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Search results 1 to 91 out of 91 for Lcmt1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
51451 | LCMT1
Type: gene
Organism: human
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Gene
618021 | LCMT1
Type: gene
Organism: cattle
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Gene
416565 | LCMT1
Type: gene
Organism: chicken
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Gene
447907 | lcmt1
Type: gene
Organism: zebrafish
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Gene
702050 | LCMT1
Type: gene
Organism: macaque, rhesus
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Gene
548787 | lcmt1
Type: gene
Organism: frog, western clawed
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Gene
361643 | Lcmt1
Type: gene
Organism: rat
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Gene
608360 | LCMT1
Type: gene
Organism: dog, domestic
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Gene
467930 | LCMT1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1353593 | Lcmt1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
100506655 | LCMT1-AS2
Type: gene
Organism: human
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Gene
102723510 | LCMT1-AS1
Type: gene
Organism: human
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Publication
23840384 | J:201873
First Author: MacKay KB
Year: 2013
Journal: PLoS One
Title: Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling.
Volume: 8
Issue: 6
Pages: e65967
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Publication
10600115 | J:58971
First Author: De Baere I
Year: 1999
Journal: Biochemistry
Title: Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
Volume: 38
Issue: 50
Pages: 16539-47
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Protein Coding Gene
MGP_CAROLIEiJ_G0030428 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032962 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032877 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032950 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032660 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1353593 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033456 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031988 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032633 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032738 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032101 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013638 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031542 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16381950 | J:201874
First Author: Nord AS
Year: 2006
Journal: Nucleic Acids Res
Title: The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.
Volume: 34
Issue: Database issue
Pages: D642-8
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Publication
17724024 | J:126819
First Author: Lee JA
Year: 2007
Journal: J Biol Chem
Title: Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells.
Volume: 282
Issue: 42
Pages: 30974-84
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GXD Expression
GXD Expression
 
Probe: MGI:4417709
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825885
Age: embryonic day 14.5
Image: euxassay_010513_10
Specimen Label: euxassay_010513_10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4417709
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825885
Age: embryonic day 14.5
Image: euxassay_010513_11
Specimen Label: euxassay_010513_11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4417709
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825885
Age: embryonic day 14.5
Image: euxassay_010513_12
Specimen Label: euxassay_010513_12
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4417709
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825885
Age: embryonic day 14.5
Image: euxassay_010513_14
Specimen Label: euxassay_010513_14
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4417709
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825885
Age: embryonic day 14.5
Image: euxassay_010513_15
Specimen Label: euxassay_010513_15
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4417709
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825885
Age: embryonic day 14.5
Image: euxassay_010513_16
Specimen Label: euxassay_010513_16
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4417709
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825885
Age: embryonic day 14.5
Image: euxassay_010513_17
Specimen Label: euxassay_010513_17
Detected: true
Specimen Num: 7
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Publication
32341098 | J:289529
First Author: Staniszewski A
Year: 2020
Journal: J Neurosci
Title: Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments in Mice.
Volume: 40
Issue: 23
Pages: 4596-4608
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Publication
27507813 | J:237306
First Author: Hwang J
Year: 2016
Journal: J Biol Chem
Title: Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
Volume: 291
Issue: 40
Pages: 21008-21019
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Publication
29735529 | J:264469
First Author: Lee JA
Year: 2018
Journal: J Biol Chem
Title: Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.
Volume: 293
Issue: 25
Pages: 9636-9650
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Publication
- | J:175597
     
First Author: Overbeek PA
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Overbeek Lentiviral Transgenic Lines
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q6PDZ4
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
Q78K29
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
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Publication
37644036 | J:341119
First Author: Rasool RU
Year: 2023
Journal: Nat Commun
Title: Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
Volume: 14
Issue: 1
Pages: 5253
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Publication
25202269 | J:284734
 
First Author: Sontag JM
Year: 2014
Journal: Front Aging Neurosci
Title: Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.
Volume: 6
Pages: 214
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Publication
14660564 | -
First Author: Leulliot N
Year: 2004
Journal: J Biol Chem
Title: Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity.
Volume: 279
Issue: 9
Pages: 8351-8
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Publication
11697862 | -
First Author: Kalhor HR
Year: 2001
Journal: Arch Biochem Biophys
Title: Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast.
Volume: 395
Issue: 2
Pages: 239-45
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Publication
11060018 | -
First Author: Wu J
Year: 2000
Journal: EMBO J
Title: Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo.
Volume: 19
Issue: 21
Pages: 5672-81
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Publication
11009387 | -
First Author: Rafanan ER Jr
Year: 2000
Journal: Org Lett
Title: Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O(2) and one molecule of H(2)O.
Volume: 2
Issue: 20
Pages: 3225-7
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Protein Domain
IPR007213 | Ppm1/Ppm2/Tcmp
Type: Family
Description: This entry includes a group of methyltransferases such as leucine carboxyl methyltransferase 1 (known as Ppm1 in yeast and LCMT1 in mammals), leucine carboxyl methyltransferase 2 (Ppm2/LCMT2) and O-methyltransferase TcmP. Ppm1 regulates the activity of serine/threonine phosphatase 2A (PP2A) through methylation of the C-terminal leucine residue of the catalytic subunit of PP2A [, , ]. This affects the heteromultimeric composition of PP2A which in turn affects protein recognition and substrate specificity. Like many other methyltransferases Ppm1 uses S-adenosylmethionine (SAM) as the methyl donor. Ppm1 contains the common SAM-dependent methyltransferase core fold, with various insertions and additions creating a specific PP2A binding site []. Ppm2, a homologue of Ppm1, is a S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway, which is part of tRNA modification [].Streptomyces glaucescens TcmP is an O-methyltransferase that catalyses the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2, which is then further processed to produce the antibiotic TCM C [].
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Protein
Q8BYR1
Organism: Mus musculus/domesticus
Length: 686  
Fragment?: false
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Protein
A2RTH5
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
A0A0U1RNF2
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Publication
16642040 | -
First Author: Noma A
Year: 2006
Journal: EMBO J
Title: Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.
Volume: 25
Issue: 10
Pages: 2142-54
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom