: Nat Cell Biol
Title: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.
Volume: 21
Issue: 10
Pages: 1248-1260
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Publication
37479688 | J:338452
First Author: Wang D
Year: 2023
Journal: Nat Commun
Title: MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters.
Volume: 14
Issue: 1
Pages: 4404
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Publication
37813994 | J:347290
First Author: Guhathakurta S
Year: 2023
Journal: Nat Metab
Title: COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function.
Volume: 5
Issue: 11
Pages: 1931-1952
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Protein
E9QLE2
Organism: Mus musculus/domesticus
Length: 700  
Fragment?: false
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Protein
B1AQV9
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Publication
17335777 | J:120330
First Author: Dmitriev RI
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Characterization of hampin/MSL1 as a node in the nuclear interactome.
Volume: 355
Issue: 4
Pages: 1051-7
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Publication
38961108 | J:350446
First Author: Bi S
Year: 2024
Journal: Nat Commun
Title: KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2.
Volume: 15
Issue: 1
Pages: 5602
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Publication
24842875 | J:313850
 
First Author: Chelmicki T
Year: 2014
Journal: Elife
Title: MOF-associated complexes ensure stem cell identity and Xist repression.
Volume: 3
Pages: e02024
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Protein
Q80TG1
Organism: Mus musculus/domesticus
Length: 1036  
Fragment?: false
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Protein
Q5DTI6
Organism: Mus musculus/domesticus
Length: 991  
Fragment?: false
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Protein
A2A5Y4
Organism: Mus musculus/domesticus
Length: 1099  
Fragment?: false
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Protein
F6ULJ7
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: true
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Protein
Q8BQR4
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
F8WJE3
Organism: Mus musculus/domesticus
Length: 452  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0030530 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032979 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033048 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1915023 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033557 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032091 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032735 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032887 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032840 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032981 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032872 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013737 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031644 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
21321203 | J:170483
First Author: Kumar R
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.
Volume: 108
Issue: 9
Pages: 3636-41
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Publication
33376138 | J:338707
 
First Author: Lei H
Year: 2021
Journal: J Biol Chem
Title: Dysregulation of intercellular signaling by MOF deletion leads to liver injury.
Volume: 296
Pages: 100235
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Publication
28202522 | J:242085
First Author: Valerio DG
Year: 2017
Journal: Cancer Res
Title: Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.
Volume: 77
Issue: 7
Pages: 1753-1762
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Publication
18541669 | J:139761
First Author: Thomas T
Year: 2008
Journal: Mol Cell Biol
Title: Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture.
Volume: 28
Issue: 16
Pages: 5093-105
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Publication
23386701 | J:210129
First Author: Gupta A
Year: 2013
Journal: Mutagenesis
Title: T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.
Volume: 28
Issue: 3
Pages: 263-70
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Publication
29975939 | J:272095
First Author: Yang Y
Year: 2018
Journal: Cell Physiol Biochem
Title: Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis.
Volume: 47
Issue: 5
Pages: 2159-2169
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Publication
22862943 | J:338458
First Author: Li X
Year: 2012
Journal: Cell Stem Cell
Title: The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network.
Volume: 11
Issue: 2
Pages: 163-78
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Publication
27768893 | J:238087
First Author: Chatterjee A
Year: 2016
Journal: Cell
Title: MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Volume: 167
Issue: 3
Pages: 722-738.e23
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Publication
26387537 | J:234312
First Author: Sheikh BN
Year: 2016
Journal: Oncogene
Title: MOF maintains transcriptional programs regulating cellular stress response.
Volume: 35
Issue: 21
Pages: 2698-710
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Publication
38034359 | J:351416
First Author: Guo X
Year: 2023
Journal: iScience
Title: Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions.
Volume: 26
Issue: 12
Pages: 108446
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Publication
34362741 | J:314355
 
First Author: Pessoa Rodrigues C
Year: 2021
Journal: Sci Adv
Title: Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells.
Volume: 7
Issue: 32
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Publication
24898753 | J:347144
   
First Author: Ravens S
Year: 2014
Journal: Elife
Title: Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation.
Volume: 3
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Publication
24802406 | J:222012
First Author: Qiao W
Year: 2014
Journal: Biochem Biophys Res Commun
Title: The histone acetyltransferase MOF overexpression blunts cardiac hypertrophy by targeting ROS in mice.
Volume: 448
Issue: 4
Pages: 379-84
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3713376
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Brain
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624728
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Gut
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Heart
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Liver
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Lung
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Muscle
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Skin
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Spleen
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Testis
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3713376
Age: postnatal adult
Image: 1
Specimen Label: Thymus
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3713389
Age: embryonic day 12.5
Image: 5
Specimen Label: E12.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797227
Stage: TS27
Assay Id: MGI:3713389
Age: postnatal day 0
Image: 5
Specimen Label: PN0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 7
Image: 5
Specimen Label: PN7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 14
Image: 5
Specimen Label: PN14
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 21
Image: 5
Specimen Label: PN21
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 28
Image: 5
Specimen Label: PN28
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 35
Image: 5
Specimen Label: PN35
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 42
Image: 5
Specimen Label: PN42
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 14
Image: 5
Specimen Label: PN14
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 21
Image: 5
Specimen Label: PN21
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 28
Image: 5
Specimen Label: PN28
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 35
Image: 5
Specimen Label: PN35
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3713368
Assay Type: Northern blot
Annotation Date: 2007-07-02
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3713389
Age: postnatal day 42
Image: 5
Specimen Label: PN42
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6115785
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Male
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:6115826
Age: embryonic day 14.5
Image: 2
Specimen Label: WT-M
Detected: true
Specimen Num: 1
•
•
•
•
•




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