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Search results 1 to 100 out of 140 for Kcnk9

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0.074s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: guinea pig
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: TASK is a member of the TWIK-related (two P-domain) K+channel familyidentified in human tissues []. It is widely distributed, being particularly abundant in the pancreas and placenta, but it is also found inthe brain, heart, lung and kidney. Its amino acid identity to TWIK-1 and TREK-1 is rather low, being about 25-28%. However, it is thought to share the same topology of four TM segments, with two P-domains. TASK is very sensitive to variations in extracellular pH in the physiological range, changing from fully-open to closed in approximately 0.5 pH units around pH 7.4. Thus, it may well be a biological sensor of external pH variations.Potassium channel subfamily K member 9 (KCNK9, also known as TASK3) is a pH-dependent, voltage-insensitive, background potassium channel protein [, ].
Protein
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: false
Publication
First Author: Duprat F
Year: 1997
Journal: EMBO J
Title: TASK, a human background K+ channel to sense external pH variations near physiological pH.
Volume: 16
Issue: 17
Pages: 5464-71
Publication
First Author: Chapman CG
Year: 2000
Journal: Brain Res Mol Brain Res
Title: Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.
Volume: 82
Issue: 1-2
Pages: 74-83
Publication
First Author: Vega-Saenz de Miera E
Year: 2001
Journal: J Neurophysiol
Title: KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1.
Volume: 86
Issue: 1
Pages: 130-42
Publication
First Author: Cooper A
Year: 2020
Journal: Nat Commun
Title: Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.
Volume: 11
Issue: 1
Pages: 480
Publication
First Author: Bando Y
Year: 2014
Journal: Cereb Cortex
Title: Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex.
Volume: 24
Issue: 4
Pages: 1017-29
Publication
First Author: Hur CG
Year: 2012
Journal: Reproduction
Title: K(+) efflux through two-pore domain K(+) channels is required for mouse embryonic development.
Volume: 143
Issue: 5
Pages: 625-36
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Penton D
Year: 2012
Journal: Endocrinology
Title: Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension.
Volume: 153
Issue: 10
Pages: 4740-8
Publication  
First Author: Gotter AL
Year: 2011
Journal: Brain Res
Title: TASK-3 as a potential antidepressant target.
Volume: 1416
Pages: 69-79
Publication
First Author: Brickley SG
Year: 2007
Journal: J Neurosci
Title: TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons.
Volume: 27
Issue: 35
Pages: 9329-40
Publication
First Author: Linden AM
Year: 2007
Journal: J Pharmacol Exp Ther
Title: TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation anesthetics.
Volume: 323
Issue: 3
Pages: 924-34
Publication
First Author: Guagliardo NA
Year: 2012
Journal: Hypertension
Title: TASK-3 channel deletion in mice recapitulates low-renin essential hypertension.
Volume: 59
Issue: 5
Pages: 999-1005
Publication  
First Author: Liao P
Year: 2019
Journal: Sci Transl Med
Title: Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models.
Volume: 11
Issue: 519
Publication
First Author: Wen X
Year: 2022
Journal: Sci Adv
Title: Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina.
Volume: 8
Issue: 36
Pages: eabn8785
Publication
First Author: Clarke CE
Year: 2008
Journal: J Biol Chem
Title: The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function.
Volume: 283
Issue: 25
Pages: 16985-92
Publication
First Author: Yoshida K
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Leak potassium channels regulate sleep duration.
Volume: 115
Issue: 40
Pages: E9459-E9468
Publication
First Author: Maltby CJ
Year: 2020
Journal: Nucleic Acids Res
Title: A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
Volume: 48
Issue: 17
Pages: 9822-9839
GXD Expression      
Probe: MGI:5433551
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:5433719
Age: embryonic day 1.0
Specimen Label: 2-Cell
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5433551
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:5433719
Age: embryonic day 2.5
Specimen Label: 8-Cell
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5433551
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:5433719
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5433551
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:5433719
Age: embryonic day 3.5
Specimen Label: Blastocyst
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5433553
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:5433724
Age: embryonic day 1.0
Specimen Label: 2-Cell
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5433553
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:5433724
Age: embryonic day 2.5
Specimen Label: 8-Cell
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5433553
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:5433724
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5433553
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:5433724
Age: embryonic day 3.5
Specimen Label: Blastocyst
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5433551
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:5433719
Age: postnatal adult
Specimen Label: OocyteMII
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5433553
Assay Type: RT-PCR
Annotation Date: 2012-09-13
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:5433724
Age: postnatal adult
Specimen Label: OocyteMII
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6196589
Age: embryonic day 15.0
Specimen Label: 1B E15
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6196589
Age: embryonic day 17.0
Specimen Label: 1B E17
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 0
Specimen Label: 1B P0
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 3
Specimen Label: 1B P3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 0
Specimen Label: 1B P0
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 3
Specimen Label: 1B P3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6196589
Age: embryonic day 15.0
Specimen Label: 1B E15
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 3
Note: Increased expression after birth.
Specimen Label: 1B P3
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 0
Note: Increased expression after birth.
Specimen Label: 1B P0
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6196589
Age: embryonic day 17.0
Specimen Label: 1B E17
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6196589
Age: embryonic day 15.0
Specimen Label: 1B E15
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6196589
Age: embryonic day 17.0
Specimen Label: 1B E17
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 0
Specimen Label: 1B P0
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 3
Specimen Label: 1B P3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6196589
Age: embryonic day 17.0
Specimen Label: 1B E17
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 0
Specimen Label: 1B P0
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 3
Specimen Label: 1B P3
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:5433560
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:5433736
Age: embryonic day 3.5
Note: Expressed in the plasma membrane.
Specimen Label: 2C Blastocyst
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6196589
Age: embryonic day 15.0
Specimen Label: 1B E15
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6196589
Age: embryonic day 15.0
Specimen Label: 1B E15
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6196589
Age: embryonic day 17.0
Specimen Label: 1B E17
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3525527
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 0
Specimen Label: 1B P0
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3525527
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 3
Specimen Label: 1B P3
Detected: false
Specimen Num: 4
GXD Expression  
Probe: MGI:5433560
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-13
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5433736
Age: postnatal adult
Note: Expressed in the plasma membrane.
Specimen Label: 2C OocyteMII
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 0
Specimen Label: 1B P0
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6196576
Assay Type: RNA in situ
Annotation Date: 2018-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6196589
Age: postnatal day 3
Specimen Label: 1B P3
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:5433560
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:5433736
Age: embryonic day 1.0
Note: Expressed in the plasma membrane.
Specimen Label: 2C 2-Cell
Detected: true
Specimen Num: 2
Publication
First Author: Dadi PK
Year: 2014
Journal: Endocrinology
Title: Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.
Volume: 155
Issue: 10
Pages: 3757-68
Publication
First Author: Mulkey DK
Year: 2007
Journal: J Neurosci
Title: TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity.
Volume: 27
Issue: 51
Pages: 14049-58
Publication
First Author: Trapp S
Year: 2008
Journal: J Neurosci
Title: A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing.
Volume: 28
Issue: 35
Pages: 8844-50
Publication
First Author: Turner PJ
Year: 2013
Journal: J Physiol
Title: Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells.
Volume: 591
Issue: 23
Pages: 5977-98
Publication
First Author: Pang DS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.
Volume: 106
Issue: 41
Pages: 17546-51
Publication  
First Author: Buehler PK
Year: 2017
Journal: Respir Physiol Neurobiol
Title: Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice.
Volume: 244
Pages: 17-25
Publication
First Author: Muhammad S
Year: 2010
Journal: Neuroscience
Title: Expression of the kcnk3 potassium channel gene lessens the injury from cerebral ischemia, most likely by a general influence on blood pressure.
Volume: 167
Issue: 3
Pages: 758-64
Publication
First Author: Inoue M
Year: 2019
Journal: FASEB J
Title: Lack of p11 expression facilitates acidity-sensing function of TASK1 channels in mouse adrenal medullary cells.
Volume: 33
Issue: 1
Pages: 455-468
Publication
First Author: Guagliardo NA
Year: 2011
Journal: Mol Cell Endocrinol
Title: TASK channels are not required to mount an aldosterone secretory response to metabolic acidosis in mice.
Volume: 336
Issue: 1-2
Pages: 47-52
Publication
First Author: Manoury B
Year: 2011
Journal: J Physiol
Title: Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice.
Volume: 589
Issue: Pt 13
Pages: 3231-46
Publication
First Author: Duan W
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
Volume: 318
Issue: 3
Pages: H566-H580
Publication
First Author: Goldberg EM
Year: 2011
Journal: Cereb Cortex
Title: Rapid developmental maturation of neocortical FS cell intrinsic excitability.
Volume: 21
Issue: 3
Pages: 666-82
Publication
First Author: Bista P
Year: 2015
Journal: J Physiol
Title: Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons.
Volume: 593
Issue: 1
Pages: 127-44
Publication
First Author: González JA
Year: 2009
Journal: Eur J Neurosci
Title: Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons.
Volume: 30
Issue: 1
Pages: 57-64
Publication  
First Author: Yao C
Year: 2017
Journal: Sci Rep
Title: TASK channels contribute to neuroprotective action of inhalational anesthetics.
Volume: 7
Pages: 44203