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Search results 1 to 100 out of 383 for Keap1

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Hits by Pathway

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Type Details Score
Gene
9817 | KEAP1
Type: gene
Organism: human
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Gene
532791 | KEAP1
Type: gene
Organism: cattle
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Gene
720514 | KEAP1
Type: gene
Organism: macaque, rhesus
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Gene
493386 | keap1
Type: gene
Organism: frog, western clawed
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Gene
117519 | Keap1
Type: gene
Organism: rat
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Gene
476713 | KEAP1
Type: gene
Organism: dog, domestic
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Gene
455706 | KEAP1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1858732 | Keap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR030563 | KEAP1
Type: Family
Description: Kelch-like ECH-associated protein 1 (KEAP1, also known as KLHL19) is a BTB-Kelch substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex that functions as a sensor for thiol-reactive chemopreventive compounds and oxidative stress. It targets NFE2L2/NRF2 (a transcription factor) for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression [, ]. Another KEAP1 substrate, PGAM5, a Bcl-XL-interacting protein, has also been identified [].The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ].
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Publication
15983046 | -
First Author: Zhang DD
Year: 2005
Journal: J Biol Chem
Title: Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
Volume: 280
Issue: 34
Pages: 30091-9
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Publication
14585973 | -
First Author: Zhang DD
Year: 2003
Journal: Mol Cell Biol
Title: Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
Volume: 23
Issue: 22
Pages: 8137-51
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Publication
32487458 | J:315966
 
First Author: Kopacz A
Year: 2020
Journal: Redox Biol
Title: Keap1 governs ageing-induced protein aggregation in endothelial cells.
Volume: 34
Pages: 101572
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Publication
33103077 | J:316007
First Author: Knatko EV
Year: 2020
Journal: iScience
Title: Downregulation of Keap1 Confers Features of a Fasted Metabolic State.
Volume: 23
Issue: 10
Pages: 101638
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Publication
27804998 | J:266717
 
First Author: Tan RJ
Year: 2016
Journal: Sci Rep
Title: Keap1 hypomorphism protects against ischemic and obstructive kidney disease.
Volume: 6
Pages: 36185
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Publication
31491600 | J:297207
 
First Author: Kopacz A
Year: 2020
Journal: Redox Biol
Title: Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells.
Volume: 28
Pages: 101304
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Publication
21177379 | J:169317
First Author: Suzuki T
Year: 2011
Journal: Cancer Res
Title: Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.
Volume: 71
Issue: 5
Pages: 1700-9
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Publication
25483186 | J:278501
First Author: Hu M
Year: 2014
Journal: Cell Cycle
Title: Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver.
Volume: 13
Issue: 15
Pages: 2349-58
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Publication
26527616 | J:235914
First Author: Saito R
Year: 2015
Journal: Mol Cell Biol
Title: Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.
Volume: 36
Issue: 2
Pages: 271-84
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Publication
22872865 | J:188592
First Author: Taguchi K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Keap1 degradation by autophagy for the maintenance of redox homeostasis.
Volume: 109
Issue: 34
Pages: 13561-6
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Publication
24489685 | J:212699
First Author: Kim S
Year: 2014
Journal: PLoS One
Title: Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation.
Volume: 9
Issue: 1
Pages: e85984
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Publication
37889752 | J:342861
First Author: Zavitsanou AM
Year: 2023
Journal: Cell Rep
Title: KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance.
Volume: 42
Issue: 11
Pages: 113295
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Publication
27335232 | J:252012
First Author: Xie L
Year: 2016
Journal: Diabetes
Title: Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.
Volume: 65
Issue: 10
Pages: 3171-84
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Publication
19520915 | J:170960
First Author: Blake DJ
Year: 2010
Journal: Am J Respir Cell Mol Biol
Title: Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.
Volume: 42
Issue: 5
Pages: 524-36
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Publication
16507366 | J:108124
First Author: Padmanabhan B
Year: 2006
Journal: Mol Cell
Title: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
Volume: 21
Issue: 5
Pages: 689-700
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Publication
16293230 | J:103791
First Author: Okawa H
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.
Volume: 339
Issue: 1
Pages: 79-88
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Publication
12145307 | J:79285
First Author: Zipper LM
Year: 2002
Journal: J Biol Chem
Title: The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.
Volume: 277
Issue: 39
Pages: 36544-52
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Publication
19167360 | J:146141
First Author: Satoh T
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice.
Volume: 380
Issue: 2
Pages: 298-302
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Publication
31941926 | J:292849
First Author: Yin Y
Year: 2020
Journal: Sci Rep
Title: Moderate Nrf2 Activation by Genetic Disruption of Keap1 Has Sex-Specific Effects on Bone Mass in Mice.
Volume: 10
Issue: 1
Pages: 348
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Publication
24769730 | J:229860
First Author: Cazanave SC
Year: 2014
Journal: Cell Death Differ
Title: Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis.
Volume: 21
Issue: 8
Pages: 1303-12
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Publication
12653965 | J:270874
First Author: Itoh K
Year: 2003
Journal: Genes Cells
Title: Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.
Volume: 8
Issue: 4
Pages: 379-91
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Publication
21383067 | J:172813
First Author: Sun Z
Year: 2011
Journal: Mol Cell Biol
Title: KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.
Volume: 31
Issue: 9
Pages: 1800-11
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Publication
23274085 | J:195093
First Author: Bae SH
Year: 2013
Journal: Cell Metab
Title: Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Volume: 17
Issue: 1
Pages: 73-84
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Publication
38048653 | J:343759
 
First Author: Ziros PG
Year: 2023
Journal: Redox Biol
Title: Transcriptomic profiling of the response to excess iodide in Keap1 hypomorphic mice reveals new gene-environment interactions in thyroid homeostasis.
Volume: 69
Pages: 102978
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Publication
20956331 | J:166156
First Author: McMahon M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.
Volume: 107
Issue: 44
Pages: 18838-43
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Publication
22342405 | J:318951
First Author: Williamson TP
Year: 2012
Journal: Neurotoxicology
Title: Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.
Volume: 33
Issue: 3
Pages: 272-9
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Publication
18268004 | J:133900
First Author: Yamamoto T
Year: 2008
Journal: Mol Cell Biol
Title: Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.
Volume: 28
Issue: 8
Pages: 2758-70
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Publication
20421418 | J:162670
First Author: Lau A
Year: 2010
Journal: Mol Cell Biol
Title: A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
Volume: 30
Issue: 13
Pages: 3275-85
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Publication
28971839 | J:270385
First Author: Hamada S
Year: 2018
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.
Volume: 314
Issue: 1
Pages: G65-G74
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Publication
15282312 | J:279942
First Author: Kobayashi A
Year: 2004
Journal: Mol Cell Biol
Title: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Volume: 24
Issue: 16
Pages: 7130-9
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Publication
9887101 | J:61871
First Author: Itoh K
Year: 1999
Journal: Genes Dev
Title: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
Volume: 13
Issue: 1
Pages: 76-86
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Publication
19386581 | J:149475
First Author: Yates MS
Year: 2009
Journal: Carcinogenesis
Title: Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
Volume: 30
Issue: 6
Pages: 1024-31
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Publication
31169361 | J:292826
First Author: Hirose H
Year: 2019
Journal: Chembiochem
Title: A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.
Volume: 20
Issue: 16
Pages: 2089-2100
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Publication
15899855 | J:99135
First Author: Velichkova M
Year: 2005
Journal: Mol Cell Biol
Title: Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.
Volume: 25
Issue: 11
Pages: 4501-13
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Publication
16581765 | J:240280
First Author: Tong KI
Year: 2006
Journal: Mol Cell Biol
Title: Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
Volume: 26
Issue: 8
Pages: 2887-900
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Publication
20133743 | J:157548
First Author: Ogura T
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
Volume: 107
Issue: 7
Pages: 2842-7
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Publication
33857757 | J:337886
 
First Author: Onoki T
Year: 2021
Journal: Redox Biol
Title: Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice.
Volume: 43
Pages: 101966
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Publication
17046835 | -
First Author: Lo SC
Year: 2006
Journal: J Biol Chem
Title: PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.
Volume: 281
Issue: 49
Pages: 37893-903
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Publication
21799073 | J:207596
First Author: Kong X
Year: 2011
Journal: Am J Respir Crit Care Med
Title: Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis.
Volume: 184
Issue: 8
Pages: 928-38
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Publication
14764898 | J:219105
First Author: Kang MI
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.
Volume: 101
Issue: 7
Pages: 2046-51
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Protein
O89076
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
Q3UWI4
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
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Protein
Q9Z2X8
Organism: Mus musculus/domesticus
Length: 624  
Fragment?: false
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Protein
A0A1L1SS10
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Protein
Q05DM3
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: true
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Publication
12193649 | J:78907
First Author: Dinkova-Kostova AT
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
Volume: 99
Issue: 18
Pages: 11908-13
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Publication
10603472 | -
First Author: Adams J
Year: 2000
Journal: Trends Cell Biol
Title: The kelch repeat superfamily of proteins: propellers of cell function.
Volume: 10
Issue: 1
Pages: 17-24
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Publication
14528312 | -
First Author: Furukawa M
Year: 2003
Journal: Nat Cell Biol
Title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
Volume: 5
Issue: 11
Pages: 1001-7
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Publication
23135275 | -
First Author: Oberg EA
Year: 2012
Journal: J Biol Chem
Title: Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.
Volume: 287
Issue: 52
Pages: 43378-89
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Publication
15544948 | -
First Author: Stogios PJ
Year: 2004
Journal: Trends Biochem Sci
Title: The BACK domain in BTB-kelch proteins.
Volume: 29
Issue: 12
Pages: 634-7
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Publication
23676014 | -
 
First Author: Dhanoa BS
Year: 2013
Journal: Hum Genomics
Title: Update on the Kelch-like (KLHL) gene family.
Volume: 7
Pages: 13
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Publication
16785233 | J:116771
First Author: He X
Year: 2006
Journal: J Biol Chem
Title: Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
Volume: 281
Issue: 33
Pages: 23620-31
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Publication
31961719 | J:293394
First Author: Nabeshima T
Year: 2020
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Keap1 deletion accelerates mutant K-ras/p53-driven cholangiocarcinoma.
Volume: 318
Issue: 3
Pages: G419-G427
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Publication
31315052 | J:284404
First Author: Suzuki T
Year: 2019
Journal: Cell Rep
Title: Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1.
Volume: 28
Issue: 3
Pages: 746-758.e4
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Publication
33149211 | J:300417
First Author: Tamatam CM
Year: 2020
Journal: Sci Rep
Title: Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Volume: 10
Issue: 1
Pages: 19034
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Publication
23986495 | J:201047
First Author: Baird L
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex.
Volume: 110
Issue: 38
Pages: 15259-64
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Publication
12682069 | J:83874
First Author: McMahon M
Year: 2003
Journal: J Biol Chem
Title: Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
Volume: 278
Issue: 24
Pages: 21592-600
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Publication
24492006 | J:206722
First Author: Ishimura R
Year: 2014
Journal: FEBS Lett
Title: Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.
Volume: 588
Issue: 5
Pages: 822-8
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Publication
17904103 | J:127336
First Author: Toyama T
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity.
Volume: 363
Issue: 3
Pages: 645-50
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Publication
15367669 | J:279946
First Author: Cullinan SB
Year: 2004
Journal: Mol Cell Biol
Title: The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
Volume: 24
Issue: 19
Pages: 8477-86
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Publication
28233855 | J:244759
 
First Author: Suzuki T
Year: 2017
Journal: Nat Commun
Title: Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus.
Volume: 8
Pages: 14577
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Publication
26827822 | J:230721
 
First Author: Shinkai Y
Year: 2016
Journal: Toxicol Appl Pharmacol
Title: Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells.
Volume: 295
Pages: 37-46
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Publication
33069734 | J:300854
 
First Author: Yang F
Year: 2021
Journal: Brain Res
Title: Sestrin1 exerts a cytoprotective role against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by potentiating Nrf2 activation via the modulation of Keap1.
Volume: 1750
Pages: 147165
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Publication
24675090 | J:215356
First Author: Kensler KH
Year: 2014
Journal: Toxicol Sci
Title: Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice.
Volume: 139
Issue: 2
Pages: 293-300
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Publication
14517554 | J:86392
First Author: Wakabayashi N
Year: 2003
Journal: Nat Genet
Title: Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Volume: 35
Issue: 3
Pages: 238-45
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Publication
30995469 | J:284339
First Author: Pyaram K
Year: 2019
Journal: Cell Rep
Title: Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Volume: 27
Issue: 3
Pages: 699-707.e4
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Publication
20628156 | J:185406
First Author: Wakabayashi N
Year: 2010
Journal: Sci Signal
Title: Regulation of notch1 signaling by nrf2: implications for tissue regeneration.
Volume: 3
Issue: 130
Pages: ra52
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Publication
19560419 | J:150409
First Author: Chen W
Year: 2009
Journal: Mol Cell
Title: Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response.
Volume: 34
Issue: 6
Pages: 663-73
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Publication
29775963 | J:315621
 
First Author: Yang T
Year: 2018
Journal: Redox Biol
Title: Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation.
Volume: 17
Pages: 323-337
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Publication
37339955 | J:340706
First Author: Cai C
Year: 2023
Journal: Nat Commun
Title: USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.
Volume: 14
Issue: 1
Pages: 3648
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Publication
23716596 | J:204575
First Author: Uruno A
Year: 2013
Journal: Mol Cell Biol
Title: The Keap1-Nrf2 system prevents onset of diabetes mellitus.
Volume: 33
Issue: 15
Pages: 2996-3010
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Publication
19732748 | J:155010
First Author: Okada K
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.
Volume: 389
Issue: 3
Pages: 431-6
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Publication
17903176 | J:135362
First Author: Watai Y
Year: 2007
Journal: Genes Cells
Title: Subcellular localization and cytoplasmic complex status of endogenous Keap1.
Volume: 12
Issue: 10
Pages: 1163-78
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Publication
24463449 | J:208444
First Author: Kim JH
Year: 2014
Journal: J Clin Invest
Title: NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.
Volume: 124
Issue: 2
Pages: 730-41
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Publication
29542224 | J:271937
First Author: Yoshida E
Year: 2018
Journal: Genes Cells
Title: Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo.
Volume: 23
Issue: 5
Pages: 386-392
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Publication
23572560 | J:204496
First Author: Suzuki T
Year: 2013
Journal: Mol Cell Biol
Title: Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.
Volume: 33
Issue: 12
Pages: 2402-12
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Publication
26371321 | J:226999
First Author: Keleku-Lukwete N
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation.
Volume: 112
Issue: 39
Pages: 12169-74
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Publication
24186865 | J:209004
First Author: Yagishita Y
Year: 2014
Journal: Diabetes
Title: Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice.
Volume: 63
Issue: 2
Pages: 605-18
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Publication
24206218 | J:208388
First Author: Ludtmann MH
Year: 2014
Journal: Biochem J
Title: Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.
Volume: 457
Issue: 3
Pages: 415-24
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26701603 | J:230722
 
First Author: Slocum SL
Year: 2016
Journal: Arch Biochem Biophys
Title: Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet.
Volume: 591
Pages: 57-65
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Publication
24580727 | J:215699
First Author: Murakami S
Year: 2014
Journal: Genes Cells
Title: Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.
Volume: 19
Issue: 3
Pages: 239-53
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Publication
34298930 | J:322205
 
First Author: Eswaran S
Year: 2021
Journal: Int J Mol Sci
Title: Upregulation of Anti-Oxidative Stress Response Improves Metabolic Changes in L-Selectin-Deficient Mice but Does Not Prevent NAFLD Progression or Fecal Microbiota Shifts.
Volume: 22
Issue: 14
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Publication
24556415 | J:212030
 
First Author: Wang XJ
Year: 2014
Journal: Free Radic Biol Med
Title: Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs.
Volume: 70
Pages: 68-77
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Publication
32031966 | J:345264
First Author: Jiang Z
Year: 2020
Journal: J Endocrinol
Title: MicroRNA-200a improves diabetic endothelial dysfunction by targeting KEAP1/NRF2.
Volume: 245
Issue: 1
Pages: 129-140
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Publication
22353756 | J:183255
 
First Author: Mimoto T
Year: 2012
Journal: Brain Res
Title: Impaired antioxydative Keap1/Nrf2 system and the downstream stress protein responses in the motor neuron of ALS model mice.
Volume: 1446
Pages: 109-18
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Publication
28457936 | J:319253
 
First Author: Sun W
Year: 2017
Journal: Free Radic Biol Med
Title: Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1.
Volume: 108
Pages: 840-857
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Publication
23250896 | J:317506
First Author: Ohkoshi A
Year: 2013
Journal: Cancer Prev Res (Phila)
Title: Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis.
Volume: 6
Issue: 2
Pages: 149-59
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Publication
29526543 | J:262000
First Author: Best SA
Year: 2018
Journal: Cell Metab
Title: Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment.
Volume: 27
Issue: 4
Pages: 935-943.e4
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Publication
35504291 | J:325477
First Author: Best SA
Year: 2022
Journal: Cell Metab
Title: Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer.
Volume: 34
Issue: 6
Pages: 874-887.e6
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Publication
30409900 | J:274722
First Author: Fu J
Year: 2019
Journal: J Biol Chem
Title: Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.
Volume: 294
Issue: 1
Pages: 327-340
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Publication
28674188 | J:244499
 
First Author: Murakami S
Year: 2017
Journal: Mol Cell Biol
Title: NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells.
Volume: 37
Issue: 19
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