|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 97 out of 97 for L3mbtl3

0.445s

Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
84456 | L3MBTL3
Type: gene
Organism: human
•
•
•
•
•
Gene
100496330 | l3mbtl3
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
309550 | L3mbtl3
Type: gene
Organism: rat
•
•
•
•
•
Gene
462996 | L3MBTL3
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
612721 | L3MBTL3
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
524334 | L3MBTL3
Type: gene
Organism: cattle
•
•
•
•
•
Gene
421705 | L3MBTL3
Type: gene
Organism: chicken
•
•
•
•
•
Gene
403075 | l3mbtl3
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
710947 | L3MBTL3
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Coding Gene
MGI:2143628 | L3mbtl3
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
29691401 | J:265473
First Author: Leng F
Year: 2018
Journal: Nat Commun
Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
Volume: 9
Issue: 1
Pages: 1641
•
•
•
•
•
Publication
30442713 | J:331350
First Author: Zhang C
Year: 2019
Journal: J Biol Chem
Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
Volume: 294
Issue: 2
Pages: 476-489
•
•
•
•
•
Publication
15889154 | J:98498
First Author: Arai S
Year: 2005
Journal: EMBO J
Title: Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1.
Volume: 24
Issue: 10
Pages: 1863-73
•
•
•
•
•
Publication
29030483 | J:331358
First Author: Xu T
Year: 2017
Journal: EMBO J
Title: RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.
Volume: 36
Issue: 21
Pages: 3232-3249
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0015199 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
ENSMUSG00200008662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00195013908 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00220010748 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00180016701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00175023670 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_2143628 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00215007528 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00210023104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00185006628 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00205009547 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00230008988 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00190015242 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00225029558 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0023821 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6285856
Assay Type: RT-PCR
Annotation Date: 2019-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:6287383
Age: embryonic day 13.5
Image: 6
Specimen Label: +RT
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
36335117 | J:330708
First Author: Guo P
Year: 2022
Journal: Nat Commun
Title: The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis.
Volume: 13
Issue: 1
Pages: 6696
•
•
•
•
•
Publication
33980486 | J:384085
 
First Author: Stielow B
Year: 2021
Journal: Sci Adv
Title: The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Volume: 7
Issue: 20
•
•
•
•
•
Publication
38346162 | J:346895
   
First Author: Guo P
Year: 2024
Journal: Elife
Title: A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.
Volume: 13
•
•
•
•
•
Publication
29977079 | J:268318
First Author: Miesfeld JB
Year: 2018
Journal: Sci Rep
Title: Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.
Volume: 8
Issue: 1
Pages: 10195
•
•
•
•
•
Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
•
•
•
•
•
Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
•
•
•
•
•
Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
•
•
•
•
•
Publication
- | J:384794
     
First Author: MGI and IMPC
Year: 2026
Journal: Database Release
Title: MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:389486
     
First Author: Mouse Genome Informatics and Ensembl Genome Database Project
Year: 2026
Journal: Database Release
Title: MGI Strain Genome Feature and Gene Model Load from Ensembl.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
26317848 | -
First Author: Baughman BM
Year: 2016
Journal: ACS Chem Biol
Title: The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer.
Volume: 11
Issue: 3
Pages: 722-8
•
•
•
•
•
Publication
29256585 | -
First Author: Baughman BM
Year: 2018
Journal: ACS Chem Biol
Title: Retraction of "The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer".
Volume: 13
Issue: 1
Pages: 281
•
•
•
•
•
Allele
L3mbtl3<+> | MGI:3048873
   
Name: L3MBTL3 histone methyl-lysine binding protein; wild type
•
•
•
•
•
Allele
L3mbtl3<tm1Tmiy> | MGI:3579468
Name: L3MBTL3 histone methyl-lysine binding protein; targeted mutation 1, Toru Miyazaki
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Allele
L3mbtl3<em1Cya> | MGI:8229556
Name: L3MBTL3 histone methyl-lysine binding protein; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Allele
L3mbtl3<em2Cya> | MGI:8229557
Name: L3MBTL3 histone methyl-lysine binding protein; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Interaction Experiment
Zhang C (2019)
Description: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.
•
•
•
•
•
Strain
MGI:6333881 | B6;129-L3mbtl3<tm1Tmiy>/Tmiy
Attribute String: targeted mutation, mutant stock
•
•
•
•
•
Allele
L3mbtl3<Gt(AF0390)Wtsi> | MGI:3852756
 
Name: L3MBTL3 histone methyl-lysine binding protein; gene trap AF0390, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
•
•
•
•
•
Allele
L3mbtl3<Gt(IST12509D10)Tigm> | MGI:4072579
 
Name: L3MBTL3 histone methyl-lysine binding protein; gene trap IST12509D10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
L3mbtl3<tm1a(EUCOMM)Hmgu> | MGI:5428639
Name: L3MBTL3 histone methyl-lysine binding protein; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
L3mbtl3<tm1e(EUCOMM)Hmgu> | MGI:5430084
Name: L3MBTL3 histone methyl-lysine binding protein; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
L3mbtl3<em2(IMPC)Tcp> | MGI:5754603
Name: L3MBTL3 histone methyl-lysine binding protein; endonuclease-mediated mutation 2, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Allele
L3mbtl3<em1Gpt> | MGI:7301478
Name: L3MBTL3 histone methyl-lysine binding protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Allele
L3mbtl3<tm1c(EUCOMM)Hmgu> | MGI:7766964
Name: L3MBTL3 histone methyl-lysine binding protein; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready
•
•
•
•
•
Strain
MGI:8232106 | C57BL/6JCya-L3mbtl3<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Strain
MGI:8232107 | C57BL/6JCya-L3mbtl3<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: L3mbtl3/L3mbtl3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Strain
MGI:6866475 | C57BL/6NCrl-L3mbtl3<em2(IMPC)Tcp>/CmmrMmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Strain
MGI:6260818 | C57BL/6NCrl-L3mbtl3<em2(IMPC)Tcp>/Tcp
Attribute String: coisogenic, targeted mutation
•
•
•
•
•
Strain
MGI:6334769 | C57BL/6N-L3mbtl3<em2(IMPC)Tcp>
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Strain
MGI:6425894 | C57BL/6JGpt-L3mbtl3<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Genotype
Genotype
Symbol: L3mbtl3/L3mbtl3
Background: C57BL/6NCrl-L3mbtl3/Tcp
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: L3mbtl3/L3mbtl3<+>
Background: C57BL/6NCrl-L3mbtl3/Tcp
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: L3mbtl3/L3mbtl3<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Protein Domain
IPR065094 | L3MBTL3_MBT1
Type: Domain
Description: This entry represents the first malignant brain tumour (MBT) unit found in Lethal(3)malignant brain tumour-like protein 3 (L3MBTL3) from vertebrates. L3MBTL3 acts as a negative regulator of Notch target gene expression and is required for RBPJ-mediated transcriptional repression []. It functions by recruiting the histone demethylase KDM1A to Notch-responsive elements, promoting H3K4me demethylation []. Furthermore, L3MBTL3 regulates the ubiquitin-dependent degradation of methylated non-histone proteins, including SOX2, DNMT1, and E2F1, acting as an adapter that recruits the CRL4-DCAF5 E3 ubiquitin ligase complex to these methylated targets [, ]. L3MBTL3 is also essential for the normal maturation of myeloid progenitor cells [, , , , , ]. This entry typically co-occurs with two other MBT units, a C2H2C-type zinc finger, and a sterile alpha motif (SAM) domain.
•
•
•
•
•
Publication
24040942 | -
First Author: James LI
Year: 2013
Journal: J Med Chem
Title: Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.
Volume: 56
Issue: 18
Pages: 7358-71
•
•
•
•
•
Protein Domain
IPR065095 | L3MBTL3_MBT3
Type: Domain
Description: This entry represents the third malignant brain tumour (MBT) unit found in lethal(3)malignant brain tumour-like protein 3 (L3MBTL3). L3MBTL3 acts as a negative regulator of Notch target gene expression and is required for RBPJ-mediated transcriptional repression []. It is also involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 [, ]. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. L3MBTL3 typically contains three MBT units, along with a SAM domain and a C2H2C-type zinc finger [, , ].
•
•
•
•
•
Protein
Q8BLB7
Organism: Mus musculus/domesticus
Length: 883  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom