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Search results 1 to 100 out of 438 for Ldb1

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0.066s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: LIM domain-binding protein 1 (LDB1) binds to the LIM domain of LIM homeodomain proteins which are transcriptional regulators. LDB1 is a multi-adaptor protein that mediates interactions between different classes of transcription factors and their co-regulators, and hence determine cell fate and differentiation []. In erythroid cells LDB1 is recruited to the beta-globin locus via LMO2 and is required for looping of the beta-globin locus control region (LCR) to the active beta-globin promoter [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Krivega I
Year: 2014
Journal: Genes Dev
Title: Role of LDB1 in the transition from chromatin looping to transcription activation.
Volume: 28
Issue: 12
Pages: 1278-90
GXD Expression  
Probe: MGI:5784658
Assay Type: Immunohistochemistry
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6150320
Age: embryonic day 12.0
Image: S2 Ldb1
Specimen Label: S2 Ldb1
Detected: true
Specimen Num: 5
Publication
First Author: Loyd C
Year: 2017
Journal: Endocrinology
Title: LDB1 Regulates Energy Homeostasis During Diet-Induced Obesity.
Volume: 158
Issue: 5
Pages: 1289-1297
Publication
First Author: Dey-Guha I
Year: 2009
Journal: Int J Biol Sci
Title: Role of ldb1 in adult intestinal homeostasis.
Volume: 5
Issue: 7
Pages: 686-94
Publication
First Author: Matthews JM
Year: 2003
Journal: EMBO Rep
Title: LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins.
Volume: 4
Issue: 12
Pages: 1132-7
Protein
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
Publication
First Author: Song SH
Year: 2012
Journal: Biochim Biophys Acta
Title: Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation.
Volume: 1819
Issue: 8
Pages: 885-91
Publication
First Author: Meier N
Year: 2006
Journal: Development
Title: Novel binding partners of Ldb1 are required for haematopoietic development.
Volume: 133
Issue: 24
Pages: 4913-23
Publication
First Author: Agulnick AD
Year: 1996
Journal: Nature
Title: Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins.
Volume: 384
Issue: 6606
Pages: 270-2
Publication
First Author: Kimura N
Year: 1999
Journal: J Biochem
Title: A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains.
Volume: 126
Issue: 1
Pages: 180-7
Publication
First Author: Li L
Year: 2020
Journal: Blood
Title: Ldb1 is required for Lmo2 oncogene-induced thymocyte self-renewal and T-cell acute lymphoblastic leukemia.
Volume: 135
Issue: 25
Pages: 2252-2265
Publication
First Author: Zhang F
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program.
Volume: 112
Issue: 5
Pages: 1380-5
Publication
First Author: Song SH
Year: 2010
Journal: Blood
Title: Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.
Volume: 116
Issue: 13
Pages: 2356-64
Publication
First Author: Li L
Year: 2011
Journal: Nat Immunol
Title: Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.
Volume: 12
Issue: 2
Pages: 129-36
Publication
First Author: Galloway JR
Year: 2015
Journal: Mol Endocrinol
Title: SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.
Volume: 29
Issue: 12
Pages: 1774-86
Publication
First Author: Storbeck CJ
Year: 2009
Journal: Mol Biol Cell
Title: The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration.
Volume: 20
Issue: 19
Pages: 4174-82
Publication
First Author: Gueta K
Year: 2016
Journal: Development
Title: The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis.
Volume: 143
Issue: 22
Pages: 4182-4192
Publication
First Author: Magli A
Year: 2019
Journal: Nat Commun
Title: Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification.
Volume: 10
Issue: 1
Pages: 2316
Publication
First Author: Makarev E
Year: 2014
Journal: PLoS One
Title: Islet1 and its co-factor Ldb1 are expressed in quiescent cells of mouse intestinal epithelium.
Volume: 9
Issue: 4
Pages: e95256
Publication
First Author: Mukhopadhyay M
Year: 2003
Journal: Development
Title: Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation.
Volume: 130
Issue: 3
Pages: 495-505
Publication
First Author: Mylona A
Year: 2013
Journal: Blood
Title: Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis.
Volume: 121
Issue: 15
Pages: 2902-13
Publication
First Author: Kim S
Year: 2016
Journal: Stem Cells Dev
Title: Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons.
Volume: 25
Issue: 13
Pages: 986-94
Publication  
First Author: Kinare V
Year: 2019
Journal: eNeuro
Title: LDB1 Is Required for the Early Development of the Dorsal Telencephalon and the Thalamus.
Volume: 6
Issue: 1
Publication  
First Author: Almaidhan A
Year: 2014
Journal: BMC Dev Biol
Title: Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation.
Volume: 14
Pages: 3
Publication
First Author: Zhao Y
Year: 2014
Journal: Dev Biol
Title: Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon.
Volume: 385
Issue: 1
Pages: 94-106
GXD Expression    
Probe: MGI:6176342
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190698
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ldb1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6176342
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190698
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ldb1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6176342
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190698
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ldb1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6176342
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190698
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ldb1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6176342
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190698
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ldb1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6176342
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190698
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ldb1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6176342
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190698
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ldb1
Detected: true
Specimen Num: 7
Publication
First Author: Visvader JE
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.
Volume: 94
Issue: 25
Pages: 13707-12
Publication
First Author: Suleiman H
Year: 2007
Journal: Dev Biol
Title: The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes.
Volume: 304
Issue: 2
Pages: 701-12
Publication  
First Author: Xiao D
Year: 2018
Journal: Front Mol Neurosci
Title: Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.
Volume: 11
Pages: 271
Publication
First Author: Hunter CS
Year: 2013
Journal: Diabetes
Title: Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.
Volume: 62
Issue: 3
Pages: 875-86
Publication
First Author: Costello I
Year: 2015
Journal: Genes Dev
Title: Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.
Volume: 29
Issue: 20
Pages: 2108-22
Publication
First Author: Li L
Year: 2010
Journal: J Exp Med
Title: A requirement for Lim domain binding protein 1 in erythropoiesis.
Volume: 207
Issue: 12
Pages: 2543-50
Publication
First Author: Krivega I
Year: 2017
Journal: Nucleic Acids Res
Title: LDB1-mediated enhancer looping can be established independent of mediator and cohesin.
Volume: 45
Issue: 14
Pages: 8255-8268
Publication
First Author: Ahmed S
Year: 2018
Journal: Biochim Biophys Acta Mol Cell Res
Title: The LIM domain binding protein 1, Ldb1, has distinct roles in Neu-induced mammary tumorigenesis.
Volume: 1865
Issue: 11 Pt A
Pages: 1590-1597
Publication
First Author: Yamashita T
Year: 1998
Journal: Genomics
Title: Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1.
Volume: 48
Issue: 1
Pages: 87-92
Publication
First Author: Cai Y
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Single-stranded DNA-binding proteins regulate the abundance and function of the LIM-homeodomain transcription factor LHX2 in pituitary cells.
Volume: 373
Issue: 2
Pages: 303-8
Publication
First Author: Li J
Year: 2014
Journal: J Immunol
Title: Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.
Volume: 193
Issue: 9
Pages: 4654-62
Publication
First Author: Breen JJ
Year: 1998
Journal: J Biol Chem
Title: Interactions between LIM domains and the LIM domain-binding protein Ldb1.
Volume: 273
Issue: 8
Pages: 4712-7
Publication
First Author: Ediger BN
Year: 2017
Journal: J Clin Invest
Title: LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.
Volume: 127
Issue: 1
Pages: 215-229
Publication  
First Author: Kinare V
Year: 2020
Journal: Development
Title: An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity.
Volume: 147
Issue: 20
Publication
First Author: Bhati M
Year: 2008
Journal: EMBO J
Title: Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.
Volume: 27
Issue: 14
Pages: 2018-29
Publication
First Author: Monahan K
Year: 2019
Journal: Nature
Title: LHX2- and LDB1-mediated trans interactions regulate olfactory receptor choice.
Volume: 565
Issue: 7740
Pages: 448-453
Publication
First Author: Asbreuk CH
Year: 2002
Journal: Mol Cell Neurosci
Title: CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systems.
Volume: 21
Issue: 3
Pages: 410-20
Publication
First Author: Caputo L
Year: 2015
Journal: Cell Stem Cell
Title: The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.
Volume: 17
Issue: 3
Pages: 287-99
Publication
First Author: Leone DP
Year: 2017
Journal: Cereb Cortex
Title: Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.
Volume: 27
Issue: 2
Pages: 1686-1699
Publication
First Author: Bethea M
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.
Volume: 316
Issue: 3
Pages: E397-E409
Publication  
First Author: de Melo J
Year: 2018
Journal: Development
Title: Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina.
Volume: 145
Issue: 9
Publication
First Author: Bach I
Year: 1999
Journal: Nat Genet
Title: RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.
Volume: 22
Issue: 4
Pages: 394-9
Publication
First Author: Nishioka N
Year: 2005
Journal: Development
Title: Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.
Volume: 132
Issue: 11
Pages: 2535-46
Publication
First Author: Tzchori I
Year: 2009
Journal: Development
Title: LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.
Volume: 136
Issue: 8
Pages: 1375-85
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Jurata LW
Year: 1997
Journal: Mol Cell Biol
Title: Functional analysis of the nuclear LIM domain interactor NLI.
Volume: 17
Issue: 10
Pages: 5688-98
GXD Expression    
Probe: MGI:3521653
Assay Type: RT-PCR
Annotation Date: 2005-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675215
Stage: TS15
Assay Id: MGI:3521700
Age: embryonic day 9.5
Image: 3
Specimen Label: PSM
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3056618
Assay Type: Northern blot
Annotation Date: 2004-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3056621
Age: postnatal adult
Image: 3
Specimen Label: kidney
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3815861
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816665
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3815861
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816665
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3815861
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816665
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3056618
Assay Type: Northern blot
Annotation Date: 2004-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3056621
Age: postnatal adult
Image: 3
Specimen Label: heart
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3056618
Assay Type: Northern blot
Annotation Date: 2004-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3056621
Age: embryonic day 11.0
Image: 3
Specimen Label: E11
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3056618
Assay Type: Northern blot
Annotation Date: 2004-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3056621
Age: embryonic day 15.0
Image: 3
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3056618
Assay Type: Northern blot
Annotation Date: 2004-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3056621
Age: embryonic day 17.0
Image: 3
Specimen Label: E17
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3815861
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816665
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3815861
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816665
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3056618
Assay Type: Northern blot
Annotation Date: 2004-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3056621
Age: postnatal adult
Image: 3
Specimen Label: liver
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3815861
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816665
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: true
Specimen Num: 6