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Search results 1 to 99 out of 99 for Lamtor5

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
10542 | LAMTOR5
Type: gene
Organism: human
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Gene
100135168 | lamtor5
Type: gene
Organism: frog, western clawed
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Gene
295357 | Lamtor5
Type: gene
Organism: rat
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Gene
479907 | LAMTOR5
Type: gene
Organism: dog, domestic
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Gene
457120 | LAMTOR5
Type: gene
Organism: chimpanzee
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Gene
516090 | LAMTOR5
Type: gene
Organism: cattle
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Gene
419811 | LAMTOR5
Type: gene
Organism: chicken
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Gene
100333504 | lamtor5
Type: gene
Organism: zebrafish
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Gene
701645 | LAMTOR5
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR024135 | LAMTOR5
Type: Family
Description: Hepatitis B X-interacting protein (HBXIP, also known as LAMTOR5) was originally recognised for its association with the X protein of hepatitis B virus (HBV) and ability to down-regulate HBV replication []. When complexed to the anti-apoptotic protein survivin, HBXIP interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerised APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway []. HBXIP is one of the Ragulator components that are required for mTORC1 activation by amino acids []. It is also part of the AA (amino acid) sensing machinery in human CD4+ T cells [].
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Protein Coding Gene
MGI:1915826 | Lamtor5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22980980 | J:320116
First Author: Bar-Peled L
Year: 2012
Journal: Cell
Title: Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Volume: 150
Issue: 6
Pages: 1196-208
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Protein
Q9D1L9
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Protein
G3UW70
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: false
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Publication
12773388 | -
First Author: Marusawa H
Year: 2003
Journal: EMBO J
Title: HBXIP functions as a cofactor of survivin in apoptosis suppression.
Volume: 22
Issue: 11
Pages: 2729-40
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Publication
9499022 | -
First Author: Melegari M
Year: 1998
Journal: J Virol
Title: Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication.
Volume: 72
Issue: 3
Pages: 1737-43
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Publication
26084023 | -
First Author: Kolev M
Year: 2015
Journal: Immunity
Title: Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.
Volume: 42
Issue: 6
Pages: 1033-47
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Publication
31337951 | J:293660
First Author: Yang QC
Year: 2019
Journal: Int J Med Sci
Title: Increased Expression of LAMTOR5 Predicts Poor Prognosis and Is Associated with Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma.
Volume: 16
Issue: 6
Pages: 783-792
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Gene
101410535 | LAMTOR5-AS1
Type: gene
Organism: human
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Gene
106998903 | LOC106998903
Type: gene
Organism: macaque, rhesus
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Publication
20381137 | J:320089
First Author: Sancak Y
Year: 2010
Journal: Cell
Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Volume: 141
Issue: 2
Pages: 290-303
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Protein Coding Gene
MGP_CAROLIEiJ_G0025499 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027745 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027705 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027670 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027447 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1915826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028161 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026903 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027422 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027564 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027532 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027671 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027562 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028216 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026983 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026945 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026449 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:7316897
Assay Type: Immunohistochemistry
Annotation Date: 2022-08-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:7325450
Age: embryonic day 7.5
Image: 4Aa
Specimen Label: 4Aa
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7316897
Assay Type: Immunohistochemistry
Annotation Date: 2022-08-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:7325450
Age: embryonic day 7.5
Image: 4Aa'
Specimen Label: 4Aa'
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7316897
Assay Type: Immunohistochemistry
Annotation Date: 2022-08-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:7325450
Age: embryonic day 8.5
Image: 4Ba
Specimen Label: 4Ba
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7316897
Assay Type: Immunohistochemistry
Annotation Date: 2022-08-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7325450
Age: embryonic day 8.5
Image: 4Ba'
Specimen Label: 4Ba'
Detected: false
Specimen Num: 4
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Publication
29259128 | J:258406
First Author: Li H
Year: 2018
Journal: J Biol Chem
Title: Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/Neurod1 in animal pancreatic β-cells.
Volume: 293
Issue: 6
Pages: 2053-2065
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Publication
35608036 | J:326159
 
First Author: Qin Y
Year: 2022
Journal: Development
Title: Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1.
Volume: 149
Issue: 12
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Ragulator complex protein LAMTOR5
Type: chain
End: 91
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Allele
Lamtor5<em1Smoc> | MGI:7290779
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6770896 | C57BL/6JSmoc-Lamtor5<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein
D3YTS4
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: false
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Protein Domain
IPR037587 | LAMTOR2-like
Type: Family
Description: This entry represents the Ragulator complex protein LAMTOR2. The Ragulator complex consists of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 []. The Ragulator complex is involved in amino acid sensing and activation of the mTORC1 signalling pathway. The complex is activated by amino acids through a mechanism involving the lysosomal V-ATPase, and functions as a guanine nucleotide exchange factor activating the small GTPases Rag [], []. This entry also includes uncharacterised proteins from bacteria and archaea.
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GO Term
GO:0071986 | Ragulator complex
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Protein
Q9JHS3
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein Coding Gene
MGI:1929467 | Lamtor3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913346 | Lamtor4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1932697 | Lamtor2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918839 | Slc38a9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913758 | Lamtor1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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