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Search results 1 to 100 out of 351 for Lat

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
27040 | LAT
Type: gene
Organism: human
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Gene
100495612 | lat
Type: gene
Organism: frog, western clawed
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Gene
81511 | Lat
Type: gene
Organism: rat
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Gene
607947 | LAT
Type: gene
Organism: dog, domestic
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Gene
514735 | LAT
Type: gene
Organism: cattle
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Gene
100233211 | lat
Type: gene
Organism: zebrafish
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Gene
704656 | LAT
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1342293 | Lat
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12932362 | J:85187
First Author: Su YW
Year: 2003
Journal: Immunity
Title: LAT links the pre-BCR to calcium signaling.
Volume: 19
Issue: 2
Pages: 295-305
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Publication
36569841 | J:332689
 
First Author: Arbulo-Echevarria MM
Year: 2022
Journal: Front Immunol
Title: Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation.
Volume: 13
Pages: 1054920
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Protein
Q546H1
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
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Publication
10843385 | J:111435
First Author: Saitoh S
Year: 2000
Journal: Immunity
Title: LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
Volume: 12
Issue: 5
Pages: 525-35
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Publication
- | J:152363
     
First Author: Malissen M
Year: 2009
Journal: Personal Communication
Title: Personal Communication concerning Lat null mice
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Publication
12970761 | J:94074
First Author: Nuñez-Cruz S
Year: 2003
Journal: Nat Immunol
Title: LAT regulates gammadelta T cell homeostasis and differentiation.
Volume: 4
Issue: 10
Pages: 999-1008
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Publication
10204488 | J:54059
First Author: Zhang W
Year: 1999
Journal: Immunity
Title: Essential role of LAT in T cell development.
Volume: 10
Issue: 3
Pages: 323-32
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Publication
10712938 | J:61029
First Author: Pivniouk VI
Year: 2000
Journal: Curr Opin Immunol
Title: The role of SLP-76 and LAT in lymphocyte development.
Volume: 12
Issue: 2
Pages: 173-8
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Publication
29915297 | J:282544
First Author: Lo WL
Year: 2018
Journal: Nat Immunol
Title: Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.
Volume: 19
Issue: 7
Pages: 733-741
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Publication
22566687 | J:186663
First Author: Ou-Yang CW
Year: 2012
Journal: Mol Cell Biol
Title: Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
Volume: 32
Issue: 14
Pages: 2674-84
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Publication
12065840 | J:77099
First Author: Sommers CL
Year: 2002
Journal: Science
Title: A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
Volume: 296
Issue: 5575
Pages: 2040-3
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Publication
9729044 | J:49412
First Author: Zhang W
Year: 1998
Journal: Immunity
Title: LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
Volume: 9
Issue: 2
Pages: 239-46
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Publication
20837489 | J:166860
First Author: Shen S
Year: 2010
Journal: J Biol Chem
Title: The importance of LAT in the activation, homeostasis, and regulatory function of T cells.
Volume: 285
Issue: 46
Pages: 35393-405
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Publication
31611699 | J:292899
First Author: Lo WL
Year: 2019
Journal: Nat Immunol
Title: Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.
Volume: 20
Issue: 11
Pages: 1481-1493
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Publication
12807480 | J:84079
First Author: Oya K
Year: 2003
Journal: Immunology
Title: Appearance of the LAT protein at an early stage of B-cell development and its possible role.
Volume: 109
Issue: 3
Pages: 351-9
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Publication
28965845 | J:262330
First Author: Loviglio MN
Year: 2017
Journal: Am J Hum Genet
Title: The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.
Volume: 101
Issue: 4
Pages: 564-577
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Publication
15795236 | J:98048
First Author: Sommers CL
Year: 2005
Journal: J Exp Med
Title: Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.
Volume: 201
Issue: 7
Pages: 1125-34
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Publication
23240581 | J:195095
First Author: GarcĂ­a-Blesa A
Year: 2013
Journal: Biochem J
Title: The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion.
Volume: 450
Issue: 3
Pages: 511-21
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Publication
19682930 | J:151840
First Author: Mingueneau M
Year: 2009
Journal: Immunity
Title: Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
Volume: 31
Issue: 2
Pages: 197-208
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Publication
12065839 | J:77098
First Author: Aguado E
Year: 2002
Journal: Science
Title: Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.
Volume: 296
Issue: 5575
Pages: 2036-40
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Publication
15549729 | J:94601
First Author: Su YW
Year: 2004
Journal: Eur J Immunol
Title: The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion.
Volume: 34
Issue: 12
Pages: 3614-22
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Publication
19380807 | J:147946
First Author: Shen S
Year: 2009
Journal: J Immunol
Title: The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
Volume: 182
Issue: 9
Pages: 5596-604
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Publication
29440364 | J:261585
First Author: Carpier JM
Year: 2018
Journal: J Exp Med
Title: Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
Volume: 215
Issue: 4
Pages: 1245-1265
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Publication
32727906 | J:293930
First Author: Liu C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens.
Volume: 117
Issue: 32
Pages: 19388-19398
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Publication
31911947 | J:288343
First Author: Thumkeo D
Year: 2020
Journal: Sci Adv
Title: mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.
Volume: 6
Issue: 1
Pages: eaay2432
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Publication
11901197 | J:75708
First Author: Judd BA
Year: 2002
Journal: J Exp Med
Title: Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.
Volume: 195
Issue: 6
Pages: 705-17
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Publication
15899851 | J:98894
First Author: Wang Y
Year: 2005
Journal: Mol Cell Biol
Title: Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
Volume: 25
Issue: 11
Pages: 4455-65
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Publication
15719364 | J:96734
First Author: Ardouin L
Year: 2005
Journal: Eur J Immunol
Title: Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells.
Volume: 35
Issue: 3
Pages: 977-86
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Publication
17420272 | J:122341
First Author: Yamasaki S
Year: 2007
Journal: Mol Cell Biol
Title: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.
Volume: 27
Issue: 12
Pages: 4406-15
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Publication
26121028 | J:233886
First Author: Rouquette-Jazdanian AK
Year: 2015
Journal: PLoS One
Title: miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.
Volume: 10
Issue: 6
Pages: e0131823
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Publication
24222714 | J:260297
First Author: Kortum RL
Year: 2013
Journal: Sci Signal
Title: The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.
Volume: 6
Issue: 301
Pages: ra99
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Publication
24584089 | J:209882
First Author: Roncagalli R
Year: 2014
Journal: Nat Immunol
Title: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Volume: 15
Issue: 4
Pages: 384-392
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Publication
19449311 | J:149450
First Author: Clarke RL
Year: 2009
Journal: Eur J Immunol
Title: A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
Volume: 39
Issue: 6
Pages: 1619-31
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Publication
36914891 | J:354080
First Author: Lo WL
Year: 2023
Journal: Nat Immunol
Title: A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.
Volume: 24
Issue: 4
Pages: 676-689
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Publication
15976034 | J:99970
First Author: Prinz I
Year: 2005
Journal: Int Immunol
Title: Autistic effector T cells in mice with a point mutation in the LAT adaptor fail to respond to Listeria monocytogenes infection.
Volume: 17
Issue: 7
Pages: 951-7
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Publication
17579183 | J:125744
First Author: Ragab A
Year: 2007
Journal: Blood
Title: Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation.
Volume: 110
Issue: 7
Pages: 2466-74
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Publication
12871507 | J:103904
First Author: Trumel C
Year: 2003
Journal: J Thromb Haemost
Title: Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 requires the docking protein LAT but is largely independent of alphaIIb/beta3.
Volume: 1
Issue: 2
Pages: 320-9
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Publication
12570875 | J:83355
First Author: Kabouridis PS
Year: 2003
Journal: Biochem J
Title: Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.
Volume: 371
Issue: Pt 3
Pages: 907-15
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Publication
14098049 | J:36893
 
First Author: BADE EG
Year: 1963
Journal: Acta Physiol Lat Am
Title: INCREASE IN THE WEIGHT OF THE LIVER AND OF THE KIDNEY DURING LACTATION. INFLUENCE OF PREVIOUS HEPATECTOMY.
Volume: 13
Pages: 193-4
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Publication
15153499 | J:116964
First Author: Janssen E
Year: 2004
Journal: J Immunol
Title: Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.
Volume: 172
Issue: 11
Pages: 6810-9
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Publication
34862403 | J:320372
First Author: Imbert A
Year: 2021
Journal: Sci Data
Title: ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis.
Volume: 8
Issue: 1
Pages: 311
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Publication
19380761 | J:147721
First Author: Bezman NA
Year: 2009
Journal: J Immunol
Title: Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76.
Volume: 182
Issue: 9
Pages: 5183-7
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Publication
19592663 | J:151596
First Author: Hundt M
Year: 2009
Journal: J Immunol
Title: Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
Volume: 183
Issue: 3
Pages: 1685-94
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Publication
11457888 | J:77695
First Author: Sommers CL
Year: 2001
Journal: J Exp Med
Title: Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.
Volume: 194
Issue: 2
Pages: 135-42
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Publication
15470052 | J:93702
First Author: Malbec O
Year: 2004
Journal: J Immunol
Title: Linker for activation of T cells integrates positive and negative signaling in mast cells.
Volume: 173
Issue: 8
Pages: 5086-94
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Publication
23401587 | J:193682
First Author: Ou-Yang CW
Year: 2013
Journal: J Immunol
Title: The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.
Volume: 190
Issue: 6
Pages: 2938-47
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Publication
16380508 | J:118835
First Author: Koonpaew S
Year: 2006
Journal: J Exp Med
Title: LAT-mediated signaling in CD4+CD25+ regulatory T cell development.
Volume: 203
Issue: 1
Pages: 119-29
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Publication
19701892 | J:152149
First Author: Miazek A
Year: 2009
Journal: Eur J Immunol
Title: Peripheral Thy1+ lymphocytes rearranging TCR-gammadelta genes in LAT-deficient mice.
Volume: 39
Issue: 9
Pages: 2596-605
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Publication
20133676 | J:157561
First Author: Azar GA
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes.
Volume: 107
Issue: 8
Pages: 3675-80
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Publication
23825558 | J:203457
First Author: Sommers CL
Year: 2013
Journal: PLoS One
Title: miRNA signature of mouse helper T cell hyper-proliferation.
Volume: 8
Issue: 6
Pages: e66709
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Publication
29902238 | J:262891
First Author: Yamada K
Year: 2018
Journal: PLoS One
Title: LatY136F knock-in mouse model for human IgG4-related disease.
Volume: 13
Issue: 6
Pages: e0198417
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Publication
33661938 | J:304605
First Author: Waseda Y
Year: 2021
Journal: PLoS One
Title: The pronounced lung lesions developing in LATY136F knock-in mice mimic human IgG4-related lung disease.
Volume: 16
Issue: 3
Pages: e0247173
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Publication
17081783 | J:116157
First Author: Zhu M
Year: 2006
Journal: Immunity
Title: Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB.
Volume: 25
Issue: 5
Pages: 757-68
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Publication
16002666 | J:100686
First Author: Prinz I
Year: 2005
Journal: J Immunol
Title: The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells.
Volume: 175
Issue: 2
Pages: 713-9
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Publication
18539897 | J:138401
First Author: Helft J
Year: 2008
Journal: Blood
Title: Antigen-specific T-T interactions regulate CD4 T-cell expansion.
Volume: 112
Issue: 4
Pages: 1249-58
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Publication
24523509 | J:209918
First Author: Sullivan SA
Year: 2014
Journal: J Immunol
Title: The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
Volume: 192
Issue: 6
Pages: 2865-74
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Publication
18645037 | J:140144
First Author: Whittaker GC
Year: 2008
Journal: Blood
Title: Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
Volume: 112
Issue: 7
Pages: 2869-77
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Publication
20130215 | J:159644
First Author: Chuck MI
Year: 2010
Journal: J Immunol
Title: The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.
Volume: 184
Issue: 5
Pages: 2476-86
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Publication
31135971 | J:279081
First Author: Fan D
Year: 2019
Journal: Immunology
Title: Protein 4.1R negatively regulates CD8+ T-cell activation by modulating phosphorylation of linker for activation of T cells.
Volume: 157
Issue: 4
Pages: 312-321
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Publication
17938199 | J:129025
First Author: Balagopalan L
Year: 2007
Journal: Mol Cell Biol
Title: c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
Volume: 27
Issue: 24
Pages: 8622-36
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Publication
16291591 | J:125723
First Author: Chiesa S
Year: 2006
Journal: Blood
Title: Multiplicity and plasticity of natural killer cell signaling pathways.
Volume: 107
Issue: 6
Pages: 2364-72
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Publication
28538176 | J:256192
First Author: Myers DR
Year: 2017
Journal: Cell Rep
Title: Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
Volume: 19
Issue: 8
Pages: 1558-1571
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Publication
16878135 | J:112658
First Author: Prinz I
Year: 2006
Journal: Nat Immunol
Title: Visualization of the earliest steps of gammadelta T cell development in the adult thymus.
Volume: 7
Issue: 9
Pages: 995-1003
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Publication
20498282 | J:162651
First Author: Hashimoto-Tane A
Year: 2010
Journal: Mol Cell Biol
Title: T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering.
Volume: 30
Issue: 14
Pages: 3421-9
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Publication
22561606 | J:186446
First Author: Wang D
Year: 2012
Journal: Nat Immunol
Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
Volume: 13
Issue: 6
Pages: 560-8
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Publication
15477350 | J:93951
First Author: Zhu M
Year: 2004
Journal: J Exp Med
Title: Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
Volume: 200
Issue: 8
Pages: 991-1000
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Publication
22984075 | J:190654
First Author: Fuller DM
Year: 2012
Journal: J Immunol
Title: The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.
Volume: 189
Issue: 8
Pages: 4005-13
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Publication
18322174 | J:132908
First Author: Roget K
Year: 2008
Journal: J Immunol
Title: Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells.
Volume: 180
Issue: 6
Pages: 3689-98
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Publication
17277139 | J:143982
First Author: Herzog S
Year: 2007
Journal: J Immunol
Title: The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.
Volume: 178
Issue: 4
Pages: 2336-43
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Publication
17374738 | J:145409
First Author: Rabie T
Year: 2007
Journal: Blood
Title: Diverging signaling events control the pathway of GPVI down-regulation in vivo.
Volume: 110
Issue: 2
Pages: 529-35
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Publication
23407547 | J:196459
First Author: May RM
Year: 2013
Journal: Blood
Title: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Volume: 121
Issue: 16
Pages: 3135-46
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Publication
24265393 | J:223622
First Author: DĂĽtting S
Year: 2014
Journal: Circ Res
Title: Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.
Volume: 114
Issue: 3
Pages: 444-453
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Publication
34391459 | J:345493
First Author: Honda F
Year: 2021
Journal: Arthritis Res Ther
Title: Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis.
Volume: 23
Issue: 1
Pages: 214
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Publication
15477348 | J:93950
First Author: Volná P
Year: 2004
Journal: J Exp Med
Title: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
Volume: 200
Issue: 8
Pages: 1001-13
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Publication
19667175 | J:151946
First Author: Miyaji M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Volume: 106
Issue: 34
Pages: 14502-7
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Publication
25455592 | J:319083
First Author: Thaker YR
Year: 2015
Journal: Immunol Lett
Title: TCR and CD28 activate the transcription factor NF-ÎşB in T-cells via distinct adaptor signaling complexes.
Volume: 163
Issue: 1
Pages: 113-9
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Publication
15985541 | J:119538
First Author: Liu J
Year: 2005
Journal: Blood
Title: Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner.
Volume: 106
Issue: 8
Pages: 2750-6
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Publication
21487392 | J:172064
First Author: Cao Y
Year: 2011
Journal: EMBO J
Title: LKB1 regulates TCR-mediated PLCÎł1 activation and thymocyte positive selection.
Volume: 30
Issue: 10
Pages: 2083-93
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Publication
27505889 | J:246349
First Author: Semeniak D
Year: 2016
Journal: J Cell Sci
Title: Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling.
Volume: 129
Issue: 18
Pages: 3473-84
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Publication
14764585 | J:124423
First Author: Reynolds LF
Year: 2004
Journal: J Biol Chem
Title: Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.
Volume: 279
Issue: 18
Pages: 18239-46
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Protein Coding Gene
MGP_CAROLIEiJ_G0030441 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032958 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
Protein Coding Gene
MGP_BALBcJ_G0032963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0032673 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1342293 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0033469 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0032001 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0032646 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0032798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0032751 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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