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Search results 1 to 100 out of 375 for Kmt2a

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0.042s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Histone-lysine N-methyltransferase 2A (KMT2A; ) is the catalytic subunit of the MLL1/MLL complex, mediating methylation of 'Lys-4' of histone H3 (H3K4me), a specific tag for epigenetic transcriptional activation []. KMT2A is processed by the threonine endopeptidase taspase, releasing products N320 and C180 []. KMT2A contains a CxxC (x for any residue) zinc finger domain, three plant homeodomain (PHD) fingers, a Bromodomain domain, an extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, twoFY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Kerimoglu C
Year: 2017
Journal: Cell Rep
Title: KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.
Volume: 20
Issue: 3
Pages: 538-548
Publication
First Author: Nanya M
Year: 2015
Journal: PLoS One
Title: Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.
Volume: 10
Issue: 12
Pages: e0144540
Protein
Organism: Mus musculus
Length: 173  
Fragment?: true
Protein
Organism: Mus musculus
Length: 639  
Fragment?: true
Publication
First Author: Hsieh JJ
Year: 2003
Journal: Mol Cell Biol
Title: Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
Volume: 23
Issue: 1
Pages: 186-94
Publication
First Author: Dou Y
Year: 2005
Journal: Cell
Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Volume: 121
Issue: 6
Pages: 873-85
Protein
Organism: Mus musculus
Length: 1438  
Fragment?: true
Protein
Organism: Mus musculus
Length: 629  
Fragment?: true
Protein
Organism: Mus musculus
Length: 3966  
Fragment?: false
Protein
Organism: Mus musculus
Length: 762  
Fragment?: true
Publication
First Author: Dobson CL
Year: 1999
Journal: EMBO J
Title: The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis.
Volume: 18
Issue: 13
Pages: 3564-74
Publication
First Author: Chen W
Year: 2011
Journal: Blood
Title: Modeling human infant MLL leukemia in mice: leukemia from fetal liver differs from that originating in postnatal marrow.
Volume: 117
Issue: 12
Pages: 3474-5
Publication
First Author: Corral J
Year: 1996
Journal: Cell
Title: An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes.
Volume: 85
Issue: 6
Pages: 853-61
Publication  
First Author: Lobato MN
Year: 2008
Journal: J Natl Cancer Inst Monogr
Title: Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
Issue: 39
Pages: 58-63
Publication
First Author: Bergerson RJ
Year: 2012
Journal: Blood
Title: An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.
Volume: 119
Issue: 19
Pages: 4512-23
Publication
First Author: Chen W
Year: 2008
Journal: Cancer Cell
Title: Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells.
Volume: 13
Issue: 5
Pages: 432-40
Publication
First Author: Kumar AR
Year: 2004
Journal: Blood
Title: Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia.
Volume: 103
Issue: 5
Pages: 1823-8
Publication
First Author: Chen W
Year: 2006
Journal: Blood
Title: A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.
Volume: 108
Issue: 2
Pages: 669-77
Publication
First Author: Pomeroy EJ
Year: 2017
Journal: Oncogene
Title: Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.
Volume: 36
Issue: 23
Pages: 3263-3273
Publication
First Author: Kim WI
Year: 2009
Journal: Blood
Title: RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia.
Volume: 113
Issue: 5
Pages: 1086-96
Publication
First Author: Vukovic M
Year: 2015
Journal: J Exp Med
Title: Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.
Volume: 212
Issue: 13
Pages: 2223-34
Publication
First Author: Dorrance AM
Year: 2006
Journal: J Clin Invest
Title: Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.
Volume: 116
Issue: 10
Pages: 2707-16
Publication
First Author: Hönes JM
Year: 2016
Journal: Leukemia
Title: GFI1 as a novel prognostic and therapeutic factor for AML/MDS.
Volume: 30
Issue: 6
Pages: 1237-45
Publication
First Author: Zhu X
Year: 2014
Journal: Nat Genet
Title: Identification of functional cooperative mutations of SETD2 in human acute leukemia.
Volume: 46
Issue: 3
Pages: 287-93
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lim DA
Year: 2009
Journal: Nature
Title: Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.
Volume: 458
Issue: 7237
Pages: 529-33
Publication
First Author: Gan T
Year: 2010
Journal: Leukemia
Title: Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis.
Volume: 24
Issue: 10
Pages: 1732-41
Publication
First Author: Yamashita M
Year: 2006
Journal: Immunity
Title: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.
Volume: 24
Issue: 5
Pages: 611-22
Publication
First Author: Shima Y
Year: 2017
Journal: Leukemia
Title: MLL is essential for NUP98-HOXA9-induced leukemia.
Volume: 31
Issue: 10
Pages: 2200-2210
Publication
First Author: Wang J
Year: 2005
Journal: EMBO J
Title: Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
Volume: 24
Issue: 2
Pages: 368-81
Publication
First Author: Krivtsov AV
Year: 2008
Journal: Cancer Cell
Title: H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Volume: 14
Issue: 5
Pages: 355-68
Publication
First Author: Mishra BP
Year: 2014
Journal: Cell Rep
Title: The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis.
Volume: 7
Issue: 4
Pages: 1239-47
Publication
First Author: Zhang Y
Year: 2012
Journal: Blood
Title: Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Volume: 120
Issue: 5
Pages: 1118-29
Publication
First Author: Sun Q
Year: 2008
Journal: J Leukoc Biol
Title: Aberrant dendritic cell differentiation initiated by the Mll-Een fusion gene does not require leukemic transformation.
Volume: 83
Issue: 1
Pages: 173-80
Publication
First Author: Thiel AT
Year: 2010
Journal: Cancer Cell
Title: MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.
Volume: 17
Issue: 2
Pages: 148-59
Publication
First Author: McMahon KA
Year: 2007
Journal: Cell Stem Cell
Title: Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.
Volume: 1
Issue: 3
Pages: 338-45
Publication
First Author: Takacova S
Year: 2012
Journal: Cancer Cell
Title: DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo.
Volume: 21
Issue: 4
Pages: 517-31
Publication
First Author: Milne TA
Year: 2002
Journal: Mol Cell
Title: MLL targets SET domain methyltransferase activity to Hox gene promoters.
Volume: 10
Issue: 5
Pages: 1107-17
Publication
First Author: Ernst P
Year: 2004
Journal: Curr Biol
Title: An Mll-dependent Hox program drives hematopoietic progenitor expansion.
Volume: 14
Issue: 22
Pages: 2063-9
Publication
First Author: Dobson CL
Year: 2000
Journal: EMBO J
Title: Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
Volume: 19
Issue: 5
Pages: 843-51
Publication
First Author: Djabali M
Year: 1992
Journal: Nat Genet
Title: A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.
Volume: 2
Issue: 2
Pages: 113-8
Publication
First Author: Canaani E
Year: 2004
Journal: Br J Cancer
Title: ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.
Volume: 90
Issue: 4
Pages: 756-60
Publication
First Author: Popovic R
Year: 2009
Journal: Blood
Title: Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.
Volume: 113
Issue: 14
Pages: 3314-22
Publication
First Author: Mi S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia.
Volume: 107
Issue: 8
Pages: 3710-5
Publication
First Author: Huang G
Year: 2011
Journal: Blood
Title: The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.
Volume: 118
Issue: 25
Pages: 6544-52
Publication
First Author: Wang X
Year: 2014
Journal: Biochim Biophys Acta
Title: Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation.
Volume: 1843
Issue: 11
Pages: 2592-602
Publication
First Author: Zhang H
Year: 2016
Journal: Cell Stem Cell
Title: MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency.
Volume: 18
Issue: 4
Pages: 481-94
Publication
First Author: Schaller M
Year: 2015
Journal: J Leukoc Biol
Title: Epigenetic regulation of IL-12-dependent T cell proliferation.
Volume: 98
Issue: 4
Pages: 601-13
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187322
Stage: TS22
Assay Id: MGI:5824573
Age: embryonic day 14.5
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187320
Stage: TS20
Assay Id: MGI:5824573
Age: embryonic day 12.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187319
Stage: TS19
Assay Id: MGI:5824573
Age: embryonic day 11.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608522
Stage: TS22
Assay Id: MGI:5824573
Age: embryonic day 14.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608520
Stage: TS20
Assay Id: MGI:5824573
Age: embryonic day 12.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608519
Stage: TS19
Assay Id: MGI:5824573
Age: embryonic day 11.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5824573
Age: embryonic day 14.5
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:5824573
Age: embryonic day 12.5
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684619
Stage: TS19
Assay Id: MGI:5824573
Age: embryonic day 11.5
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3540220
Stage: TS20
Assay Id: MGI:5824573
Age: embryonic day 12.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3540219
Stage: TS19
Assay Id: MGI:5824573
Age: embryonic day 11.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753622
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3506794
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753627
Stage: TS27
Assay Id: MGI:3508236
Age: postnatal newborn
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506794
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753621
Stage: TS21
Assay Id: MGI:3508236
Age: embryonic day 13.5
Image: 1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274322
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5824568
Assay Type: Immunohistochemistry
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187320
Pattern: Widespread
Stage: TS20
Assay Id: MGI:5824575
Age: embryonic day 12.5
Note: Authors report widespread expression, with cells in and around the major vessels, including the umbilical artery.
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:348152
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:3573928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585672
Age: postnatal adult
Image: Adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647022
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:348152
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585672
Age: postnatal day 6
Note: Expression was widespread.
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:3506794
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3509472
Age: embryonic day 10.5
Image: 1
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Num: 1
GXD Expression  
Probe: MGI:3506794
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647027
Pattern: Single cells
Stage: TS27
Assay Id: MGI:3508236
Age: postnatal newborn
Note: Expression was detected in some cells.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3506794
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647021
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3508236
Age: embryonic day 13.5
Image: 1
Note: Expression was detected in some cells.
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5824568
Assay Type: Immunohistochemistry
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5824575
Age: embryonic day 14.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3272922
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Note: Expression was not detected in the skeleton (limbs, shoulder, hip).
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4422650
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1781522
Stage: TS22
Assay Id: MGI:5422048
Age: embryonic day 14.5
Detected: false
Specimen Num: 1