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Search results 1 to 83 out of 83 for Klhl25

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Hits by Category

Type Details Score
Gene
64410 | KLHL25
Type: gene
Organism: human
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Gene
529905 | KLHL25
Type: gene
Organism: cattle
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Gene
770701 | KLHL25
Type: gene
Organism: chicken
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Gene
697129 | KLHL25
Type: gene
Organism: macaque, rhesus
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Gene
779996 | klhl25
Type: gene
Organism: frog, western clawed
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Gene
293023 | Klhl25
Type: gene
Organism: rat
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Gene
488725 | KLHL25
Type: gene
Organism: dog, domestic
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Gene
453622 | KLHL25
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2668031 | Klhl25
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR030565 | KLHL25
Type: Family
Description: Kelch-like protein 25 (KLHL25, also known as ENC-2) serves as a substrate-specific adapter in the Cul3-dependent ubiquitin ligase complex that targets hypophosphorylated 4E-BP1 (4E-binding protein 1) for degradation []. 4E-BPs regulate the activity of eIF4E, a mRNA 5' cap-binding protein and a major target for translational control [].The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ].
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Gene
127379729 | KLHL25P1
Type: gene
Organism: human
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Publication
22578813 | -
First Author: Yanagiya A
Year: 2012
Journal: Mol Cell
Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.
Volume: 46
Issue: 6
Pages: 847-58
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Protein
Q8R2P1
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
A0A0U1RNK3
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
A0A0U1RQ03
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
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Publication
15544948 | -
First Author: Stogios PJ
Year: 2004
Journal: Trends Biochem Sci
Title: The BACK domain in BTB-kelch proteins.
Volume: 29
Issue: 12
Pages: 634-7
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Publication
23676014 | -
 
First Author: Dhanoa BS
Year: 2013
Journal: Hum Genomics
Title: Update on the Kelch-like (KLHL) gene family.
Volume: 7
Pages: 13
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Publication
10603472 | -
First Author: Adams J
Year: 2000
Journal: Trends Cell Biol
Title: The kelch repeat superfamily of proteins: propellers of cell function.
Volume: 10
Issue: 1
Pages: 17-24
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Publication
14528312 | -
First Author: Furukawa M
Year: 2003
Journal: Nat Cell Biol
Title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
Volume: 5
Issue: 11
Pages: 1001-7
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Publication
23135275 | -
First Author: Oberg EA
Year: 2012
Journal: J Biol Chem
Title: Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.
Volume: 287
Issue: 52
Pages: 43378-89
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Protein Coding Gene
MGP_CAROLIEiJ_G0029866 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032354 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032366 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032079 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2668031 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031407 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032045 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032155 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032281 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032192 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032876 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031127 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031525 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013088 | -
Type: protein_coding_gene
Organism: Mus pahari
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GXD Expression
GXD Expression
 
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585991
Age: postnatal day 6
Note: Expression was detected in a subset of the PNS.
Specimen Label: CNS
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716826
Pattern: Uniform
Stage: TS26
Assay Id: MGI:3585991
Age: embryonic day 18.0
Note: Expression was panretinal.
Specimen Label: E18
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Pattern: Uniform
Stage: TS27
Assay Id: MGI:3585991
Age: postnatal day 0-1
Note: Expression was panretinal.
Specimen Label: P0/1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Pattern: Uniform
Stage: TS27
Assay Id: MGI:3585991
Age: postnatal day 2-3
Note: Expression was panretinal.
Specimen Label: P2/3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Uniform
Stage: TS28
Assay Id: MGI:3585991
Age: postnatal day 4-5
Note: Expression was panretinal.
Specimen Label: P4/5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Uniform
Stage: TS28
Assay Id: MGI:3585991
Age: postnatal day 6-7
Note: Expression was panretinal.
Specimen Label: P6/7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Uniform
Stage: TS28
Assay Id: MGI:3585991
Age: postnatal day 8-10
Note: Expression was panretinal.
Specimen Label: P8/10
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585991
Age: embryonic day 16.0
Specimen Label: Embryo
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:1086659
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1646928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585991
Age: postnatal day 6
Note: Expression was detected in a scattered neuronal subset.
Specimen Label: CNS
Detected: true
Specimen Num: 7
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Publication
34491895 | J:316927
   
First Author: Tian M
Year: 2021
Journal: Elife
Title: ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation.
Volume: 10
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Publication
31541165 | J:284228
First Author: Ikegami K
Year: 2019
Journal: Sci Rep
Title: Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.
Volume: 9
Issue: 1
Pages: 13634
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Publication
10932192 | J:68708
First Author: Hrabé de Angelis MH
Year: 2000
Journal: Nat Genet
Title: Genome-wide, large-scale production of mutant mice by ENU mutagenesis.
Volume: 25
Issue: 4
Pages: 444-7
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Publication
32541003 | J:291493
 
First Author: Najas S
Year: 2020
Journal: Development
Title: A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex.
Volume: 147
Issue: 13
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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