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Search results 1 to 100 out of 124 for Lat2

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
746841 | LAT2
Type: gene
Organism: chimpanzee
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Gene
505016 | LAT2
Type: gene
Organism: cattle
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Gene
417489 | LAT2
Type: gene
Organism: chicken
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Gene
693676 | LAT2
Type: gene
Organism: macaque, rhesus
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Gene
102156541 | LAT2
Type: gene
Organism: dog, domestic
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Gene
7462 | LAT2
Type: gene
Organism: human
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Gene
317676 | Lat2
Type: gene
Organism: rat
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Protein Domain
IPR031428 | LAT2
Type: Family
Description: The adaptor protein linker activator of T-cells 2 (LAT2), also called non-T-cell activation linker (NTAL), linker activator for B-cells (LAB) or Williams Beuren Syndrome critical region 5 (WBSCR5), is expressed in various myeloid and lymphoid cells []. Given the wide expression pattern, it may modulate signalling in most types of leukocytes []. It has been shown to be involved in immunoreceptor signaling [], B cell activation [], negative regulation of T cell activation [], and regulation of mast cell physiology [].
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Protein Coding Gene
MGI:1926479 | Lat2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17081783 | J:116157
First Author: Zhu M
Year: 2006
Journal: Immunity
Title: Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB.
Volume: 25
Issue: 5
Pages: 757-68
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Publication
12514734 | J:121605
First Author: Janssen E
Year: 2003
Journal: Nat Immunol
Title: LAB: a new membrane-associated adaptor molecule in B cell activation.
Volume: 4
Issue: 2
Pages: 117-23
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Publication
25153696 | J:221082
First Author: Polakovicova I
Year: 2014
Journal: PLoS One
Title: Multiple regulatory roles of the mouse transmembrane adaptor protein NTAL in gene transcription and mast cell physiology.
Volume: 9
Issue: 8
Pages: e105539
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Publication
24819605 | J:216253
First Author: Núñez B
Year: 2014
Journal: PLoS One
Title: Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.
Volume: 9
Issue: 5
Pages: e96915
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Protein
Q9JHL0
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
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Protein
A0A0J9YU43
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
A0A0J9YV28
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: true
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Protein
A0A0J9YVD5
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Publication
16160011 | -
First Author: Tedoldi S
Year: 2006
Journal: Blood
Title: Transmembrane adaptor molecules: a new category of lymphoid-cell markers.
Volume: 107
Issue: 1
Pages: 213-21
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Publication
12486104 | -
First Author: Brdicka T
Year: 2002
Journal: J Exp Med
Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
Volume: 196
Issue: 12
Pages: 1617-26
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Publication
20643813 | -
First Author: Orr SJ
Year: 2011
Journal: J Leukoc Biol
Title: LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?
Volume: 89
Issue: 1
Pages: 11-9
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Publication
20606011 | J:163285
First Author: Kambayashi T
Year: 2010
Journal: Mol Cell Biol
Title: Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.
Volume: 30
Issue: 17
Pages: 4188-96
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Publication
21264952 | J:167825
First Author: Braun D
Year: 2011
Journal: Glia
Title: Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells.
Volume: 59
Issue: 3
Pages: 463-71
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Publication
19133747 | J:146910
First Author: Capelo LP
Year: 2009
Journal: Thyroid
Title: The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells.
Volume: 19
Issue: 2
Pages: 171-80
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Protein Coding Gene
MGP_CAROLIEiJ_G0027815 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030061 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030138 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1926479 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029263 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029824 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029930 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029962 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030631 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028978 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029337 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024369 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028813 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22308309 | J:181866
First Author: Zhu M
Year: 2012
Journal: J Immunol
Title: Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB.
Volume: 188
Issue: 6
Pages: 2733-41
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Publication
17911602 | J:153034
First Author: Dráberová L
Year: 2007
Journal: J Immunol
Title: Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.
Volume: 179
Issue: 8
Pages: 5169-80
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Publication
30425164 | J:281863
 
First Author: Halova I
Year: 2018
Journal: Sci Signal
Title: The transmembrane adaptor protein NTAL limits mast cell chemotaxis toward prostaglandin E2.
Volume: 11
Issue: 556
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: liver
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: skeletal
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:1926959
Age: embryonic day 7.0
Specimen Label: 7-d embryo
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:1926959
Age: embryonic day 11.0
Specimen Label: 11-d embryo
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:1926959
Age: embryonic day 15.0
Specimen Label: 15-d embryo
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:1926959
Age: embryonic day 17.0
Specimen Label: 17-d embryo
Detected: true
Specimen Num: 12
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Publication
18645037 | J:140144
First Author: Whittaker GC
Year: 2008
Journal: Blood
Title: Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
Volume: 112
Issue: 7
Pages: 2869-77
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Publication
15539154 | J:93888
First Author: Stork B
Year: 2004
Journal: Immunity
Title: Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
Volume: 21
Issue: 5
Pages: 681-91
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Publication
21061444 | J:165918
First Author: Tůmová M
Year: 2010
Journal: Eur J Immunol
Title: The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho.
Volume: 40
Issue: 11
Pages: 3235-45
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Publication
19948717 | J:159944
First Author: Whittaker GC
Year: 2010
Journal: J Biol Chem
Title: The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
Volume: 285
Issue: 5
Pages: 2976-85
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Publication
11003705 | J:64707
First Author: Martindale DW
Year: 2000
Journal: Mamm Genome
Title: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.
Volume: 11
Issue: 10
Pages: 890-8
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Publication
11124535 | J:66919
First Author: Doyle JL
Year: 2000
Journal: Cytogenet Cell Genet
Title: Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome.
Volume: 90
Issue: 3-4
Pages: 285-90
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Publication
15899851 | J:98894
First Author: Wang Y
Year: 2005
Journal: Mol Cell Biol
Title: Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
Volume: 25
Issue: 11
Pages: 4455-65
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Publication
23407547 | J:196459
First Author: May RM
Year: 2013
Journal: Blood
Title: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Volume: 121
Issue: 16
Pages: 3135-46
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Publication
18322174 | J:132908
First Author: Roget K
Year: 2008
Journal: J Immunol
Title: Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells.
Volume: 180
Issue: 6
Pages: 3689-98
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Publication
23675302 | J:213405
First Author: Orr SJ
Year: 2013
Journal: PLoS Pathog
Title: LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
Volume: 9
Issue: 5
Pages: e1003357
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Publication
17277139 | J:143982
First Author: Herzog S
Year: 2007
Journal: J Immunol
Title: The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.
Volume: 178
Issue: 4
Pages: 2336-43
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Publication
15477348 | J:93950
First Author: Volná P
Year: 2004
Journal: J Exp Med
Title: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
Volume: 200
Issue: 8
Pages: 1001-13
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Publication
16291591 | J:125723
First Author: Chiesa S
Year: 2006
Journal: Blood
Title: Multiplicity and plasticity of natural killer cell signaling pathways.
Volume: 107
Issue: 6
Pages: 2364-72
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Publication
17918199 | J:126321
First Author: Grégoire C
Year: 2007
Journal: Eur J Immunol
Title: Deletion of the LIME adaptor protein minimally affects T and B cell development and function.
Volume: 37
Issue: 11
Pages: 3259-69
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Publication
27500644 | J:237248
First Author: Freund J
Year: 2016
Journal: PLoS Biol
Title: Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.
Volume: 14
Issue: 8
Pages: e1002526
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Publication
17420272 | J:122341
First Author: Yamasaki S
Year: 2007
Journal: Mol Cell Biol
Title: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.
Volume: 27
Issue: 12
Pages: 4406-15
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Publication
15477350 | J:93951
First Author: Zhu M
Year: 2004
Journal: J Exp Med
Title: Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
Volume: 200
Issue: 8
Pages: 991-1000
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Publication
11779826 | J:73830
First Author: DeSilva U
Year: 2002
Journal: Genome Res
Title: Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.
Volume: 12
Issue: 1
Pages: 3-15
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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