Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
TASK is a member of the TWIK-related (two P-domain) K+channel familyidentified in human tissues []. It is widely distributed, being particularly abundant in the pancreas and placenta, but it is also found inthe brain, heart, lung and kidney. Its amino acid identity to TWIK-1 and TREK-1 is rather low, being about 25-28%. However, it is thought to share the same topology of four TM segments, with two P-domains. TASK is very sensitive to variations in extracellular pH in the physiological range, changing from fully-open to closed in approximately 0.5 pH units around pH 7.4. Thus, it may well be a biological sensor of external pH variations.Potassium channel subfamily K member 3 (KCNK3, also known as TASK-1) was the first member of the TASK family to be cloned. It is widelydistributed, being particularly abundant in the pancreas and placenta, but is also found in the brain, heart, lung and kidney. In addition to the maintenance of the resting membrane potential, it is also involved in K+ transport associated with recycling/secretion and the modulation of electrical activity of excitable cells []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Duprat F |
Year: |
1997 |
Journal: |
EMBO J |
Title: |
TASK, a human background K+ channel to sense external pH variations near physiological pH. |
Volume: |
16 |
Issue: |
17 |
Pages: |
5464-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manjunath NA |
Year: |
1999 |
Journal: |
Cytogenet Cell Genet |
Title: |
Assignment of the 2P domain, acid-sensitive potassium channel OAT1 gene KCNK3 to human chromosome bands 2p24.1-->p23.3 and murine 5B by in situ hybridization. |
Volume: |
86 |
Issue: |
3-4 |
Pages: |
242-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muhammad S |
Year: |
2010 |
Journal: |
Neuroscience |
Title: |
Expression of the kcnk3 potassium channel gene lessens the injury from cerebral ischemia, most likely by a general influence on blood pressure. |
Volume: |
167 |
Issue: |
3 |
Pages: |
758-64 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
409
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
299
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lesage F |
Year: |
2000 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Molecular and functional properties of two-pore-domain potassium channels. |
Volume: |
279 |
Issue: |
5 |
Pages: |
F793-801 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murtaza G |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
TASK-1 potassium channel is not critically involved in mediating hypoxic pulmonary vasoconstriction of murine intra-pulmonary arteries. |
Volume: |
12 |
Issue: |
3 |
Pages: |
e0174071 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2017 |
Journal: |
Cell |
Title: |
Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity. |
Volume: |
171 |
Issue: |
4 |
Pages: |
836-848.e13 |
|
•
•
•
•
•
|
Publication |
First Author: |
El Wakil A |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex. |
Volume: |
21 |
Issue: |
22 |
Pages: |
4922-9 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Dadi PK |
Year: |
2015 |
Journal: |
Mol Endocrinol |
Title: |
TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion. |
Volume: |
29 |
Issue: |
5 |
Pages: |
777-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aller MI |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons. |
Volume: |
25 |
Issue: |
49 |
Pages: |
11455-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jungbauer S |
Year: |
2017 |
Journal: |
Respir Physiol Neurobiol |
Title: |
Sex-dependent differences in the in vivo respiratory phenotype of the TASK-1 potassium channel knockout mouse. |
Volume: |
245 |
|
Pages: |
13-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meuth SG |
Year: |
2006 |
Journal: |
Mol Pharmacol |
Title: |
The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons. |
Volume: |
69 |
Issue: |
4 |
Pages: |
1468-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heitzmann D |
Year: |
2008 |
Journal: |
EMBO J |
Title: |
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis. |
Volume: |
27 |
Issue: |
1 |
Pages: |
179-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murtaza G |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Avertin®, but Not Volatile Anesthetics Addressing the Two-Pore Domain K+ Channel, TASK-1, Slows Down Cilia-Driven Particle Transport in the Mouse Trachea. |
Volume: |
11 |
Issue: |
12 |
Pages: |
e0167919 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meuth SG |
Year: |
2009 |
Journal: |
Neurobiol Dis |
Title: |
The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice. |
Volume: |
33 |
Issue: |
1 |
Pages: |
1-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi L |
Year: |
2019 |
Journal: |
Front Physiol |
Title: |
Mineralocorticoid Receptor-Dependent Impairment of Baroreflex Contributes to Hypertension in a Mouse Model of Primary Aldosteronism. |
Volume: |
10 |
|
Pages: |
1434 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitagawa MG |
Year: |
2017 |
Journal: |
Front Med (Lausanne) |
Title: |
Hemodynamic and Pathologic Characterization of the TASK-1(-/-) Mouse Does Not Demonstrate Pulmonary Hypertension. |
Volume: |
4 |
|
Pages: |
177 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Z |
Year: |
2023 |
Journal: |
Front Physiol |
Title: |
Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism. |
Volume: |
14 |
|
Pages: |
1136574 |
|
•
•
•
•
•
|
Publication |
First Author: |
Albrecht S |
Year: |
2019 |
Journal: |
Glia |
Title: |
The K2P -channel TASK1 affects Oligodendroglial differentiation but not myelin restoration. |
Volume: |
67 |
Issue: |
5 |
Pages: |
870-883 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hawkins V |
Year: |
2013 |
Journal: |
Neurobiol Dis |
Title: |
TASK-1 channels in oligodendrocytes: a role in ischemia mediated disruption. |
Volume: |
55 |
|
Pages: |
87-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donner BC |
Year: |
2011 |
Journal: |
Basic Res Cardiol |
Title: |
Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability. |
Volume: |
106 |
Issue: |
1 |
Pages: |
75-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiedmann F |
Year: |
2018 |
Journal: |
Basic Res Cardiol |
Title: |
Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K2P) channels in murine disease models: focus on TASK-1. |
Volume: |
113 |
Issue: |
4 |
Pages: |
27 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3707785 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-05-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1733125 |
|
Stage: |
TS25 |
Assay Id: |
MGI:3707988 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
Fetus |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3707785 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-05-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1733127 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3707988 |
Age: |
postnatal day 1 |
|
|
Specimen Label: |
Neonate |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3707785 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-05-14 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1733128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3707988 |
Age: |
postnatal week 5-8 |
|
|
Specimen Label: |
Adult |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3707785 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-05-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610525 |
|
Stage: |
TS25 |
Assay Id: |
MGI:3709286 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
Fetus |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3707785 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-05-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3709286 |
Age: |
postnatal day 1 |
|
|
Specimen Label: |
Neonate |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3707785 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-05-17 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3709286 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Adult |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433546 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360422 |
|
Stage: |
TS02 |
Assay Id: |
MGI:5433718 |
Age: |
embryonic day 1.0 |
|
|
Specimen Label: |
2-Cell |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433546 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360443 |
|
Stage: |
TS03 |
Assay Id: |
MGI:5433718 |
Age: |
embryonic day 2.5 |
|
|
Specimen Label: |
8-Cell |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433546 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360453 |
|
Stage: |
TS03 |
Assay Id: |
MGI:5433718 |
Age: |
embryonic day 3.0 |
|
|
Specimen Label: |
Morula |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433546 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:5433718 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
Blastocyst |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433548 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360422 |
|
Stage: |
TS02 |
Assay Id: |
MGI:5433723 |
Age: |
embryonic day 1.0 |
|
|
Specimen Label: |
2-Cell |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433548 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360443 |
|
Stage: |
TS03 |
Assay Id: |
MGI:5433723 |
Age: |
embryonic day 2.5 |
|
|
Specimen Label: |
8-Cell |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433548 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360453 |
|
Stage: |
TS03 |
Assay Id: |
MGI:5433723 |
Age: |
embryonic day 3.0 |
|
|
Specimen Label: |
Morula |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433548 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:5433723 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
Blastocyst |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433546 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3575528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5433718 |
Age: |
postnatal adult |
|
|
Specimen Label: |
OocyteMII |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433548 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3575528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5433723 |
Age: |
postnatal adult |
|
|
Specimen Label: |
OocyteMII |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3515226 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 18.5 |
Image: |
5I |
Note: |
Expression is in the right bundle branch of the interventricular septum. |
Specimen Label: |
5I |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3542826 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 18.5 |
Image: |
5G |
|
Specimen Label: |
5G |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3542821 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 13.5 |
Image: |
5E |
|
Specimen Label: |
5E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268813 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 8.5 |
Image: |
5A |
|
Specimen Label: |
5A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268815 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 9.5 |
Image: |
5B |
|
Specimen Label: |
5B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1733321 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 13.5 |
Image: |
5E |
Note: |
Expression is at the outer edges. |
Specimen Label: |
5E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268617 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 10.5 |
Image: |
5C |
Note: |
Expression is in regions of endocardium undergoing endocardial to mesenchymal transition. |
Specimen Label: |
5C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433709 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:5433735 |
Age: |
embryonic day 3.5 |
|
Note: |
Expressed in the plasma membrane. |
Specimen Label: |
2C Blastocyst |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274617 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 10.5 |
Image: |
5C |
|
Specimen Label: |
5C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635317 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 10.5 |
Image: |
5C |
|
Specimen Label: |
5C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433709 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-09-13 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3575528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5433735 |
Age: |
postnatal adult |
|
Note: |
Expressed in the plasma membrane. |
Specimen Label: |
2C OocyteMII |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5433709 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-09-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:160362 |
Pattern: |
Not Specified |
Stage: |
TS02 |
Assay Id: |
MGI:5433735 |
Age: |
embryonic day 1.0 |
|
Note: |
Expressed in the plasma membrane. |
Specimen Label: |
2C 2-Cell |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274821 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 13.5 |
Image: |
5E |
Note: |
Expression is in the trabeculated myocardium of the ventricles. |
Specimen Label: |
5E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3672126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 18.5 |
Image: |
5G |
|
Specimen Label: |
5G |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3672117 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 10.5 |
Image: |
5C |
Note: |
Expression is strongest in the trabecular myocardium of the ventricles. |
Specimen Label: |
5C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6750849 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3672121 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6750852 |
Age: |
embryonic day 13.5 |
Image: |
5E |
Note: |
Expression is in the trabeculated myocardium of the ventricles. |
Specimen Label: |
5E |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guagliardo NA |
Year: |
2011 |
Journal: |
Mol Cell Endocrinol |
Title: |
TASK channels are not required to mount an aldosterone secretory response to metabolic acidosis in mice. |
Volume: |
336 |
Issue: |
1-2 |
Pages: |
47-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davies LA |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
TASK channel deletion in mice causes primary hyperaldosteronism. |
Volume: |
105 |
Issue: |
6 |
Pages: |
2203-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mulkey DK |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity. |
Volume: |
27 |
Issue: |
51 |
Pages: |
14049-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manoury B |
Year: |
2011 |
Journal: |
J Physiol |
Title: |
Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice. |
Volume: |
589 |
Issue: |
Pt 13 |
Pages: |
3231-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buehler PK |
Year: |
2017 |
Journal: |
Respir Physiol Neurobiol |
Title: |
Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice. |
Volume: |
244 |
|
Pages: |
17-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue M |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Lack of p11 expression facilitates acidity-sensing function of TASK1 channels in mouse adrenal medullary cells. |
Volume: |
33 |
Issue: |
1 |
Pages: |
455-468 |
|
•
•
•
•
•
|
Publication |
First Author: |
Turner PJ |
Year: |
2013 |
Journal: |
J Physiol |
Title: |
Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells. |
Volume: |
591 |
Issue: |
23 |
Pages: |
5977-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pang DS |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action. |
Volume: |
106 |
Issue: |
41 |
Pages: |
17546-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Trapp S |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing. |
Volume: |
28 |
Issue: |
35 |
Pages: |
8844-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vu MT |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
TASK Channels on Basal Forebrain Cholinergic Neurons Modulate Electrocortical Signatures of Arousal by Histamine. |
Volume: |
35 |
Issue: |
40 |
Pages: |
13555-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goldberg EM |
Year: |
2011 |
Journal: |
Cereb Cortex |
Title: |
Rapid developmental maturation of neocortical FS cell intrinsic excitability. |
Volume: |
21 |
Issue: |
3 |
Pages: |
666-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
González JA |
Year: |
2009 |
Journal: |
Eur J Neurosci |
Title: |
Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons. |
Volume: |
30 |
Issue: |
1 |
Pages: |
57-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duan W |
Year: |
2020 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction. |
Volume: |
318 |
Issue: |
3 |
Pages: |
H566-H580 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao C |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
TASK channels contribute to neuroprotective action of inhalational anesthetics. |
Volume: |
7 |
|
Pages: |
44203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bista P |
Year: |
2015 |
Journal: |
J Physiol |
Title: |
Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. |
Volume: |
593 |
Issue: |
1 |
Pages: |
127-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao J |
Year: |
2017 |
Journal: |
Hypertension |
Title: |
Functional TASK-3-Like Channels in Mitochondria of Aldosterone-Producing Zona Glomerulosa Cells. |
Volume: |
70 |
Issue: |
2 |
Pages: |
347-356 |
|
•
•
•
•
•
|