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Search results 1 to 100 out of 126 for Lat2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
7462 | LAT2
Type: gene
Organism: human
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Gene
317676 | Lat2
Type: gene
Organism: rat
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Gene
746841 | LAT2
Type: gene
Organism: chimpanzee
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Gene
505016 | LAT2
Type: gene
Organism: cattle
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Gene
417489 | LAT2
Type: gene
Organism: chicken
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Gene
693676 | LAT2
Type: gene
Organism: macaque, rhesus
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Gene
102156541 | LAT2
Type: gene
Organism: dog, domestic
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Protein Domain
IPR031428 | LAT2
Type: Family
Description: The adaptor protein linker activator of T-cells 2 (LAT2), also called non-T-cell activation linker (NTAL), linker activator for B-cells (LAB) or Williams Beuren Syndrome critical region 5 (WBSCR5), is expressed in various myeloid and lymphoid cells []. Given the wide expression pattern, it may modulate signalling in most types of leukocytes []. It has been shown to be involved in immunoreceptor signaling [], B cell activation [], negative regulation of T cell activation [], and regulation of mast cell physiology [].
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Protein Coding Gene
MGI:1926479 | Lat2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17081783 | J:116157
First Author: Zhu M
Year: 2006
Journal: Immunity
Title: Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB.
Volume: 25
Issue: 5
Pages: 757-68
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Publication
12514734 | J:121605
First Author: Janssen E
Year: 2003
Journal: Nat Immunol
Title: LAB: a new membrane-associated adaptor molecule in B cell activation.
Volume: 4
Issue: 2
Pages: 117-23
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Publication
25153696 | J:221082
First Author: Polakovicova I
Year: 2014
Journal: PLoS One
Title: Multiple regulatory roles of the mouse transmembrane adaptor protein NTAL in gene transcription and mast cell physiology.
Volume: 9
Issue: 8
Pages: e105539
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Publication
24819605 | J:216253
First Author: Núñez B
Year: 2014
Journal: PLoS One
Title: Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.
Volume: 9
Issue: 5
Pages: e96915
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Protein
Q9JHL0
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
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Protein
A0A0J9YU43
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
A0A0J9YV28
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: true
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Protein
A0A0J9YVD5
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Publication
16160011 | -
First Author: Tedoldi S
Year: 2006
Journal: Blood
Title: Transmembrane adaptor molecules: a new category of lymphoid-cell markers.
Volume: 107
Issue: 1
Pages: 213-21
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Publication
12486104 | -
First Author: Brdicka T
Year: 2002
Journal: J Exp Med
Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
Volume: 196
Issue: 12
Pages: 1617-26
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Publication
20643813 | -
First Author: Orr SJ
Year: 2011
Journal: J Leukoc Biol
Title: LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?
Volume: 89
Issue: 1
Pages: 11-9
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Publication
20606011 | J:163285
First Author: Kambayashi T
Year: 2010
Journal: Mol Cell Biol
Title: Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.
Volume: 30
Issue: 17
Pages: 4188-96
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Publication
21264952 | J:167825
First Author: Braun D
Year: 2011
Journal: Glia
Title: Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells.
Volume: 59
Issue: 3
Pages: 463-71
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Publication
19133747 | J:146910
First Author: Capelo LP
Year: 2009
Journal: Thyroid
Title: The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells.
Volume: 19
Issue: 2
Pages: 171-80
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Protein Coding Gene
MGP_CAROLIEiJ_G0027815 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030061 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030138 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1926479 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029263 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029824 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029930 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029962 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030631 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028978 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029337 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024369 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028813 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22308309 | J:181866
First Author: Zhu M
Year: 2012
Journal: J Immunol
Title: Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB.
Volume: 188
Issue: 6
Pages: 2733-41
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Publication
17911602 | J:153034
First Author: Dráberová L
Year: 2007
Journal: J Immunol
Title: Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.
Volume: 179
Issue: 8
Pages: 5169-80
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Publication
30425164 | J:281863
 
First Author: Halova I
Year: 2018
Journal: Sci Signal
Title: The transmembrane adaptor protein NTAL limits mast cell chemotaxis toward prostaglandin E2.
Volume: 11
Issue: 556
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: liver
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: skeletal
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:1926959
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:1926959
Age: embryonic day 7.0
Specimen Label: 7-d embryo
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:1926959
Age: embryonic day 11.0
Specimen Label: 11-d embryo
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:1926959
Age: embryonic day 15.0
Specimen Label: 15-d embryo
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:1926889
Assay Type: RT-PCR
Annotation Date: 2000-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:1926959
Age: embryonic day 17.0
Specimen Label: 17-d embryo
Detected: true
Specimen Num: 12
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Publication
18645037 | J:140144
First Author: Whittaker GC
Year: 2008
Journal: Blood
Title: Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
Volume: 112
Issue: 7
Pages: 2869-77
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Publication
15539154 | J:93888
First Author: Stork B
Year: 2004
Journal: Immunity
Title: Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
Volume: 21
Issue: 5
Pages: 681-91
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Publication
19948717 | J:159944
First Author: Whittaker GC
Year: 2010
Journal: J Biol Chem
Title: The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
Volume: 285
Issue: 5
Pages: 2976-85
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Publication
21061444 | J:165918
First Author: Tůmová M
Year: 2010
Journal: Eur J Immunol
Title: The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho.
Volume: 40
Issue: 11
Pages: 3235-45
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Publication
11003705 | J:64707
First Author: Martindale DW
Year: 2000
Journal: Mamm Genome
Title: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.
Volume: 11
Issue: 10
Pages: 890-8
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Publication
11124535 | J:66919
First Author: Doyle JL
Year: 2000
Journal: Cytogenet Cell Genet
Title: Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome.
Volume: 90
Issue: 3-4
Pages: 285-90
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Publication
15899851 | J:98894
First Author: Wang Y
Year: 2005
Journal: Mol Cell Biol
Title: Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
Volume: 25
Issue: 11
Pages: 4455-65
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Publication
23407547 | J:196459
First Author: May RM
Year: 2013
Journal: Blood
Title: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Volume: 121
Issue: 16
Pages: 3135-46
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Publication
18322174 | J:132908
First Author: Roget K
Year: 2008
Journal: J Immunol
Title: Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells.
Volume: 180
Issue: 6
Pages: 3689-98
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Publication
23675302 | J:213405
First Author: Orr SJ
Year: 2013
Journal: PLoS Pathog
Title: LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
Volume: 9
Issue: 5
Pages: e1003357
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Publication
17277139 | J:143982
First Author: Herzog S
Year: 2007
Journal: J Immunol
Title: The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.
Volume: 178
Issue: 4
Pages: 2336-43
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Publication
15477348 | J:93950
First Author: Volná P
Year: 2004
Journal: J Exp Med
Title: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
Volume: 200
Issue: 8
Pages: 1001-13
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Publication
27500644 | J:237248
First Author: Freund J
Year: 2016
Journal: PLoS Biol
Title: Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.
Volume: 14
Issue: 8
Pages: e1002526
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Publication
16291591 | J:125723
First Author: Chiesa S
Year: 2006
Journal: Blood
Title: Multiplicity and plasticity of natural killer cell signaling pathways.
Volume: 107
Issue: 6
Pages: 2364-72
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Publication
17918199 | J:126321
First Author: Grégoire C
Year: 2007
Journal: Eur J Immunol
Title: Deletion of the LIME adaptor protein minimally affects T and B cell development and function.
Volume: 37
Issue: 11
Pages: 3259-69
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Publication
17420272 | J:122341
First Author: Yamasaki S
Year: 2007
Journal: Mol Cell Biol
Title: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.
Volume: 27
Issue: 12
Pages: 4406-15
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Publication
15477350 | J:93951
First Author: Zhu M
Year: 2004
Journal: J Exp Med
Title: Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
Volume: 200
Issue: 8
Pages: 991-1000
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Publication
11779826 | J:73830
First Author: DeSilva U
Year: 2002
Journal: Genome Res
Title: Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.
Volume: 12
Issue: 1
Pages: 3-15
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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