|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 348 for Lats2

<< First    < Previous  |  Next >    Last >>
0.074s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: There are two mammalian homologue of Drosophila tumor suppressor Lats (large tumor suppressor, also known as Warts): LATS1 and LATS2. Lats/Warts is a serine/threonine-protein kinase that negatively regulates YAP1 (Drosophila Yorkie (Yki) homologue) in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis [, ]. This entry represents LATS2, which plays an important part in centrosome duplication, maintenance of mitotic fidelity and genomic stability []. This entry also includes Warts from Drosophila melanogaster which is a negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: McPherson JP
Year: 2004
Journal: EMBO J
Title: Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.
Volume: 23
Issue: 18
Pages: 3677-88
Protein
Organism: Mus musculus
Length: 288  
Fragment?: true
Protein
Organism: Mus musculus
Length: 895  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1042  
Fragment?: false
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Hao Y
Year: 2008
Journal: J Biol Chem
Title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP.
Volume: 283
Issue: 9
Pages: 5496-509
Publication
First Author: Huang J
Year: 2005
Journal: Cell
Title: The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.
Volume: 122
Issue: 3
Pages: 421-34
Protein
Organism: Mus musculus
Length: 853  
Fragment?: false
Publication
First Author: Yabuta N
Year: 2000
Journal: Genomics
Title: Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.
Volume: 63
Issue: 2
Pages: 263-70
Publication
First Author: Aylon Y
Year: 2016
Journal: Genes Dev
Title: The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.
Volume: 30
Issue: 7
Pages: 786-97
Publication
First Author: Aylon Y
Year: 2014
Journal: Cell Death Differ
Title: Lats2 is critical for the pluripotency and proper differentiation of stem cells.
Volume: 21
Issue: 4
Pages: 624-33
Publication
First Author: Matsui Y
Year: 2008
Journal: Circ Res
Title: Lats2 is a negative regulator of myocyte size in the heart.
Volume: 103
Issue: 11
Pages: 1309-18
Publication
First Author: Yabuta N
Year: 2007
Journal: J Biol Chem
Title: Lats2 is an essential mitotic regulator required for the coordination of cell division.
Volume: 282
Issue: 26
Pages: 19259-71
Publication  
First Author: Ménard A
Year: 2020
Journal: Endocrinology
Title: Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.
Volume: 161
Issue: 5
Publication
First Author: Tsoi M
Year: 2019
Journal: FASEB J
Title: Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance.
Volume: 33
Issue: 10
Pages: 10819-10832
Publication  
First Author: St-Jean G
Year: 2019
Journal: Development
Title: Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme.
Volume: 146
Issue: 20
Publication
First Author: Gan W
Year: 2020
Journal: Nat Cell Biol
Title: LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.
Volume: 22
Issue: 2
Pages: 246-256
Publication
First Author: Yabuta N
Year: 2013
Journal: J Cell Sci
Title: N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability.
Volume: 126
Issue: Pt 2
Pages: 508-20
Publication
First Author: Xiao Y
Year: 2018
Journal: Dev Cell
Title: Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.
Volume: 45
Issue: 2
Pages: 153-169.e6
Publication
First Author: Eder N
Year: 2020
Journal: Nat Commun
Title: YAP1/TAZ drives ependymoma-like tumour formation in mice.
Volume: 11
Issue: 1
Pages: 2380
Publication    
First Author: Szymaniak AD
Year: 2017
Journal: Elife
Title: The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.
Volume: 6
Publication
First Author: Park J
Year: 2020
Journal: Mol Cells
Title: WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice.
Volume: 43
Issue: 5
Pages: 491-499
Publication  
First Author: Lee DH
Year: 2016
Journal: Nat Commun
Title: LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.
Volume: 7
Pages: 11961
Publication
First Author: McNeill H
Year: 2017
Journal: J Am Soc Nephrol
Title: Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.
Volume: 28
Issue: 3
Pages: 852-861
Publication  
First Author: Nantie LB
Year: 2018
Journal: Development
Title: Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing.
Volume: 145
Issue: 21
Publication
First Author: Zou J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Neddylation mediates ventricular chamber maturation through repression of Hippo signaling.
Volume: 115
Issue: 17
Pages: E4101-E4110
Publication
First Author: Du X
Year: 2018
Journal: Nature
Title: Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.
Volume: 558
Issue: 7708
Pages: 141-145
Publication
First Author: Yi J
Year: 2016
Journal: Hepatology
Title: Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.
Volume: 64
Issue: 5
Pages: 1757-1772
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1755028
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3519728
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 30
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925228
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 29
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 17
GXD Expression      
Probe: MGI:5763421
Assay Type: RT-PCR
Annotation Date: 2016-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:5763601
Age: embryonic day 1.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 20
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 25
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5763421
Assay Type: RT-PCR
Annotation Date: 2016-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5763601
Age: embryonic day 9.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 28
GXD Expression      
Probe: MGI:5763421
Assay Type: RT-PCR
Annotation Date: 2016-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:5763601
Age: embryonic day 2.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 23
GXD Expression      
Probe: MGI:5763421
Assay Type: RT-PCR
Annotation Date: 2016-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:5763601
Age: embryonic day 3.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 18
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Male
Emaps: EMAPS:2979428
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 34
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:5763421
Assay Type: RT-PCR
Annotation Date: 2016-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:5763601
Age: embryonic day 0.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 26
GXD Expression      
Probe: MGI:5763421
Assay Type: RT-PCR
Annotation Date: 2016-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:5763601
Age: embryonic day 3.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Male
Emaps: EMAPS:1918028
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 33
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 24
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 31
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 35
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 16
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 21
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 22
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 19
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 27
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 32
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915328
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3592628
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 38
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 37
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3624992
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3624993
Age: postnatal
Detected: true
Specimen Num: 36
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Strong
Sex: Male
Emaps: EMAPS:3579528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639168
Age: postnatal day 61
Image: Mouse 351633 - Image 99224127
Note: There is scattered expression in the white matter.
Detected: true
Specimen Num: 76
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Moderate
Sex: Male
Emaps: EMAPS:1716128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639168
Age: postnatal day 54
Image: Mouse 350886 - Image 99226235
Note: There is scattered expression in the cornea.
Detected: true
Specimen Num: 36
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Strong
Sex: Male
Emaps: EMAPS:1876728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3639168
Age: postnatal day 54
Image: Mouse 350886 - Image 99220384
Note: Expression is frequently seen in the blood vessels in the spleen.
Detected: true
Specimen Num: 17
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Strong
Sex: Male
Emaps: EMAPS:3552428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639168
Age: postnatal day 54
Image: Mouse 350886 - Image 99227255
Note: There is scattered expression in the capsule.
Detected: true
Specimen Num: 58