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Search results 1 to 100 out of 220 for Letm1

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0.042s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Domain
Description: This is a group of mainly eukaryotic proteins are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange [, ]. Some features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site [], are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans [].
Protein
Organism: Mus musculus
Length: 480  
Fragment?: false
Publication
First Author: Endele S
Year: 1999
Journal: Genomics
Title: LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients.
Volume: 60
Issue: 2
Pages: 218-25
Protein
Organism: Mus musculus
Length: 360  
Fragment?: false
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 171  
Fragment?: false
Protein
Organism: Mus musculus
Length: 221  
Fragment?: false
Protein
Organism: Mus musculus
Length: 288  
Fragment?: false
Publication
First Author: Huang E
Year: 2017
Journal: Nat Commun
Title: PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress.
Volume: 8
Issue: 1
Pages: 1399
Protein
Organism: Mus musculus
Length: 738  
Fragment?: false
Publication
First Author: Caggese C
Year: 1999
Journal: Mol Gen Genet
Title: Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database.
Volume: 261
Issue: 1
Pages: 64-70
Publication
First Author: Froschauer E
Year: 2005
Journal: Biochim Biophys Acta
Title: Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins.
Volume: 1711
Issue: 1
Pages: 41-8
Publication  
First Author: Shao J
Year: 2016
Journal: Sci Rep
Title: Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2+/H+ antiporter.
Volume: 6
Pages: 34174
Publication
First Author: Jiang D
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
Volume: 110
Issue: 24
Pages: E2249-54
Publication
First Author: Kuum M
Year: 2012
Journal: J Cell Sci
Title: Endoplasmic reticulum potassium-hydrogen exchanger and small conductance calcium-activated potassium channel activities are essential for ER calcium uptake in neurons and cardiomyocytes.
Volume: 125
Issue: Pt 3
Pages: 625-33
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3527622
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674419
Stage: TS19
Assay Id: MGI:3527623
Age: embryonic day 11.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3527622
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1636715
Stage: TS15
Assay Id: MGI:3527623
Age: embryonic day 9.5
Note: There is no expression present in the urogenital ridge.
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3527622
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Present
Sex: Male
Emaps: EMAPS:1868522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3527623
Age: embryonic day 14.5
Note: Expression is present in the testis cords.
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3527622
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3527623
Age: embryonic day 11.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3527622
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Absent
Sex: Female
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:3527623
Age: embryonic day 14.5
Detected: false
Specimen Num: 5
Publication    
First Author: Osada N
Year: 2000
Journal: GenBank Submission
Title: Mus musculus brain cDNA, clone MNCb-2242, similar to Mus musculus leucine zipper-EF-hand containing transmembrane protein 1 (Letm1) mRNA
Pages: AB041582
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Publication
First Author: Näf D
Year: 2001
Journal: Hum Mol Genet
Title: Mouse models for the Wolf-Hirschhorn deletion syndrome.
Volume: 10
Issue: 2
Pages: 91-8
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication
First Author: Wertz K
Year: 2000
Journal: Mech Dev
Title: Large-scale screen for genes involved in gonad development.
Volume: 98
Issue: 1-2
Pages: 51-70
Publication
First Author: Georgas K
Year: 2009
Journal: Dev Biol
Title: Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Volume: 332
Issue: 2
Pages: 273-86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Da Cruz S
Year: 2003
Journal: J Biol Chem
Title: Proteomic analysis of the mouse liver mitochondrial inner membrane.
Volume: 278
Issue: 42
Pages: 41566-71
Publication
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication
First Author: Bauerschmitt H
Year: 2010
Journal: Mol Biol Cell
Title: Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation.
Volume: 21
Issue: 12
Pages: 1937-44
Publication
First Author: Lupo D
Year: 2011
Journal: Traffic
Title: Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane.
Volume: 12
Issue: 10
Pages: 1457-66
Protein Domain
Type: Domain
Description: Mitochondrial ribosomes synthesise core subunits of the inner membranerespiratory chain complexes. In mitochondria, ribosomes are mainly membraneassociated and translation is tightly coupled to the inner mitochondrialmembrane. Mdm38/Letm1 is a conserved membrane receptor for mitochondrialribosomes and specifically involved in respiratory chain biogenesis.The Letm1 ribosome-binding domain (RBD) is necessary and sufficient forinteraction with mitochondrial ribosomes. It exhibits a predominantly alpha-helical compact fold and contains extended, highly chargedsurface patches. The conserved regions most probably represent interactionsites for ribosomal RNA or protein subunits, or for proteins involved inmitochondrial protein biogenesis [, ].
UniProt Feature
Begin: 1
Description: LETM1 domain-containing protein 1
Type: chain
End: 360
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
UniProt Feature
Begin: 26
Description: LETM1 domain-containing protein LETM2, mitochondrial
Type: chain
End: 480
Protein
Organism: Mus musculus
Length: 196  
Fragment?: false
Publication
First Author: Jiang D
Year: 2009
Journal: Science
Title: Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
Volume: 326
Issue: 5949
Pages: 144-7
Protein
Organism: Mus musculus
Length: 203  
Fragment?: false
Protein
Organism: Mus musculus
Length: 271  
Fragment?: false
Protein
Organism: Mus musculus
Length: 123  
Fragment?: false
Allele      
Name: LETM1 domain containing 1; wild type
ProxyCollection
Publication
First Author: Lim SG
Year: 2020
Journal: J Immunol
Title: LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages.
Volume: 204
Issue: 5
Pages: 1299-1309
Allele  
Name: LETM1 domain containing 1; gene trap OST279538, Lexicon Genetics
Allele Type: Gene trapped
Publication categories: ProxyCollection
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus