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Search results 1 to 100 out of 269 for Khk

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0.047s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars []. It is found in higher eukaryotes where it is believed to function as a dimer and requires K(+) and ATP to be active []. In humans, hepatic KHK deficiency causes fructosuria, a benign inborn error of metabolism [, ].
Publication
First Author: Hayward BE
Year: 1998
Journal: Eur J Biochem
Title: Structure and alternative splicing of the ketohexokinase gene.
Volume: 257
Issue: 1
Pages: 85-91
Publication
First Author: Kozak M
Year: 2001
Journal: Acta Crystallogr D Biol Crystallogr
Title: Expression, purification and preliminary crystallographic studies of human ketohexokinase.
Volume: 57
Issue: Pt 4
Pages: 586-8
Publication
First Author: Asipu A
Year: 2003
Journal: Diabetes
Title: Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria.
Volume: 52
Issue: 9
Pages: 2426-32
Publication
First Author: Bonthron DT
Year: 1994
Journal: Hum Mol Genet
Title: Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase).
Volume: 3
Issue: 9
Pages: 1627-31
Protein
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
Publication  
First Author: Wong KHK
Year: 2018
Journal: J Mol Cell Cardiol
Title: Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations.
Volume: 115
Pages: 1-9
Publication
First Author: Tee SS
Year: 2022
Journal: Sci Adv
Title: Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging.
Volume: 8
Issue: 14
Pages: eabm7985
Publication
First Author: Diggle CP
Year: 2009
Journal: J Histochem Cytochem
Title: Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme.
Volume: 57
Issue: 8
Pages: 763-74
Publication  
First Author: Chabbert CD
Year: 2018
Journal: F1000Res
Title: Correction of gene model annotations improves isoform abundance estimates: the example of ketohexokinase ( Khk).
Volume: 7
Pages: 1956
Publication
First Author: Miller CO
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects.
Volume: 315
Issue: 3
Pages: E386-E393
Publication
First Author: Guccini I
Year: 2023
Journal: iScience
Title: Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development.
Volume: 26
Issue: 8
Pages: 107368
Publication
First Author: Mirtschink P
Year: 2015
Journal: Nature
Title: HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Volume: 522
Issue: 7557
Pages: 444-449
Publication
First Author: Diggle CP
Year: 2010
Journal: Physiol Genomics
Title: Both isoforms of ketohexokinase are dispensable for normal growth and development.
Volume: 42A
Issue: 4
Pages: 235-43
Publication
First Author: Patel C
Year: 2015
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice.
Volume: 309
Issue: 9
Pages: G779-90
Publication
First Author: Lanaspa MA
Year: 2018
Journal: J Clin Invest
Title: Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.
Volume: 128
Issue: 6
Pages: 2226-2238
Publication
First Author: Patel C
Year: 2015
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK.
Volume: 309
Issue: 5
Pages: R499-509
Publication
First Author: Marek G
Year: 2015
Journal: Diabetes
Title: Adiponectin resistance and proinflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway.
Volume: 64
Issue: 2
Pages: 508-18
Author
Author
Publication  
First Author: Eberhart T
Year: 2020
Journal: Front Cell Dev Biol
Title: Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression.
Volume: 8
Pages: 566
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Andres-Hernando A
Year: 2020
Journal: Cell Metab
Title: Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction.
Volume: 32
Issue: 1
Pages: 117-127.e3
Publication
First Author: Ishimoto T
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.
Volume: 109
Issue: 11
Pages: 4320-5
Publication
First Author: Roncal Jimenez CA
Year: 2014
Journal: Kidney Int
Title: Fructokinase activity mediates dehydration-induced renal injury.
Volume: 86
Issue: 2
Pages: 294-302
Publication  
First Author: Doke T
Year: 2018
Journal: Metabolism
Title: Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice.
Volume: 85
Pages: 161-170
Publication
First Author: Song 宋志林 Z
Year: 2017
Journal: J Neurophysiol
Title: Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice.
Volume: 117
Issue: 2
Pages: 646-654
Publication
First Author: Ishimoto T
Year: 2013
Journal: Hepatology
Title: High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.
Volume: 58
Issue: 5
Pages: 1632-43
Publication
First Author: Lanaspa MA
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.
Volume: 115
Issue: 12
Pages: 3138-3143
Publication
First Author: Lanaspa MA
Year: 2014
Journal: J Am Soc Nephrol
Title: Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.
Volume: 25
Issue: 11
Pages: 2526-38
Publication  
First Author: Andres-Hernando A
Year: 2023
Journal: Biomolecules
Title: High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome.
Volume: 13
Issue: 5
Publication  
First Author: Lanaspa MA
Year: 2013
Journal: Nat Commun
Title: Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.
Volume: 4
Pages: 2434
Publication
First Author: Zhang X
Year: 2019
Journal: FASEB J
Title: Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism.
Volume: 33
Issue: 6
Pages: 7126-7142
Publication
First Author: Roncal-Jimenez CA
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Aging-associated renal disease in mice is fructokinase dependent.
Volume: 311
Issue: 4
Pages: F722-F730
Publication  
First Author: Andres-Hernando A
Year: 2017
Journal: Nat Commun
Title: Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice.
Volume: 8
Pages: 14181
Publication  
First Author: Mastrocola R
Year: 2016
Journal: Neurobiol Dis
Title: High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons.
Volume: 89
Pages: 65-75
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945504
Age: embryonic day 11.5
Image: g01032 E11.5
Specimen Label: g01032 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945504
Age: embryonic day 15.5
Image: g01032 E15.5
Specimen Label: g01032 E15.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945504
Age: embryonic day 15.5
Image: g01032 E15.5
Specimen Label: g01032 E15.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945504
Age: postnatal day 7
Image: g01032 P7
Specimen Label: g01032 P7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945504
Age: postnatal day 42
Image: g01032 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01032 Adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945504
Age: embryonic day 11.5
Image: g01032 E11.5
Specimen Label: g01032 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945504
Age: embryonic day 15.5
Image: g01032 E15.5
Specimen Label: g01032 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945504
Age: postnatal day 7
Image: g01032 P7
Specimen Label: g01032 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945504
Age: postnatal day 42
Image: g01032 Adult
Specimen Label: g01032 Adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697422
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665922
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654222
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684922
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945504
Age: postnatal day 7
Image: g01032 P7
Specimen Label: g01032 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885029
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945504
Age: postnatal day 42
Image: g01032 Adult
Specimen Label: g01032 Adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5310287
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:5423611
Age: embryonic day 14.5
Specimen Label: ES972; Specimen S367
Detected: false
Specimen Num: 1