Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Kelch-like protein 3 (KLHL3) is a substrate adaptor protein in the CUL3-KLHL3 E3 ubiquitin ligase complex. It targets WNK4 kinase 1 for ubiquitination and degradation, which in turn regulates electrolyte homeostasis []. Mutations in the KLHL3 gene cause cause pseudohypoaldosteronism type II (PHAII), which is a rare Mendelian syndrome featuring hypertension and hyperkalemia resulting from constitutive renal salt reabsorption and impaired K(+) secretion [, ]. The CUL3-KLHL3 E3 ligase complex may regulate blood pressure via its ability to interact with and ubiquitylate WNK isoforms [, ].The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata S |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. |
Volume: |
110 |
Issue: |
19 |
Pages: |
7838-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ostrosky-Frid M |
Year: |
2021 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression. |
Volume: |
320 |
Issue: |
5 |
Pages: |
F734-F747 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki E |
Year: |
2017 |
Journal: |
Mol Cell Biol |
Title: |
KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. |
Volume: |
37 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gong Y |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. |
Volume: |
112 |
Issue: |
14 |
Pages: |
4340-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin CM |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain. |
Volume: |
33 |
Issue: |
1 |
Pages: |
1051-1061 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin CM |
Year: |
2022 |
Journal: |
FASEB J |
Title: |
Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domain. |
Volume: |
36 |
Issue: |
6 |
Pages: |
e22363 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jang JH |
Year: |
2022 |
Journal: |
Exp Mol Med |
Title: |
KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure. |
Volume: |
54 |
Issue: |
8 |
Pages: |
1250-1261 |
|
•
•
•
•
•
|
Publication |
First Author: |
Susa K |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. |
Volume: |
23 |
Issue: |
19 |
Pages: |
5052-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohta A |
Year: |
2013 |
Journal: |
Biochem J |
Title: |
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. |
Volume: |
451 |
Issue: |
1 |
Pages: |
111-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wakabayashi M |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. |
Volume: |
3 |
Issue: |
3 |
Pages: |
858-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boyden LM |
Year: |
2012 |
Journal: |
Nature |
Title: |
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. |
Volume: |
482 |
Issue: |
7383 |
Pages: |
98-102 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
587
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams J |
Year: |
2000 |
Journal: |
Trends Cell Biol |
Title: |
The kelch repeat superfamily of proteins: propellers of cell function. |
Volume: |
10 |
Issue: |
1 |
Pages: |
17-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Furukawa M |
Year: |
2003 |
Journal: |
Nat Cell Biol |
Title: |
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. |
Volume: |
5 |
Issue: |
11 |
Pages: |
1001-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oberg EA |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. |
Volume: |
287 |
Issue: |
52 |
Pages: |
43378-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stogios PJ |
Year: |
2004 |
Journal: |
Trends Biochem Sci |
Title: |
The BACK domain in BTB-kelch proteins. |
Volume: |
29 |
Issue: |
12 |
Pages: |
634-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhanoa BS |
Year: |
2013 |
Journal: |
Hum Genomics |
Title: |
Update on the Kelch-like (KLHL) gene family. |
Volume: |
7 |
|
Pages: |
13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Susa K |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3. |
Volume: |
491 |
Issue: |
3 |
Pages: |
727-732 |
|
•
•
•
•
•
|
Publication |
First Author: |
McCormick JA |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3. |
Volume: |
124 |
Issue: |
11 |
Pages: |
4723-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maeoka Y |
Year: |
2022 |
Journal: |
J Am Soc Nephrol |
Title: |
Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice. |
Volume: |
33 |
Issue: |
3 |
Pages: |
584-600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata S |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. |
Volume: |
111 |
Issue: |
43 |
Pages: |
15556-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mori Y |
Year: |
2015 |
Journal: |
Biochem J |
Title: |
Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation. |
Volume: |
472 |
Issue: |
1 |
Pages: |
33-41 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1777828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313108 |
|
Specimen Label: |
MRC Harwell_1313108 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1777828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313114 |
|
Specimen Label: |
MRC Harwell_1313114 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1737328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313109 |
Note: |
kidney |
Specimen Label: |
MRC Harwell_1313109 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1666528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313107 |
|
Specimen Label: |
MRC Harwell_1313107 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3267828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313108 |
|
Specimen Label: |
MRC Harwell_1313108 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3267828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313114 |
|
Specimen Label: |
MRC Harwell_1313114 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313108 |
|
Specimen Label: |
MRC Harwell_1313108 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313110 |
|
Specimen Label: |
MRC Harwell_1313110 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313114 |
|
Specimen Label: |
MRC Harwell_1313114 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1898428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313111 |
|
Specimen Label: |
MRC Harwell_1313111 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1753628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313108 |
|
Specimen Label: |
MRC Harwell_1313108 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1753628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313114 |
|
Specimen Label: |
MRC Harwell_1313114 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1778728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313108 |
|
Specimen Label: |
MRC Harwell_1313108 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1778728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313114 |
|
Specimen Label: |
MRC Harwell_1313114 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313108 |
|
Specimen Label: |
MRC Harwell_1313108 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313110 |
|
Specimen Label: |
MRC Harwell_1313110 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313114 |
|
Specimen Label: |
MRC Harwell_1313114 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1672828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313106 |
|
Specimen Label: |
MRC Harwell_1313106 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313108 |
|
Specimen Label: |
MRC Harwell_1313108 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313110 |
|
Specimen Label: |
MRC Harwell_1313110 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313114 |
|
Specimen Label: |
MRC Harwell_1313114 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1610528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313113 |
|
Specimen Label: |
MRC Harwell_1313113 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1842628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313115 |
|
Specimen Label: |
MRC Harwell_1313115 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313104 |
|
Specimen Label: |
MRC Harwell_1313104 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1757728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313105 |
|
Specimen Label: |
MRC Harwell_1313105 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3281228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313112 |
|
Specimen Label: |
MRC Harwell_1313112 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313108 |
|
Specimen Label: |
MRC Harwell_1313108 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313110 |
|
Specimen Label: |
MRC Harwell_1313110 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692718 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1313114 |
|
Specimen Label: |
MRC Harwell_1313114 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
Pages: |
508-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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|
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|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
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|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
|