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Search results 1 to 100 out of 511 for Klf5

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0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Krueppel-like factor 5 (KLF5) belongs to the Kruppel family, whose members bind GC-rich DNA elements and activate or repress their target genes in a promoter context and/or cellular environment-dependent manner []. KLF5 is a zinc-finger transcription factor promoting cell proliferation, cell-cycle progression and survival []. It regulates transcription of a number of genes, such as the platelet-derived growth factor-alpha (PDGF-alpha), CyclinD1, Pim1 and PPARgamma []. It has been implicated in pathways critical to carcinogenesis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:282280
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825990
Age: embryonic day 14.5
Image: Additional file 4 Klf5
Specimen Label: Additional file 4 Klf5
Detected: true
Specimen Num: 1
Publication
First Author: Zheng HQ
Year: 2009
Journal: Oncogene
Title: Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.
Volume: 28
Issue: 42
Pages: 3702-13
Publication
First Author: Zhang Z
Year: 2003
Journal: Nucleic Acids Res
Title: Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function.
Volume: 31
Issue: 8
Pages: 2196-208
Publication
First Author: Zhao Y
Year: 2008
Journal: Oncogene
Title: Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells.
Volume: 27
Issue: 1
Pages: 1-8
Publication
First Author: Lin SC
Year: 2010
Journal: Development
Title: Klf5 regulates lineage formation in the pre-implantation mouse embryo.
Volume: 137
Issue: 23
Pages: 3953-63
Protein
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
Publication
First Author: Parisi S
Year: 2008
Journal: J Cell Sci
Title: Klf5 is involved in self-renewal of mouse embryonic stem cells.
Volume: 121
Issue: Pt 16
Pages: 2629-34
Publication
First Author: Drosatos K
Year: 2016
Journal: Circ Res
Title: Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.
Volume: 118
Issue: 2
Pages: 241-53
Publication
First Author: Lyu Y
Year: 2022
Journal: Genes Dev
Title: KLF5 governs sphingolipid metabolism and barrier function of the skin.
Volume: 36
Issue: 13-14
Pages: 822-42
Publication
First Author: Nakaya T
Year: 2014
Journal: Cancer Res
Title: KLF5 regulates the integrity and oncogenicity of intestinal stem cells.
Volume: 74
Issue: 10
Pages: 2882-91
Publication
First Author: Zhang B
Year: 2020
Journal: Nat Commun
Title: Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration.
Volume: 11
Issue: 1
Pages: 997
Publication
First Author: Kyriazis ID
Year: 2021
Journal: Circ Res
Title: KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy.
Volume: 128
Issue: 3
Pages: 335-357
Publication
First Author: Oishi Y
Year: 2005
Journal: Cell Metab
Title: Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Volume: 1
Issue: 1
Pages: 27-39
Publication
First Author: Ma D
Year: 2020
Journal: PLoS Biol
Title: Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Volume: 18
Issue: 8
Pages: e3000808
Publication
First Author: Shahrin NH
Year: 2016
Journal: Blood
Title: Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor.
Volume: 128
Issue: 1
Pages: 55-9
Publication
First Author: Zempo H
Year: 2016
Journal: Hypertens Res
Title: Influence of periostin-positive cell-specific Klf5 deletion on aortic thickening in DOCA-salt hypertensive mice.
Volume: 39
Issue: 11
Pages: 764-768
Publication  
First Author: Shieh J
Year: 2022
Journal: JCI Insight
Title: KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model.
Volume: 7
Issue: 7
Publication
First Author: Okada H
Year: 2018
Journal: J Biol Chem
Title: The transcription factor Klf5 is essential for intrahepatic biliary epithelial tissue remodeling after cholestatic liver injury.
Volume: 293
Issue: 17
Pages: 6214-6229
Publication
First Author: Sur I
Year: 2006
Journal: J Cell Sci
Title: Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis.
Volume: 119
Issue: Pt 17
Pages: 3593-601
Publication  
First Author: Aksoy I
Year: 2014
Journal: Nat Commun
Title: Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells.
Volume: 5
Pages: 3719
Publication
First Author: Kenchegowda D
Year: 2012
Journal: PLoS One
Title: Critical role of Klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneas.
Volume: 7
Issue: 9
Pages: e44771
Publication
First Author: Pol CJ
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.
Volume: 1865
Issue: 9
Pages: 2125-2137
Publication
First Author: Liberti DC
Year: 2022
Journal: Dev Cell
Title: Klf5 defines alveolar epithelial type 1 cell lineage commitment during lung development and regeneration.
Volume: 57
Issue: 14
Pages: 1742-1757.e5
Publication
First Author: Zhao T
Year: 2015
Journal: PLoS One
Title: Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells.
Volume: 10
Issue: 9
Pages: e0138168
Publication
First Author: Xing C
Year: 2014
Journal: Neoplasia
Title: Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways.
Volume: 16
Issue: 11
Pages: 883-99
Publication    
First Author: Hayashi S
Year: 2016
Journal: Elife
Title: Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice.
Volume: 5
Publication
First Author: Xing C
Year: 2013
Journal: PLoS One
Title: Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells.
Volume: 8
Issue: 6
Pages: e65538
Publication
First Author: Zhang ML
Year: 2017
Journal: Biochim Biophys Acta
Title: iNOS-derived peroxynitrite mediates high glucose-induced inflammatory gene expression in vascular smooth muscle cells through promoting KLF5 expression and nitration.
Volume: 1863
Issue: 11
Pages: 2821-2834
Publication
First Author: Zhang B
Year: 2013
Journal: Mol Cell Biol
Title: KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells.
Volume: 33
Issue: 24
Pages: 4919-35
Publication  
First Author: Ci X
Year: 2015
Journal: Mol Cancer
Title: KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation.
Volume: 14
Pages: 91
Publication
First Author: Zhang XH
Year: 2015
Journal: Hypertension
Title: TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 during Ang II-induced vascular remodeling.
Volume: 66
Issue: 2
Pages: 412-21
Publication  
First Author: Taniguchi Ishikawa E
Year: 2013
Journal: Nat Commun
Title: Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking.
Volume: 4
Pages: 1660
Publication
First Author: Ma D
Year: 2017
Journal: Biochem Biophys Res Commun
Title: 1, 25(OH)2D3-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation.
Volume: 482
Issue: 2
Pages: 366-374
Publication
First Author: Kenchegowda D
Year: 2011
Journal: Dev Biol
Title: Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells.
Volume: 356
Issue: 1
Pages: 5-18
Publication
First Author: Azami T
Year: 2017
Journal: Development
Title: Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4.
Volume: 144
Issue: 20
Pages: 3706-3718
Publication      
First Author: Turer E
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Bernie.
Publication
First Author: Liu R
Year: 2018
Journal: J Pathol
Title: Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis.
Volume: 246
Issue: 4
Pages: 497-507
Publication
First Author: Bergström Å
Year: 2021
Journal: Transgenic Res
Title: Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5).
Volume: 30
Issue: 5
Pages: 701-707
Publication
First Author: McConnell BB
Year: 2008
Journal: Gastroenterology
Title: Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection.
Volume: 134
Issue: 4
Pages: 1007-16
Publication
First Author: Takeda N
Year: 2010
Journal: J Clin Invest
Title: Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.
Volume: 120
Issue: 1
Pages: 254-65
Publication  
First Author: Liu L
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy.
Volume: 118
Issue: 35
Publication
First Author: McConnell BB
Year: 2011
Journal: Gastroenterology
Title: Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine.
Volume: 141
Issue: 4
Pages: 1302-13, 1313.e1-6
Publication
First Author: Fujiu K
Year: 2011
Journal: J Clin Invest
Title: Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice.
Volume: 121
Issue: 9
Pages: 3425-41
Publication
First Author: Oishi Y
Year: 2008
Journal: Nat Med
Title: SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
Volume: 14
Issue: 6
Pages: 656-66
Publication
First Author: Goldstein BG
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells.
Volume: 292
Issue: 6
Pages: G1784-92
Publication
First Author: Tetreault MP
Year: 2012
Journal: PLoS One
Title: Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo.
Volume: 7
Issue: 5
Pages: e38338
Publication
First Author: Sun X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation.
Volume: 109
Issue: 4
Pages: 1145-50
Publication
First Author: Liu Y
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Krüppel-like factor 5 is essential for maintenance of barrier function in mouse colon.
Volume: 313
Issue: 5
Pages: G478-G491
Publication  
First Author: Yamane M
Year: 2018
Journal: Development
Title: Overlapping functions of Krüppel-like factor family members: targeting multiple transcription factors to maintain the naïve pluripotency of mouse embryonic stem cells.
Volume: 145
Issue: 10
Publication
First Author: Ma D
Year: 2017
Journal: Circ Res
Title: Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
Volume: 120
Issue: 5
Pages: 799-815
Publication
First Author: Li M
Year: 2015
Journal: Int J Biol Sci
Title: Krüppel-Like Factor 5 Promotes Epithelial Proliferation and DNA Damage Repair in the Intestine of Irradiated Mice.
Volume: 11
Issue: 12
Pages: 1458-68
Publication
First Author: Oh GS
Year: 2020
Journal: FASEB J
Title: Regulation of adipocyte differentiation by clusterin-mediated Krüppel-like factor 5 stabilization.
Volume: 34
Issue: 12
Pages: 16276-16290
Publication
First Author: Du JX
Year: 2007
Journal: J Biol Chem
Title: Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5.
Volume: 282
Issue: 7
Pages: 4782-93
Publication
First Author: Zheng B
Year: 2018
Journal: Biochim Biophys Acta
Title: Regulatory crosstalk between KLF5, miR-29a and Fbw7/CDC4 cooperatively promotes atherosclerotic development.
Volume: 1864
Issue: 2
Pages: 374-386
Publication
First Author: Yang J
Year: 2019
Journal: Stem Cell Reports
Title: Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming.
Volume: 12
Issue: 4
Pages: 757-771
Publication
First Author: Nandan MO
Year: 2014
Journal: Dev Biol
Title: Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon.
Volume: 387
Issue: 2
Pages: 191-202
Publication
First Author: Ohnishi S
Year: 2000
Journal: Dev Dyn
Title: Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5.
Volume: 217
Issue: 4
Pages: 421-9
Publication
First Author: Meyer SE
Year: 2010
Journal: Am J Pathol
Title: Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.
Volume: 177
Issue: 3
Pages: 1503-13
Publication
First Author: Chen WC
Year: 2015
Journal: Am J Pathol
Title: Matrix-Stiffness-Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis.
Volume: 185
Issue: 9
Pages: 2468-81
Publication
First Author: Kim CK
Year: 2020
Journal: Cell Mol Gastroenterol Hepatol
Title: Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells.
Volume: 9
Issue: 4
Pages: 587-609
Publication
First Author: Ema M
Year: 2008
Journal: Cell Stem Cell
Title: Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.
Volume: 3
Issue: 5
Pages: 555-67
Publication
First Author: Shindo T
Year: 2002
Journal: Nat Med
Title: Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Volume: 8
Issue: 8
Pages: 856-63
Publication
First Author: Delgado-Olguín P
Year: 2014
Journal: Development
Title: Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature.
Volume: 141
Issue: 23
Pages: 4610-7
Publication
First Author: Fujii Y
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.
Volume: 109
Issue: 50
Pages: 20584-9
Publication
First Author: Huan W
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: Involvement of DHX9/YB-1 complex induced alternative splicing of Krüppel-like factor 5 mRNA in phenotypic transformation of vascular smooth muscle cells.
Volume: 317
Issue: 2
Pages: C262-C269
Publication
First Author: Wan H
Year: 2008
Journal: Development
Title: Kruppel-like factor 5 is required for perinatal lung morphogenesis and function.
Volume: 135
Issue: 15
Pages: 2563-72
Publication
First Author: Fu J
Year: 2022
Journal: J Biol Chem
Title: A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice.
Volume: 298
Issue: 8
Pages: 102220
Publication
First Author: Kinoshita M
Year: 2010
Journal: Mol Endocrinol
Title: Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5.
Volume: 24
Issue: 10
Pages: 1978-87
Publication
First Author: Jiang J
Year: 2008
Journal: Nat Cell Biol
Title: A core Klf circuitry regulates self-renewal of embryonic stem cells.
Volume: 10
Issue: 3
Pages: 353-60
Publication
First Author: McConnell BB
Year: 2009
Journal: Cancer Res
Title: Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine.
Volume: 69
Issue: 10
Pages: 4125-33
Publication
First Author: Yang Y
Year: 2008
Journal: J Biol Chem
Title: Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase.
Volume: 283
Issue: 27
Pages: 18812-20
Publication
First Author: Du JX
Year: 2008
Journal: J Biol Chem
Title: SUMOylation regulates nuclear localization of Krüppel-like factor 5.
Volume: 283
Issue: 46
Pages: 31991-2002
Publication
First Author: Shinoda Y
Year: 2008
Journal: J Biol Chem
Title: Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.
Volume: 283
Issue: 36
Pages: 24682-9
Publication
First Author: Moore-Scott BA
Year: 2007
Journal: Dev Dyn
Title: Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation.
Volume: 236
Issue: 7
Pages: 1997-2003
Publication
First Author: He P
Year: 2018
Journal: Gastroenterology
Title: Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice.
Volume: 154
Issue: 5
Pages: 1494-1508.e13
Publication
First Author: Davis H
Year: 2011
Journal: J Pathol
Title: FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.
Volume: 224
Issue: 2
Pages: 180-9
Publication
First Author: Bell SM
Year: 2011
Journal: Dev Biol
Title: Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium.
Volume: 358
Issue: 1
Pages: 79-90
Publication  
First Author: Li R
Year: 2022
Journal: Dev Biol
Title: E3 ubiquitin ligase FBXW7 balances airway cell fates.
Volume: 483
Pages: 89-97
Publication
First Author: Bell SM
Year: 2013
Journal: Dev Biol
Title: Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.
Volume: 375
Issue: 2
Pages: 128-39
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory