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Search results 1 to 100 out of 339 for Klf1

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Hits by Category

Hits by Strain

Type Details Score
Gene
10661 | KLF1
Type: gene
Organism: human
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Gene
304666 | Klf1
Type: gene
Organism: rat
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Gene
484924 | KLF1
Type: gene
Organism: dog, domestic
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Gene
468741 | KLF1
Type: gene
Organism: chimpanzee
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Gene
784295 | KLF1
Type: gene
Organism: cattle
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Gene
30104 | klf1
Type: gene
Organism: zebrafish
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Gene
716842 | KLF1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR031785 | KLF1
Type: Family
Description: Krueppel-like factor 1 (KLF1 or EKLF) is a transcription factor that globally activates genes involved in erythroid cell development . It belongs to the KLF family of transcription factors that binds the G-rich strand of so-called CACCC-box motifs located in regulatory regions of numerous erythroid genes []. It regulates erythroid lineage commitment, globin switching, and the terminal maturation of red blood cells. Mutations in the KLF1 gene have been associated with microcytic hypochromic anemia and increased fetal hemoglobin [].
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Protein Coding Gene
MGI:1342771 | Klf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25585695 | -
First Author: Huang J
Year: 2015
Journal: Eur J Hum Genet
Title: Compound heterozygosity for KLF1 mutations is associated with microcytic hypochromic anemia and increased fetal hemoglobin.
Volume: 23
Issue: 10
Pages: 1341-8
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Publication
20676097 | J:164803
First Author: Zhou D
Year: 2010
Journal: Nat Genet
Title: KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.
Volume: 42
Issue: 9
Pages: 742-4
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Gene
117125595 | LOC117125595
Type: gene
Organism: human
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Gene
117125593 | LOC117125593
Type: gene
Organism: human
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Gene
117125588 | LOC117125588
Type: gene
Organism: human
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Publication
22835905 | J:192660
First Author: Tallack MR
Year: 2012
Journal: Genome Res
Title: Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.
Volume: 22
Issue: 12
Pages: 2385-98
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Publication
31818881 | -
 
First Author: Kulczynska K
Year: 2020
Journal: Mol Cell Biol
Title: A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity.
Volume: 40
Issue: 5
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Publication
30921348 | J:274331
First Author: Cantú I
Year: 2019
Journal: PLoS One
Title: The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
Volume: 14
Issue: 3
Pages: e0208659
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Publication
30143664 | J:285768
First Author: Nébor D
Year: 2018
Journal: Sci Rep
Title: Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis.
Volume: 8
Issue: 1
Pages: 12793
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Publication
22933519 | J:192480
First Author: Southwood CM
Year: 2012
Journal: Biol Reprod
Title: Tissue-restricted transcription from a conserved intragenic CpG island in the Klf1 gene in mice.
Volume: 87
Issue: 5
Pages: 108
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Publication
29230002 | J:268895
First Author: Manchinu MF
Year: 2018
Journal: Cell Death Differ
Title: Deficiency in interferon type 1 receptor improves definitive erythropoiesis in Klf1 null mice.
Volume: 25
Issue: 3
Pages: 589-599
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Publication
20508144 | J:163355
First Author: Tallack MR
Year: 2010
Journal: Genome Res
Title: A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells.
Volume: 20
Issue: 8
Pages: 1052-63
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Publication
21610079 | J:175394
First Author: Alhashem YN
Year: 2011
Journal: J Biol Chem
Title: Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding.
Volume: 286
Issue: 28
Pages: 24819-27
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Publication
34940950 | J:333864
First Author: Li Z
Year: 2022
Journal: J Mol Histol
Title: Zkscan3 affects erythroblast development by regulating the transcriptional activity of GATA1 and KLF1 in mice.
Volume: 53
Issue: 2
Pages: 423-436
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Publication
20691777 | J:166654
First Author: Heruth DP
Year: 2010
Journal: Genomics
Title: Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model.
Volume: 96
Issue: 5
Pages: 303-7
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Publication
18687676 | J:142311
First Author: Eaton SA
Year: 2008
Journal: J Biol Chem
Title: A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo.
Volume: 283
Issue: 40
Pages: 26937-47
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Gene
117125597 | LOC117125597
Type: gene
Organism: human
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Gene
117125587 | LOC117125587
Type: gene
Organism: human
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Publication
25150253 | J:310313
First Author: Vinjamur DS
Year: 2014
Journal: Haematologica
Title: Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.
Volume: 99
Issue: 10
Pages: 1565-73
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Protein
P46099
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein
E9QNP6
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein
Q3TZ82
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
A0A6I8MWY6
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q1RME5
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Publication
39147774 | J:353480
First Author: Huang S
Year: 2024
Journal: Nat Commun
Title: Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis.
Volume: 15
Issue: 1
Pages: 7019
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Publication
25451176 | J:223531
First Author: Sorolla A
Year: 2015
Journal: Genomics
Title: Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation.
Volume: 105
Issue: 2
Pages: 116-22
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Publication
21807894 | J:175864
First Author: Porcu S
Year: 2011
Journal: Mol Cell Biol
Title: Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis.
Volume: 31
Issue: 19
Pages: 4144-54
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Publication
33182781 | J:306881
 
First Author: Hung CH
Year: 2020
Journal: Int J Mol Sci
Title: Negative Regulation of the Differentiation of Flk2- CD34- LSK Hematopoietic Stem Cells by EKLF/KLF1.
Volume: 21
Issue: 22
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Publication
34360789 | J:310414
 
First Author: Hung CH
Year: 2021
Journal: Int J Mol Sci
Title: A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.
Volume: 22
Issue: 15
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Publication
- | J:346489
   
First Author: Xue L
Year: 2024
Journal: Front Hematol
Title: Generation, characterization, and use of EKLF(Klf1)/CRE knock-in mice for cell-restricted analyses.
Volume: 2
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Publication
20010836 | J:166574
First Author: Schoenfelder S
Year: 2010
Journal: Nat Genet
Title: Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.
Volume: 42
Issue: 1
Pages: 53-61
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Publication
22157820 | J:181759
First Author: Stadhouders R
Year: 2012
Journal: EMBO J
Title: Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development.
Volume: 31
Issue: 4
Pages: 986-99
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Publication
28541545 | J:249139
First Author: Ilsley MD
Year: 2017
Journal: Nucleic Acids Res
Title: Krüppel-like factors compete for promoters and enhancers to fine-tune transcription.
Volume: 45
Issue: 11
Pages: 6572-6588
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Publication
23361909 | J:196405
First Author: Esteghamat F
Year: 2013
Journal: Blood
Title: Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.
Volume: 121
Issue: 13
Pages: 2553-62
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Publication
22357756 | J:182134
First Author: Wontakal SN
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation.
Volume: 109
Issue: 10
Pages: 3832-7
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Publication
16728274 | J:111912
First Author: Nilson DG
Year: 2006
Journal: Exp Hematol
Title: Major erythrocyte membrane protein genes in EKLF-deficient mice.
Volume: 34
Issue: 6
Pages: 705-12
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Publication
22566683 | J:186666
First Author: Pang CJ
Year: 2012
Journal: Mol Cell Biol
Title: Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis.
Volume: 32
Issue: 13
Pages: 2628-44
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Protein Coding Gene
MGP_CAROLIEiJ_G0031315 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033861 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033564 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1342771 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034374 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033693 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033683 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034391 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022920 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032434 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10688844 | J:60760
First Author: Perkins AC
Year: 2000
Journal: Blood
Title: Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos.
Volume: 95
Issue: 5
Pages: 1827-33
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Publication
16380451 | J:131239
First Author: Hodge D
Year: 2006
Journal: Blood
Title: A global role for EKLF in definitive and primitive erythropoiesis.
Volume: 107
Issue: 8
Pages: 3359-70
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Publication
17715392 | J:149103
First Author: Frontelo P
Year: 2007
Journal: Blood
Title: Novel role for EKLF in megakaryocyte lineage commitment.
Volume: 110
Issue: 12
Pages: 3871-80
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Publication
20720183 | J:166633
First Author: Isern J
Year: 2010
Journal: Blood
Title: Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf.
Volume: 116
Issue: 19
Pages: 3972-80
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Publication
11069894 | J:121689
First Author: Tanimoto K
Year: 2000
Journal: Genes Dev
Title: Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.
Volume: 14
Issue: 21
Pages: 2778-94
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Publication
11566887 | J:133738
First Author: Ristaldi MS
Year: 2001
Journal: EMBO J
Title: The role of the -50 region of the human gamma-globin gene in switching.
Volume: 20
Issue: 18
Pages: 5242-9
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Publication
9545245 | J:47376
First Author: Tewari R
Year: 1998
Journal: EMBO J
Title: Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.
Volume: 17
Issue: 8
Pages: 2334-41
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Publication
- | J:13933
 
First Author: Lyon MF
Year: 1983
Journal: Mouse News Lett
Title: Dominant haemolytic anemia.
Volume: 68
Pages: 68
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Publication
- | J:14002
 
First Author: Lyon MF
Year: 1985
Journal: Mouse News Lett
Title: Neonatal anemia (Nan) on Chromosome 8.
Volume: 72
Pages: 107
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Publication
27480112 | J:236528
First Author: Gnanapragasam MN
Year: 2016
Journal: Blood
Title: EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation.
Volume: 128
Issue: 12
Pages: 1631-41
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Publication
28180284 | J:250279
First Author: Gillinder KR
Year: 2017
Journal: Nucleic Acids Res
Title: Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability.
Volume: 45
Issue: 3
Pages: 1130-1143
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Publication
28143845 | J:244984
First Author: Planutis A
Year: 2017
Journal: Development
Title: Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.
Volume: 144
Issue: 3
Pages: 430-440
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Publication
23530053 | J:204029
First Author: Liu S
Year: 2013
Journal: Mol Cell Biol
Title: Erythropoiesis in the absence of adult hemoglobin.
Volume: 33
Issue: 11
Pages: 2241-51
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Publication
15489291 | J:93146
First Author: Drissen R
Year: 2004
Journal: Genes Dev
Title: The active spatial organization of the beta-globin locus requires the transcription factor EKLF.
Volume: 18
Issue: 20
Pages: 2485-90
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Publication
19251649 | J:150316
First Author: Sengupta T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Distinct modes of gene regulation by a cell-specific transcriptional activator.
Volume: 106
Issue: 11
Pages: 4213-8
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Publication
8924208 | J:33112
First Author: Bieker JJ
Year: 1996
Journal: DNA Cell Biol
Title: Isolation, genomic structure, and expression of human erythroid Krüppel-like factor (EKLF).
Volume: 15
Issue: 5
Pages: 347-52
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Publication
8896981 | J:33704
First Author: Southwood CM
Year: 1996
Journal: Dev Dyn
Title: Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny.
Volume: 206
Issue: 3
Pages: 248-59
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Publication
9119377 | J:38416
First Author: van Ree JH
Year: 1997
Journal: Genomics
Title: The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.
Volume: 39
Issue: 3
Pages: 393-5
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Publication
16705186 | J:109613
First Author: Pilon AM
Year: 2006
Journal: Mol Cell Biol
Title: Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.
Volume: 26
Issue: 11
Pages: 4368-77
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Publication
17242208 | J:118858
First Author: Shyu YC
Year: 2007
Journal: Mol Cell Biol
Title: Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription.
Volume: 27
Issue: 6
Pages: 2309-23
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Publication
18448565 | J:136715
First Author: Lohmann F
Year: 2008
Journal: Development
Title: Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment.
Volume: 135
Issue: 12
Pages: 2071-82
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Publication
18523154 | J:138412
First Author: Bouilloux F
Year: 2008
Journal: Blood
Title: EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation.
Volume: 112
Issue: 3
Pages: 576-84
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Publication
21900194 | J:178374
First Author: Pilon AM
Year: 2011
Journal: Blood
Title: Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.
Volume: 118
Issue: 17
Pages: e139-48
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Publication
24866116 | J:221271
First Author: Xue L
Year: 2014
Journal: Development
Title: Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.
Volume: 141
Issue: 11
Pages: 2245-54
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GXD Expression
GXD Expression
     
Probe: MGI:1328797
Assay Type: Western blot
Annotation Date: 1999-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:1328800
Age: embryonic day 13.5
Specimen Label: wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1328797
Assay Type: Western blot
Annotation Date: 1999-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:1328800
Age: embryonic day 13.5
Specimen Label: wt
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1261564
Assay Type: Northern blot
Annotation Date: 1999-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604217
Stage: TS17
Assay Id: MGI:1328802
Age: embryonic day 10.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1261564
Assay Type: Northern blot
Annotation Date: 1999-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604217
Stage: TS17
Assay Id: MGI:1328802
Age: embryonic day 10.5
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1261564
Assay Type: Northern blot
Annotation Date: 1999-02-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604217
Stage: TS17
Assay Id: MGI:1328802
Age: embryonic day 10.5
Specimen Label: -/-
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Heart
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Brain
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Spleen
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Lung
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Liver
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2661457
Assay Type: Northern blot
Annotation Date: 2003-06-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2662301
Age: postnatal adult
Specimen Label: Skel. Muscle
Detected: false
Specimen Num: 6
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