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Search results 1 to 100 out of 448 for Kmt2a

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
4297 | KMT2A
Type: gene
Organism: human
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Gene
100135006 | kmt2a
Type: gene
Organism: frog, western clawed
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Gene
315606 | Kmt2a
Type: gene
Organism: rat
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Gene
451587 | KMT2A
Type: gene
Organism: chimpanzee
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Gene
479417 | KMT2A
Type: gene
Organism: dog, domestic
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Gene
414897 | KMT2A
Type: gene
Organism: chicken
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Gene
557048 | kmt2a
Type: gene
Organism: zebrafish
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Gene
705511 | KMT2A
Type: gene
Organism: macaque, rhesus
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Gene
508330 | KMT2A
Type: gene
Organism: cattle
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Protein Domain
IPR037927 | KMT2A
Type: Family
Description: Histone-lysine N-methyltransferase 2A (KMT2A; ) is the catalytic subunit of the MLL1/MLL complex, mediating methylation of 'Lys-4' of histone H3 (H3K4me), a specific tag for epigenetic transcriptional activation []. KMT2A is processed by the threonine endopeptidase taspase, releasingproducts N320 and C180 []. KMT2A contains a CxxC (x for any residue) zinc finger domain, three plant homeodomain (PHD) fingers, a Bromodomain domain, an extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain.
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Protein Coding Gene
MGI:96995 | Kmt2a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P55200
Organism: Mus musculus/domesticus
Length: 3966  
Fragment?: false
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Publication
28723559 | J:254228
First Author: Kerimoglu C
Year: 2017
Journal: Cell Rep
Title: KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.
Volume: 20
Issue: 3
Pages: 538-548
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Publication
27801610 | J:317252
First Author: Lin W
Year: 2016
Journal: Cancer Biol Ther
Title: Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.
Volume: 17
Issue: 12
Pages: 1274-1281
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Publication
32483278 | J:315647
First Author: Vallianatos CN
Year: 2020
Journal: Commun Biol
Title: Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation.
Volume: 3
Issue: 1
Pages: 278
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Protein
S4R199
Organism: Mus musculus/domesticus
Length: 639  
Fragment?: true
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Protein
A0A1L1SQS9
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Publication
26657054 | J:243790
First Author: Nanya M
Year: 2015
Journal: PLoS One
Title: Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.
Volume: 10
Issue: 12
Pages: e0144540
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Gene
101929089 | TTC36-AS1
Type: gene
Organism: human
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Publication
12482972 | -
First Author: Hsieh JJ
Year: 2003
Journal: Mol Cell Biol
Title: Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
Volume: 23
Issue: 1
Pages: 186-94
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Protein
D3Z5H5
Organism: Mus musculus/domesticus
Length: 1438  
Fragment?: true
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Protein
S4R2S5
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: true
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Publication
15960975 | J:156231
First Author: Dou Y
Year: 2005
Journal: Cell
Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Volume: 121
Issue: 6
Pages: 873-85
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Protein
Q5DTR3
Organism: Mus musculus/domesticus
Length: 762  
Fragment?: true
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Publication
10393173 | J:56340
First Author: Dobson CL
Year: 1999
Journal: EMBO J
Title: The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis.
Volume: 18
Issue: 13
Pages: 3564-74
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Publication
8681380 | J:75959
First Author: Corral J
Year: 1996
Journal: Cell
Title: An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes.
Volume: 85
Issue: 6
Pages: 853-61
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Publication
32999332 | J:296343
First Author: Hermetet F
Year: 2020
Journal: Sci Rep
Title: High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells.
Volume: 10
Issue: 1
Pages: 16187
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Publication
18648005 | J:140415
 
First Author: Lobato MN
Year: 2008
Journal: J Natl Cancer Inst Monogr
Title: Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
Issue: 39
Pages: 58-63
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Publication
36052997 | J:348142
   
First Author: Vilaplana-Lopera N
Year: 2022
Journal: Elife
Title: Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells.
Volume: 11
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Publication
22427200 | J:185178
First Author: Bergerson RJ
Year: 2012
Journal: Blood
Title: An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.
Volume: 119
Issue: 19
Pages: 4512-23
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Publication
21436082 | J:170308
First Author: Chen W
Year: 2011
Journal: Blood
Title: Modeling human infant MLL leukemia in mice: leukemia from fetal liver differs from that originating in postnatal marrow.
Volume: 117
Issue: 12
Pages: 3474-5
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Publication
18455126 | J:134770
First Author: Chen W
Year: 2008
Journal: Cancer Cell
Title: Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells.
Volume: 13
Issue: 5
Pages: 432-40
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Publication
14615372 | J:88494
First Author: Kumar AR
Year: 2004
Journal: Blood
Title: Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia.
Volume: 103
Issue: 5
Pages: 1823-8
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Publication
32768438 | J:299913
 
First Author: Young K
Year: 2020
Journal: Exp Hematol
Title: Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias.
Volume: 89
Pages: 61-67.e3
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Publication
16551973 | J:110241
First Author: Chen W
Year: 2006
Journal: Blood
Title: A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.
Volume: 108
Issue: 2
Pages: 669-77
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Publication
27991934 | J:243158
First Author: Pomeroy EJ
Year: 2017
Journal: Oncogene
Title: Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.
Volume: 36
Issue: 23
Pages: 3263-3273
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Publication
34958665 | J:326060
First Author: Cai H
Year: 2022
Journal: Blood
Title: Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression.
Volume: 139
Issue: 20
Pages: 3040-3057
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Publication
12515728 | J:82943
First Author: Johnson JJ
Year: 2003
Journal: Blood
Title: Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia.
Volume: 101
Issue: 8
Pages: 3229-35
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Publication
35177813 | J:324038
First Author: Caplan M
Year: 2022
Journal: Leukemia
Title: Multi-omics reveals mitochondrial metabolism proteins susceptible for drug discovery in AML.
Volume: 36
Issue: 5
Pages: 1296-1305
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Publication
18952898 | J:144858
First Author: Kim WI
Year: 2009
Journal: Blood
Title: RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia.
Volume: 113
Issue: 5
Pages: 1086-96
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Publication
32763164 | J:296614
First Author: van Gastel N
Year: 2020
Journal: Cell Metab
Title: Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.
Volume: 32
Issue: 3
Pages: 391-403.e6
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Publication
28282266 | J:302616
First Author: Chen X
Year: 2017
Journal: Autophagy
Title: Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Volume: 13
Issue: 5
Pages: 955-966
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Publication
24509477 | J:258985
First Author: Zhu X
Year: 2014
Journal: Nat Genet
Title: Identification of functional cooperative mutations of SETD2 in human acute leukemia.
Volume: 46
Issue: 3
Pages: 287-93
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Publication
16981007 | J:115001
First Author: Dorrance AM
Year: 2006
Journal: J Clin Invest
Title: Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.
Volume: 116
Issue: 10
Pages: 2707-16
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Publication
37587260 | J:341189
First Author: Eifert T
Year: 2023
Journal: Leukemia
Title: Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.
Volume: 37
Issue: 10
Pages: 2027-2035
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Publication
26847026 | J:231923
First Author: Hönes JM
Year: 2016
Journal: Leukemia
Title: GFI1 as a novel prognostic and therapeutic factor for AML/MDS.
Volume: 30
Issue: 6
Pages: 1237-45
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Publication
38889007 | J:352992
First Author: Kim J
Year: 2024
Journal: Cell Rep
Title: An enhancer RNA recruits KMT2A to regulate transcription of Myb.
Volume: 43
Issue: 7
Pages: 114378
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Publication
26642852 | J:229015
First Author: Vukovic M
Year: 2015
Journal: J Exp Med
Title: Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.
Volume: 212
Issue: 13
Pages: 2223-34
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Publication
38413714 | J:354545
First Author: Dong H
Year: 2024
Journal: Nat Cancer
Title: Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity.
Volume: 5
Issue: 4
Pages: 601-624
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Protein Coding Gene
MGP_CAROLIEiJ_G0032129 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034721 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034693 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034404 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034376 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034616 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034520 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033431 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014998 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033267 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19212323 | J:147104
First Author: Lim DA
Year: 2009
Journal: Nature
Title: Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.
Volume: 458
Issue: 7237
Pages: 529-33
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Publication
20724987 | J:165595
First Author: Gan T
Year: 2010
Journal: Leukemia
Title: Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis.
Volume: 24
Issue: 10
Pages: 1732-41
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Publication
18977325 | J:140628
First Author: Krivtsov AV
Year: 2008
Journal: Cancer Cell
Title: H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Volume: 14
Issue: 5
Pages: 355-68
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Publication
15635450 | J:95914
First Author: Wang J
Year: 2005
Journal: EMBO J
Title: Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
Volume: 24
Issue: 2
Pages: 368-81
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Publication
16713978 | J:113362
First Author: Yamashita M
Year: 2006
Journal: Immunity
Title: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.
Volume: 24
Issue: 5
Pages: 611-22
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Publication
28210005 | J:245733
First Author: Shima Y
Year: 2017
Journal: Leukemia
Title: MLL is essential for NUP98-HOXA9-induced leukemia.
Volume: 31
Issue: 10
Pages: 2200-2210
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Publication
24813891 | J:211796
First Author: Mishra BP
Year: 2014
Journal: Cell Rep
Title: The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis.
Volume: 7
Issue: 4
Pages: 1239-47
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Publication
20159607 | J:157685
First Author: Thiel AT
Year: 2010
Journal: Cancer Cell
Title: MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.
Volume: 17
Issue: 2
Pages: 148-59
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Publication
22740449 | J:189185
First Author: Zhang Y
Year: 2012
Journal: Blood
Title: Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Volume: 120
Issue: 5
Pages: 1118-29
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Publication
26059830 | J:242733
First Author: Schaller M
Year: 2015
Journal: J Leukoc Biol
Title: Epigenetic regulation of IL-12-dependent T cell proliferation.
Volume: 98
Issue: 4
Pages: 601-13
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Publication
17895399 | J:129986
First Author: Sun Q
Year: 2008
Journal: J Leukoc Biol
Title: Aberrant dendritic cell differentiation initiated by the Mll-Een fusion gene does not require leukemic transformation.
Volume: 83
Issue: 1
Pages: 173-80
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Publication
34706236 | J:337687
First Author: Symeonidou V
Year: 2021
Journal: Cell Rep
Title: Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements.
Volume: 37
Issue: 4
Pages: 109900
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Publication
22516260 | J:189329
First Author: Takacova S
Year: 2012
Journal: Cancer Cell
Title: DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo.
Volume: 21
Issue: 4
Pages: 517-31
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Publication
12453418 | J:80575
First Author: Milne TA
Year: 2002
Journal: Mol Cell
Title: MLL targets SET domain methyltransferase activity to Hox gene promoters.
Volume: 10
Issue: 5
Pages: 1107-17
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Publication
15556871 | J:219101
First Author: Ernst P
Year: 2004
Journal: Curr Biol
Title: An Mll-dependent Hox program drives hematopoietic progenitor expansion.
Volume: 14
Issue: 22
Pages: 2063-9
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Publication
10698926 | J:60894
First Author: Dobson CL
Year: 2000
Journal: EMBO J
Title: Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
Volume: 19
Issue: 5
Pages: 843-51
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Publication
1303259 | J:34111
First Author: Djabali M
Year: 1992
Journal: Nat Genet
Title: A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.
Volume: 2
Issue: 2
Pages: 113-8
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Publication
14970849 | J:88995
First Author: Canaani E
Year: 2004
Journal: Br J Cancer
Title: ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.
Volume: 90
Issue: 4
Pages: 756-60
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Publication
19188669 | J:148123
First Author: Popovic R
Year: 2009
Journal: Blood
Title: Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.
Volume: 113
Issue: 14
Pages: 3314-22
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Publication
20133587 | J:157930
First Author: Mi S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia.
Volume: 107
Issue: 8
Pages: 3710-5
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Publication
22012064 | J:179072
First Author: Huang G
Year: 2011
Journal: Blood
Title: The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.
Volume: 118
Issue: 25
Pages: 6544-52
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Publication
24983772 | J:218498
First Author: Wang X
Year: 2014
Journal: Biochim Biophys Acta
Title: Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation.
Volume: 1843
Issue: 11
Pages: 2592-602
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Publication
26996599 | J:234811
First Author: Zhang H
Year: 2016
Journal: Cell Stem Cell
Title: MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency.
Volume: 18
Issue: 4
Pages: 481-94
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Publication
32467231 | J:297151
First Author: Wang H
Year: 2020
Journal: J Biol Chem
Title: An aberrantly sustained emergency granulopoiesis response accelerates postchemotherapy relapse in MLL1-rearranged acute myeloid leukemia in mice.
Volume: 295
Issue: 28
Pages: 9663-9675
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Publication
26725110 | J:345498
First Author: Deng C
Year: 2016
Journal: Cell Rep
Title: HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development.
Volume: 14
Issue: 1
Pages: 103-114
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GXD Expression
GXD Expression
   
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608519
Stage: TS19
Assay Id: MGI:5824573
Age: embryonic day 11.5
Image: 1
Specimen Label: E11 YS
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608520
Stage: TS20
Assay Id: MGI:5824573
Age: embryonic day 12.5
Image: 1
Specimen Label: E12 YS
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608522
Stage: TS22
Assay Id: MGI:5824573
Age: embryonic day 14.5
Image: 1
Specimen Label: E14 YS
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684619
Stage: TS19
Assay Id: MGI:5824573
Age: embryonic day 11.5
Image: 1
Specimen Label: E11 FL
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:5824573
Age: embryonic day 12.5
Image: 1
Specimen Label: E12 FL
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5824573
Age: embryonic day 14.5
Image: 1
Specimen Label: E14 FL
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:5824566
Assay Type: RT-PCR
Annotation Date: 2017-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187319
Stage: TS19
Assay Id: MGI:5824573
Age: embryonic day 11.5
Image: 1
Specimen Label: E11 Pla
Detected: true
Specimen Num: 6
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