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Search results 1 to 100 out of 116 for Leo1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
694874 | LEO1
Type: gene
Organism: macaque, rhesus
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Gene
123169 | LEO1
Type: gene
Organism: human
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Gene
404599 | leo1
Type: gene
Organism: zebrafish
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Gene
507524 | LEO1
Type: gene
Organism: cattle
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Gene
769405 | LEO1
Type: gene
Organism: chicken
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Gene
100135118 | leo1
Type: gene
Organism: frog, western clawed
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Gene
300837 | Leo1
Type: gene
Organism: rat
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Gene
478310 | LEO1
Type: gene
Organism: dog, domestic
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Gene
453438 | LEO1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR007149 | Leo1
Type: Family
Description: In budding yeasts, Leo1 is part of the Paf1 complex, an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1. Paf1 complex is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection []. This entry also includes Leo1 homologues from animals and plants. Human Leo1, also known as RDL, is a component of the human Paf1 complex (Paf1C), which consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications []. Human Leo1 promotes senescence of 2BS fibroblasts [].Arabidopsis Paf1C related proteins such as VIP4 (Leo1), VIP5 (Rtf1), ELF7 (Paf1), ELF8 (Ctr9) and ATXR7 (Set1) are required for the induction of seed dormancy. They control both germination and flowering time [].
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Protein Coding Gene
MGI:2685031 | Leo1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q5XJE5
Organism: Mus musculus/domesticus
Length: 667  
Fragment?: false
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Publication
15791002 | -
First Author: Zhao L
Year: 2005
Journal: FASEB J
Title: Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts.
Volume: 19
Issue: 6
Pages: 521-32
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Publication
20178742 | -
First Author: Kim J
Year: 2010
Journal: Cell
Title: The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Volume: 140
Issue: 4
Pages: 491-503
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Publication
21799800 | -
First Author: Liu Y
Year: 2011
Journal: PLoS One
Title: Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a role for the polymerase associated factor 1 complex in seed dormancy.
Volume: 6
Issue: 7
Pages: e22241
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Gene
100422556 | LOC100422556
Type: gene
Organism: human
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Publication
19345177 | J:149841
First Author: Ding L
Year: 2009
Journal: Cell Stem Cell
Title: A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Volume: 4
Issue: 5
Pages: 403-15
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Publication
27749823 | J:283190
First Author: Strikoudis A
Year: 2016
Journal: Nat Cell Biol
Title: Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.
Volume: 18
Issue: 11
Pages: 1127-1138
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Publication
27864380 | J:237500
First Author: Osipovich AB
Year: 2016
Journal: Development
Title: Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.
Volume: 143
Issue: 24
Pages: 4595-4607
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Protein Coding Gene
MGP_CAROLIEiJ_G0032442 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035040 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034950 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034722 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2685031 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035531 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034694 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034796 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034935 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034837 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035554 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033748 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015307 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033581 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:5636728
Assay Type: Western blot
Annotation Date: 2015-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691018
Stage: TS18
Assay Id: MGI:5636784
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5636728
Assay Type: Western blot
Annotation Date: 2015-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:5636784
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5636728
Assay Type: Western blot
Annotation Date: 2015-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:5636784
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5636728
Assay Type: Western blot
Annotation Date: 2015-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Stage: TS25
Assay Id: MGI:5636784
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5636728
Assay Type: Western blot
Annotation Date: 2015-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:5636784
Age: embryonic day 19.0
Specimen Label: E19
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5636728
Assay Type: Western blot
Annotation Date: 2015-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:5636784
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5636728
Assay Type: Western blot
Annotation Date: 2015-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:5636784
Age: postnatal day 5
Specimen Label: P5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:5636728
Assay Type: Western blot
Annotation Date: 2015-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:5636784
Age: postnatal adult
Specimen Label: adult
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:6466988
Assay Type: RNA in situ
Annotation Date: 2020-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6466995
Age: embryonic day 10.5
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3527643
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674419
Stage: TS19
Assay Id: MGI:3527644
Age: embryonic day 11.5
Specimen Label: E11.5 mesonephros
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6466988
Assay Type: RNA in situ
Annotation Date: 2020-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1681017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6466995
Age: embryonic day 10.5
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6466988
Assay Type: RNA in situ
Annotation Date: 2020-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1681017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6466995
Age: embryonic day 10.5
Image: 2B
Specimen Label: 2B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3527643
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1636715
Stage: TS15
Assay Id: MGI:3527644
Age: embryonic day 9.5
Note: There is no expression present in the urogenital ridge.
Specimen Label: E9.5 urogenital ridge
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3527643
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Present
Sex: Male
Emaps: EMAPS:1868522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3527644
Age: embryonic day 14.5
Note: Expression is present in the testis cords.
Specimen Label: E14.5 testis
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3527643
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738319
Stage: TS19
Assay Id: MGI:3527644
Age: embryonic day 11.5
Specimen Label: E11.5 genital ridge
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6466988
Assay Type: RNA in situ
Annotation Date: 2020-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6466995
Age: embryonic day 10.5
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3527643
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Present
Sex: Female
Emaps: EMAPS:1796222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:3527644
Age: embryonic day 14.5
Specimen Label: E14.5 ovary
Detected: true
Specimen Num: 5
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Publication
22252316 | J:183708
First Author: Vethantham V
Year: 2012
Journal: Mol Cell Biol
Title: Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation.
Volume: 32
Issue: 6
Pages: 1044-55
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Publication
23791194 | J:201693
First Author: Zhang C
Year: 2013
Journal: Neuron
Title: The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.
Volume: 78
Issue: 6
Pages: 986-93
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Publication
31940751 | J:294771
 
First Author: Lantz B
Year: 2020
Journal: Genes (Basel)
Title: Finding the Unicorn, a New Mouse Model of Midfacial Clefting.
Volume: 11
Issue: 1
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Publication
30642949 | J:294106
 
First Author: Soulez M
Year: 2019
Journal: Mol Cell Biol
Title: Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.
Volume: 39
Issue: 6
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Publication
11044607 | J:65653
First Author: Wertz K
Year: 2000
Journal: Mech Dev
Title: Large-scale screen for genes involved in gonad development.
Volume: 98
Issue: 1-2
Pages: 51-70
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Gene
101905723 | LOC101905723
Type: gene
Organism: cattle
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UniProt Feature
UniProt Feature
Begin: 2
Description: RNA polymerase-associated protein LEO1
Type: chain
End: 667
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Protein
Q5XJE5-2
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
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Gene
108711388 | leo1.L
Type: gene
Organism: frog, African clawed
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Gene
443607 | leo1.S
Type: gene
Organism: frog, African clawed
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Publication
11884586 | -
First Author: Mueller CL
Year: 2002
Journal: Mol Cell Biol
Title: Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex.
Volume: 22
Issue: 7
Pages: 1971-80
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Protein
Q8K2T8
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Protein
Q6IQZ4
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: false
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Publication
16491129 | -
First Author: Moniaux N
Year: 2006
Journal: Oncogene
Title: The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.
Volume: 25
Issue: 23
Pages: 3247-57
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Publication
22419161 | -
First Author: Marazzi I
Year: 2012
Journal: Nature
Title: Suppression of the antiviral response by an influenza histone mimic.
Volume: 483
Issue: 7390
Pages: 428-33
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Publication
24385927 | -
First Author: Mbogning J
Year: 2013
Journal: PLoS Genet
Title: The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast.
Volume: 9
Issue: 12
Pages: e1004029
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