| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Touvier T |
| Year: |
2009 |
| Journal: |
J Clin Invest |
| Title: |
LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. |
| Volume: |
119 |
| Issue: |
12 |
| Pages: |
3830-8 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Couturier C |
| Year: |
2007 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. |
| Volume: |
104 |
| Issue: |
49 |
| Pages: |
19476-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vauthier V |
| Year: |
2017 |
| Journal: |
Mol Metab |
| Title: |
Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling. |
| Volume: |
6 |
| Issue: |
1 |
| Pages: |
159-172 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Roca-Rivada A |
| Year: |
2024 |
| Journal: |
JCI Insight |
| Title: |
Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations. |
| Volume: |
9 |
| Issue: |
9 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Micallef MJ |
| Year: |
1997 |
| Journal: |
Cancer Immunol Immunother |
| Title: |
In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites. |
| Volume: |
43 |
| Issue: |
6 |
| Pages: |
361-7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3586132 |
| Age: |
postnatal day 8-10 |
| Image: |
P8/10 |
|
| Specimen Label: |
P8/10 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1915528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3586132 |
| Age: |
postnatal adult |
| Image: |
Adult |
|
| Specimen Label: |
Adult |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1398288 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-03-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3576022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7444128 |
| Age: |
embryonic day 14.5 |
| Image: |
S1A |
| Note: |
Expression was detected throughout the valve endothelium and mesenchyme. |
| Specimen Label: |
S1A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1398288 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-03-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3515422 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7444128 |
| Age: |
embryonic day 14.5 |
| Image: |
S1A |
| Note: |
Expression was detected throughout the valve endothelium and mesenchyme. |
| Specimen Label: |
S1A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1647028 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3586132 |
| Age: |
postnatal day 6 |
|
| Note: |
Expression was widespread. |
| Specimen Label: |
CNS |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915726 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:3586132 |
| Age: |
embryonic day 18.0 |
|
| Note: |
Expression was detected in the outer neuroblastic layer. |
| Specimen Label: |
E18 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915727 |
| Pattern: |
Not Specified |
| Stage: |
TS27 |
| Assay Id: |
MGI:3586132 |
| Age: |
postnatal day 0-1 |
| Image: |
P0/1 |
| Note: |
Expression was detected in the outer neuroblastic layer. |
| Specimen Label: |
P0/1 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915727 |
| Pattern: |
Not Specified |
| Stage: |
TS27 |
| Assay Id: |
MGI:3586132 |
| Age: |
postnatal day 2-3 |
| Image: |
P2/3 |
| Note: |
Expression was detected in the outer neuroblastic layer. |
| Specimen Label: |
P2/3 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3586132 |
| Age: |
postnatal day 8-10 |
| Image: |
P8/10 |
|
| Specimen Label: |
P8/10 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1915728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3586132 |
| Age: |
postnatal adult |
| Image: |
Adult |
|
| Specimen Label: |
Adult |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3585222 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1859224 |
| Pattern: |
Regionally restricted |
| Stage: |
TS24 |
| Assay Id: |
MGI:3586132 |
| Age: |
embryonic day 16.0 |
|
| Note: |
Expression was detected in the outer neuroblastic layer. |
| Specimen Label: |
E16 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Satoh T |
| Year: |
2009 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Isolation of a novel leptin receptor gene promoter preferentially functioning in neuronal cells. |
| Volume: |
389 |
| Issue: |
4 |
| Pages: |
673-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bailleul B |
| Year: |
1997 |
| Journal: |
Nucleic Acids Res |
| Title: |
The leptin receptor promoter controls expression of a second distinct protein. |
| Volume: |
25 |
| Issue: |
14 |
| Pages: |
2752-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ahuja N |
| Year: |
2022 |
| Journal: |
Dev Biol |
| Title: |
Endothelial Cyp26b1 restrains murine heart valve growth during development. |
| Volume: |
486 |
|
| Pages: |
81-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP) |
| Year: |
2011 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ingham NJ |
| Year: |
2019 |
| Journal: |
PLoS Biol |
| Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
| Volume: |
17 |
| Issue: |
4 |
| Pages: |
e3000194 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blackshaw S |
| Year: |
2004 |
| Journal: |
PLoS Biol |
| Title: |
Genomic analysis of mouse retinal development. |
| Volume: |
2 |
| Issue: |
9 |
| Pages: |
E247 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dickinson ME |
| Year: |
2016 |
| Journal: |
Nature |
| Title: |
High-throughput discovery of novel developmental phenotypes. |
| Volume: |
537 |
| Issue: |
7621 |
| Pages: |
508-514 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Knockout Mouse Consortium |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
leptin receptor overlapping transcript; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Bernard Bailleul |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain, coisogenic |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
131
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
131
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
131
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
79
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Belgareh-Touzé N |
| Year: |
2002 |
| Journal: |
Mol Biol Cell |
| Title: |
Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking. |
| Volume: |
13 |
| Issue: |
5 |
| Pages: |
1694-708 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang CX |
| Year: |
2016 |
| Journal: |
Gene |
| Title: |
Leptin receptor overlapping transcript (LepROT) gene participates in insulin pathway through FoxO. |
| Volume: |
587 |
| Issue: |
1 |
| Pages: |
64-9 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes Vps55 from budding yeasts and obesity receptor gene-related protein (OB-RGRP or LEPROT) from animals. Both Vps55 and OB-RGRP are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells [].Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase []. The leptin receptor overlapping transcript (LEPROT) is co-transcribed with Leptin receptor (LepR) but without similarity to the LepR. Mammals have a single LEPROT homologue called LEPROT like-1 (LEPROTL1), which is also included in this entry. LepROT plays roles in insulin pathway []. LEPROT and LEPROTL1 have also been shown to influence liver growth hormone signaling in mice []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lancel S |
| Year: |
2018 |
| Journal: |
JCI Insight |
| Title: |
Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity. |
| Volume: |
3 |
| Issue: |
9 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu S |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression. |
| Volume: |
288 |
| Issue: |
38 |
| Pages: |
27375-83 |
|
•
•
•
•
•
|