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Search results 1 to 100 out of 5595 for Kl

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Type Details Score
Gene
Type: gene
Organism: frog, African clawed
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Han X
Year: 2020
Journal: Hypertension
Title: Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.
Volume: 75
Issue: 5
Pages: 1233-1241
Publication
First Author: Pellegrini M
Year: 2008
Journal: Cell Cycle
Title: ATRA and KL promote differentiation toward the meiotic program of male germ cells.
Volume: 7
Issue: 24
Pages: 3878-88
Publication
First Author: Wilson KL
Year: 2000
Journal: Trends Cell Biol
Title: The nuclear envelope, muscular dystrophy and gene expression.
Volume: 10
Issue: 4
Pages: 125-9
Publication
First Author: Parker KL
Year: 1998
Journal: Mol Cell Endocrinol
Title: The roles of steroidogenic factor 1 in endocrine development and function.
Volume: 145
Issue: 1-2
Pages: 15-20
Publication
First Author: Ito S
Year: 2000
Journal: Mech Dev
Title: Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.
Volume: 98
Issue: 1-2
Pages: 115-9
Publication
First Author: Utsugi T
Year: 2000
Journal: Metabolism
Title: Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging.
Volume: 49
Issue: 9
Pages: 1118-23
Publication  
First Author: Liu T
Year: 2019
Journal: Free Radic Biol Med
Title: miR-15b induces premature ovarian failure in mice via inhibition of α-Klotho expression in ovarian granulosa cells.
Volume: 141
Pages: 383-392
Publication
First Author: Kokkinaki M
Year: 2013
Journal: J Neurosci
Title: Klotho regulates retinal pigment epithelial functions and protects against oxidative stress.
Volume: 33
Issue: 41
Pages: 16346-59
Publication  
First Author: Gao D
Year: 2020
Journal: Redox Biol
Title: In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage.
Volume: 37
Pages: 101692
Publication  
First Author: Garth J
Year: 2019
Journal: Front Med (Lausanne)
Title: The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance.
Volume: 6
Pages: 339
Publication
First Author: Yamashita T
Year: 1998
Journal: J Endocrinol
Title: Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging.
Volume: 159
Issue: 1
Pages: 1-8
Publication
First Author: Chen K
Year: 2019
Journal: J Mol Med (Berl)
Title: Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension.
Volume: 97
Issue: 11
Pages: 1615-1625
Publication
First Author: Mohlke KL
Year: 1998
Journal: Genomics
Title: Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level.
Volume: 54
Issue: 1
Pages: 19-30
Publication
First Author: Barnes JW
Year: 2019
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis.
Volume: 317
Issue: 1
Pages: L141-L154
Publication
First Author: Zhou X
Year: 2016
Journal: J Am Soc Nephrol
Title: Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.
Volume: 27
Issue: 6
Pages: 1765-76
Publication
First Author: Zhou X
Year: 2015
Journal: J Am Soc Nephrol
Title: Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation.
Volume: 26
Issue: 1
Pages: 121-32
Publication  
First Author: Jiang W
Year: 2019
Journal: Mol Cell Endocrinol
Title: Klotho inhibits PKCα/p66SHC-mediated podocyte injury in diabetic nephropathy.
Volume: 494
Pages: 110490
Publication
First Author: Fernández ÁF
Year: 2018
Journal: Nature
Title: Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Volume: 558
Issue: 7708
Pages: 136-140
Publication
First Author: Mori K
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Disruption of klotho gene causes an abnormal energy homeostasis in mice.
Volume: 278
Issue: 3
Pages: 665-70
Publication
First Author: Li SA
Year: 2004
Journal: Cell Struct Funct
Title: Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice.
Volume: 29
Issue: 4
Pages: 91-9
Publication
First Author: Yamashita T
Year: 2000
Journal: J Endocrinol
Title: High-resolution micro-computed tomography analyses of the abnormal trabecular bone structures in klotho gene mutant mice.
Volume: 164
Issue: 2
Pages: 239-45
Publication
First Author: Okada S
Year: 2000
Journal: Int Immunol
Title: Impairment of B lymphopoiesis in precocious aging (klotho) mice.
Volume: 12
Issue: 6
Pages: 861-71
Publication
First Author: Jorge LB
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Klotho deficiency aggravates sepsis-related multiple organ dysfunction.
Volume: 316
Issue: 3
Pages: F438-F448
Publication  
First Author: Maruyama N
Year: 2015
Journal: Biomaterials
Title: Bone micro-fragility caused by the mimetic aging processes in α-klotho deficient mice: in situ nanoindentation assessment of dilatational bands.
Volume: 47
Pages: 62-71
Publication
First Author: Yoshida T
Year: 2002
Journal: Endocrinology
Title: Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
Volume: 143
Issue: 2
Pages: 683-9
Publication
First Author: Nakano-Kurimoto R
Year: 2009
Journal: Am J Physiol Heart Circ Physiol
Title: Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition.
Volume: 297
Issue: 5
Pages: H1673-84
Publication
First Author: Flenner F
Year: 2016
Journal: Cardiovasc Res
Title: Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.
Volume: 109
Issue: 1
Pages: 90-102
Publication
First Author: Sasaki M
Year: 2013
Journal: Bone
Title: Altered distribution of bone matrix proteins and defective bone mineralization in klotho-deficient mice.
Volume: 57
Issue: 1
Pages: 206-19
Publication
First Author: Zhu WS
Year: 2019
Journal: Aging (Albany NY)
Title: Immune system development and age-dependent maintenance in Klotho-hypomorphic mice.
Volume: 11
Issue: 14
Pages: 5246-5257
Publication  
First Author: Verlinden L
Year: 2024
Journal: Front Endocrinol (Lausanne)
Title: Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging.
Volume: 15
Pages: 1310466
Publication
First Author: Lin Y
Year: 2016
Journal: Hypertension
Title: Antiaging Gene Klotho Deficiency Promoted High-Fat Diet-Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase.
Volume: 67
Issue: 3
Pages: 564-73
Publication
First Author: Yamamoto M
Year: 2005
Journal: J Biol Chem
Title: Regulation of oxidative stress by the anti-aging hormone klotho.
Volume: 280
Issue: 45
Pages: 38029-34
Publication
First Author: Carpinelli MR
Year: 2011
Journal: Hear Res
Title: Vitamin D-deficient diet rescues hearing loss in Klotho mice.
Volume: 275
Issue: 1-2
Pages: 105-9
Publication
First Author: Segawa H
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice.
Volume: 292
Issue: 2
Pages: F769-79
Publication
First Author: Masuda H
Year: 2005
Journal: Mech Ageing Dev
Title: Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice.
Volume: 126
Issue: 12
Pages: 1274-83
Publication
First Author: Voelkl J
Year: 2018
Journal: J Am Soc Nephrol
Title: Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-κB.
Volume: 29
Issue: 6
Pages: 1636-1648
Publication
First Author: Voelkl J
Year: 2013
Journal: J Clin Invest
Title: Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.
Volume: 123
Issue: 2
Pages: 812-22
Publication
First Author: Min D
Year: 2007
Journal: Blood
Title: Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.
Volume: 109
Issue: 6
Pages: 2529-37
Publication
First Author: Yamauchi M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism.
Volume: 473
Issue: 4
Pages: 845-852
Publication
First Author: Borst O
Year: 2014
Journal: FASEB J
Title: 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Volume: 28
Issue: 5
Pages: 2108-19
Publication
First Author: Satoh M
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling.
Volume: 303
Issue: 12
Pages: F1641-51
Publication
First Author: Sahu A
Year: 2018
Journal: Nat Commun
Title: Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.
Volume: 9
Issue: 1
Pages: 4859
Publication
First Author: Fischer SS
Year: 2010
Journal: Am J Physiol Renal Physiol
Title: Hyperaldosteronism in Klotho-deficient mice.
Volume: 299
Issue: 5
Pages: F1171-7
Publication
First Author: Fukino K
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Regulation of angiogenesis by the aging suppressor gene klotho.
Volume: 293
Issue: 1
Pages: 332-7
Publication
First Author: Panesso MC
Year: 2014
Journal: Kidney Int
Title: Klotho has dual protective effects on cisplatin-induced acute kidney injury.
Volume: 85
Issue: 4
Pages: 855-70
Publication
First Author: Chen K
Year: 2015
Journal: Hypertension
Title: Haplodeficiency of Klotho Gene Causes Arterial Stiffening via Upregulation of Scleraxis Expression and Induction of Autophagy.
Volume: 66
Issue: 5
Pages: 1006-13
Publication
First Author: Suzuki H
Year: 2005
Journal: Arch Histol Cytol
Title: Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice.
Volume: 68
Issue: 5
Pages: 371-81
Publication
First Author: Nagai T
Year: 2003
Journal: FASEB J
Title: Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress.
Volume: 17
Issue: 1
Pages: 50-2
Publication
First Author: Yamashita T
Year: 2000
Journal: Endocrinology
Title: Retardation in bone resorption after bone marrow ablation in klotho mutant mice.
Volume: 141
Issue: 1
Pages: 438-45
Publication
First Author: Gui T
Year: 2012
Journal: Lab Invest
Title: MicroRNAs that target Ca(2+) transporters are involved in vascular smooth muscle cell calcification.
Volume: 92
Issue: 9
Pages: 1250-9
Publication
First Author: Sopjani M
Year: 2011
Journal: FEBS Lett
Title: Regulation of the Na+/K+ ATPase by Klotho.
Volume: 585
Issue: 12
Pages: 1759-64
Publication
First Author: Abousaab A
Year: 2016
Journal: Cell Physiol Biochem
Title: β-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2.
Volume: 40
Issue: 5
Pages: 874-882
Publication  
First Author: Okada N
Year: 2021
Journal: Gene
Title: Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.
Volume: 794
Pages: 145752
Publication
First Author: Kim SA
Year: 2018
Journal: Aging (Albany NY)
Title: Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice.
Volume: 10
Issue: 9
Pages: 2338-2355
Publication
First Author: Imura A
Year: 2007
Journal: Science
Title: alpha-Klotho as a regulator of calcium homeostasis.
Volume: 316
Issue: 5831
Pages: 1615-8
Publication
First Author: Hu MC
Year: 2011
Journal: J Am Soc Nephrol
Title: Klotho deficiency causes vascular calcification in chronic kidney disease.
Volume: 22
Issue: 1
Pages: 124-36
Publication
First Author: Kimura T
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney.
Volume: 315
Issue: 2
Pages: F345-F352
Publication
First Author: Chen CD
Year: 2013
Journal: J Neurosci
Title: The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.
Volume: 33
Issue: 5
Pages: 1927-39
Publication
First Author: Toan NK
Year: 2022
Journal: Aging (Albany NY)
Title: Ascorbic acid induces salivary gland function through TET2/acetylcholine receptor signaling in aging SAMP1/Klotho (-/-) mice.
Volume: 14
Issue: 15
Pages: 6028-6046
Publication
First Author: Lin Y
Year: 2013
Journal: Endocrinology
Title: Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice.
Volume: 154
Issue: 10
Pages: 3855-63
Publication
First Author: Toyama R
Year: 2006
Journal: Endocrinology
Title: Impaired regulation of gonadotropins leads to the atrophy of the female reproductive system in klotho-deficient mice.
Volume: 147
Issue: 1
Pages: 120-9
Publication
First Author: Manabe N
Year: 2001
Journal: J Immunol
Title: Connection between B lymphocyte and osteoclast differentiation pathways.
Volume: 167
Issue: 5
Pages: 2625-31
Publication
First Author: Phelps M
Year: 2013
Journal: Biogerontology
Title: Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice.
Volume: 14
Issue: 6
Pages: 729-39
Publication  
First Author: Chen K
Year: 2021
Journal: Redox Biol
Title: Estrogen inhibits renal Na-Pi Co-transporters and improves klotho deficiency-induced acute heart failure.
Volume: 47
Pages: 102173
Publication
First Author: Yang K
Year: 2015
Journal: J Am Soc Nephrol
Title: Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.
Volume: 26
Issue: 10
Pages: 2434-46
Publication
First Author: Urabe A
Year: 2021
Journal: PLoS One
Title: Klotho deficiency intensifies hypoxia-induced expression of IFN-α/β through upregulation of RIG-I in kidneys.
Volume: 16
Issue: 10
Pages: e0258856
Publication
First Author: Azuma M
Year: 2012
Journal: FASEB J
Title: Promoter methylation confers kidney-specific expression of the Klotho gene.
Volume: 26
Issue: 10
Pages: 4264-74
Publication
First Author: Kwon SM
Year: 2018
Journal: J Cell Physiol
Title: Global analysis of gene expression profiles in the submandibular salivary gland of klotho knockout mice.
Volume: 233
Issue: 4
Pages: 3282-3294
Publication  
First Author: Kosakai A
Year: 2011
Journal: Brain Res
Title: Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure.
Volume: 1382
Pages: 109-17
Publication
First Author: Fan J
Year: 2016
Journal: Stem Cells
Title: The Antiaging Gene Klotho Regulates Proliferation and Differentiation of Adipose-Derived Stem Cells.
Volume: 34
Issue: 6
Pages: 1615-25
Publication  
First Author: Sato Y
Year: 2020
Journal: Front Immunol
Title: Analysis of Immune Responses in Acinetobacter baumannii-Infected Klotho Knockout Mice: A Mouse Model of Acinetobacter baumannii Infection in Aged Hosts.
Volume: 11
Pages: 601614
Publication
First Author: Kamemori M
Year: 2002
Journal: Hear Res
Title: Expression of Klotho protein in the inner ear.
Volume: 171
Issue: 1-2
Pages: 103-110
Publication
First Author: Hu MC
Year: 2010
Journal: Kidney Int
Title: Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective.
Volume: 78
Issue: 12
Pages: 1240-51
Publication
First Author: Leibrock CB
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Bicarbonate-sensitive calcification and lifespan of klotho-deficient mice.
Volume: 310
Issue: 1
Pages: F102-8
Publication
First Author: Alesutan I
Year: 2016
Journal: Cardiovasc Res
Title: Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine.
Volume: 110
Issue: 3
Pages: 408-18
Publication
First Author: Sugiura H
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis.
Volume: 302
Issue: 10
Pages: F1252-64
Publication
First Author: Nakamura K
Year: 2017
Journal: PLoS One
Title: Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice.
Volume: 12
Issue: 8
Pages: e0181009
Publication
First Author: Suzuki H
Year: 2008
Journal: J Anat
Title: Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice.
Volume: 212
Issue: 3
Pages: 275-85
Publication
First Author: Tai NC
Year: 2019
Journal: Aging (Albany NY)
Title: Soluble klotho regulates the function of salivary glands by activating KLF4 pathways.
Volume: 11
Issue: 19
Pages: 8254-8269
Publication  
First Author: Porter T
Year: 2019
Journal: Neurobiol Aging
Title: Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease.
Volume: 76
Pages: 162-165
Publication
First Author: Coelho FO
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Chronic nicotine exposure reduces klotho expression and triggers different renal and hemodynamic responses in klotho-haploinsufficient mice.
Volume: 314
Issue: 5
Pages: F992-F998
Publication
First Author: Takahashi M
Year: 2012
Journal: PLoS One
Title: Reduction of type IV collagen by upregulated miR-29 in normal elderly mouse and klotho-deficient, senescence-model mouse.
Volume: 7
Issue: 11
Pages: e48974
Publication
First Author: Ravikumar P
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: α-Klotho protects against oxidative damage in pulmonary epithelia.
Volume: 307
Issue: 7
Pages: L566-75
Publication
First Author: Lai L
Year: 2021
Journal: Int J Biol Sci
Title: Bovine serum albumin aggravates macrophage M1 activation and kidney injury in heterozygous Klotho-deficient mice via the gut microbiota-immune axis.
Volume: 17
Issue: 3
Pages: 742-755
Publication  
First Author: Maique J
Year: 2020
Journal: Front Pharmacol
Title: High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis.
Volume: 11
Pages: 1273
Publication
First Author: Suga T
Year: 2000
Journal: Am J Respir Cell Mol Biol
Title: Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.
Volume: 22
Issue: 1
Pages: 26-33
Publication
First Author: Yahata K
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Regulation of stanniocalcin 1 and 2 expression in the kidney by klotho gene.
Volume: 310
Issue: 1
Pages: 128-34
Publication
First Author: Shiozaki M
Year: 2008
Journal: Neuroscience
Title: Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice.
Volume: 152
Issue: 4
Pages: 924-41
Publication
First Author: Reish NJ
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: The age-regulating protein klotho is vital to sustain retinal function.
Volume: 54
Issue: 10
Pages: 6675-85