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Search results 1 to 100 out of 334 for Klf1

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Categories

Hits by Strain

Hits by Category

Type Details Score
Gene
10661 | KLF1
Type: gene
Organism: human
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Gene
784295 | KLF1
Type: gene
Organism: cattle
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Gene
30104 | klf1
Type: gene
Organism: zebrafish
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Gene
716842 | KLF1
Type: gene
Organism: macaque, rhesus
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Gene
304666 | Klf1
Type: gene
Organism: rat
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Gene
484924 | KLF1
Type: gene
Organism: dog, domestic
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Gene
468741 | KLF1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR031785 | KLF1
Type: Family
Description: Krueppel-like factor 1 (KLF1 or EKLF) is a transcription factor that globally activates genes involved in erythroid cell development . It belongs to the KLF family of transcription factors that binds the G-rich strand of so-called CACCC-box motifs located in regulatory regions of numerous erythroid genes []. It regulates erythroid lineage commitment, globin switching, and the terminal maturation of red blood cells. Mutations in the KLF1 gene have been associated with microcytic hypochromic anemia and increased fetal hemoglobin [].
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Protein Coding Gene
MGI:1342771 | Klf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25585695 | -
First Author: Huang J
Year: 2015
Journal: Eur J Hum Genet
Title: Compound heterozygosity for KLF1 mutations is associated with microcytic hypochromic anemia and increased fetal hemoglobin.
Volume: 23
Issue: 10
Pages: 1341-8
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Publication
20676097 | J:164803
First Author: Zhou D
Year: 2010
Journal: Nat Genet
Title: KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.
Volume: 42
Issue: 9
Pages: 742-4
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Gene
117125595 | LOC117125595
Type: gene
Organism: human
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Gene
117125593 | LOC117125593
Type: gene
Organism: human
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Gene
117125588 | LOC117125588
Type: gene
Organism: human
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Publication
22835905 | J:192660
First Author: Tallack MR
Year: 2012
Journal: Genome Res
Title: Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.
Volume: 22
Issue: 12
Pages: 2385-98
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Publication
30921348 | J:274331
First Author: Cantú I
Year: 2019
Journal: PLoS One
Title: The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
Volume: 14
Issue: 3
Pages: e0208659
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Publication
31818881 | -
 
First Author: Kulczynska K
Year: 2020
Journal: Mol Cell Biol
Title: A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity.
Volume: 40
Issue: 5
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Publication
22933519 | J:192480
First Author: Southwood CM
Year: 2012
Journal: Biol Reprod
Title: Tissue-restricted transcription from a conserved intragenic CpG island in the Klf1 gene in mice.
Volume: 87
Issue: 5
Pages: 108
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Publication
30143664 | J:285768
First Author: Nébor D
Year: 2018
Journal: Sci Rep
Title: Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis.
Volume: 8
Issue: 1
Pages: 12793
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Publication
29230002 | J:268895
First Author: Manchinu MF
Year: 2018
Journal: Cell Death Differ
Title: Deficiency in interferon type 1 receptor improves definitive erythropoiesis in Klf1 null mice.
Volume: 25
Issue: 3
Pages: 589-599
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Publication
20508144 | J:163355
First Author: Tallack MR
Year: 2010
Journal: Genome Res
Title: A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells.
Volume: 20
Issue: 8
Pages: 1052-63
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Publication
34940950 | J:333864
First Author: Li Z
Year: 2022
Journal: J Mol Histol
Title: Zkscan3 affects erythroblast development by regulating the transcriptional activity of GATA1 and KLF1 in mice.
Volume: 53
Issue: 2
Pages: 423-436
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Publication
20691777 | J:166654
First Author: Heruth DP
Year: 2010
Journal: Genomics
Title: Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model.
Volume: 96
Issue: 5
Pages: 303-7
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Publication
21610079 | J:175394
First Author: Alhashem YN
Year: 2011
Journal: J Biol Chem
Title: Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding.
Volume: 286
Issue: 28
Pages: 24819-27
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Publication
18687676 | J:142311
First Author: Eaton SA
Year: 2008
Journal: J Biol Chem
Title: A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo.
Volume: 283
Issue: 40
Pages: 26937-47
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Gene
117125597 | LOC117125597
Type: gene
Organism: human
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Gene
117125587 | LOC117125587
Type: gene
Organism: human
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Publication
25150253 | J:310313
First Author: Vinjamur DS
Year: 2014
Journal: Haematologica
Title: Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.
Volume: 99
Issue: 10
Pages: 1565-73
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Protein
P46099
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein
E9QNP6
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein
Q3TZ82
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
A0A6I8MWY6
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q1RME5
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Publication
25451176 | J:223531
First Author: Sorolla A
Year: 2015
Journal: Genomics
Title: Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation.
Volume: 105
Issue: 2
Pages: 116-22
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Publication
21807894 | J:175864
First Author: Porcu S
Year: 2011
Journal: Mol Cell Biol
Title: Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis.
Volume: 31
Issue: 19
Pages: 4144-54
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Publication
33182781 | J:306881
 
First Author: Hung CH
Year: 2020
Journal: Int J Mol Sci
Title: Negative Regulation of the Differentiation of Flk2- CD34- LSK Hematopoietic Stem Cells by EKLF/KLF1.
Volume: 21
Issue: 22
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Publication
34360789 | J:310414
 
First Author: Hung CH
Year: 2021
Journal: Int J Mol Sci
Title: A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.
Volume: 22
Issue: 15
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Publication
- | J:346489
   
First Author: Xue L
Year: 20242
Journal: Front Hematol
Title: Generation, characterization, and use of EKLF(Klf1)/CRE knock-in mice for cell-restricted analyses.
Volume: 2
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Publication
20010836 | J:166574
First Author: Schoenfelder S
Year: 2010
Journal: Nat Genet
Title: Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.
Volume: 42
Issue: 1
Pages: 53-61
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Publication
22157820 | J:181759
First Author: Stadhouders R
Year: 2012
Journal: EMBO J
Title: Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development.
Volume: 31
Issue: 4
Pages: 986-99
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Publication
28541545 | J:249139
First Author: Ilsley MD
Year: 2017
Journal: Nucleic Acids Res
Title: Krüppel-like factors compete for promoters and enhancers to fine-tune transcription.
Volume: 45
Issue: 11
Pages: 6572-6588
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Publication
23361909 | J:196405
First Author: Esteghamat F
Year: 2013
Journal: Blood
Title: Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.
Volume: 121
Issue: 13
Pages: 2553-62
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Publication
22357756 | J:182134
First Author: Wontakal SN
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation.
Volume: 109
Issue: 10
Pages: 3832-7
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Publication
16728274 | J:111912
First Author: Nilson DG
Year: 2006
Journal: Exp Hematol
Title: Major erythrocyte membrane protein genes in EKLF-deficient mice.
Volume: 34
Issue: 6
Pages: 705-12
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Publication
22566683 | J:186666
First Author: Pang CJ
Year: 2012
Journal: Mol Cell Biol
Title: Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis.
Volume: 32
Issue: 13
Pages: 2628-44
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Protein Coding Gene
MGP_CAROLIEiJ_G0031315 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033861 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033564 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1342771 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034374 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033693 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033683 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034391 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022920 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032434 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
17715392 | J:149103
First Author: Frontelo P
Year: 2007
Journal: Blood
Title: Novel role for EKLF in megakaryocyte lineage commitment.
Volume: 110
Issue: 12
Pages: 3871-80
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Publication
10688844 | J:60760
First Author: Perkins AC
Year: 2000
Journal: Blood
Title: Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos.
Volume: 95
Issue: 5
Pages: 1827-33
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Publication
16380451 | J:131239
First Author: Hodge D
Year: 2006
Journal: Blood
Title: A global role for EKLF in definitive and primitive erythropoiesis.
Volume: 107
Issue: 8
Pages: 3359-70
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Publication
20720183 | J:166633
First Author: Isern J
Year: 2010
Journal: Blood
Title: Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf.
Volume: 116
Issue: 19
Pages: 3972-80
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Publication
11069894 | J:121689
First Author: Tanimoto K
Year: 2000
Journal: Genes Dev
Title: Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.
Volume: 14
Issue: 21
Pages: 2778-94
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Publication
9545245 | J:47376
First Author: Tewari R
Year: 1998
Journal: EMBO J
Title: Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.
Volume: 17
Issue: 8
Pages: 2334-41
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Publication
11566887 | J:133738
First Author: Ristaldi MS
Year: 2001
Journal: EMBO J
Title: The role of the -50 region of the human gamma-globin gene in switching.
Volume: 20
Issue: 18
Pages: 5242-9
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Publication
28143845 | J:244984
First Author: Planutis A
Year: 2017
Journal: Development
Title: Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.
Volume: 144
Issue: 3
Pages: 430-440
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Publication
- | J:13933
 
First Author: Lyon MF
Year: 1983
Journal: Mouse News Lett
Title: Dominant haemolytic anemia.
Volume: 68
Pages: 68
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Publication
- | J:14002
 
First Author: Lyon MF
Year: 1985
Journal: Mouse News Lett
Title: Neonatal anemia (Nan) on Chromosome 8.
Volume: 72
Pages: 107
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Publication
28180284 | J:250279
First Author: Gillinder KR
Year: 2017
Journal: Nucleic Acids Res
Title: Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability.
Volume: 45
Issue: 3
Pages: 1130-1143
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Publication
27480112 | J:236528
First Author: Gnanapragasam MN
Year: 2016
Journal: Blood
Title: EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation.
Volume: 128
Issue: 12
Pages: 1631-41
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Publication
23530053 | J:204029
First Author: Liu S
Year: 2013
Journal: Mol Cell Biol
Title: Erythropoiesis in the absence of adult hemoglobin.
Volume: 33
Issue: 11
Pages: 2241-51
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Publication
19251649 | J:150316
First Author: Sengupta T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Distinct modes of gene regulation by a cell-specific transcriptional activator.
Volume: 106
Issue: 11
Pages: 4213-8
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Publication
15489291 | J:93146
First Author: Drissen R
Year: 2004
Journal: Genes Dev
Title: The active spatial organization of the beta-globin locus requires the transcription factor EKLF.
Volume: 18
Issue: 20
Pages: 2485-90
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Publication
8924208 | J:33112
First Author: Bieker JJ
Year: 1996
Journal: DNA Cell Biol
Title: Isolation, genomic structure, and expression of human erythroid Krüppel-like factor (EKLF).
Volume: 15
Issue: 5
Pages: 347-52
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Publication
8896981 | J:33704
First Author: Southwood CM
Year: 1996
Journal: Dev Dyn
Title: Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny.
Volume: 206
Issue: 3
Pages: 248-59
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Publication
9119377 | J:38416
First Author: van Ree JH
Year: 1997
Journal: Genomics
Title: The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.
Volume: 39
Issue: 3
Pages: 393-5
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Publication
16705186 | J:109613
First Author: Pilon AM
Year: 2006
Journal: Mol Cell Biol
Title: Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.
Volume: 26
Issue: 11
Pages: 4368-77
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Publication
17242208 | J:118858
First Author: Shyu YC
Year: 2007
Journal: Mol Cell Biol
Title: Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription.
Volume: 27
Issue: 6
Pages: 2309-23
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Publication
18448565 | J:136715
First Author: Lohmann F
Year: 2008
Journal: Development
Title: Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment.
Volume: 135
Issue: 12
Pages: 2071-82
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Publication
18523154 | J:138412
First Author: Bouilloux F
Year: 2008
Journal: Blood
Title: EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation.
Volume: 112
Issue: 3
Pages: 576-84
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Publication
21900194 | J:178374
First Author: Pilon AM
Year: 2011
Journal: Blood
Title: Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.
Volume: 118
Issue: 17
Pages: e139-48
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Publication
24866116 | J:221271
First Author: Xue L
Year: 2014
Journal: Development
Title: Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.
Volume: 141
Issue: 11
Pages: 2245-54
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GXD Expression
GXD Expression
     
Probe: MGI:1328797
Assay Type: Western blot
Annotation Date: 1999-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:1328800
Age: embryonic day 13.5
Specimen Label: wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1328797
Assay Type: Western blot
Annotation Date: 1999-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:1328800
Age: embryonic day 13.5
Specimen Label: wt
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1261564
Assay Type: Northern blot
Annotation Date: 1999-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604217
Stage: TS17
Assay Id: MGI:1328802
Age: embryonic day 10.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1261564
Assay Type: Northern blot
Annotation Date: 1999-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604217
Stage: TS17
Assay Id: MGI:1328802
Age: embryonic day 10.5
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1261564
Assay Type: Northern blot
Annotation Date: 1999-02-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604217
Stage: TS17
Assay Id: MGI:1328802
Age: embryonic day 10.5
Specimen Label: -/-
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Heart
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Brain
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Spleen
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Lung
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Liver
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Skel. Muscle
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Kidney
Detected: false
Specimen Num: 7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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